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Medical therapy for at least 12\u00a0months with D, D\u2009+\u2009EE or D\u2009+\u2009EV was required. Women were evaluated at baseline visit (V1) and after 6 (V2) and 12\u00a0months (V3) of therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>297 patients were enrolled (156 in the D group, 58 in the D\u2009+\u2009EE group, 83 in the D\u2009+\u2009EV group). Medical treatment leaded to a significant reduction in size of endometriomas after 12\u00a0months, with no differences between the three groups. When comparing D and D\u2009+\u2009EE\/D\u2009+\u2009EV groups, a significant decrease of dysmenorrhea was detected in the D group than in D\u2009+\u2009EE\/D\u2009+\u2009EV group. Conversely, the reduction of dysuria was more significative in the D\u2009+\u2009EE\/D\u2009+\u2009EV groups rather than in the D group. Regarding tolerability, treatment associated side effects were reported by 16.2% patients. The most frequent one was uterine bleeding\/spotting, significantly higher in the D\u2009+\u2009EV group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dienogest alone or associated with estrogens (EE\/EV) seems to be equally effective in reducing endometriotic lesions mean diameter. The reduction of dysmenorrhea was more significative when D was administered alone, while dysuria seems to improve more when D is associated with estrogens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-023-07125-2","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T22:01:41Z","timestamp":1689112901000},"page":"1341-1349","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dienogest alone or dienogest combined with estrogens in the treatment of ovarian endometriomas, that is the question. 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