{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:21:48Z","timestamp":1786980108365,"version":"build-2736575974"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Fund of China","doi-asserted-by":"crossref","award":["82101720"],"award-info":[{"award-number":["82101720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hunan Province Innovation and Entrepreneurship Training Program for College Students","award":["S202210555248"],"award-info":[{"award-number":["S202210555248"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"DOI":"10.1007\/s00404-023-07269-1","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T13:01:58Z","timestamp":1699880518000},"page":"1151-1163","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["GnRH antagonist protocol versus progestin-primed ovarian stimulation in patients with polycystic ovary syndrome: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"309","author":[{"given":"Renhe","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7666-5082","authenticated-orcid":false,"given":"Xiaocan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"7269_CR1","doi-asserted-by":"publisher","first-page":"4650","DOI":"10.1210\/jc.2005-0628","volume":"90","author":"R Azziz","year":"2005","unstructured":"Azziz R, Marin C, Hoq L, Badamgarav E, Song P (2005) Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J Clin Endocrinol Metab 90:4650\u20134658","journal-title":"J Clin Endocrinol Metab"},{"key":"7269_CR2","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/humupd\/dmv029","volume":"21","author":"S Palomba","year":"2015","unstructured":"Palomba S, de Wilde MA, Falbo A, Koster MPH, La Sala GB, Fauser BCJM (2015) Pregnancy complications in women with polycystic ovary syndrome. Hum Reprod Update 21:575\u2013592","journal-title":"Hum Reprod Update"},{"key":"7269_CR3","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/humupd\/3.3.235","volume":"3","author":"IE Messinis","year":"1997","unstructured":"Messinis IE, Milingos SD (1997) Current and future status of ovulation induction in polycystic ovary syndrome. Hum Reprod Update 3:235\u2013253","journal-title":"Hum Reprod Update"},{"key":"7269_CR4","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1210\/er.2018-00052","volume":"39","author":"RC Anderson","year":"2018","unstructured":"Anderson RC, Newton CL, Anderson RA, Millar RP (2018) Gonadotropins and their analogs: current and potential clinical applications. Endocr Rev 39:911\u2013937","journal-title":"Endocr Rev"},{"key":"7269_CR5","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1093\/humupd\/dmr004","volume":"17","author":"HG Al-Inany","year":"2011","unstructured":"Al-Inany HG, Youssef MA, Aboulghar M, Broekmans F, Sterrenburg M, Smit J, Abou-Setta AM (2011) GnRH antagonists are safer than agonists: an update of a Cochrane review. Hum Reprod Update 17:435","journal-title":"Hum Reprod Update"},{"key":"7269_CR6","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/humrep\/del337","volume":"22","author":"A Allegra","year":"2007","unstructured":"Allegra A, Marino A, Coffaro F, Scaglione P, Sammartano F, Rizza G, Volpes A (2007) GnRH antagonist-induced inhibition of the premature LH surge increases pregnancy rates in IUI-stimulated cycles. A prospective randomized trial. Hum Reprod 22:101\u2013108","journal-title":"Hum Reprod"},{"key":"7269_CR7","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1002\/uog.15898","volume":"48","author":"M Kollmann","year":"2016","unstructured":"Kollmann M, Martins WP, Lima MLS, Craciunas L, Nastri CO, Richardson A, Raine-Fenning N (2016) Strategies for improving outcome of assisted reproduction in women with polycystic ovary syndrome: systematic review and meta-analysis. Ultrasound Obstet Gynecol 48:709\u2013718","journal-title":"Ultrasound Obstet Gynecol"},{"key":"7269_CR8","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1093\/humrep\/den107","volume":"23","author":"TG Lainas","year":"2008","unstructured":"Lainas TG, Sfontouris IA, Papanikolaou EG, Zorzovilis JZ, Petsas GK, Lainas GT, Kolibianakis EM (2008) Flexible GnRH antagonist versus flare-up GnRH agonist protocol in poor responders treated by IVF: a randomized controlled trial. Hum Reprod 23:1355\u20131358","journal-title":"Hum Reprod"},{"key":"7269_CR9","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.2147\/DDDT.S201871","volume":"13","author":"Q Chen","year":"2019","unstructured":"Chen Q, Yu F, Li Y, Zhang AJ, Zhu XB (2019) Comparative proteomics reveal negative effects of gonadotropin-releasing hormone agonist and antagonist on human endometrium. Drug Des Dev Ther 13:1855\u20131863","journal-title":"Drug Des Dev Ther"},{"key":"7269_CR10","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1530\/REP-19-0578","volume":"159","author":"Q Chen","year":"2020","unstructured":"Chen Q, Fan Y, Zhou X, Yan Z, Kuang Y, Zhang A, Xu C (2020) GnRH antagonist alters the migration of endometrial epithelial cells by reducing CKB. Reproduction 159:733\u2013743","journal-title":"Reproduction"},{"key":"7269_CR11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12958-021-00787-0","volume":"19","author":"D Zhang","year":"2021","unstructured":"Zhang D, Han M, Zhou M, Liu M, Li Y, Xu B, Zhang A (2021) Down-regulation of S100P induces apoptosis in endometrial epithelial cell during GnRH antagonist protocol. Reprod Biol Endocrinol 19:99","journal-title":"Reprod Biol Endocrinol"},{"key":"7269_CR12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1093\/humupd\/dmaa040","volume":"27","author":"B Ata","year":"2021","unstructured":"Ata B, Capuzzo M, Turkgeldi E, Yildiz S, La Marca A (2021) Progestins for pituitary suppression during ovarian stimulation for ART: a comprehensive and systematic review including meta-analyses. Hum Reprod Update 27:48\u201366","journal-title":"Hum Reprod Update"},{"key":"7269_CR13","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1056\/NEJMoa1513873","volume":"375","author":"ZJ Chen","year":"2016","unstructured":"Chen ZJ et al (2016) Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med 375:523\u2013533","journal-title":"N Engl J Med"},{"key":"7269_CR14","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.2147\/DDDT.S210228","volume":"13","author":"J Huang","year":"2019","unstructured":"Huang J, Xie Q, Lin J, Lu X, Wang N, Gao H, Cai R, Kuang Y (2019) Neonatal outcomes and congenital malformations in children born after dydrogesterone application in progestin-primed ovarian stimulation protocol for IVF: a retrospective cohort study. Drug Des Dev Ther 13:2553\u20132563","journal-title":"Drug Des Dev Ther"},{"key":"7269_CR15","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1046\/j.1538-7836.2003.00264.x","volume":"1","author":"FR Rosendaal","year":"2003","unstructured":"Rosendaal FR, Van Hylckama VA, Tanis BC, Helmerhorst FM (2003) Estrogens, progestogens and thrombosis. J Thromb Haemost 1:1371\u20131380","journal-title":"J Thromb Haemost"},{"key":"7269_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116940","volume":"236","author":"J Wang","year":"2019","unstructured":"Wang J, Wu D, Guo H, Li M (2019) Hyperandrogenemia and insulin resistance: the chief culprit of polycystic ovary syndrome. Life Sci 236:116940","journal-title":"Life Sci"},{"key":"7269_CR17","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1093\/humupd\/dmw025","volume":"22","author":"AH Balen","year":"2016","unstructured":"Balen AH, Morley LC, Misso M, Franks S, Legro RS, Wijeyaratne CN, Stener-Victorin E, Fauser BC, Norman RJ, Teede H (2016) The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update 22:687\u2013708","journal-title":"Hum Reprod Update"},{"issue":"62\u201370","key":"7269_CR18","volume":"104","author":"Y Kuang","year":"2015","unstructured":"Kuang Y, Chen Q, Fu Y, Wang Y, Hong Q, Lyu Q, Ai A, Shoham Z (2015) Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization. Fertil Steril 104(62\u201370):e63","journal-title":"Fertil Steril"},{"key":"7269_CR19","doi-asserted-by":"publisher","first-page":"387","DOI":"10.21037\/atm-20-1592","volume":"9","author":"X Zhu","year":"2021","unstructured":"Zhu X, Ye H, Ye J, Fu Y (2021) Progesterone protocol versus gonadotropin-releasing hormone antagonist protocol in women with polycystic ovarian syndrome undergoing in vitro fertilization treatments with frozen\u2013thawed embryo transfer: a prospective randomized controlled trial. Ann Transl Med 9:387","journal-title":"Ann Transl Med"},{"key":"7269_CR20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13048-020-00620-z","volume":"13","author":"E Mathieu d'Argent","year":"2020","unstructured":"Mathieu d\u2019Argent E, Ferrier C, Zacharopoulou C, Ahdad-Yata N, Boudy AS, Cantalloube A, Levy R, Antoine JM, Darai E, Bendifallah S (2020) Outcomes of fertility preservation in women with endometriosis: comparison of progestin-primed ovarian stimulation versus antagonist protocols. J Ovarian Res 13:18","journal-title":"J Ovarian Res"},{"key":"7269_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.938500","volume":"13","author":"Z Li","year":"2022","unstructured":"Li Z, Jia R, Wang K, Zhang J, Ren B, Guan Y (2022) Analysis of cumulative live birth rate and perinatal outcomes in young patients with low anti-mullerian hormone levels using two ovulation promotion protocols: a cohort study. Front Endocrinol (Lausanne) 13:938500","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7269_CR22","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s11596-019-2055-x","volume":"39","author":"ZN Xiao","year":"2019","unstructured":"Xiao ZN, Peng JL, Yang J, Xu WM (2019) Flexible GnRH antagonist protocol versus progestin-primed ovarian stimulation (PPOS) protocol in patients with polycystic ovary syndrome: comparison of clinical outcomes and ovarian response. Curr Med Sci 39:431\u2013436","journal-title":"Curr Med Sci"},{"key":"7269_CR23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12958-018-0335-0","volume":"16","author":"CY Huang","year":"2018","unstructured":"Huang CY, Chen GY, Shieh ML, Li HY (2018) An extremely patient-friendly and efficient stimulation protocol for assisted reproductive technology in normal and high responders. Reprod Biol Endocrinol 16:18","journal-title":"Reprod Biol Endocrinol"},{"key":"7269_CR24","first-page":"211","volume":"23","author":"N Massin","year":"2017","unstructured":"Massin N (2017) New stimulation regimens: endogenous and exogenous progesterone use to block the LH surge during ovarian stimulation for IVF. Hum Reprod Update 23:211\u2013220","journal-title":"Hum Reprod Update"},{"key":"7269_CR25","first-page":"671","volume":"17","author":"M Eftekhar","year":"2019","unstructured":"Eftekhar M, Hoseini M, Saeed L (2019) Progesterone-primed ovarian stimulation in polycystic ovarian syndrome: an RCT. Int J Reprod Biomed 17:671\u2013676","journal-title":"Int J Reprod Biomed"}],"updated-by":[{"DOI":"10.1007\/s00404-024-07541-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000}}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-023-07269-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-023-07269-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-023-07269-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T02:06:30Z","timestamp":1715652390000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-023-07269-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["7269"],"URL":"https:\/\/doi.org\/10.1007\/s00404-023-07269-1","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,13]]},"assertion":[{"value":"6 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00404-024-07541-y","URL":"https:\/\/doi.org\/10.1007\/s00404-024-07541-y","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}