{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T21:17:26Z","timestamp":1774905446581,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Unidade Local de Sa\u00fade de S\u00e3o Jos\u00e9"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>This study aimed to determine the association of first-trimester maternal serum biomarkers with preterm birth (PTB), fetal growth restriction (FGR) and hypertensive disorders of pregnancy (HDP) in twin pregnancies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This is a retrospective cohort study of twin pregnancies followed at Maternidade Dr. Alfredo da Costa, Lisbon, Portugal, between January 2010 and December 2022. We included women who completed first-trimester screening in our unit and had ongoing pregnancies with two live fetuses, and delivered after 24\u00a0weeks. Maternal characteristics, pregnancy-associated plasma protein-A (PAPP-A) and \u03b2-human chorionic gonadotropin (\u03b2-hCG) levels were analyzed for different outcomes: small for gestational age (SGA), gestational hypertension (GH), early and late-onset pre-eclampsia (PE), as well as the composite outcome of PTB associated with FGR and\/or HDP. Univariable, multivariable logistic regression analyses and receiver-operating characteristic curve were used.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>466 twin pregnancies met the inclusion criteria. Overall, 185 (39.7%) pregnancies were affected by SGA\u2009&lt;\u20095th percentile and\/or HDP. PAPP-A demonstrated a linear association with gestational age at birth and mean birth weight. PAPP-A proved to be an independent risk factor for SGA and PTB (&lt;\u200934 and\u2009&lt;\u200936\u00a0weeks) related to FGR and\/or HDP. None of the women with PAPP-A MoM\u2009&gt;\u200990th percentile developed early-onset PE or PTB\u2009&lt;\u200934\u00a0weeks.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A high serum PAPP-A (&gt;\u200990th percentile) ruled out early-onset PE and PTB\u2009&lt;\u200934\u00a0weeks. Unless other major risk factors for hypertensive disorders are present, these women should not be considered candidates for aspirin prophylaxis. Nevertheless, close monitoring of all TwP for adverse obstetric outcomes is still recommended.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-024-07547-6","type":"journal-article","created":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T15:01:24Z","timestamp":1715526084000},"page":"315-325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes\u2013a single center cohort study"],"prefix":"10.1007","volume":"310","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-1825","authenticated-orcid":false,"given":"Alexandra","family":"Queir\u00f3s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00eas","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1dia","family":"Charepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Plancha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lu\u00edsa","family":"Papoila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresinha","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"key":"7547_CR1","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1097\/GRF.0b013e3182446f51","volume":"55","author":"J Santolaya","year":"2012","unstructured":"Santolaya J (2012) Twins-twice more trouble? 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Both retrospective analyses before 2020 and prospective inclusions after 2020 were approved by the ethical committees, according to institutional policies and national laws.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Verbal informed consent was obtained from all subjects for participation and publication of data collection and obstetric outcomes in this cohort. Written consent was not sought for the present study before 2020 due to its retrospective nature and anonymous data collection. After 2020, written consent was obtained from all subjects for participation and publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and for publication"}}]}}