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Illumination with a 630-nm laser light was applied to the lesions 48\u201372\u00a0h after intravenous injection of 2\u00a0mg\/kg HiPorfin<jats:sup>\u00ae<\/jats:sup>. The light dose to the lesions was 150\u00a0J\/cm<jats:sup>2<\/jats:sup>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean age of the 18 patients was 45.8\u00a0years (range, 24 to 63). The complete response (CR) rate was 66.7% (12\/18), 83.3% (15\/18) and 83.3% (15\/18) at 3, 6 and 12\u00a0months after PDT, respectively. Patients who achieved CR showed no signs of recurrence during long-term follow-up. There were three cases of persistent disease showing partial response (PR) and the lesion area was significantly reduced more than 50%. One patient with persistent disease then underwent thermocoagulation one time and subsequently showed no evidence of HSIL. Pre-treatment, 100% (18\/18) patients were high-risk human papilloma virus (HR-HPV)-positive. HPV eradication rate was 16.7% (3\/18), 22.2% (4\/18) and 44.4% (8\/18) after PDT at 3, 6 and 12 months, respectively. Before treatment, liquid-based cytology test\u2009\u2265\u2009atypical squamous cells of undetermined significance (ASCUS) was 94.4% (17\/18). Negative conversion ratio of cytology was 47.1% (8\/17), 52.9% (9\/17) and 76.5% (13\/17) at 3, 6 and 12\u00a0months, respectively. There were no serious adverse effects during and after PDT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>HiPorfin-PDT may be an effective alternative treatment for vaginal HSIL for organ-saving and sexual function protection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-024-07600-4","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T10:06:18Z","timestamp":1718877978000},"page":"1197-1205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["HiPorfin photodynamic therapy for vaginal high-grade squamous intraepithelial lesion"],"prefix":"10.1007","volume":"310","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9401-2330","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lvfang","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-8790","authenticated-orcid":false,"given":"Lihui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6621-839X","authenticated-orcid":false,"given":"Ruizhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"issue":"3","key":"7600_CR1","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1097\/LGT.0b013e31823da7fb","volume":"16","author":"M Gurumurthy","year":"2012","unstructured":"Gurumurthy M, Cruickshank ME (2012) Management of vaginal intraepithelial neoplasia. 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