{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:04:34Z","timestamp":1788869074848,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Roma La Sapienza"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>This cross-sectional study aims to assess the interplay between the vaginal microbiota and endometriosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>123 consecutive Italian fertile women, aged between 20 and 40\u00a0years old, were enrolled during a routine gynecological consultation; 24 were diagnosed with endometriosis and 99 did not complain of any gynecological disease. All women underwent a vaginal swab for the evaluation of the composition and diversity of vaginal microbiota by means of 16\u00a0s rDNA metagenomic sequencing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Compared to women with no gynecological disease, the vaginal microbiota in women with endometriosis showed a similar abundance of <jats:italic>Lactobacillus<\/jats:italic> spp.; however, a statistically significant lower abundance in the genera Pseudomonas (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), Bifidobacterium (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), Novispirillum (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0000001) and Sphingomonas (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0000001), and a statistically significant increase in the abundance of the genera Escherichia (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001), Megasphaera (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001), and Sneathia (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) were observed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>There is a complex interplay between vaginal microbiota composition and endometriosis, showing a distinct microbial signature in the bacterial genera usually found in dysbiosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-024-07631-x","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T12:01:55Z","timestamp":1723809715000},"page":"2141-2151","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterization of the vaginal microbiota in Italian women with endometriosis: preliminary study"],"prefix":"10.1007","volume":"310","author":[{"given":"Rosa","family":"Sessa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Filardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Federica","family":"Viscardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Brandolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Muzii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Di Pietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-3933","authenticated-orcid":false,"given":"Maria Grazia","family":"Porpora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"7631_CR1","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","volume":"364","author":"LC Giudice","year":"2009","unstructured":"Giudice LC, Kao LC (2009) Endometriosis. 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