{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:57:27Z","timestamp":1792177047865,"version":"4.4.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"DOI":"10.1007\/s00404-024-07678-w","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T06:02:50Z","timestamp":1723183370000},"page":"1365-1376","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Advanced maternal age (AMA) and pregnancy: a feasible but problematic event"],"prefix":"10.1007","volume":"310","author":[{"given":"Radmila","family":"Spari\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Stojkovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana","family":"Ple\u0161inac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pecorella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Malvasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8426-8490","authenticated-orcid":false,"given":"Andrea","family":"Tinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"issue":"1","key":"7678_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jaging.2007.05.009","volume":"22","author":"C Friese","year":"2008","unstructured":"Friese C, Becker G, Nachtigall RD (2008) Older motherhood and the changing life course in the era of assisted reproductive technologies. J Aging Stud 22(1):65\u201373","journal-title":"J Aging Stud"},{"key":"7678_CR2","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3389\/fendo.2019.00094","volume":"10","author":"FM Ubaldi","year":"2019","unstructured":"Ubaldi FM, Cimadomo D, Vaiarelli A et al (2019) Advanced maternal age in IVF: still a challenge? The present and the future of its treatment. Front Endocrinol 10:94","journal-title":"Front Endocrinol"},{"issue":"1","key":"7678_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/humupd\/dmr040","volume":"18","author":"L Schmidt","year":"2012","unstructured":"Schmidt L, Sobotka T, Bentzen JG, on behalf of the ESHRE Reproduction and Society Task Force et al (2012) Demographic and medical consequences of the postponement of parenthood. Hum Reprod Update 18(1):29\u201343","journal-title":"Hum Reprod Update"},{"key":"7678_CR4","doi-asserted-by":"publisher","first-page":"313","DOI":"10.4054\/DemRes.2009.20.14","volume":"20","author":"G Andersson","year":"2009","unstructured":"Andersson G, R\u00f8nsen M, Knudsen LB et al (2009) Cohort fertility patterns in the Nordic countries. Demogr Res 20:313\u2013352","journal-title":"Demogr Res"},{"key":"7678_CR5","doi-asserted-by":"publisher","first-page":"751","DOI":"10.2147\/IJWH.S283216","volume":"13","author":"I Glick","year":"2021","unstructured":"Glick I, Kadish E, Rottenstreich M (2021) Management of pregnancy in women of advanced maternal age: improving outcomes for mother and baby. Int J Womens Health 13:751\u2013759","journal-title":"Int J Womens Health"},{"issue":"2","key":"7678_CR6","first-page":"117","volume":"98","author":"K Traisrisilp","year":"2015","unstructured":"Traisrisilp K, Tongsong T (2015) Pregnancy outcomes of mothers with very advanced maternal age (40 years or more). J Med Assoc Thail Chotmaihet Thangphaet 98(2):117\u2013122","journal-title":"J Med Assoc Thail Chotmaihet Thangphaet"},{"key":"7678_CR7","first-page":"1","volume":"232","author":"TJ Mathews","year":"2016","unstructured":"Mathews TJ (2016) Mean age of mothers is on the rise: United States, 2000\u20132014. NCHS Data Brief 232:1\u20138","journal-title":"NCHS Data Brief"},{"key":"7678_CR8","unstructured":"NCHS Pressroom\u20142002 news release\u2014mean age of mother. Published May 24, 2019. https:\/\/www.cdc.gov\/nchs\/pressroom\/02news\/ameriwomen.htm. Accessed March 10, 2024"},{"issue":"1","key":"7678_CR9","first-page":"1","volume":"72","author":"MJK Osterman","year":"2023","unstructured":"Osterman MJK, Hamilton BE, Martin JA et al (2023) Births: final data for 2021. Natl Vital Stat Rep 72(1):1\u201353","journal-title":"Natl Vital Stat Rep"},{"key":"7678_CR10","doi-asserted-by":"publisher","DOI":"10.15620\/cdc:122080","volume-title":"Fertility of men and women aged 15\u201349 in the United States: National survey of family growth, 2015\u20132019","author":"G Martinez","year":"2023","unstructured":"Martinez G, Daniels K (2023) Fertility of men and women aged 15\u201349 in the United States: National survey of family growth, 2015\u20132019. National Center for Health Statistics (U.S.), Maryland"},{"issue":"1","key":"7678_CR11","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1186\/s12889-024-17810-9","volume":"24","author":"C Zhu","year":"2024","unstructured":"Zhu C, Zhang S, Shen L et al (2024) Changes in the characteristics and outcomes of high-risk pregnant women who delivered prior to and after China\u2019s universal two-child policy: a real-world retrospective study, 2010\u20132021. BMC Public Health 24(1):336","journal-title":"BMC Public Health"},{"issue":"3","key":"7678_CR12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1080\/19485565.2014.1001887","volume":"61","author":"A Goisis","year":"2015","unstructured":"Goisis A (2015) How are children of older mothers doing? Evidence from the United Kingdom. Biodemography Soc Biol 61(3):231\u2013251","journal-title":"Biodemography Soc Biol"},{"issue":"10","key":"7678_CR13","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00129-017-4124-1","volume":"50","author":"M Myrskyl\u00e4","year":"2017","unstructured":"Myrskyl\u00e4 M, Barclay K, Goisis A (2017) Advantages of later motherhood. Gynakologe 50(10):767\u2013772","journal-title":"Gynakologe"},{"issue":"2","key":"7678_CR14","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.tem.2007.01.004","volume":"18","author":"FJ Broekmans","year":"2007","unstructured":"Broekmans FJ, Knauff EAH, Te Velde ER et al (2007) Female reproductive ageing: current knowledge and future trends. Trends Endocrinol Metab 18(2):58\u201365","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"7678_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41580-022-00517-3","volume":"24","author":"C Charalambous","year":"2023","unstructured":"Charalambous C, Webster A, Schuh M (2023) Aneuploidy in mammalian oocytes and the impact of maternal ageing. Nat Rev Mol Cell Biol 24(1):27\u201344","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"7678_CR16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/humupd\/dmi006","volume":"11","author":"ESHRE Capri Workshop Group","year":"2005","unstructured":"ESHRE Capri Workshop Group (2005) Fertility and ageing. Hum Reprod Update 11(3):261\u2013276","journal-title":"Hum Reprod Update"},{"key":"7678_CR17","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.1038\/s41467-020-17764-7","volume":"11","author":"MN Shahbazi","year":"2020","unstructured":"Shahbazi MN, Wang T, Tao X et al (2020) Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun 11:3987","journal-title":"Nat Commun"},{"key":"7678_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.892753","volume":"13","author":"N Ranisavljevic","year":"2022","unstructured":"Ranisavljevic N, Huberlant S, Montagut M et al (2022) Low luteal serum progesterone levels are associated with lower ongoing pregnancy and live birth rates in ART: systematic review and meta-analyses. Front Endocrinol 13:892753","journal-title":"Front Endocrinol"},{"issue":"5","key":"7678_CR19","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1055\/s-2007-984740","volume":"25","author":"J Hall","year":"2007","unstructured":"Hall J (2007) Neuroendocrine changes with reproductive aging in women. Semin Reprod Med 25(5):344\u2013351","journal-title":"Semin Reprod Med"},{"issue":"8","key":"7678_CR20","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S2213-8587(18)30026-3","volume":"6","author":"AW van den Beld","year":"2018","unstructured":"van den Beld AW, Kaufman JM, Zillikens MC et al (2018) The physiology of endocrine systems with ageing. Lancet Diabetes Endocrinol 6(8):647\u2013658","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"4","key":"7678_CR21","first-page":"268","volume":"6","author":"G Furau","year":"2011","unstructured":"Furau G, Dascau V, Furau C et al (2011) Gynecological cancer age groups at the \u201cDr. Salvator Vuia\u201d clinical obstetrics and gynecology hospital during the 2000\u20132009 period. M\u00e6dica 6(4):268\u2013271","journal-title":"M\u00e6dica"},{"issue":"10","key":"7678_CR22","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1200\/JOP.2017.023705","volume":"13","author":"N Pereira","year":"2017","unstructured":"Pereira N, Schattman GL (2017) Fertility Preservation and sexual health after cancer therapy. J Oncol Pract 13(10):643\u2013651","journal-title":"J Oncol Pract"},{"issue":"18","key":"7678_CR23","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.2174\/1381612826666200316160145","volume":"26","author":"M Pargianas","year":"2020","unstructured":"Pargianas M, Salta S, Apostolopoulou K et al (2020) Pathways involved in premature ovarian failure: a systematic review of experimental studies. Curr Pharm Des 26(18):2087\u20132095","journal-title":"Curr Pharm Des"},{"issue":"1","key":"7678_CR24","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3390\/ijms25010322","volume":"25","author":"A Tinelli","year":"2024","unstructured":"Tinelli A, Andji\u0107 M, Morciano A et al (2024) Uterine aging and reproduction: dealing with a puzzle biologic topic. Int J Mol Sci 25(1):322","journal-title":"Int J Mol Sci"},{"issue":"4","key":"7678_CR25","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.3390\/ijms24043767","volume":"24","author":"A Malvasi","year":"2023","unstructured":"Malvasi A, Cicinelli E, Baldini GM et al (2023) Prolonged dystocic labor in neuraxial analgesia and the role of enkephalin neurotransmitters: an experimental study. Int J Mol Sci 24(4):3767","journal-title":"Int J Mol Sci"},{"issue":"5","key":"7678_CR26","doi-asserted-by":"publisher","first-page":"440","DOI":"10.2174\/1389203720666190717115744","volume":"21","author":"A Tinelli","year":"2020","unstructured":"Tinelli A, Vergara D, Ma Y et al (2020) Dystocia, uterine healing and uterine innervation: an unexplored intersection. Curr Protein Pept Sci 21(5):440\u2013442","journal-title":"Curr Protein Pept Sci"},{"issue":"1","key":"7678_CR27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/humupd\/dms043","volume":"19","author":"SM Nelson","year":"2013","unstructured":"Nelson SM, Telfer EE, Anderson RA (2013) The ageing ovary and uterus: new biological insights. Hum Reprod Update 19(1):67\u201383","journal-title":"Hum Reprod Update"},{"key":"7678_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101879","volume":"86","author":"Y Wu","year":"2023","unstructured":"Wu Y, Li M, Zhang J et al (2023) Unveiling uterine aging: much more to learn. Ageing Res Rev 86:101879","journal-title":"Ageing Res Rev"},{"issue":"4","key":"7678_CR29","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1007\/s00404-023-07135-0","volume":"308","author":"A Tinelli","year":"2023","unstructured":"Tinelli A, Kosmas I, Medvediev MV et al (2023) Myomectomy in adult women of reproductive age: a propensity score-matched study for pregnancy rates. Arch Gynecol Obstet 308(4):1351\u20131360","journal-title":"Arch Gynecol Obstet"},{"issue":"8","key":"7678_CR30","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1007\/s43032-021-00656-6","volume":"29","author":"LM Coutinho","year":"2022","unstructured":"Coutinho LM, Assis WA, Spagnuolo-Souza A et al (2022) Uterine fibroids and pregnancy: how do they affect each other? Reprod Sci 29(8):2145\u20132151","journal-title":"Reprod Sci"},{"issue":"1","key":"7678_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1021\/acschemneuro.3c00531","volume":"15","author":"R Tenchov","year":"2024","unstructured":"Tenchov R, Sasso JM, Wang X et al (2024) Aging hallmarks and progression and age-related diseases: a landscape view of research advancement. ACS Chem Neurosci 15(1):1\u201330","journal-title":"ACS Chem Neurosci"},{"issue":"1","key":"7678_CR32","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/s12889-023-15235-4","volume":"23","author":"C Huang","year":"2023","unstructured":"Huang C, Jiang Q, Su W et al (2023) Age-specific effects on adverse pregnancy outcomes vary by maternal characteristics: a population-based retrospective study in Xiamen, China. BMC Public Health 23(1):326","journal-title":"BMC Public Health"},{"key":"7678_CR33","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.bpobgyn.2020.07.005","volume":"70","author":"AP Frick","year":"2021","unstructured":"Frick AP (2021) Advanced maternal age and adverse pregnancy outcomes. Best Pract Res Clin Obstet Gynaecol 70:92\u2013100","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"13","key":"7678_CR34","first-page":"2158","volume":"13","author":"LY Huang","year":"2023","unstructured":"Huang LY, Liu CH, Chen FY et al (2023) Aging affects insulin resistance, insulin secretion, and glucose effectiveness in subjects with normal blood glucose and body weight. Diagn Basel Switz 13(13):2158","journal-title":"Diagn Basel Switz"},{"issue":"7","key":"7678_CR35","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.2337\/db05-1692","volume":"55","author":"R Basu","year":"2006","unstructured":"Basu R, Dalla Man C, Campioni M et al (2006) Effects of age and sex on postprandial glucose metabolism: differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction. Diabetes 55(7):2001\u20132014","journal-title":"Diabetes"},{"issue":"1","key":"7678_CR36","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1186\/s12884-018-1984-x","volume":"18","author":"B Kahveci","year":"2018","unstructured":"Kahveci B, Melekoglu R, Evruke IC et al (2018) The effect of advanced maternal age on perinatal outcomes in nulliparous singleton pregnancies. BMC Pregnancy Childbirth 18(1):343","journal-title":"BMC Pregnancy Childbirth"},{"issue":"12","key":"7678_CR37","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.3889\/oamjms.2019.587","volume":"7","author":"M Rado\u0144-Pokracka","year":"2019","unstructured":"Rado\u0144-Pokracka M, Adrianowicz B, P\u0142onka M et al (2019) Evaluation of pregnancy outcomes at advanced maternal age. Open Access Maced J Med Sci 7(12):1951\u20131956","journal-title":"Open Access Maced J Med Sci"},{"issue":"2","key":"7678_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056583","volume":"8","author":"LC Kenny","year":"2013","unstructured":"Kenny LC, Lavender T, McNamee R et al (2013) Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort. PLoS ONE 8(2):e56583","journal-title":"PLoS ONE"},{"issue":"11","key":"7678_CR39","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1007\/s10995-016-2055-4","volume":"20","author":"M Lavecchia","year":"2016","unstructured":"Lavecchia M, Sabbah M, Abenhaim HA (2016) Effect of planned mode of delivery in women with advanced maternal age. Matern Child Health J 20(11):2318\u20132327","journal-title":"Matern Child Health J"},{"issue":"9","key":"7678_CR40","first-page":"844","volume":"19","author":"A Moini","year":"2014","unstructured":"Moini A, Hosseini R, Jahangiri N et al (2014) Risk factors for ectopic pregnancy: a case\u2013control study. J Res Med Sci 19(9):844\u2013849","journal-title":"J Res Med Sci"},{"key":"7678_CR41","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.ejogrb.2018.10.054","volume":"231","author":"IS San Lazaro Campillo","year":"2018","unstructured":"San Lazaro Campillo IS, Meaney S, O\u2019Donoghue K et al (2018) Ectopic pregnancy hospitalisations: a national population-based study of rates, management and outcomes. Eur J Obstet Gynecol Reprod Biol 231:174\u2013179","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"5","key":"7678_CR42","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1111\/aogs.14064","volume":"100","author":"D Rademaker","year":"2021","unstructured":"Rademaker D, Hukkelhoven CWPM, van Pampus MG (2021) Adverse maternal and perinatal pregnancy outcomes related to very advanced maternal age in primigravida and multigravida in the Netherlands: a population-based cohort. Acta Obstet Gynecol Scand 100(5):941\u2013948","journal-title":"Acta Obstet Gynecol Scand"},{"key":"7678_CR43","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bpobgyn.2020.06.006","volume":"70","author":"E Attali","year":"2021","unstructured":"Attali E, Yogev Y (2021) The impact of advanced maternal age on pregnancy outcome. Best Pract Res Clin Obstet Gynaecol 70:2\u20139","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"10","key":"7678_CR44","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1007\/s43032-020-00207-5","volume":"27","author":"M Bustan-Nahumson","year":"2020","unstructured":"Bustan-Nahumson M, Bornstein S, Feldstein O et al (2020) Preeclampsia in different maternal age groups\u2014is there an association with pregnancy outcomes and placental pathology? Reprod Sci 27(10):1879\u20131887","journal-title":"Reprod Sci"},{"issue":"5","key":"7678_CR45","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/01.ogx.0000430381.52864.c3","volume":"68","author":"SK Gill","year":"2013","unstructured":"Gill SK, Broussard C, Devine O et al (2013) Association between maternal age and birth defects of unknown etiology\u2014United States, 1997\u20132007. Obstet Gynecol Surv 68(5):346\u2013347","journal-title":"Obstet Gynecol Surv"},{"issue":"6","key":"7678_CR46","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/s00404-014-3367-5","volume":"290","author":"L Ciancimino","year":"2014","unstructured":"Ciancimino L, Lagan\u00e0 AS, Chiofalo B et al (2014) Would it be too late? A retrospective case\u2013control analysis to evaluate maternal\u2013fetal outcomes in advanced maternal age. Arch Gynecol Obstet 290(6):1109\u20131114","journal-title":"Arch Gynecol Obstet"},{"issue":"10","key":"7678_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186287","volume":"12","author":"SC Lean","year":"2017","unstructured":"Lean SC, Derricott H, Jones RL et al (2017) Advanced maternal age and adverse pregnancy outcomes: a systematic review and meta-analysis. PLoS ONE 12(10):e0186287","journal-title":"PLoS ONE"},{"issue":"1","key":"7678_CR48","doi-asserted-by":"publisher","first-page":"153","DOI":"10.21106\/ijma.346","volume":"9","author":"D Dongarwar","year":"2020","unstructured":"Dongarwar D, Aggarwal A, Barning K et al (2020) Stillbirths among advanced maternal age women in the United States: 2003\u20132017. Int J Matern Child Health AIDS 9(1):153\u2013156","journal-title":"Int J Matern Child Health AIDS"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-024-07678-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-024-07678-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-024-07678-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T02:07:59Z","timestamp":1725242879000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-024-07678-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["7678"],"URL":"https:\/\/doi.org\/10.1007\/s00404-024-07678-w","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]},"assertion":[{"value":"22 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}