{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:56:22Z","timestamp":1777424182555,"version":"3.51.4"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality, affecting 2\u20138% of all pregnancies. Typically, the increased glomerular filtration rate of pregnancy results in a decrease in serum creatinine. It is unknown if women without the expected decrease in serum creatinine during pregnancy are more likely to be diagnosed with preeclampsia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>We sought to determine if the absence of a pregnancy-related decrease in serum creatinine was associated with the development of preeclampsia in patients deemed to be at high risk for developing preeclampsia. We hypothesized that the absence of the expected decrease in serum creatinine may be a marker of impaired renal function and therefore may be associated with increased risk of preeclampsia in this cohort.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Study design<\/jats:title>\n                <jats:p>We conducted a retrospective cohort study of deliveries between November 2, 2017 and June 30, 2020 at a single institution. Pregnancies were included if a baseline serum creatinine (measured between one year prior to conception through 6\u00a0weeks gestation), and another serum creatinine value prior to 20\u00a0weeks of gestation were measured. Decrease in serum creatinine was defined as any decrease (at least 0.01\u00a0mg\/dL) from baseline. The primary outcome was diagnosis of preeclampsia. Exclusion criteria included fetal anomalies, fetal demise, multiple gestation, or delivery prior to 20\u00a0weeks. Bivariable analyses were performed using Chi-square, ANOVA, and Student\u2019s t test. Logistic regression was used to determine odds of developing preeclampsia controlling for confounders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We identified 392 pregnancies that met inclusion criteria. Preeclampsia was diagnosed in 56 (14.3%) pregnancies. Patients diagnosed with preeclampsia were more likely to have a history of preeclampsia in a prior pregnancy, chronic hypertension (HTN), and diabetes. They were also more likely to have aspirin prescribed in the current pregnancy. Prevalence of advanced maternal age, multiparity, obesity, smoking, history of autoimmune disease, history of CKD, gestational HTN, or multiple pregnancy were not significantly different between patients with and without a diagnosis of preeclampsia. After controlling for confounders, a decrease in serum creatinine from baseline was not significantly associated with a diagnosis of preeclampsia (OR 0.76, CI 0.32\u20131.78).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>After controlling for risk factors associated with preeclampsia, a decrease in serum creatinine from baseline was not significantly associated with a diagnosis of preeclampsia in this high-risk cohort.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00404-024-07685-x","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T03:16:43Z","timestamp":1723778203000},"page":"1975-1980","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between pregnancy-related changes in serum creatinine and preeclampsia diagnosis"],"prefix":"10.1007","volume":"310","author":[{"given":"Lynsa M.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelby A.","family":"Crants","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christin M.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa C.","family":"Zuckerwise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Grace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"issue":"1","key":"7685_CR1","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1097\/AOG.0000000000002708","volume":"132","author":"ACOG Committee Opinion No","year":"2018","unstructured":"ACOG Committee Opinion No (2018) 743: Low-dose aspirin use during pregnancy. Obstet Gynecol 132(1):e44\u2013e52. https:\/\/doi.org\/10.1097\/AOG.0000000000002708. (PMID: 29939940)","journal-title":"Obstet Gynecol"},{"key":"7685_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12802","author":"LC Poon","year":"2019","unstructured":"Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, McAuliffe F, da Silva Costa F, von Dadelszen P, McIntyre HD, Kihara AB, Di Renzo GC, Romero R, D\u2019Alton M, Berghella V, Nicolaides KH, Hod M (2019) The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention. Int J Gynaecol Obstet. https:\/\/doi.org\/10.1002\/ijgo.12802. (Erratum in: Int J Gynaecol Obstet. 2019 Sep;146(3):390-391. PMID: 31111484; PMCID: PMC6944283)","journal-title":"Int J Gynaecol Obstet"},{"issue":"3","key":"7685_CR3","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1053\/j.ackd.2013.01.012.PMID:23928384;PMCID:PMC4089195","volume":"20","author":"KL Cheung","year":"2013","unstructured":"Cheung KL, Lafayette RA (2013) Renal physiology of pregnancy. Adv Chronic Kidney Dis 20(3):209\u2013214. https:\/\/doi.org\/10.1053\/j.ackd.2013.01.012.PMID:23928384;PMCID:PMC4089195","journal-title":"Adv Chronic Kidney Dis"},{"key":"7685_CR4","first-page":"141","volume-title":"Creasy & Resnik\u2019s Maternal-Fetal Medicine Principles and Practice","author":"R Resnik","year":"2019","unstructured":"Resnik R, Lockwood CJ, Copel JA et al (2019) Maternal Cardiovascular, Respiratory, and Renal Adaptation to Pregnancy. Creasy & Resnik\u2019s Maternal-Fetal Medicine Principles and Practice, 8th edn. Elsevier, Philadelphia, PA, pp 141\u2013147","edition":"8"},{"issue":"2","key":"7685_CR5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1053\/j.ajkd.2020.02.437","volume":"76","author":"Z Harel","year":"2020","unstructured":"Harel Z, Park AL, Ray JG (2020) Blunted glomerular hyperfiltration in pregnancy and risk of adverse perinatal outcomes. Am J Kidney Dis 76(2):297\u2013299. https:\/\/doi.org\/10.1053\/j.ajkd.2020.02.437. (Epub 2020 May 5 PMID: 32387024)","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"7685_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/AOG.0000000000003018","volume":"133","author":"ACOG Practice Bulletin No","year":"2019","unstructured":"ACOG Practice Bulletin No (2019) 202: Gestational hypertension and preeclampsia. Obstet Gynecol 133(1):1. https:\/\/doi.org\/10.1097\/AOG.0000000000003018. (PMID: 30575675)","journal-title":"Obstet Gynecol"},{"key":"7685_CR7","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00404-023-07284-2","volume":"310","author":"J Ren","year":"2023","unstructured":"Ren J, Zhao C, Fan Z, Wang Y, Sheng H, Hua S (2023) The interval between the onset of increased blood pressure and proteinuria in preeclampsia and the contributing factors. Arch Gynecol Obstet 310:757\u2013767. https:\/\/doi.org\/10.1007\/s00404-023-07284-2","journal-title":"Arch Gynecol Obstet"},{"key":"7685_CR8","volume-title":"Trends in maternal mortality 2000 to 2017: estimates by WHO, UNICEF, UNFPA","author":"World Health Organization","year":"2019","unstructured":"World Health Organization (2019) Trends in maternal mortality 2000 to 2017: estimates by WHO, UNICEF, UNFPA. World Health Organization, World Bank Group and the United Nations Population Division"},{"issue":"2","key":"7685_CR9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1001\/jama.2018.17948","volume":"321","author":"Z Harel","year":"2019","unstructured":"Harel Z, McArthur E, Hladunewich M et al (2019) Serum creatinine levels before, during, and after pregnancy. JAMA 321(2):205\u2013207. https:\/\/doi.org\/10.1001\/jama.2018.17948","journal-title":"JAMA"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-024-07685-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-024-07685-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-024-07685-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T08:27:16Z","timestamp":1726129636000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-024-07685-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["7685"],"URL":"https:\/\/doi.org\/10.1007\/s00404-024-07685-x","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,16]]},"assertion":[{"value":"15 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}