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The subjects were randomized (1:1) to receive synbiotic supplementation (Synbiotic Group) or placebo (Placebo Group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Subjects in the Placebo Group and the Synbiotic Group experienced significant reduction of BMI (\u2212\u00a08% and \u2212\u00a011%, respectively; both at\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and body fat percentage (\u2212\u00a011% and \u2212\u00a014%, respectively; both at\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). These effects were statistically comparable for both groups. Total testosterone was not significantly changed in the Placebo Group (\u2212\u00a05%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.41) while it greatly declined in the Synbiotic Group (\u2212\u00a040%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001); the difference between these groups was significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0002). Synbiotic supplementation was superior to placebo in reducing LH (\u2212\u00a021%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.047), total cholesterol (\u2212\u00a06%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002), low-density lipoprotein cholesterol (\u2212\u00a06%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.044), triglycerides (\u2212\u00a029%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.049), LPS (\u2212\u00a023%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) and LPS-binding protein (\u2212\u00a021%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Synbiotic supplementation led to a marked improvement of several key clinical and laboratory aspects of PCOS including an improvement of hyperandrogenism, lipid profile, and markers of endotoxemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Clinical Trial Registration Number: NCT03325023 (URL, clinicaltrials.gov; date of registration 10\/26\/2017).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-024-07833-3","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T07:00:30Z","timestamp":1733382030000},"page":"499-506","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Six-month randomized, placebo controlled trial of synbiotic supplementation in women with polycystic ovary syndrome undergoing lifestyle modifications"],"prefix":"10.1007","volume":"311","clinical-trial-number":[{"clinical-trial-number":"nct03325023","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Izabela","family":"Chudzicka-Struga\u0142a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kubiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Banaszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wysocka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Zwozdziak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyna","family":"Siakowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leszek","family":"Pawelczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1419-6502","authenticated-orcid":false,"given":"Antoni J.","family":"Duleba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"7833_CR1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00404-020-05951-2","volume":"303","author":"S Abraham Gnanadass","year":"2021","unstructured":"Abraham Gnanadass S, Divakar Prabhu Y, Valsala Gopalakrishnan A (2021) Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update. 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