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We aimed to examine the role of maternal and fetal polymorphisms in risk of HDP and severe-spectrum disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Cases of HDP (143) and controls (169) from mother-baby dyads were recruited at the Los Angeles County Women\u2019s and Children\u2019s Hospital (WCH). Cases of severe disease (99) and controls (31) from mother-father-baby triads were recruited through HELLP syndrome websites. Four sFLT-1 SNPs (rs7993594, rs3751395, rs7983774, and rs664393) were genotyped. Data was analyzed using a log-linear regression model in the Haplin package in R.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Maternal double dose of the A allele (rs7993594) exhibited a nominally significant increased risk of HDP (RR\u2009=\u20093.52, 95% CI 1.08, 11.20). In the severe-spectrum cohort, a marginally significant protective effect among mothers carrying infants with a single dose of the A allele (rs7993594) was observed (RR\u2009=\u20090.59, 95% CI 0.36, 0.98) and double-dose maternal carriage of the G-t-G-G haplotype increased risk of severe disease (RR\u2009=\u20094.13, 95% CI 1.22, 13.80).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The maternal rs7993594 A allele appears to be associated with increased risk of HDP. Double-dose maternal carriage of the G-t-G-G haplotype increased risk of severe disease whereas the fetal rs7983774 A allele appears to be associated with decreased risk.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00404-024-07917-0","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T16:42:18Z","timestamp":1736786538000},"page":"609-619","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Soluble Fms-like tyrosine kinase-1 polymorphisms associated with severe-spectrum hypertensive disorders of pregnancy"],"prefix":"10.1007","volume":"311","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0820-8859","authenticated-orcid":false,"given":"Tracy","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8888-1476","authenticated-orcid":false,"given":"Claire E.","family":"Baldauf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2477-2846","authenticated-orcid":false,"given":"Kevin S.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9181-8745","authenticated-orcid":false,"given":"Sue Ann","family":"Ingles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-641X","authenticated-orcid":false,"given":"Trevor A.","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-4221","authenticated-orcid":false,"given":"Melissa L.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"issue":"9","key":"7917_CR1","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1161\/01.RES.0000147365.86159.f5","volume":"95","author":"S Ahmad","year":"2004","unstructured":"Ahmad S, Ahmed A (2004) Elevated Placental Soluble Vascular Endothelial Growth Factor Receptor-1 Inhibits Angiogenesis in Preeclampsia. 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