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Patients were categorized into three groups based on gestational age (GA) at PPROM (&lt;\u200924, 24 to 28, 28 to 32 weeks). Latency to delivery, obstetric outcomes and neonatal survival were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\u00a086 women who had PPROM before 32\u00a0weeks were identified. The mean GA at PPROM was 26.1\u00a0weeks and the median latency to delivery was 16\u00a0days (IQR 4, 27). The median latency to delivery was 22\u00a0days for previable PPROM, 11\u00a0days for PPROM between 24 and 28\u00a0weeks, and 16\u00a0days for PPROM between 28 and 32\u00a0weeks (p\u2009=\u20090.29). All cases of placental abruption (7\/86, 8%) and cord prolapse (6\/86, 7%) occurred in women with PPROM before 28\u00a0weeks.\u00a0In 44% of PPROM, placental histology demonstrated chorionamnionitis. Neonatal survival at discharge was significantly lower in previable PPROM (&lt;\u200924\u00a0weeks) compared to PPROM at 24\u201326\u00a0weeks (58% vs 92%, p\u2009=\u20090.04), and it reached 100% in cases of PPROM after 28\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In PPROM occurring before 32\u00a0weeks the median latency to delivery ranged between 11 and 22\u00a0days. Neonatal survival improves with higher GA at PPROM, and it increases by more than 33% when PPROM occurs after 24\u00a0weeks of gestation. These data may be valuable for patient counselling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-025-07970-3","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T01:10:55Z","timestamp":1739149855000},"page":"1569-1577","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Latency to delivery and incidence of adverse obstetric and perinatal outcomes in preterm premature rupture of membranes before 32\u00a0weeks"],"prefix":"10.1007","volume":"311","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-3925","authenticated-orcid":false,"given":"Viola","family":"Seravalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Colucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Di Cencio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Morucchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Barsanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Di Tommaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"issue":"1","key":"7970_CR1","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1016\/S2214-109X(18)30451-0","volume":"7","author":"S Chawanpaiboon","year":"2019","unstructured":"Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, Landoulsi S, Jampathong N, Kongwattanakul K, Laopaiboon M, Lewis C, Rattanakanokchai S, Teng DN, Thinkhamrop J, Watananirun K, Zhang J, Zhou W, G\u00fclmezoglu AM (2019) Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. 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Approval was granted by the Ethics Committee of Careggi University Hospital (study ID 23388).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Given the retrospective nature of the study, the ethics committee, complying with our Institution\u2019s research guidelines for clinical observational and retrospective studies, waived the requirement for informed consent when it was impracticable to contact the patient to obtain the consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}