{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:59:17Z","timestamp":1762329557374,"version":"build-2065373602"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the residual risk of long-term adverse neurodevelopmental outcomes in monochorionic twins following co-twin fetal demise and normal fetal brain imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All monochorionic twin pregnancies with co-twin fetal demise were included. Patients were identified through a search of inpatient medical records for co-twin fetal demise. Cases involving fetal demise following intrauterine procedures (e.g., laser ablation or termination of pregnancy following findings on fetal brain imaging) were excluded. Following co-twin demise, fetal brain imaging, including serial neurosonogram and fetal brain MRI, was performed on the surviving fetus. Neurodevelopmental outcomes were assessed postnatally using standardized age-appropriate developmental evaluation of personal\u2013social, language, gross and fine motor skills, as well as hearing and vision screening. Additionally, parents completed a phone-based adaptive behavior questionnaire using the Vineland-II Adaptive Behavior Scales (VABS-II).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen patients met the inclusion criteria. Two patients underwent urgent cesarean delivery due to fetal distress following co-twin demise and did not undergo any imaging. Of the 17 patients who underwent fetal brain imaging, 2 had evidence of CNS injury, one of whom later presented with mild speech delay, and the other who achieved an adequate VABS-II\u00a0score. Among the fetuses with normal brain imaging and available follow-up, 45.4% (5\/11) had abnormal developmental evaluations including one global delay, one motor delay, one mild hypotonia, and two moderately low scores on VABS-II.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Normal fetal CNS imaging following co-twin fetal demise in monochorionic twins does not guarantee normal neurodevelopmental outcome. This residual risk should be clearly discussed with parents during counseling to aid clinical decision- making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-025-08149-6","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T14:57:10Z","timestamp":1755874630000},"page":"1591-1597","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does normal fetal brain imaging in monochorionic twins following co-twin fetal demise eliminate the risk of adverse neurodevelopmental outcome?"],"prefix":"10.1007","volume":"312","author":[{"given":"Daphna","family":"Amitai Komem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tally","family":"Pinchas Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shir","family":"Nov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Weissbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Rabinovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Furman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagai","family":"Avnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boaz","family":"Weisz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Yinon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"issue":"5","key":"8149_CR1","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/1471-0528.15530","volume":"126","author":"FL Mackie","year":"2019","unstructured":"Mackie FL et al (2019) Prognosis of the co-twin following spontaneous single intrauterine fetal death in twin pregnancies: a systematic review and meta-analysis. 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