{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:26:41Z","timestamp":1792873601564,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Natural Science Foundation of Beijing Municipality,China\u5317\u4eac\u5e02\u81ea\u7136\u79d1\u5b66\u57fa\u91d1","award":["7222206"],"award-info":[{"award-number":["7222206"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"DOI":"10.1007\/s00404-025-08164-7","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T03:19:37Z","timestamp":1756955977000},"page":"1727-1735","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes and prognostic factors in patients with synchronous endometrial and ovarian cancer"],"prefix":"10.1007","volume":"312","author":[{"given":"Xiaofei","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"8164_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1291602","author":"W Gan","year":"2023","unstructured":"Gan W, Bian C (2023) The research progress on synchronous endometrial and ovarian carcinoma. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2023.1291602","journal-title":"Front Oncol"},{"issue":"1","key":"8164_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ejogrb.2006.09.010","volume":"136","author":"S-Y Tong","year":"2008","unstructured":"Tong S-Y, Lee Y-S, Park J-S, Bae S-N, Lee J-M, Namkoong S-E (2008) Clinical analysis of synchronous primary neoplasms of the female reproductive tract. Eur J Obstet Gynecol Reprod Biol 136(1):78\u201382. https:\/\/doi.org\/10.1016\/j.ejogrb.2006.09.010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"8164_CR3","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1006\/gyno.2001.6400","volume":"83","author":"R Zaino","year":"2001","unstructured":"Zaino R, Whitney C, Brady MF, DeGeest K, Burger RA, Buller RE (2001) Simultaneously detected endometrial and ovarian carcinomas\u2014a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol 83(2):355\u2013362. https:\/\/doi.org\/10.1006\/gyno.2001.6400","journal-title":"Gynecol Oncol"},{"issue":"1","key":"8164_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1525-1438.2007.00975.x","volume":"18","author":"YC Chiang","year":"2008","unstructured":"Chiang YC, Chen CA, Huang CY, Hsieh CY, Cheng WF (2008) Synchronous primary cancers of the endometrium and ovary. Int J Gynecol Cancer 18(1):159\u2013164. https:\/\/doi.org\/10.1111\/j.1525-1438.2007.00975.x","journal-title":"Int J Gynecol Cancer"},{"issue":"4","key":"8164_CR5","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1097\/AOG.0b013e31819c7bdf","volume":"113","author":"MG Williams","year":"2009","unstructured":"Williams MG, Bandera EV, Demissie K, Rodr\u00edguez-Rodr\u00edguez L (2009) Synchronous primary ovarian and endometrial cancers: a population-based assessment of survival. Obstet Gynecol 113(4):783\u2013789. https:\/\/doi.org\/10.1097\/AOG.0b013e31819c7bdf","journal-title":"Obstet Gynecol"},{"issue":"1","key":"8164_CR6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ygyno.2011.12.444","volume":"125","author":"MM AlHilli","year":"2012","unstructured":"AlHilli MM, Dowdy SC, Weaver AL, St. Sauver JL, Keeney GL, Mariani A et al (2012) Incidence and factors associated with synchronous ovarian and endometrial cancer: a population-based case-control study. Gynecol Oncol 125(1):109\u2013113. https:\/\/doi.org\/10.1016\/j.ygyno.2011.12.444","journal-title":"Gynecol Oncol"},{"key":"8164_CR7","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2023.34.e6","author":"I Sakamoto","year":"2023","unstructured":"Sakamoto I, Hirotsu Y, Amemiya K, Nozaki T, Mochizuki H, Omata M (2023) Elucidation of genomic origin of synchronous endometrial and ovarian cancer (SEO) by genomic and microsatellite analysis. J Gynecol Oncol. https:\/\/doi.org\/10.3802\/jgo.2023.34.e6","journal-title":"J Gynecol Oncol"},{"issue":"3","key":"8164_CR8","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.ygyno.2013.09.009","volume":"131","author":"T Song","year":"2013","unstructured":"Song T, Seong SJ, Bae D-S, Suh DH, Kim D-Y, Lee K-H et al (2013) Synchronous primary cancers of the endometrium and ovary in young women: a Korean Gynecologic Oncology Group study. Gynecol Oncol 131(3):624\u2013628. https:\/\/doi.org\/10.1016\/j.ygyno.2013.09.009","journal-title":"Gynecol Oncol"},{"issue":"2","key":"8164_CR9","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.ygyno.2004.05.006","volume":"94","author":"PT Soliman","year":"2004","unstructured":"Soliman PT, Slomovitz BM, Broaddus RR, Sun CC, Oh JC, Eifel PJ et al (2004) Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases. Gynecol Oncol 94(2):456\u2013462. https:\/\/doi.org\/10.1016\/j.ygyno.2004.05.006","journal-title":"Gynecol Oncol"},{"issue":"5","key":"8164_CR10","doi-asserted-by":"publisher","first-page":"508","DOI":"10.5301\/tj.5000378","volume":"102","author":"U Solmaz","year":"2015","unstructured":"Solmaz U, Karatasli V, Mat E, Dereli L, Hasdemir PS, Ekin A et al (2015) Synchronous primary endometrial and ovarian cancers: a multicenter review of 63 cases. Tumori J 102(5):508\u2013513. https:\/\/doi.org\/10.5301\/tj.5000378","journal-title":"Tumori J"},{"key":"8164_CR11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9163","author":"N Khalid","year":"2020","unstructured":"Khalid N, Ullah F, Zafar H, Anwer AW, Abbas T, Shakeel O et al (2020) Synchronous primary endometrial and ovarian cancers: trends and outcomes of the rare disease at a South Asian Tertiary Care Cancer Center. Cureus. https:\/\/doi.org\/10.7759\/cureus.9163","journal-title":"Cureus"},{"issue":"5","key":"8164_CR12","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s10552-017-0855-5","volume":"28","author":"LE Kelemen","year":"2017","unstructured":"Kelemen LE, Rambau PF, Koziak JM, Steed H, K\u00f6bel M (2017) Synchronous endometrial and ovarian carcinomas: predictors of risk and associations with survival and tumor expression profiles. Cancer Causes Control 28(5):447\u2013457. https:\/\/doi.org\/10.1007\/s10552-017-0855-5","journal-title":"Cancer Causes Control"},{"issue":"181","key":"8164_CR13","doi-asserted-by":"publisher","first-page":"366","DOI":"10.24976\/Discov.Med.202436181.34","volume":"36","author":"N Vatansever","year":"2024","unstructured":"Vatansever N, Y\u0131lmaz S, Bilir F, Chkhikvadze M, Cicekli N, Celik F et al (2024) The role of lymphovascular space invasion and cytology in the prognosis of endometrial cancer. Discov Med 36(181):366. https:\/\/doi.org\/10.24976\/Discov.Med.202436181.34","journal-title":"Discov Med"},{"issue":"2","key":"8164_CR14","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/his.15272","volume":"86","author":"EEM Peters","year":"2024","unstructured":"Peters EEM, Nucci MR, Gilks CB, McCluggage WG, Bosse T (2024) Practical guidance for assessing and reporting lymphovascular space invasion (LVSI) in endometrial carcinoma. Histopathology 86(2):173\u2013182. https:\/\/doi.org\/10.1111\/his.15272","journal-title":"Histopathology"},{"issue":"5","key":"8164_CR15","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/s1470-2045(20)30178-9","volume":"21","author":"RT Penson","year":"2020","unstructured":"Penson RT (2020) Platinum-sensitive ovarian cancer: liminal advances. Lancet Oncol 21(5):614\u2013615. https:\/\/doi.org\/10.1016\/s1470-2045(20)30178-9","journal-title":"Lancet Oncol"},{"issue":"2","key":"8164_CR16","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.ygyno.2007.05.039","volume":"107","author":"M Thomas","year":"2007","unstructured":"Thomas M, Mariani A, Cliby W, Keeney G, Podratz K, Dowdy S (2007) Role of cytoreduction in stage III and IV uterine papillary serous carcinoma. Gynecol Oncol 107(2):190\u2013193. https:\/\/doi.org\/10.1016\/j.ygyno.2007.05.039","journal-title":"Gynecol Oncol"},{"issue":"4","key":"8164_CR17","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2015.26.4.336","volume":"26","author":"S-J Chang","year":"2015","unstructured":"Chang S-J, Bristow RE, Chi DS, Cliby WA (2015) Role of aggressive surgical cytoreduction in advanced ovarian cancer. J Gynecol Oncol 26(4):336. https:\/\/doi.org\/10.3802\/jgo.2015.26.4.336","journal-title":"J Gynecol Oncol"},{"issue":"5","key":"8164_CR18","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s00404-014-3364-8","volume":"290","author":"F Zeppernick","year":"2014","unstructured":"Zeppernick F, Meinhold-Heerlein I (2014) The new FIGO staging system for ovarian, fallopian tube, and primary peritoneal cancer. Arch Gynecol Obstet 290(5):839\u2013842. https:\/\/doi.org\/10.1007\/s00404-014-3364-8","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"8164_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijgo.2013.10.001","volume":"124","author":"J Prat","year":"2013","unstructured":"Prat J (2013) Staging classification for cancer of the ovary, fallopian tube, and peritoneum. Int J Gynaecol Obstet 124(1):1\u20135. https:\/\/doi.org\/10.1016\/j.ijgo.2013.10.001","journal-title":"Int J Gynaecol Obstet"},{"issue":"2","key":"8164_CR20","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ijgo.2009.02.012","volume":"105","author":"S Pecorelli","year":"2009","unstructured":"Pecorelli S (2009) Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 105(2):103\u2013104. https:\/\/doi.org\/10.1016\/j.ijgo.2009.02.012","journal-title":"Int J Gynaecol Obstet"},{"issue":"2","key":"8164_CR21","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/ijgo.14923","volume":"162","author":"JS Berek","year":"2023","unstructured":"Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S et al (2023) FIGO staging of endometrial cancer: 2023. Int J Gynaecol Obstet 162(2):383\u2013394. https:\/\/doi.org\/10.1002\/ijgo.14923","journal-title":"Int J Gynaecol Obstet"},{"issue":"4 Suppl","key":"8164_CR22","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1002\/cncr.2820710409","volume":"71","author":"JJ Mikuta","year":"1993","unstructured":"Mikuta JJ (1993) International Federation of Gynecology and Obstetrics staging of endometrial cancer 1988. Cancer 71(4 Suppl):1460\u20131463. https:\/\/doi.org\/10.1002\/cncr.2820710409","journal-title":"Cancer"},{"issue":"47","key":"8164_CR23","doi-asserted-by":"publisher","first-page":"28757","DOI":"10.18632\/oncotarget.25550","volume":"9","author":"K Matsuo","year":"2018","unstructured":"Matsuo K, Machida H, Blake EA, Holman LL, Rimel BJ, Roman LD et al (2018) Trends and outcomes of women with synchronous endometrial and ovarian cancer. Oncotarget 9(47):28757\u201328771. https:\/\/doi.org\/10.18632\/oncotarget.25550","journal-title":"Oncotarget"},{"key":"8164_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08220-w","author":"W Shin","year":"2021","unstructured":"Shin W, Park S-Y, Kang S, Lim MC, Seo S-S (2021) How to manage synchronous endometrial and ovarian cancer patients? BMC Cancer. https:\/\/doi.org\/10.1186\/s12885-021-08220-w","journal-title":"BMC Cancer"},{"issue":"11","key":"8164_CR25","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1158\/1055-9965.epi-22-0587","volume":"31","author":"RL Dood","year":"2022","unstructured":"Dood RL, Pappas LM, Collin LJ, Vranes C, Trabert B, Doherty JA (2022) Mortality patterns of synchronous uterine and ovarian cancers: a SEER registry analysis. Cancer Epidemiol Biomarkers Prev 31(11):2038\u20132045. https:\/\/doi.org\/10.1158\/1055-9965.epi-22-0587","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"8164_CR26","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00404-008-0800-7","volume":"279","author":"T Gungor","year":"2008","unstructured":"Gungor T, Kanat-Pektas M, Ustunyurt E, Mollamahmutoglu L (2008) Synchronous primary tumors of the female genital tract: a single center experience. Arch Gynecol Obstet 279(5):667\u2013672. https:\/\/doi.org\/10.1007\/s00404-008-0800-7","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"8164_CR27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.gocm.2023.01.011","volume":"3","author":"J Tabata","year":"2023","unstructured":"Tabata J, Takenaka M, Okamoto A (2023) Molecular typing guiding treatment and prognosis of endometrial cancer. Gynecol Obstet Clin Med 3(1):7\u201317. https:\/\/doi.org\/10.1016\/j.gocm.2023.01.011","journal-title":"Gynecol Obstet Clin Med"},{"key":"8164_CR28","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20240534","author":"F Kazanci","year":"2024","unstructured":"Kazanci F, \u00c7elik ZY, Polat M, Karademir F, Erdem O, \u015eahin F\u0130 et al (2024) Homologous recombination deficiency gene panel analysis results in synchronous endometrial and ovarian cancers. Rev Assoc Med Bras. https:\/\/doi.org\/10.1590\/1806-9282.20240534","journal-title":"Rev Assoc Med Bras"},{"issue":"2","key":"8164_CR29","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/ijc.32907","volume":"147","author":"C Reijnen","year":"2020","unstructured":"Reijnen C, K\u00fcsters-Vandevelde HVN, Ligtenberg MJL, Bulten J, Oosterwegel M, Snijders MPLM et al (2020) Molecular profiling identifies synchronous endometrial and ovarian cancers as metastatic endometrial cancer with favorable clinical outcome. Int J Cancer 147(2):478\u2013489. https:\/\/doi.org\/10.1002\/ijc.32907","journal-title":"Int J Cancer"},{"issue":"4","key":"8164_CR30","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2011.22.4.239","volume":"22","author":"YK Lim","year":"2011","unstructured":"Lim YK, Padma R, Foo L, Chia YN, Yam P, Chia J et al (2011) Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study. J Gynecol Oncol 22(4):239. https:\/\/doi.org\/10.3802\/jgo.2011.22.4.239","journal-title":"J Gynecol Oncol"},{"issue":"9","key":"8164_CR31","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.prp.2008.02.001","volume":"204","author":"A Caldarella","year":"2008","unstructured":"Caldarella A, Crocetti E, Taddei GL, Paci E (2008) Coexisting endometrial and ovarian carcinomas: a retrospective clinicopathological study. Pathol Res Pract 204(9):643\u2013648. https:\/\/doi.org\/10.1016\/j.prp.2008.02.001","journal-title":"Pathol Res Pract"},{"issue":"1","key":"8164_CR32","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3892\/ol.2012.943","volume":"5","author":"Y Liu","year":"2013","unstructured":"Liu Y, Li JUN, Jin H, Lu Y, Lu XIN (2013) Clinicopathological characteristics of patients with synchronous primary endometrial and ovarian cancers: a review of 43 cases. Oncol Lett 5(1):267\u2013270. https:\/\/doi.org\/10.3892\/ol.2012.943","journal-title":"Oncol Lett"},{"key":"8164_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2023.100731","volume":"36","author":"N Hoorshad","year":"2023","unstructured":"Hoorshad N, Nassiri S, Najibi S, Feizabad E, Zamani N (2023) Synchronous endometrial and ovarian cancer and its recurrent risk factors: case series. Cancer Treat Res Commun 36:100731. https:\/\/doi.org\/10.1016\/j.ctarc.2023.100731","journal-title":"Cancer Treat Res Commun"},{"issue":"1","key":"8164_CR34","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.ygyno.2016.07.114","volume":"143","author":"A Chao","year":"2016","unstructured":"Chao A, Wu R-C, Jung S-M, Lee Y-S, Chen S-J, Lu Y-L et al (2016) Implication of genomic characterization in synchronous endometrial and ovarian cancers of endometrioid histology. Gynecol Oncol 143(1):60\u201367. https:\/\/doi.org\/10.1016\/j.ygyno.2016.07.114","journal-title":"Gynecol Oncol"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-025-08164-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-025-08164-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-025-08164-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:29:33Z","timestamp":1762327773000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-025-08164-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["8164"],"URL":"https:\/\/doi.org\/10.1007\/s00404-025-08164-7","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]},"assertion":[{"value":"14 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki Approval was granted by the Ethics Committee of Peking University People\u2019s Hospital Ethics Committee(approval no. 2025PHB223-001).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"This study is a retrospective study and informed consent had been waived by Ethics Committee of Peking University People\u2019s Hospital.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}