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Neuropathic pain has been increasingly recognized as a significant component in a subset of patients with CPP related to endometriosis. The study objective was to assess the prevalence of neuropathic-like pain in women with deep endometriosis (DE) and CPP, and to analyze its influence on pain perception and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective monocentric cohort study included 149 women with DE and CPP treated at a tertiary pain center between 2013 and 2017. Pain characteristics were assessed using validated tools, including the DN4 questionnaire for neuropathic pain, the abridged Saint-Antoine Pain Questionnaire (QDSA) for sensory and emotional dimensions of pain, and the EQ-VAS for quality of life. Psychological factors, including anxiety, depression, and catastrophizing, were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Neuropathic-like pain was identified in 36% of patients. These patients reported significantly higher global and minimum pain intensity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), greater emotional (QDSA affective subscore,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and sensory (QDSA sensory subscore,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) pain impact, and higher catastrophizing scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Quality of life was notably impaired (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Neuropathic-like pain was not associated with the stage of endometriosis or surgical complexity. Anxiety and depression scores did not differ significantly between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.47 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.52, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neuropathic-like pain was retrieved in over one-third of patients with DE and CPP, contributing to greater pain intensity, emotional distress, and reduced quality of life. Systematic screening for neuropathic-like pain and tailored multidisciplinary care are essential to optimize pain management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-025-08178-1","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T12:19:48Z","timestamp":1757506788000},"page":"1789-1797","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neuropathic-like pain affects pain perception in patients with deep endometriosis: an observational study"],"prefix":"10.1007","volume":"312","author":[{"given":"Carolina","family":"Dolci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Jean dit Gautier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Lannez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Lebuffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Michel","family":"Wattier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystele","family":"Rubod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"issue":"13","key":"8178_CR1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1056\/NEJMra1810764","volume":"382","author":"KT Zondervan","year":"2020","unstructured":"Zondervan KT, Becker CM, Missmer SA (2020) Endometriosis. 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Dolci, E Jean dit Gautier, L Lannez, JM Wattier, G Lebuffe report no conflict of interest. C. Rubod led training courses with Olympus and Nordicpharma.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}