{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T21:10:36Z","timestamp":1794085836078,"version":"4.8.0"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005187","name":"University of Athens","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005187","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The ability of antioxidant therapy to mitigate oxidative stress (OS)-induced sperm function impairment makes it a popular treatment for male infertility. Reductive stress (RS), a condition characterized by an overcompensation in redox balance that favors reduction over oxidation, may be brought on by excessive or extended antioxidant use, according to mounting evidence. The purpose of this review is to examine the processes by which an excess of antioxidants causes RS and to evaluate any potential negative impacts on men's reproductive health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive overview of recent clinical and experimental studies focused on the effects of excessive antioxidant use on redox biology, mitochondrial function, spermatogenesis, and sperm quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RS has been shown to affect sperm growth and function, interfere with cellular signaling, and damage mitochondrial integrity. Antioxidants are commonly employed, although there are currently no clear clinical guidelines or biomarkers for diagnosis to monitor redox equilibrium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In male infertility treatments based on antioxidants, RS poses a paradoxical risk. A personalized, balanced approach to antioxidant therapy is essential, alongside the development of biomarkers and standardized protocols to ensure redox homeostasis and avoid potential harm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-025-08184-3","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T03:43:15Z","timestamp":1758080595000},"page":"1503-1514","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Reductive stress and the role of antioxidants in male infertility: a narrative review"],"prefix":"10.1007","volume":"312","author":[{"given":"Efthalia","family":"Moustakli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Christopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7716-1521","authenticated-orcid":false,"given":"Anastasios","family":"Potiris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Zikopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkis","family":"Matsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Arkoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despoina","family":"Mavrogianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Drakaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Zachariou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Drakakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofoklis","family":"Stavros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"8184_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","volume":"13","author":"A Agarwal","year":"2015","unstructured":"Agarwal A, Mulgund A, Hamada A, Chyatte MR (2015) A unique view on male infertility around the globe. Reprod Biol Endocrinol 13:37","journal-title":"Reprod Biol Endocrinol"},{"key":"8184_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60061008","author":"H Pavuluri","year":"2024","unstructured":"Pavuluri H, Bakhtiary Z, Panner Selvam MK, Hellstrom WJG (2024) Oxidative stress-associated male infertility: current diagnostic and therapeutic approaches. Medicina (Kaunas). https:\/\/doi.org\/10.3390\/medicina60061008","journal-title":"Medicina (Kaunas)"},{"key":"8184_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810167","author":"S Stavros","year":"2024","unstructured":"Stavros S, Potiris A, Molopodi E, Mavrogianni D, Zikopoulos A, Louis K et al (2024) Sperm DNA fragmentation: unraveling its imperative impact on male infertility based on recent evidence. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms251810167","journal-title":"Int J Mol Sci"},{"key":"8184_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1520835","volume":"16","author":"Y Wang","year":"2025","unstructured":"Wang Y, Fu X, Li H (2025) Mechanisms of oxidative stress-induced sperm dysfunction. Front Endocrinol (Lausanne) 16:1520835","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"8184_CR5","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","volume":"97","author":"K Jomova","year":"2023","unstructured":"Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K et al (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch Toxicol 97(10):2499\u20132574","journal-title":"Arch Toxicol"},{"key":"8184_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12111937","author":"M Lahimer","year":"2023","unstructured":"Lahimer M, Gherissi O, Ben Salem N, Ben Mustapha H, Bach V, Khorsi-Cauet H et al (2023) Effect of micronutrients and L-carnitine as antioxidant on sperm parameters, genome integrity, and ICSI outcomes: randomized, double-blind, and placebo-controlled clinical trial. Antioxidants. https:\/\/doi.org\/10.3390\/antiox12111937","journal-title":"Antioxidants"},{"key":"8184_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.810242","volume":"13","author":"KP Li","year":"2022","unstructured":"Li KP, Yang XS, Wu T (2022) The effect of antioxidants on sperm quality parameters and pregnancy rates for idiopathic male infertility: a network meta-analysis of randomized controlled trials. Front Endocrinol (Lausanne) 13:810242","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"8184_CR8","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3390\/antiox14060656","volume":"14","author":"F Bellanti","year":"2025","unstructured":"Bellanti F, Coda ARD, Trecca MI, Lo Buglio A, Serviddio G, Vendemiale G (2025) Redox imbalance in inflammation: the interplay of oxidative and reductive stress. Antioxidants 14(6):656","journal-title":"Antioxidants"},{"key":"8184_CR9","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.freeradbiomed.2025.03.029","volume":"233","author":"J Mercola","year":"2025","unstructured":"Mercola J (2025) Reductive stress and mitochondrial dysfunction: The hidden link in chronic disease. Free Radic Biol Med 233:118\u2013131","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"8184_CR10","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12958-024-01252-4","volume":"22","author":"M Vahedi Raad","year":"2024","unstructured":"Vahedi Raad M, Firouzabadi AM, Tofighi Niaki M, Henkel R, Fesahat F (2024) The impact of mitochondrial impairments on sperm function and male fertility: a systematic review. Reprod Biol Endocrinol 22(1):83","journal-title":"Reprod Biol Endocrinol"},{"key":"8184_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11113014","author":"E Moustakli","year":"2023","unstructured":"Moustakli E, Zikopoulos A, Skentou C, Bouba I, Tsirka G, Stavros S et al (2023) Sperm mitochondrial content and mitochondrial DNA to nuclear DNA ratio are associated with body mass index and progressive motility. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines11113014","journal-title":"Biomedicines"},{"key":"8184_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010167","author":"S Dutta","year":"2022","unstructured":"Dutta S, Sengupta P, Roychoudhury S, Chakravarthi S, Wang CW, Slama P (2022) Antioxidant paradox in male infertility: \u201ca blind eye\u201d on inflammation. Antioxidants (Basel). https:\/\/doi.org\/10.3390\/antiox11010167","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"8184_CR13","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/acel.12528","volume":"16","author":"D Desjardins","year":"2017","unstructured":"Desjardins D, Cacho-Valadez B, Liu JL, Wang Y, Yee C, Bernard K et al (2017) Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell 16(1):104\u2013112","journal-title":"Aging Cell"},{"key":"8184_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1503905","volume":"15","author":"R Saleh","year":"2024","unstructured":"Saleh R, Sallam H, Elsuity MA, Dutta S, Sengupta P, Nasr A (2024) Antioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects. Front Endocrinol (Lausanne) 15:1503905","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"8184_CR15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3390\/metabo15060379","volume":"15","author":"E Moustakli","year":"2025","unstructured":"Moustakli E, Zikopoulos A, Katopodis P, Dafopoulos S, Paraschos VS, Zachariou A et al (2025) Dietary and lifestyle interventions to mitigate oxidative stress in male and female fertility: practical insights for infertility management\u2014a narrative review. Metabolites 15(6):379","journal-title":"Metabolites"},{"issue":"1","key":"8184_CR16","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.xfnr.2021.12.001","volume":"3","author":"E Caroppo","year":"2022","unstructured":"Caroppo E, Dattilo M (2022) Sperm redox biology challenges the role of antioxidants as a treatment for male factor infertility. F&S Reviews 3(1):90\u2013104","journal-title":"F&S Reviews"},{"issue":"4","key":"8184_CR17","doi-asserted-by":"publisher","DOI":"10.1111\/apha.14017","volume":"238","author":"NV Margaritelis","year":"2023","unstructured":"Margaritelis NV, Nastos GG, Vasileiadou O, Chatzinikolaou PN, Theodorou AA, Paschalis V et al (2023) Inter-individual variability in redox and performance responses after antioxidant supplementation: a randomized double blind crossover study. Acta Physiol (Oxf) 238(4):e14017","journal-title":"Acta Physiol (Oxf)"},{"key":"8184_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15040267","author":"A Potiris","year":"2025","unstructured":"Potiris A, Moustakli E, Trismpioti E, Drakaki E, Mavrogianni D, Matsas A et al (2025) From inflammation to infertility: how oxidative stress and infections disrupt male reproductive health. Metabolites. https:\/\/doi.org\/10.3390\/metabo15040267","journal-title":"Metabolites"},{"key":"8184_CR19","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.freeradbiomed.2020.03.008","volume":"152","author":"MK Panner Selvam","year":"2020","unstructured":"Panner Selvam MK, Agarwal A, Henkel R, Finelli R, Robert KA, Iovine C et al (2020) The effect of oxidative and reductive stress on semen parameters and functions of physiologically normal human spermatozoa. Free Radic Biol Med 152:375\u2013385","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"8184_CR20","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","volume":"9","author":"Y Zong","year":"2024","unstructured":"Zong Y, Li H, Liao P, Chen L, Pan Y, Zheng Y et al (2024) Mitochondrial dysfunction: mechanisms and advances in therapy. Signal Transduct Target Ther 9(1):124","journal-title":"Signal Transduct Target Ther"},{"key":"8184_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25189845","author":"C Boutin","year":"2024","unstructured":"Boutin C, Clement C, Rivoal J (2024) Post-translational modifications to cysteine residues in plant proteins and their impact on the regulation of metabolism and signal transduction. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25189845","journal-title":"Int J Mol Sci"},{"key":"8184_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9020134","author":"K Nowicka-Bauer","year":"2020","unstructured":"Nowicka-Bauer K, Nixon B (2020) Molecular changes induced by oxidative stress that impair human sperm motility. Antioxidants (Basel). https:\/\/doi.org\/10.3390\/antiox9020134","journal-title":"Antioxidants (Basel)"},{"key":"8184_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020146","author":"V Cammisotto","year":"2021","unstructured":"Cammisotto V, Nocella C, Bartimoccia S, Sanguigni V, Francomano D, Sciarretta S et al (2021) The role of antioxidants supplementation in clinical practice: focus on cardiovascular risk factors. Antioxidants. https:\/\/doi.org\/10.3390\/antiox10020146","journal-title":"Antioxidants"},{"key":"8184_CR24","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.freeradbiomed.2020.06.029","volume":"158","author":"NV Margaritelis","year":"2020","unstructured":"Margaritelis NV, Paschalis V, Theodorou AA, Kyparos A, Nikolaidis MG (2020) Antioxidant supplementation, redox deficiencies and exercise performance: a falsification design. Free Radic Biol Med 158:44\u201352","journal-title":"Free Radic Biol Med"},{"key":"8184_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/biom15040478","author":"C Antinozzi","year":"2025","unstructured":"Antinozzi C, Di Luigi L, Sireno L, Caporossi D, Dimauro I, Sgro P (2025) Protective role of physical activity and antioxidant systems during spermatogenesis. Biomolecules. https:\/\/doi.org\/10.3390\/biom15040478","journal-title":"Biomolecules"},{"key":"8184_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111802","author":"E Moustakli","year":"2024","unstructured":"Moustakli E, Zikopoulos A, Skentou C, Katopodis P, Domali E, Potiris A et al (2024) Impact of reductive stress on human infertility: underlying mechanisms and perspectives. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms252111802","journal-title":"Int J Mol Sci"},{"issue":"9","key":"8184_CR27","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41580-024-00730-2","volume":"25","author":"H Sies","year":"2024","unstructured":"Sies H, Mailloux RJ, Jakob U (2024) Fundamentals of redox regulation in biology. Nat Rev Mol Cell Biol 25(9):701\u2013719","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"8184_CR28","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12964-023-01080-w","volume":"21","author":"A Mostek-Majewska","year":"2023","unstructured":"Mostek-Majewska A, Majewska A, Janta A, Ciereszko A (2023) New insights into posttranslational modifications of proteins during bull sperm capacitation. Cell Commun Signal 21(1):72","journal-title":"Cell Commun Signal"},{"issue":"21","key":"8184_CR29","first-page":"2003","volume":"8","author":"C Guo","year":"2013","unstructured":"Guo C, Sun L, Chen X, Zhang D (2013) Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res 8(21):2003\u20132014","journal-title":"Neural Regen Res"},{"key":"8184_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030337","author":"R Gualtieri","year":"2021","unstructured":"Gualtieri R, Kalthur G, Barbato V, Di Nardo M, Adiga SK, Talevi R (2021) Mitochondrial dysfunction and oxidative stress caused by cryopreservation in reproductive cells. Antioxidants (Basel). https:\/\/doi.org\/10.3390\/antiox10030337","journal-title":"Antioxidants (Basel)"},{"key":"8184_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/biom15040500","author":"M Maroto","year":"2025","unstructured":"Maroto M, Torvisco SN, Garcia-Merino C, Fernandez-Gonzalez R, Pericuesta E (2025) Mechanisms of hormonal, genetic, and temperature regulation of germ cell proliferation, differentiation, and death during spermatogenesis. Biomolecules. https:\/\/doi.org\/10.3390\/biom15040500","journal-title":"Biomolecules"},{"key":"8184_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/cells14070509","author":"MK Singh","year":"2025","unstructured":"Singh MK, Han S, Ju S, Ranbhise JS, Ha J, Yeo SG et al (2025) Hsp70: a multifunctional chaperone in maintaining proteostasis and its implications in human disease. Cells. https:\/\/doi.org\/10.3390\/cells14070509","journal-title":"Cells"},{"issue":"8","key":"8184_CR33","doi-asserted-by":"publisher","first-page":"17193","DOI":"10.3390\/ijms160817193","volume":"16","author":"JF Diaz-Villanueva","year":"2015","unstructured":"Diaz-Villanueva JF, Diaz-Molina R, Garcia-Gonzalez V (2015) Protein folding and mechanisms of proteostasis. Int J Mol Sci 16(8):17193\u201317230","journal-title":"Int J Mol Sci"},{"key":"8184_CR34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/978-3-030-37972-8_9","volume-title":"Genetics of Male Infertility: A Case-Based Guide for Clinicians","author":"MK Panner Selvam","year":"2020","unstructured":"Panner Selvam MK, Sengupta P, Agarwal A (2020) Sperm DNA Fragmentation and Male Infertility. In: Arafa M, Elbardisi H, Majzoub A, Agarwal A (eds) Genetics of Male Infertility: A Case-Based Guide for Clinicians. Springer International Publishing, Cham, pp 155\u2013172"},{"key":"8184_CR35","doi-asserted-by":"publisher","first-page":"1107215","DOI":"10.3389\/frph.2023.1107215","volume":"5","author":"E Moustakli","year":"2023","unstructured":"Moustakli E, Zikopoulos A, Sakaloglou P, Bouba I, Sofikitis N, Georgiou I (2023) Functional association between telomeres, oxidation and mitochondria. Front Reprod Health 5:1107215","journal-title":"Front Reprod Health"},{"issue":"2","key":"8184_CR36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.5534\/wjmh.2017.35.2.77","volume":"35","author":"A Agarwal","year":"2017","unstructured":"Agarwal A, Majzoub A (2017) Role of antioxidants in assisted reproductive techniques. World J Mens Health 35(2):77\u201393","journal-title":"World J Mens Health"},{"issue":"5","key":"8184_CR37","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1007\/s00204-025-03997-2","volume":"99","author":"I Gulcin","year":"2025","unstructured":"Gulcin I (2025) Antioxidants: a comprehensive review. Arch Toxicol 99(5):1893\u20131997","journal-title":"Arch Toxicol"},{"issue":"3","key":"8184_CR38","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.fertnstert.2019.11.008","volume":"113","author":"AZ Steiner","year":"2020","unstructured":"Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP et al (2020) The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertil Steril 113(3):552-560 e3","journal-title":"Fertil Steril"},{"issue":"2","key":"8184_CR39","doi-asserted-by":"publisher","first-page":"233","DOI":"10.5534\/wjmh.200196","volume":"39","author":"A Agarwal","year":"2021","unstructured":"Agarwal A, Leisegang K, Majzoub A, Henkel R, Finelli R, Panner Selvam MK et al (2021) Utility of antioxidants in the treatment of male infertility: clinical guidelines based on a systematic review and analysis of evidence. World J Mens Health 39(2):233\u2013290","journal-title":"World J Mens Health"},{"key":"8184_CR40","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/407978","volume":"2012","author":"MG Nikolaidis","year":"2012","unstructured":"Nikolaidis MG, Kerksick CM, Lamprecht M, McAnulty SR (2012) Redox biology of exercise. Oxid Med Cell Longev 2012:407978","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"8184_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14010017","volume":"14","author":"YJ Shen","year":"2024","unstructured":"Shen YJ, Huang YC, Cheng YC (2024) Advancements in antioxidant-based therapeutics for spinal cord injury: a critical review of strategies and combination approaches. Antioxidants 14(1):17","journal-title":"Antioxidants"},{"issue":"3","key":"8184_CR42","doi-asserted-by":"publisher","first-page":"470","DOI":"10.5534\/wjmh.210025","volume":"39","author":"A Agarwal","year":"2021","unstructured":"Agarwal A, Finelli R, Selvam MKP, Leisegang K, Majzoub A, Tadros N et al (2021) A global survey of reproductive specialists to determine the clinical utility of oxidative stress testing and antioxidant use in male infertility. World J Mens Health 39(3):470\u2013488","journal-title":"World J Mens Health"},{"key":"8184_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/nu17020324","author":"M Lahimer","year":"2025","unstructured":"Lahimer M, Capelle S, Lefranc E, Bosquet D, Kazdar N, Ledu A et al (2025) Micronutrient-antioxidant therapy and male fertility improvement during ART cycles. Nutrients. https:\/\/doi.org\/10.3390\/nu17020324","journal-title":"Nutrients"},{"key":"8184_CR44","doi-asserted-by":"publisher","DOI":"10.2147\/NDS.S112119","author":"TC Rodick","year":"2018","unstructured":"Rodick TC, Seibels DR, Babu JR, Huggins KW, Ren G, Mathews ST (2018) Potential role of coenzyme Q10 in health and disease conditions. Nutr Diet Suppl. https:\/\/doi.org\/10.2147\/NDS.S112119","journal-title":"Nutr Diet Suppl"},{"issue":"18","key":"8184_CR45","doi-asserted-by":"publisher","first-page":"5796","DOI":"10.3390\/jcm12185796","volume":"12","author":"FG Mateus","year":"2023","unstructured":"Mateus FG, Moreira S, Martins AD, Oliveira PF, Alves MG, Pereira ML (2023) L-Carnitine and male fertility: Is supplementation beneficial? J Clin Med 12(18):5796","journal-title":"J Clin Med"},{"key":"8184_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060967","author":"M Tenorio","year":"2021","unstructured":"Tenorio M, Graciliano NG, Moura FA, Oliveira ACM, Goulart MOF (2021) N-acetylcysteine (NAC): impacts on human health. Antioxidants. https:\/\/doi.org\/10.3390\/antiox10060967","journal-title":"Antioxidants"},{"issue":"6","key":"8184_CR47","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.3390\/ijms25063264","volume":"25","author":"A Muscolo","year":"2024","unstructured":"Muscolo A, Mariateresa O, Giulio T, Mariateresa R (2024) Oxidative stress: the role of antioxidant phytochemicals in the prevention and treatment of diseases. Int J Mol Sci 25(6):3268","journal-title":"Int J Mol Sci"},{"issue":"18","key":"8184_CR48","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1080\/14786419.2018.1543686","volume":"34","author":"M Piscopo","year":"2020","unstructured":"Piscopo M, Tenore GC, Notariale R, Maresca V, Maisto M, de Ruberto F et al (2020) Antimicrobial and antioxidant activity of proteins from Feijoa sellowiana Berg. fruit before and after in vitro gastrointestinal digestion. Nat Prod Res 34(18):2607\u20132611","journal-title":"Nat Prod Res"},{"key":"8184_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.806470","volume":"13","author":"M Rudrapal","year":"2022","unstructured":"Rudrapal M, Khairnar SJ, Khan J, Dukhyil AB, Ansari MA, Alomary MN et al (2022) Dietary polyphenols and their role in oxidative stress-induced human diseases: insights into protective effects, antioxidant potentials and mechanism(s) of action. Front Pharmacol 13:806470","journal-title":"Front Pharmacol"},{"key":"8184_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8100488","author":"A Agarwal","year":"2019","unstructured":"Agarwal A, Panner Selvam MK, Samanta L, Vij SC, Parekh N, Sabanegh E et al (2019) Effect of antioxidant supplementation on the sperm proteome of idiopathic infertile men. Antioxidants. https:\/\/doi.org\/10.3390\/antiox8100488","journal-title":"Antioxidants"},{"key":"8184_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16020178","author":"CA Wilkins","year":"2024","unstructured":"Wilkins CA, Hamman H, Hamman JH, Steenekamp JH (2024) Fixed-dose combination formulations in solid oral drug therapy: advantages, limitations, and design features. Pharmaceutics. https:\/\/doi.org\/10.3390\/pharmaceutics16020178","journal-title":"Pharmaceutics"},{"issue":"20","key":"8184_CR52","doi-asserted-by":"publisher","first-page":"4527","DOI":"10.1158\/1078-0432.CCR-15-0039","volume":"21","author":"SE Bates","year":"2015","unstructured":"Bates SE, Berry DA, Balasubramaniam S, Bailey S, LoRusso PM, Rubin EH (2015) Advancing clinical trials to streamline drug development. Clin Cancer Res 21(20):4527\u20134535","journal-title":"Clin Cancer Res"},{"issue":"1","key":"8184_CR53","doi-asserted-by":"publisher","DOI":"10.1111\/and.13595","volume":"53","author":"K Leisegang","year":"2021","unstructured":"Leisegang K, Dutta S (2021) Do lifestyle practices impede male fertility? Andrologia 53(1):e13595","journal-title":"Andrologia"},{"issue":"2","key":"8184_CR54","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1249\/JES.0000000000000245","volume":"49","author":"P Lunetti","year":"2021","unstructured":"Lunetti P, Capobianco L, Zara V, Ferramosca A (2021) Physical activity and male reproductive function: a new role for gamete mitochondria. Exerc Sport Sci Rev 49(2):99\u2013106","journal-title":"Exerc Sport Sci Rev"},{"issue":"10","key":"8184_CR55","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.3390\/jcm14103442","volume":"14","author":"A Zanko","year":"2025","unstructured":"Zanko A, Pawlowski M, Milewski R (2025) The impact of physical exercise on male fertility through its association with various processes and aspects of human biology. J Clin Med 14(10):3442","journal-title":"J Clin Med"},{"key":"8184_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13050573","author":"Q Meng","year":"2024","unstructured":"Meng Q, Su CH (2024) The impact of physical exercise on oxidative and nitrosative stress: balancing the benefits and risks. Antioxidants. https:\/\/doi.org\/10.3390\/antiox13050573","journal-title":"Antioxidants"},{"key":"8184_CR57","doi-asserted-by":"crossref","unstructured":"Fatima G, Dzupina A, Mahdi AA, Fedacko J, Magomedova A, Yousif NG. Role of Vitamin-E as a Vital Nutrient in Health and Diseases. Indian Journal of Clinical Biochemistry. 2025.","DOI":"10.1007\/s12291-025-01309-0"},{"issue":"3","key":"8184_CR58","doi-asserted-by":"publisher","first-page":"502","DOI":"10.5534\/wjmh.230232","volume":"42","author":"M Gul","year":"2024","unstructured":"Gul M, Russo GI, Kandil H, Boitrelle F, Saleh R, Chung E et al (2024) Male infertility: new developments, current challenges, and future directions. World J Mens Health 42(3):502\u2013517","journal-title":"World J Mens Health"},{"key":"8184_CR59","doi-asserted-by":"publisher","DOI":"10.3390\/biology10030241","author":"E Torres-Arce","year":"2021","unstructured":"Torres-Arce E, Vizmanos B, Babio N, Marquez-Sandoval F, Salas-Huetos A (2021) Dietary antioxidants in the treatment of male infertility: counteracting oxidative stress. Biology. https:\/\/doi.org\/10.3390\/biology10030241","journal-title":"Biology"},{"key":"8184_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102071","volume":"46","author":"EPP Evans","year":"2021","unstructured":"Evans EPP, Scholten JTM, Mzyk A, Reyes-San-Martin C, Llumbet AE, Hamoh T et al (2021) Male subfertility and oxidative stress. Redox Biol 46:102071","journal-title":"Redox Biol"},{"issue":"2","key":"8184_CR61","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1080\/2090598X.2019.1599624","volume":"17","author":"S Dutta","year":"2019","unstructured":"Dutta S, Majzoub A, Agarwal A (2019) Oxidative stress and sperm function: a systematic review on evaluation and management. Arab J Urol 17(2):87\u201397","journal-title":"Arab J Urol"},{"key":"8184_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/biom14020194","author":"C Chatgilialoglu","year":"2024","unstructured":"Chatgilialoglu C (2024) Biomarkers of oxidative and radical stress. Biomolecules. https:\/\/doi.org\/10.3390\/biom14020194","journal-title":"Biomolecules"},{"issue":"6","key":"8184_CR63","first-page":"4567","volume":"38","author":"FT John Adeolu","year":"2024","unstructured":"John Adeolu FT, BasiruOlaitan A, Olawale RA, TemitayoFunmi F, Marcello I (2024) Fundamentals of reductive stress. J Biol Regulat Homeostat Agents 38(6):4567\u20134582","journal-title":"J Biol Regulat Homeostat Agents"},{"issue":"2","key":"8184_CR64","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.fertnstert.2022.04.028","volume":"118","author":"M Llavanera","year":"2022","unstructured":"Llavanera M, Delgado-Bermudez A, Ribas-Maynou J, Salas-Huetos A, Yeste M (2022) A systematic review identifying fertility biomarkers in semen: a clinical approach through omics to diagnose male infertility. Fertil Steril 118(2):291\u2013313","journal-title":"Fertil Steril"},{"key":"8184_CR65","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147827","author":"P Jakubek","year":"2024","unstructured":"Jakubek P, Parchem K, Wieckowski MR, Bartoszek A (2024) The interplay between endogenous and foodborne pro-oxidants and antioxidants in shaping redox homeostasis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25147827","journal-title":"Int J Mol Sci"},{"key":"8184_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101887","volume":"42","author":"B Korac","year":"2021","unstructured":"Korac B, Kalezic A, Pekovic-Vaughan V, Korac A, Jankovic A (2021) Redox changes in obesity, metabolic syndrome, and diabetes. Redox Biol 42:101887","journal-title":"Redox Biol"},{"key":"8184_CR67","doi-asserted-by":"publisher","first-page":"6501046","DOI":"10.1155\/2017\/6501046","volume":"2017","author":"I Marrocco","year":"2017","unstructured":"Marrocco I, Altieri F, Peluso I (2017) Measurement and clinical significance of biomarkers of oxidative stress in humans. Oxid Med Cell Longev 2017:6501046","journal-title":"Oxid Med Cell Longev"},{"issue":"7","key":"8184_CR68","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.21037\/tau-24-32","volume":"13","author":"Y Tan","year":"2024","unstructured":"Tan Y, Yuan Y, Yang X, Wang Y, Liu L (2024) Diagnostic value of oxidation-reduction potential for male infertility: a systematic review and meta-analysis. Transl Androl Urol 13(7):1228\u20131238","journal-title":"Transl Androl Urol"},{"key":"8184_CR69","doi-asserted-by":"publisher","DOI":"10.3390\/s24165143","author":"M Hemdan","year":"2024","unstructured":"Hemdan M, Ali MA, Doghish AS, Mageed SSA, Elazab IM, Khalil MM et al (2024) Innovations in biosensor technologies for healthcare diagnostics and therapeutic drug monitoring: applications, recent progress, and future research challenges. Sensors. https:\/\/doi.org\/10.3390\/s24165143","journal-title":"Sensors"},{"issue":"7","key":"8184_CR70","first-page":"e42583","volume":"15","author":"G Walke","year":"2023","unstructured":"Walke G, Gaurkar SS, Prasad R, Lohakare T, Wanjari M (2023) The impact of oxidative stress on male reproductive function: exploring the role of antioxidant supplementation. Cureus 15(7):e42583","journal-title":"Cureus"},{"key":"8184_CR71","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13050602","author":"AV Kozlov","year":"2024","unstructured":"Kozlov AV, Javadov S, Sommer N (2024) Cellular ROS and antioxidants: physiological and pathological role. Antioxidants (Basel). https:\/\/doi.org\/10.3390\/antiox13050602","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"8184_CR72","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1007\/s00345-019-02656-3","volume":"37","author":"JP Cardoso","year":"2019","unstructured":"Cardoso JP, Cocuzza M, Elterman D (2019) Optimizing male fertility: oxidative stress and the use of antioxidants. World J Urol 37(6):1029\u20131034","journal-title":"World J Urol"},{"key":"8184_CR73","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13121508","author":"T Kalogerakou","year":"2024","unstructured":"Kalogerakou T, Antoniadou M (2024) The role of dietary antioxidants, food supplements and functional foods for energy enhancement in healthcare professionals. Antioxidants. https:\/\/doi.org\/10.3390\/antiox13121508","journal-title":"Antioxidants"},{"issue":"1","key":"8184_CR74","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41392-023-01679-y","volume":"9","author":"B Chen","year":"2024","unstructured":"Chen B, Yu P, Chan WN, Xie F, Zhang Y, Liang L et al (2024) Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets. Signal Transduct Target Ther 9(1):6","journal-title":"Signal Transduct Target Ther"},{"key":"8184_CR75","doi-asserted-by":"publisher","DOI":"10.31661\/gmj.v13i.3534","volume":"13","author":"M Sagheb Ray Shirazi","year":"2024","unstructured":"Sagheb Ray Shirazi M, Salarkarimi F, Moghadasi F, Mahmoudikohani F, Tajik F, Bastani Nejad Z (2024) Infertility prevention and health promotion: the role of nurses in public health initiatives. Galen Med J 13:e3534","journal-title":"Galen Med J"},{"issue":"3","key":"8184_CR76","volume":"3","author":"RM Smits","year":"2019","unstructured":"Smits RM, Mackenzie-Proctor R, Yazdani A, Stankiewicz MT, Jordan V, Showell MG (2019) Antioxidants for male subfertility. Cochrane Database Syst Rev 3(3):CD007411","journal-title":"Cochrane Database Syst Rev"},{"key":"8184_CR77","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13071050","author":"Z Savovic","year":"2023","unstructured":"Savovic Z, Pindovic B, Nikolic M, Simic I, Davidovic G, Ignjatovic V et al (2023) Prognostic value of redox status biomarkers in patients presenting with STEMI or non-STEMI: a prospective case-control clinical study. J Pers Med. https:\/\/doi.org\/10.3390\/jpm13071050","journal-title":"J Pers Med"},{"issue":"10","key":"8184_CR78","doi-asserted-by":"publisher","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","volume":"24","author":"M Schieber","year":"2014","unstructured":"Schieber M, Chandel NS (2014) ROS function in redox signaling and oxidative stress. Curr Biol 24(10):R453\u2013R462","journal-title":"Curr Biol"},{"key":"8184_CR79","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13072145","author":"A Potiris","year":"2024","unstructured":"Potiris A, Alyfanti E, Drakaki E, Mavrogianni D, Karampitsakos T, Machairoudias P et al (2024) The contribution of proteomics in understanding endometrial protein expression in women with recurrent implantation failure. J Clin Med. https:\/\/doi.org\/10.3390\/jcm13072145","journal-title":"J Clin Med"},{"issue":"1","key":"8184_CR80","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41392-025-02141-x","volume":"10","author":"H Liu","year":"2025","unstructured":"Liu H, Wang S, Wang J, Guo X, Song Y, Fu K et al (2025) Energy metabolism in health and diseases. Signal Transduct Target Ther 10(1):69","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"8184_CR81","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3949\/ccjm.71.4.327","volume":"71","author":"BI Hasnain","year":"2004","unstructured":"Hasnain BI, Mooradian AD (2004) Recent trials of antioxidant therapy: what should we be telling our patients? Cleve Clin J Med 71(4):327\u2013334","journal-title":"Cleve Clin J Med"},{"key":"8184_CR82","doi-asserted-by":"publisher","first-page":"1521336","DOI":"10.3389\/fcell.2025.1521336","volume":"13","author":"SSK Divvela","year":"2025","unstructured":"Divvela SSK, Gallorini M, Gellisch M, Patel GD, Saso L, Brand-Saberi B (2025) Navigating redox imbalance: the role of oxidative stress in embryonic development and long-term health outcomes. Front Cell Dev Biol 13:1521336","journal-title":"Front Cell Dev Biol"},{"key":"8184_CR83","doi-asserted-by":"publisher","DOI":"10.3390\/cells14070511","author":"NR Selvaraj","year":"2025","unstructured":"Selvaraj NR, Nandan D, Nair BG, Nair VA, Venugopal P, Aradhya R (2025) Oxidative stress and redox imbalance: common mechanisms in cancer stem cells and neurodegenerative diseases. Cells. https:\/\/doi.org\/10.3390\/cells14070511","journal-title":"Cells"},{"key":"8184_CR84","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030414","author":"A Menzel","year":"2021","unstructured":"Menzel A, Samouda H, Dohet F, Loap S, Ellulu MS, Bohn T (2021) Common and novel markers for measuring inflammation and oxidative stress ex vivo in research and clinical practice-which to use regarding disease outcomes? Antioxidants. https:\/\/doi.org\/10.3390\/antiox10030414","journal-title":"Antioxidants"},{"issue":"1","key":"8184_CR85","doi-asserted-by":"publisher","DOI":"10.1111\/and.13162","volume":"51","author":"R Henkel","year":"2019","unstructured":"Henkel R, Sandhu IS, Agarwal A (2019) The excessive use of antioxidant therapy: a possible cause of male infertility? Andrologia 51(1):e13162","journal-title":"Andrologia"},{"issue":"3","key":"8184_CR86","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/aja.2011.10","volume":"13","author":"J Fujii","year":"2011","unstructured":"Fujii J, Tsunoda S (2011) Redox regulation of fertilisation and the spermatogenic process. Asian J Androl 13(3):420\u2013423","journal-title":"Asian J Androl"},{"key":"8184_CR87","doi-asserted-by":"publisher","DOI":"10.3390\/biology12060827","author":"J Costa","year":"2023","unstructured":"Costa J, Braga PC, Rebelo I, Oliveira PF, Alves MG (2023) Mitochondria quality control and male fertility. Biology. https:\/\/doi.org\/10.3390\/biology12060827","journal-title":"Biology"},{"key":"8184_CR88","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/978-3-031-12966-7_17","volume":"1391","author":"P Sengupta","year":"2022","unstructured":"Sengupta P, Dutta S, Alahmar AT (2022) Reductive stress and male infertility. Adv Exp Med Biol 1391:311\u2013321","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"8184_CR89","doi-asserted-by":"publisher","first-page":"583","DOI":"10.4103\/1008-682X.153303","volume":"17","author":"C O'Flaherty","year":"2015","unstructured":"O\u2019Flaherty C (2015) Redox regulation of mammalian sperm capacitation. Asian J Androl 17(4):583\u2013590","journal-title":"Asian J Androl"},{"issue":"5","key":"8184_CR90","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s43032-021-00795-w","volume":"29","author":"A Kowalczyk","year":"2022","unstructured":"Kowalczyk A (2022) The role of the natural antioxidant mechanism in sperm cells. Reprod Sci 29(5):1387\u20131394","journal-title":"Reprod Sci"},{"key":"8184_CR91","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/IJGM.S16275","volume":"4","author":"MK Moslemi","year":"2011","unstructured":"Moslemi MK, Tavanbakhsh S (2011) Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med 4:99\u2013104","journal-title":"Int J Gen Med"},{"issue":"4","key":"8184_CR92","doi-asserted-by":"publisher","first-page":"277","DOI":"10.5653\/cerm.2022.05463","volume":"49","author":"AT Alahmar","year":"2022","unstructured":"Alahmar AT (2022) Coenzyme Q10 improves sperm motility and antioxidant status in infertile men with idiopathic oligoasthenospermia. Clin Exp Reprod Med 49(4):277\u2013284","journal-title":"Clin Exp Reprod Med"},{"key":"8184_CR93","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144127","author":"P Santus","year":"2024","unstructured":"Santus P, Signorello JC, Danzo F, Lazzaroni G, Saad M, Radovanovic D (2024) Anti-inflammatory and anti-oxidant properties of N-acetylcysteine: a fresh perspective. J Clin Med. https:\/\/doi.org\/10.3390\/jcm13144127","journal-title":"J Clin Med"},{"key":"8184_CR94","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cofs.2016.02.002","volume":"8","author":"H Zhang","year":"2016","unstructured":"Zhang H, Tsao R (2016) Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr Opin Food Sci 8:33\u201342","journal-title":"Curr Opin Food Sci"},{"key":"8184_CR95","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020264","author":"PE Castleton","year":"2022","unstructured":"Castleton PE, Deluao JC, Sharkey DJ, McPherson NO (2022) Measuring reactive oxygen species in semen for male preconception care: a scientist perspective. Antioxidants (Basel). https:\/\/doi.org\/10.3390\/antiox11020264","journal-title":"Antioxidants (Basel)"},{"key":"8184_CR96","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310978","author":"A Silvestrini","year":"2023","unstructured":"Silvestrini A, Meucci E, Ricerca BM, Mancini A (2023) Total antioxidant capacity: biochemical aspects and clinical significance. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms241310978","journal-title":"Int J Mol Sci"},{"issue":"14","key":"8184_CR97","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1089\/ars.2015.6317","volume":"23","author":"J Frijhoff","year":"2015","unstructured":"Frijhoff J, Winyard PG, Zarkovic N, Davies SS, Stocker R, Cheng D et al (2015) Clinical relevance of biomarkers of oxidative stress. Antioxid Redox Signal 23(14):1144\u20131170","journal-title":"Antioxid Redox Signal"},{"issue":"4","key":"8184_CR98","doi-asserted-by":"publisher","first-page":"412","DOI":"10.5534\/wjmh.200128","volume":"38","author":"A Agarwal","year":"2020","unstructured":"Agarwal A, Majzoub A, Baskaran S, Panner Selvam MK, Cho CL, Henkel R et al (2020) Sperm DNA fragmentation: a new guideline for clinicians. World J Mens Health 38(4):412\u2013471","journal-title":"World J Mens Health"},{"key":"8184_CR99","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021314","author":"TH Chen","year":"2024","unstructured":"Chen TH, Wang HC, Chang CJ, Lee SY (2024) Mitochondrial glutathione in cellular redox homeostasis and disease manifestation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25021314","journal-title":"Int J Mol Sci"},{"issue":"1\u20133","key":"8184_CR100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/ars.2021.0234","volume":"37","author":"KC Heimsch","year":"2022","unstructured":"Heimsch KC, Gertzen CGW, Schuh AK, Nietzel T, Rahlfs S, Przyborski JM et al (2022) Structure and function of redox-sensitive superfolder green fluorescent protein variant. Antioxid Redox Signal 37(1\u20133):1\u201318","journal-title":"Antioxid Redox Signal"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-025-08184-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-025-08184-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-025-08184-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:02:53Z","timestamp":1762329773000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-025-08184-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":100,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["8184"],"URL":"https:\/\/doi.org\/10.1007\/s00404-025-08184-3","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]},"assertion":[{"value":"15 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}