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Obesity should not preclude offering TFA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the safety and effectiveness of transcervical radiofrequency ablation (TFA) for uterine fibroids in women with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective multicenter cohort at two German Fibroid Centers. From 574 consecutive TFA cases, we included patients with BMI\u2009\u2265\u200930 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and\u2009\u2265\u20096-month follow-up; those with incomplete data were excluded. Fibroids were characterized by ultrasound. TFA (Sonata\u00ae) was performed per instructions for use. Outcomes were perioperative complications and patient-reported improvement in abnormal uterine bleeding (AUB).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty patients were analyzed (age 43.59\u2009\u00b1\u20096.52 years; BMI 35.72\u2009\u00b1\u20096.72 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Mean operative and ablation times were 33.65 and 9.91 min, respectively. One intraoperative bleeding event (1.7%) was controlled with a balloon catheter; no postoperative complications occurred. Mean follow-up was 17.08 months (6\u201354). Overall, 42\/60 (70.0%) reported AUB improvement. By BMI category: 30\u201334.9 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      25\/39 (64.1%), 35\u201339.9 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      5\/7 (71.4%),\u2009\u2265\u200940 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      12\/14 (85.7%) (p\u2009=\u20090.3168). Considering the initial assessment, 48\/60 (80.0%) improved; six later recurred, yielding 42\/60 (70.0%) at last follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      TFA showed a very low complication rate and clinically meaningful bleeding improvement in women with obesity, with comparable outcomes across BMI strata, including\u2009\u2265\u200940 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Obesity is not a barrier to safe, effective TFA. Prospective, BMI-stratified studies with validated bleeding measures and objective endpoints are warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-025-08265-3","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:36:51Z","timestamp":1769758611000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and effectiveness of transcervical radiofrequency ablation for uterine fibroids in patients with obesity: a retrospective cohort study"],"prefix":"10.1007","volume":"313","author":[{"given":"Elvin","family":"Piriyev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Sadikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Dieter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Schiermeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan Peter","family":"Renner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"R\u00f6mer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"issue":"10","key":"8265_CR1","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1111\/1471-0528.14640","volume":"124","author":"EA Stewart","year":"2017","unstructured":"Stewart EA, Cookson CL, Gandolfo RA, Schulze-Rath R (2017) Epidemiology of uterine fibroids: a systematic review. 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S.S., S.R. and T.R. are consultants for the Sonata System. The authors report no other conflicts of interest in this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"According to 15\u00a7 of the professional code of the North Rhine Medical Association, neither advice nor an ethics vote is necessary for a retrospective study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"70"}}