{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:28:24Z","timestamp":1783981704630,"version":"3.55.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Manipal Academy of Higher Education, Manipal"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study was conducted to investigate the changes in the uterine biophysical profile (UBP) before and after intrauterine administration of Autologous Blood Cell Derivatives (ABCD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study investigates endometrial receptivity in frozen embryo transfer (FET) cycles. It focuses on patients with thin endometrium (TEM), a basal serum FSH below 10\u00a0IU\/L, and good-quality frozen embryos. The study utilizes the UBP to evaluate endometrial receptivity both before and after the ABCD procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study involved 33 women with TEM undergoing FET cycles. ABCD was administered during the first, second, and third or later FET cycles in 21.21%, 45.45%, and 33.33% of patients, respectively. Following ABCD administration, significant improvements were observed in UBP scores (from 9.06 to 14.85), EMT (from 6.6\u00a0mm to 8.67\u00a0mm), blood flow to zone III (from 0.85\u00a0mm to 3.36\u00a0mm), and uterine artery pulsatility index (PI) (from 0.7 to 0.97). Odds ratio analysis showed an association between pregnancy and endometrial layering (OR\u2009=\u20092.12), though it was not statistically significant. Multivariate analysis revealed that the UBP score predicted pregnancy with 68% accuracy, while the ROC analysis yielded an accuracy of 54%. A UBP threshold score of 20 offered 100% specificity, making it a potentially reliable predictor of successful implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that ABCD growth factors significantly enhance endometrial development in women with TEM, resulting in improved UBP scores, reduced EMT, lower uterine artery PI, and increased uterine blood flow. A UBP score cutoff of 20 demonstrated 95% sensitivity, highlighting its potential as a reliable prognostic tool in infertility treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-026-08345-y","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T19:34:38Z","timestamp":1770406478000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Uterine biophysical profile after intrauterine instillation of autologous blood cell derivative (ABCD) for thin endometrium in frozen embryo transfer cycles"],"prefix":"10.1007","volume":"313","author":[{"given":"Prathyusha","family":"Indrakanti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4389-3676","authenticated-orcid":false,"given":"Anjali","family":"Mundkur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidyashree G.","family":"Poojari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth","family":"Adiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivangi","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratap","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"issue":"19","key":"8345_CR1","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1056\/NEJMra000763","volume":"345","author":"ER Norwitz","year":"2001","unstructured":"Norwitz ER, Schust DJ, Fisher SJ (2001) Implantation and the survival of early pregnancy. N Engl J Med 345(19):1400\u20131408","journal-title":"N Engl J Med"},{"issue":"15","key":"8345_CR2","doi-asserted-by":"publisher","first-page":"1269382","DOI":"10.3389\/fendo.2024.1269382","volume":"30","author":"Y Wang","year":"2024","unstructured":"Wang Y, Tang Z, Teng X (2024) New advances in the treatment of thin endometrium. Front Endocrinol (Lausanne) 30(15):1269382","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"8345_CR3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.5005\/jp-journals-10009-1163","volume":"4","author":"N Malhotra","year":"2010","unstructured":"Malhotra N, Malhotra J, Malhotra N, Rao J, Mishra N, Kurjak A, Chervenak FA (2010) Endometrial receptivity and scoring for prediction of implantation and newer markers. DSJUOG 4(4):433\u2013440","journal-title":"DSJUOG"},{"issue":"3","key":"8345_CR4","first-page":"151","volume":"10","author":"K Murdia","year":"2023","unstructured":"Murdia K, Chandra V, Bhoi N, Gupta S, Gupta N, Mistari W, Chari S, Palanivel V (2023) Treatment of refractory thin endometrium with autologous blood cell derivative (ABCD-Endosera): advancing toward a next-generation of platelet-derived growth factors in frozen embryo transfer cycles: a pilot study. Fertil Sci Res 10(3):151\u2013157","journal-title":"Fertil Sci Res"},{"issue":"Suppl 1","key":"8345_CR5","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s13224-022-01735-7","volume":"73","author":"P Kumar","year":"2023","unstructured":"Kumar P, Mundkur A, Sai Bhavna D, Palanivel V, Adiga P, Poojari VG, Rao S, Ullagaddi R (2023) Intrauterine administration of autologous platelet-derived growth factor concentrate (aka autologous blood cell derivative) improves the endometrial thickness in \u2018thin\u2019 endometrium in the frozen embryo transfer cycle. J Obstet Gynaecol India 73(Suppl 1):108\u2013114. https:\/\/doi.org\/10.1007\/s13224-022-01735-7. (Epub 2023 Apr 22)","journal-title":"J Obstet Gynaecol India"},{"issue":"10","key":"8345_CR6","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1007\/s10815-024-03231-5","volume":"41","author":"S Tiwari","year":"2024","unstructured":"Tiwari S, Poojari VG, Mundkur A, Adiga P, Kumar P, Bhatele P, Palanivel V (2024) Efficacy of intrauterine autologous blood cell derivatives in enhancing endometrial thickness and IVF outcomes for women with recurrent implantation failure: a retrospective cohort study. J Assist Reprod Genet 41(10):2667\u20132680","journal-title":"J Assist Reprod Genet"},{"key":"8345_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead093.708","author":"P Vasanthi","year":"2023","unstructured":"Vasanthi P, Murthy P, Anitha RA, Sitamani S, Kini D, Shrinivas C (2023) Evaluation of EndoSERA autologous platelet derived growth factors for improving clinical pregnancy and live birth rate in FET cycles for women with refractory thin endometrium. Hum Reprod [Internet]. https:\/\/doi.org\/10.1093\/humrep\/dead093.708","journal-title":"Hum Reprod [Internet]"},{"issue":"2","key":"8345_CR8","doi-asserted-by":"publisher","first-page":"168","DOI":"10.15218\/zjms.2022.018","volume":"26","author":"M Sedeq","year":"2022","unstructured":"Sedeq M (2022) Role of uterine biophysical profile in predicting conception in a sample of infertile women attending an IVF center in Erbil. Zanco J Med Sci [Internet] 26(2):168\u2013177","journal-title":"Zanco J Med Sci [Internet]"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-026-08345-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-026-08345-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-026-08345-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T19:34:40Z","timestamp":1770406480000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-026-08345-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8345"],"URL":"https:\/\/doi.org\/10.1007\/s00404-026-08345-y","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]},"assertion":[{"value":"27 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was granted by the Kasturba Medical College and Kasturba Hospital Institutional Ethics Committee (IEC 1:329\/2022), and this study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"82"}}