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Maternal clinical, laboratory, and obstetric variables were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen fetuses (7.1%) were diagnosed with CHB. Mothers of affected fetuses had significantly higher anti-Ro (median 240 vs. 42;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and anti-La (median 150 vs. 10;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) levels. Anti-La positivity was more frequent in the CHB group (76.9% vs. 42.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). Lower complement C4 levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and disease duration of less than 1\u00a0year since diagnosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) were also associated with CHB. Preconception hydroxychloroquine and prednisone use were less frequent in affected pregnancies (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher maternal anti-Ro and anti-La antibody levels were significantly associated with fetal CHB. Preconception hydroxychloroquine may provide a protective effect. Early diagnosis and specialized care are essential for optimizing neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-026-08360-z","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:37:41Z","timestamp":1771641461000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between maternal anti-Ro and anti-La antibody levels and congenital heart block: a 20-year cohort study"],"prefix":"10.1007","volume":"313","author":[{"given":"Gabriel Duque","family":"Pannain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joelma Queiroz","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Ant\u00f4nio Borges","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabr\u00edcio Marcondes","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L\u00facia Jornada","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werther Brunow","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana Pulcinelli Vieira","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"8360_CR1","doi-asserted-by":"publisher","first-page":"102864","DOI":"10.1016\/j.jaut.2022.102864","volume":"132","author":"Y Tan","year":"2022","unstructured":"Tan Y, Yang S, Liu Q, Li Z, Mu R, Qiao J et al (2022) Pregnancy-related complications in systemic lupus erythematosus. 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