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Oral administration of ALA and Myo for three months significantly decreased pre-treatment serum levels of NLRP-3 (p\u2009&lt;\u20090.0001) and HMGB-1 (p\u2009&lt;\u20090.0001), as well as endometrial content of NLRP-3 (p\u2009&lt;\u20090.001) and HMGB-1 (p\u2009&lt;\u20090.0001) in uRPL women, similar to those found in controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Women with uRPL have increased systemic and endometrial inflammation than controls. Oral administration of ALA and Myo could modulate serum and endometrial levels of NLRP-3 and HMGB-1 in uRPL women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-026-08365-8","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:11:25Z","timestamp":1771999885000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of alpha\u2010lipoic acid and myoinositol on endometrial inflammation in women with unexplained recurrent pregnancy loss"],"prefix":"10.1007","volume":"313","author":[{"given":"Chiara","family":"Tersigni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elisabeth","family":"Street","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Castellani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorella","family":"Di Nicuolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Onori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Catellani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta","family":"Barbaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Ticconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Di Simone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"issue":"10285","key":"8365_CR1","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","volume":"397","author":"S Quenby","year":"2021","unstructured":"Quenby S, Gallos ID, Dhillon-Smith RK, Podesek M, Stephenson MD, Fisher J, Brosens JJ, Brewin J, Ramhorst R, Lucas ES, McCoy RC, Anderson R, Daher S, Regan L, Al-Memar M, Bourne T, MacIntyre DA, Rai R, Christiansen OB, Sugiura-Ogasawara M, Odendaal J, Devall AJ, Bennett PR, Petrou S, Coomarasamy A (2021) Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss. 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