{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:13:24Z","timestamp":1783484004134,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005005","name":"Ben-Gurion University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005005","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Maternal diabetes is a known driver of fetal metabolic programming, yet its impact on offspring cutaneous health remains poorly characterized. We investigated the impact of intrauterine exposure to various maternal diabetes subtypes on the risk of offspring seborrheic dermatitis (SD), and to explore whether this risk is modulated by maternal glycemic control or treatment modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This large-scale, population-based cohort study included 331,335 mother\u2013child pairs. Maternal diabetes subtypes\u2014type 1 (T1DM), type 2 (T2DM), and gestational diabetes mellitus (GDM)\u2014were assessed, along with glycemic control (HbA1c) and pharmacological treatment. SD was identified using physician-documented diagnoses and medication records. Multivariable logistic regression models adjusted for maternal and perinatal factors were used to estimate adjusted odds ratios (aORs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence of SD was 4.5%. SD was significantly more frequent among offspring of mothers with diabetes (4.9% vs. 4.4%, p\u2009&lt;\u20090.001), primarily driven by GDM. T1DM and T2DM showed similar trends but weren't statistically significant. SD risk did not differ by treatment modality or glycemic control. While overall associations for T1DM and T2DM did not reach significance in the full cohort, age-stratified analysis revealed that maternal diabetes was significantly associated with increased SD risk across all subtypes within the first year of life (T1DM: p\u2009=\u20090.033, T2DM: p\u2009=\u20090.024, GDM: p\u2009=\u20090.019). Multivariable analysis showed maternal diabetes was independently associated with increased SD risk (aOR 1.16, 95% CI 1.08\u20131.24).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal diabetes is associated with a significantly increased risk of infantile SD across all diabetes subtypes, suggesting that the intrauterine diabetic environment may influence early-life cutaneous homeostasis through metabolic programming of the pilosebaceous unit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-026-08398-z","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:52:55Z","timestamp":1778856775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal diabetes subtypes and offspring cutaneous health: developmental programming of sebaceous gland function in over 330,000 live births"],"prefix":"10.1007","volume":"313","author":[{"given":"Eliya","family":"Honig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Amitai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Weissmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Horev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Eshkoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"issue":"8","key":"8398_CR1","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1001\/jamadermatol.2024.1987","volume":"160","author":"MT Polaskey","year":"2024","unstructured":"Polaskey MT, Chang CH, Daftary K et al (2024) The global prevalence of seborrheic dermatitis: a systematic review and meta-analysis. JAMA Dermatol 160(8):846\u2013855. https:\/\/doi.org\/10.1001\/jamadermatol.2024.1987","journal-title":"JAMA Dermatol"},{"issue":"4","key":"8398_CR2","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1056\/NEJMcp0806464","volume":"360","author":"L Naldi","year":"2009","unstructured":"Naldi L, Rebora A (2009) Seborrheic dermatitis. N Engl J Med 360(4):387\u2013396. https:\/\/doi.org\/10.1056\/NEJMcp0806464","journal-title":"N Engl J Med"},{"key":"8398_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011380.pub2","author":"A Victoire","year":"2019","unstructured":"Victoire A, Magin P, Coughlan J, van Driel ML (2019) Interventions for infantile seborrhoeic dermatitis (including cradle cap). Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD011380.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"8398_CR4","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/exd.14006","volume":"28","author":"TC Wikramanayake","year":"2019","unstructured":"Wikramanayake TC, Borda LJ, Miteva M, Paus R (2019) Seborrheic dermatitis\u2014looking beyond Malassezia. Exp Dermatol 28(9):991\u20131001. https:\/\/doi.org\/10.1111\/exd.14006","journal-title":"Exp Dermatol"},{"issue":"10","key":"8398_CR5","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1111\/exd.14450","volume":"30","author":"R Tao","year":"2021","unstructured":"Tao R, Li R, Wang R (2021) Skin microbiome alterations in seborrheic dermatitis and dandruff: a systematic review. Exp Dermatol 30(10):1546\u20131553. https:\/\/doi.org\/10.1111\/exd.14450","journal-title":"Exp Dermatol"},{"issue":"5","key":"8398_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251136","volume":"16","author":"MGH Sanders","year":"2021","unstructured":"Sanders MGH, Nijsten T, Verlouw J, Kraaij R, Pardo LM (2021) Composition of cutaneous bacterial microbiome in seborrheic dermatitis patients: a cross-sectional study. PLoS ONE 16(5):e0251136. https:\/\/doi.org\/10.1371\/journal.pone.0251136","journal-title":"PLoS ONE"},{"issue":"5","key":"8398_CR7","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/exd.14091","volume":"29","author":"JA Adalsteinsson","year":"2020","unstructured":"Adalsteinsson JA, Kaushik S, Muzumdar S, Guttman-Yassky E, Ungar J (2020) An update on the microbiology, immunology and genetics of seborrheic dermatitis. Exp Dermatol 29(5):481\u2013489. https:\/\/doi.org\/10.1111\/exd.14091","journal-title":"Exp Dermatol"},{"issue":"4","key":"8398_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-02830-7","volume":"316","author":"CH Chang","year":"2024","unstructured":"Chang CH, Chovatiya R (2024) More yeast, more problems? Reevaluating the role of Malassezia in seborrheic dermatitis. Arch Dermatol Res 316(4):100. https:\/\/doi.org\/10.1007\/s00403-024-02830-7","journal-title":"Arch Dermatol Res"},{"issue":"6","key":"8398_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062650","volume":"26","author":"F Piacentini","year":"2025","unstructured":"Piacentini F, Camera E, Di Nardo A, Dell\u2019Anna ML (2025) Seborrheic dermatitis: exploring the complex interplay with Malassezia. Int J Mol Sci 26(6):2650. https:\/\/doi.org\/10.3390\/ijms26062650","journal-title":"Int J Mol Sci"},{"issue":"1","key":"8398_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-03005-4","volume":"30","author":"Y Xu","year":"2025","unstructured":"Xu Y, Tong X (2025) The dual roles of T cells and keratinocytes in seborrheic dermatitis: a narrative review. Eur J Med Res 30(1):853. https:\/\/doi.org\/10.1186\/s40001-025-03005-4","journal-title":"Eur J Med Res"},{"issue":"6","key":"8398_CR11","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.jaad.2025.01.082","volume":"92","author":"B Ungar","year":"2025","unstructured":"Ungar B, Manson M, Kim M et al (2025) Tape-strip profiling identifies unique immune and lipid dysregulation in patients with seborrheic dermatitis. J Am Acad Dermatol 92(6):1277\u20131287. https:\/\/doi.org\/10.1016\/j.jaad.2025.01.082","journal-title":"J Am Acad Dermatol"},{"key":"8398_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.70185","author":"T Li","year":"2025","unstructured":"Li T, Ma X, Ma L (2025) Effects of gestational diabetes mellitus on offspring: a literature review. Int J Gynaecol Obstet. https:\/\/doi.org\/10.1002\/ijgo.70185","journal-title":"Int J Gynaecol Obstet"},{"issue":"4","key":"8398_CR13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1080\/14767058.2017.1387893","volume":"32","author":"S Burlina","year":"2019","unstructured":"Burlina S, Dalfr\u00e0 MG, Lapolla A (2019) Short- and long-term consequences for offspring exposed to maternal diabetes: a review. J Matern Fetal Neonatal Med 32(4):687\u2013694. https:\/\/doi.org\/10.1080\/14767058.2017.1387893","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"18","key":"8398_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/nu14183870","volume":"14","author":"L Eletri","year":"2022","unstructured":"Eletri L, Mitanchez D (2022) How do the different types of maternal diabetes during pregnancy influence offspring outcomes? Nutrients 14(18):3870. https:\/\/doi.org\/10.3390\/nu14183870","journal-title":"Nutrients"},{"issue":"7","key":"8398_CR15","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1111\/dom.16341","volume":"27","author":"J Guan","year":"2025","unstructured":"Guan J, Qiu J, Li L et al (2025) A meta-analysis of adverse offspring health outcomes in patients with gestational diabetes mellitus. Diabetes Obes Metab 27(7):3555\u20133567. https:\/\/doi.org\/10.1111\/dom.16341","journal-title":"Diabetes Obes Metab"},{"issue":"5","key":"8398_CR16","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1111\/pai.13498","volume":"32","author":"Z Li","year":"2021","unstructured":"Li Z, Yu M, Wang P et al (2021) Association between maternal diabetes mellitus and allergic diseases in children: a systematic review and meta-analysis. Pediatr Allergy Immunol 32(5):880\u2013891. https:\/\/doi.org\/10.1111\/pai.13498","journal-title":"Pediatr Allergy Immunol"},{"issue":"10448","key":"8398_CR17","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/S0140-6736(24)00827-4","volume":"404","author":"MF Hivert","year":"2024","unstructured":"Hivert MF, Backman H, Benhalima K et al (2024) Pathophysiology from preconception, during pregnancy, and beyond. Lancet 404(10448):158\u2013174. https:\/\/doi.org\/10.1016\/S0140-6736(24)00827-4","journal-title":"Lancet"},{"key":"8398_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1125628","volume":"14","author":"K Rodolaki","year":"2023","unstructured":"Rodolaki K, Pergialiotis V, Iakovidou N et al (2023) The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence. Front Endocrinol 14:1125628. https:\/\/doi.org\/10.3389\/fendo.2023.1125628","journal-title":"Front Endocrinol"},{"issue":"3","key":"8398_CR19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/MCO.0000000000000826","volume":"25","author":"KV Dalrymple","year":"2022","unstructured":"Dalrymple KV, El-Heis S, Godfrey KM (2022) Maternal weight and gestational diabetes impacts on child health. Curr Opin Clin Nutr Metab Care 25(3):203\u2013208. https:\/\/doi.org\/10.1097\/MCO.0000000000000826","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"8398_CR20","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.diabres.2018.09.003","volume":"144","author":"H Abokaf","year":"2018","unstructured":"Abokaf H, Shoham-Vardi I, Sergienko R, Landau D, Sheiner E (2018) In utero exposure to gestational diabetes mellitus and long term endocrine morbidity of the offspring. Diabetes Res Clin Pract 144:231\u2013235. https:\/\/doi.org\/10.1016\/j.diabres.2018.09.003","journal-title":"Diabetes Res Clin Pract"},{"key":"8398_CR21","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.diabres.2018.03.050","volume":"140","author":"O Zamstein","year":"2018","unstructured":"Zamstein O, Sheiner E, Wainstock T, Landau D, Walfisch A (2018) Maternal gestational diabetes and long-term respiratory related hospitalizations of the offspring. Diabetes Res Clin Pract 140:200\u2013207. https:\/\/doi.org\/10.1016\/j.diabres.2018.03.050","journal-title":"Diabetes Res Clin Pract"},{"issue":"3","key":"8398_CR22","doi-asserted-by":"publisher","first-page":"380.e1","DOI":"10.1016\/j.ajog.2016.03.030","volume":"215","author":"K Nahum Sacks","year":"2016","unstructured":"Nahum Sacks K, Friger M, Shoham-Vardi I, Abokaf H, Spiegel E, Sergienko R, Landau D, Sheiner E (2016) Prenatal exposure to gestational diabetes mellitus as an independent risk factor for long-term neuropsychiatric morbidity of the offspring. Am J Obstet Gynecol 215(3):380.e1\u20137. https:\/\/doi.org\/10.1016\/j.ajog.2016.03.030","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"8398_CR23","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.jaci.2009.06.052","volume":"124","author":"R Kumar","year":"2009","unstructured":"Kumar R, Ouyang F, Story RE et al (2009) Gestational diabetes, atopic dermatitis, and allergen sensitization in early childhood. J Allergy Clin Immunol 124(5):1031-1038.e1-4. https:\/\/doi.org\/10.1016\/j.jaci.2009.06.052","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"8398_CR24","doi-asserted-by":"publisher","first-page":"20","DOI":"10.4161\/derm.19828","volume":"4","author":"B Melnik","year":"2012","unstructured":"Melnik B (2012) Dietary intervention in acne: attenuation of increased mTORC1 signaling promoted by Western diet. Dermatoendocrinol 4(1):20\u201332. https:\/\/doi.org\/10.4161\/derm.19828","journal-title":"Dermatoendocrinol"},{"issue":"6","key":"8398_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0326087","volume":"20","author":"M Onori","year":"2025","unstructured":"Onori M, Beneduce G, Colella F et al (2025) Placental inflammation is increased in gestational diabetes mellitus: the role of inflammasome NLRP-3 and chemokine scavenger decoy receptor D6. PLoS ONE 20(6):e0326087. https:\/\/doi.org\/10.1371\/journal.pone.0326087","journal-title":"PLoS ONE"},{"issue":"21","key":"8398_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111409","volume":"25","author":"K Zgutka","year":"2024","unstructured":"Zgutka K, Tkacz M, Tomasiak P et al (2024) Gestational diabetes mellitus-induced inflammation in the placenta via IL-1\u03b2 and toll-like receptor pathways. Int J Mol Sci 25(21):11409. https:\/\/doi.org\/10.3390\/ijms252111409","journal-title":"Int J Mol Sci"},{"issue":"18","key":"8398_CR27","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.2174\/092986706777935302","volume":"13","author":"A Jawerbaum","year":"2006","unstructured":"Jawerbaum A, Gonz\u00e1lez E (2006) Diabetic pregnancies: the challenge of developing in a pro-inflammatory environment. Curr Med Chem 13(18):2127\u20132138. https:\/\/doi.org\/10.2174\/092986706777935302","journal-title":"Curr Med Chem"},{"issue":"5","key":"8398_CR28","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","volume":"261","author":"DJ Barker","year":"2007","unstructured":"Barker DJ (2007) The origins of the developmental origins theory. J Intern Med 261(5):412\u2013417. https:\/\/doi.org\/10.1111\/j.1365-2796.2007.01809.x","journal-title":"J Intern Med"},{"issue":"12","key":"8398_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226545","volume":"14","author":"V Ponzo","year":"2019","unstructured":"Ponzo V, Ferrocino I, Zarovska A et al (2019) The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM). PLoS ONE 14(12):e0226545. https:\/\/doi.org\/10.1371\/journal.pone.0226545","journal-title":"PLoS ONE"},{"issue":"9","key":"8398_CR30","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1136\/gutjnl-2018-315988","volume":"67","author":"J Wang","year":"2018","unstructured":"Wang J, Zheng J, Shi W et al (2018) Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus. Gut 67(9):1614\u20131625. https:\/\/doi.org\/10.1136\/gutjnl-2018-315988","journal-title":"Gut"},{"issue":"2","key":"8398_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-017-0836-9","volume":"17","author":"S Singh","year":"2017","unstructured":"Singh S, Karagas MR, Mueller NT (2017) Charting the maternal and infant microbiome: what is the role of diabetes and obesity in pregnancy? Curr Diab Rep 17(2):11. https:\/\/doi.org\/10.1007\/s11892-017-0836-9","journal-title":"Curr Diab Rep"},{"key":"8398_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1600325","volume":"16","author":"Y Hu","year":"2025","unstructured":"Hu Y, Zheng S, Xu J et al (2025) Gestational diabetes mellitus alters neonatal gut microbiota and increases infection susceptibility. Front Microbiol 16:1600325. https:\/\/doi.org\/10.3389\/fmicb.2025.1600325","journal-title":"Front Microbiol"}],"container-title":["Archives of Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00404-026-08398-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-026-08398-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00404-026-08398-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:14:12Z","timestamp":1783480452000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00404-026-08398-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8398"],"URL":"https:\/\/doi.org\/10.1007\/s00404-026-08398-z","relation":{},"ISSN":["1432-0711"],"issn-type":[{"value":"1432-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"15 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Reviewed and approved by the Institutional Review Board of Soroka University Medical Center; approval No. 0049-25-SOR.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"219"}}