{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:27:08Z","timestamp":1787182028542,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Shenzhen Science and Technology Program","award":["No. RCBS20221008093243058"],"award-info":[{"award-number":["No. RCBS20221008093243058"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Gynecol Obstet"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pelvic actinomycosis is a rare, chronic infection caused by\n                      <jats:italic>Actinomyces<\/jats:italic>\n                      species, most associated with prolonged intrauterine device (IUD) use. Due to its nonspecific clinical presentation, it is frequently misdiagnosed as malignancy or other inflammatory conditions. This study aims to analyze the clinical features, diagnostic approaches, and outcomes of pelvic actinomycosis through a retrospective review of four cases and a supporting literature review.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>\n                      We reviewed the medical records of four female patients diagnosed with pelvic actinomycosis between 2021 and 2025. Diagnostic modalities included imaging, physical examination, cervical cytology, endometrial biopsy, and histopathological analysis. Empirical antibiotic therapy was administered to confirmed cases. All patients had a history of prolonged IUD use. Imaging frequently revealed pelvic masses with inflammatory features. In all cases,\n                      <jats:italic>Actinomyces<\/jats:italic>\n                      was identified via cytology or histopathology. Three of the four patients were diagnosed preoperatively, thus preventing unnecessary surgical interventions. Long-term antibiotic therapy led to clinical resolution in most patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pelvic actinomycosis should be considered in women with chronic pelvic symptoms and a history of long-term IUD use. Early identification through cytology or biopsy can reduce surgical morbidity. Increased awareness and its inclusion in the gynecologic differential diagnosis may improve patient prognoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-026-08441-z","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T10:38:29Z","timestamp":1781347109000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pelvic actinomycosis: diagnostic challenges and management strategies based on a retrospective case series and literature review"],"prefix":"10.1007","volume":"313","author":[{"given":"Shuxu","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5443-5532","authenticated-orcid":false,"given":"Xiucheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-6089","authenticated-orcid":false,"given":"Weiwen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"issue":"2","key":"8441_CR1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1128\/CMR.00100-14","volume":"28","author":"E Kononen","year":"2015","unstructured":"Kononen E, Wade WG (2015) Actinomyces and related organisms in human infections. 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