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Primary outcomes were preterm birth and cesarean delivery; placenta previa was examined as a key secondary outcome. Multivariable logistic regression models adjusted for maternal age and mode of conception were used.<\/jats:p>\n                    <jats:p>Main outcome measures.<\/jats:p>\n                    <jats:p>Preterm birth, cesarean delivery, placenta previa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 16,033 primiparous women, 118 had a diagnosis of endometriosis prior to pregnancy. After adjustment for maternal age and mode of conception, endometriosis was not independently associated with preterm birth (adjusted odds ratio 0.75; 95% confidence interval 0.44\u20131.28) or cesarean delivery (adjusted odds ratio, 1.17; 95% confidence interval, 0.81\u20131.71). In contrast, endometriosis was associated with placenta previa (adjusted odds ratio, 5.90; 95% confidence interval, 2.37\u201314.71).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In primiparous women, pre-existing endometriosis was independently associated with placenta previa, but not with preterm birth or cesarean delivery. These findings support abnormal early placentation as a potential mechanism linking endometriosis to adverse obstetric outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-026-08465-5","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:17:39Z","timestamp":1779268659000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endometriosis and adverse pregnancy outcomes in primiparous women: a retrospective cohort study"],"prefix":"10.1007","volume":"313","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4453-4506","authenticated-orcid":false,"given":"Julia","family":"T\u00e9oule","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Zikarsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9329-8958","authenticated-orcid":false,"given":"Karin","family":"Bundschu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Andres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Hancke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"8465_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ejogrb.2016.04.021","volume":"209","author":"F Parazzini","year":"2017","unstructured":"Parazzini F, Esposito G, Tozzi L, Noli S, Bianchi S (2017) Epidemiology of endometriosis and its comorbidities. 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