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It included all observational studies that reported the results of CMA testing in fetuses diagnosed with ventriculomegaly (both isolated and non-isolated),in fetuses with isolated ventriculomegaly, in fetuses with non-isolated ventriculomegaly, and in fetuses with mild isolated ventriculomegaly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>16 studies were included with a total of 2137 cases of affected fetuses that met the inclusion criteria for analysis. Combined data from these studies revealed an overall incremental yield of CMA over karyotyping of 7% (95% CI 4\u201310%) in cases with ventriculomegaly, 4% (95% CI 2\u20136%) in isolated cases, 10% (95% CI 6\u201316%) in non-isolated cases, and 2% (95% CI 1\u20134%) in mild isolated cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings may be useful in clinical practice to guide management options and the counseling of the couples to individualize patient care and facilitate clinicians when they come across such a common clinical entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-026-08470-8","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:23:13Z","timestamp":1780410193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The incremental yield of CMA over karyotype in fetal ventriculomegaly: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"313","author":[{"given":"Ioakeim","family":"Sapantzoglou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zacharias","family":"Fasoulakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Tasias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Rouvali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afroditi","family":"Pegkou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Theodora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Daskalakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Antsaklis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"issue":"4","key":"8470_CR1","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1097\/AOG.0b013e3182117471","volume":"117","author":"F Sethna","year":"2011","unstructured":"Sethna F, Tennant PWG, Rankin J, Robson CS (2011) Prevalence, natural history, and clinical outcome of mild to moderate ventriculomegaly. 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