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Serum miRNA (miR-) expression levels of selected PE-associated miRNAs (miR-210-3p, miR-518b) were quantified by real-time PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Similar expression profiles (delta CT \u00b1 standard deviation) were observed between loPE vs. controls: miR-210-3p (8.20 \u00b1 1 vs. 7.48 \u00b1 1.2; p=0.16; Hodges-Lehmann estimator (HL): \u2212\u20090.73, 95% confidence interval (CI) \u2212\u20092.2 to 0.78) and miR-518b (9.82 \u00b1 1.1 vs. 9.60 \u00b1 0.9; p=0.80, HL: \u2212\u20090.14, 95% CI \u2212\u20091.61 to 0.91). Comparing eoPE cases to controls, we found an increase of miR-210-3p concentration (7.63 \u00b1 1.1 vs. 9.31 \u00b1 1.9; p=0.019; HL: 1.23, 95% CI 0.15 to 2.66, mean fold change: 3.2; sensitivity analysis: p=0.067) and a numerical difference in miR-518b expression without reaching statistical significance (8.77 \u00b1 1.4 vs. 9.85 \u00b1 1.8; p=0.19; HL: 0.70, 95% CI \u2212\u20090.33 to 2.41; mean fold change: 2.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the eoPE, miR-210-3p levels were higher than in controls, with the same trend observed in the sensitivity analysis, although statistical significance was no longer reached (p=0.067). miR-518b showed a numerical, non-significant difference between eoPE and controls. No significant differences were observed in loPE. Given the small sample size and overlap with early-onset fetal growth restriction, these findings should be considered exploratory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00404-026-08583-0","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:53:19Z","timestamp":1790614399000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression patterns of circulating microRNA in confirmed early-onset and late-onset pre-eclampsia cases"],"prefix":"10.1007","volume":"313","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6974-3041","authenticated-orcid":false,"given":"Isabel","family":"Hoffmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Enzensberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Stickeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Graupner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"Suppl 1(Suppl 1","key":"8583_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ijgo.12802","volume":"145","author":"LC Poon","year":"2019","unstructured":"Poon LC, Shennan A, Hyett JA et al (2019) The International federation of gynecology and obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention. 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