{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:07:19Z","timestamp":1779271639886,"version":"3.51.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T00:00:00Z","timestamp":1071619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1007\/s00405-003-0719-3","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T13:15:15Z","timestamp":1097586915000},"page":"509-516","source":"Crossref","is-referenced-by-count":18,"title":["The value of screening for multiple arterio-venous malformations in hereditary hemorrhagic telangiectasia: a diagnostic study"],"prefix":"10.1007","volume":"261","author":[{"given":"Benedikt J.","family":"Folz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cerra","family":"Wollstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Alfke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja A.","family":"D\ufffdnne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkard M.","family":"Lippert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"G\ufffdrg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Joachim","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Bien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen A.","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,12,17]]},"reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1288\/00005537-199109000-00008","volume":"101","author":"AAssar","year":"1991","unstructured":"AAssar OS, Friedman CM, White RI Jr (1991) The natural history of epistaxis in hereditary hemorrhagic telangiectasia. Laryngoscope 101:977?980","journal-title":"Laryngoscope"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2500\/105065899782102890","volume":"13","author":"Lund","year":"1999","unstructured":"Lund VJ, Howard DJ (1999) A treatment algorithm for the management of epistaxis in hereditary hemorrhagic telangiectasia. Am J Rhinol 13:319?322","journal-title":"Am J Rhinol"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P","volume":"91","author":"Shovlin","year":"2000","unstructured":"Shovlin CL, Guttmacher AE, Buscarini E, Faughnan ME, Hyland RH, Westermann CJJ, et al (2000) Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). Am J Med Genet 91:66?67","journal-title":"Am J Med Genet"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/jmg.29.8.527","volume":"29","author":"Porteous","year":"1992","unstructured":"Porteous MEM, Burn J, Proctor SJ (1992) Hereditary haemorrhagic telangiectasia: a clinical analysis. J Med Genet 29:527?530","journal-title":"J Med Genet"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ng0294-205","volume":"6","author":"Shovlin","year":"1994","unstructured":"Shovlin CL, Hughes JM, Tuddenham EG, Temperley I, Perembelon YF, Scott J et al (1994) A gene for hereditary haemorrhagic telangiectasia maps to chromosome 9q3. Nat Genet 6:205?209","journal-title":"Nat Genet"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng1294-345","volume":"8","author":"McAllister","year":"1994","unstructured":"McAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE, et al (1994) Endoglin, a TGF-\u00df binding protein of endothelial cells, is the gene of hereditary hemorrhagic telangiectasia type 1. Nat Genet 8:345?351","journal-title":"Nat Genet"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/hmg\/4.5.945","volume":"4","author":"Vincent","year":"1995","unstructured":"Vincent P, Plauchu H, Hazan J, Faure S, Weissenbach J, Godet J (1995) A third locus for hereditary haemorrhagic telangiectasia maps to chromosome 12q. Hum Mol Genet 4:945?949","journal-title":"Hum Mol Genet"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng0696-189","volume":"13","author":"Johnson","year":"1996","unstructured":"Johnson DW, Berg JN, Baldwin MA, Gallione CJ, Marondel I, Yoon SJ, et al (1996) Mutations in the activin receptor-like kinase 1 gene in hereditary hemorrhagic telangiectasia type 2. Nat Genet 13:189?195","journal-title":"Nat Genet"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jmg.33.6.441","volume":"33","author":"Piantanida","year":"1996","unstructured":"Piantanida M, Buscarini E, Dellavecchia C, Minelli A, Rossi A, Buscarini L, et al (1996) Hereditary haemorrhagic telangiectasia with extensive liver involvement is not caused by either HHT1 or HHT2. J Med Genet 33:441?443","journal-title":"J Med Genet"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2307\/1532715","volume":"4","author":"Plauchu","year":"1984","unstructured":"Plauchu H, Bideau A (1984) \u00c9pid\u00e9miologie et constitution d?un registre de population \u00e0 propos d? une concentration g\u00e9ographique d?une maladie h\u00e9r\u00e9ditaire rare. Population 4:765?786","journal-title":"Population"},{"key":"CR11","first-page":"A490","volume":"100","author":"Pasche","year":"2003","unstructured":"Pasche B, Cerra Wollstein A, Zoll B, Folz B (2003) Rendu-Osler-Weber-Syndrom. Dtsch Arztebl 100:A490?493","journal-title":"Dtsch Arztebl"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.0954-6820.1985.tb08832.x","volume":"218","author":"Vase","year":"1985","unstructured":"Vase P, Holm M, Arendrup H (1985) Pulmonary arteriovenous fistulas in hereditary hemorrhagic telangiectasia. Acta Med Scand 218:105?109","journal-title":"Acta Med Scand"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00000441-198806000-00008","volume":"295","author":"Teragaki","year":"1988","unstructured":"Teragaki M, Akioka K, Yasuda M, Ikuno Y, Oku H, Takeuchi K, Takeda T (1988) Hereditary hemorrhagic telangiectasias with growing arteriovenous fistulas followed for 24\u00a0years. Am J Med Sci 295:545?547","journal-title":"Am J Med Sci"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ajmg.1320320302","volume":"32","author":"Plauchu","year":"1989","unstructured":"Plauchu H, de Chadarevian JP, Bideau A, Robert JM (1989) Age-related clinical profile of hereditary hemorrhagic telangiectasia in an epidemiologically recruited population. Am J Med Genet 32:291?297","journal-title":"Am J Med Genet"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1378\/chest.116.2.432","volume":"116","author":"Kjeldsen","year":"1999","unstructured":"Kjeldsen AD, Oxhoj H, Andersen PE, Elle B, Jacopsen JP, Vase P (1999) Pulmonary arteriovenous malformations. Screening procedures and pulmonary angiography in patients with hereditary haemorrhagic telangiectasia. Chest 116:432?440","journal-title":"Chest"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1001\/archotol.1965.00760010524014","volume":"82","author":"Stecker","year":"1965","unstructured":"Stecker RH, Lake CF (1965) Hereditary hemorrhagic telangiectasia. Arch Otolaryngol 82:522?526","journal-title":"Arch Otolaryngol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1055\/s-2007-997467","volume":"76","author":"Werner","year":"1997","unstructured":"Werner JA, Lippert BM, Geisthoff UW, Rudert H (1997) Nd:YAG-Lasertherapie der rezidivierenden Epistaxis bei heredit\u00e4rer h\u00e4morrhagischer Teleangiektasie. Laryngorhinootologie 76:495?501","journal-title":"Laryngorhinootologie"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00005537-199901000-00004","volume":"109","author":"Bergler","year":"1999","unstructured":"Bergler W, Riedel F, Baker-Schreyer A, Juncker C, H\u00f6rmann K (1999) Argon plasma coagulation for the treatment of hereditary hemorrhagic telangiectasia. Laryngoscope 109:15?20","journal-title":"Laryngoscope"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s001060050417","volume":"47","author":"Werner","year":"1999","unstructured":"Werner JA (1999) Behandlungskonzept der rezidivierenden Epistaxis bei Patienten mit heredit\u00e4rer h\u00e4morhagischer Telangiektasie. HNO 47:525?529","journal-title":"HNO"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s001060050141","volume":"9","author":"Werner","year":"1997","unstructured":"Werner JA, Geisthoff UW, Lippert BM, Rudert H (1997) Behandlung der rezidivierenden Epistaxis beim Morbus Rendu-Osler-Weber. HNO 9:673?681","journal-title":"HNO"},{"key":"CR21","first-page":"879","volume":"88","author":"Shovlin","year":"1995","unstructured":"Shovlin CL, Winstock AR, Peters AM, Jackson JE, Hughes JM (1995) Medical complications of pregnancy in hereditary haemorrhagic telangiectasia. QJM 88:879?887","journal-title":"QJM"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1378\/chest.101.5.1452","volume":"101","author":"Laroche","year":"1992","unstructured":"Laroche CM, Wells F, Shneerson J (1992) Massive hemothorax due to enlarging arteriovenous fistula in pregnancy. Chest 101:452?454","journal-title":"Chest"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1378\/chest.106.5.1387","volume":"106","author":"Ference","year":"1994","unstructured":"Ference BA, Shannon TM, White RI, Zavin M, Burdge CM (1994) Life-threatening pulmonary hemorrhage with pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia. Chest 106:1387?1390","journal-title":"Chest"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0140-6736(91)90577-C","volume":"338","author":"Mohler","year":"1991","unstructured":"Mohler ER, Monahan B, Canty MD, Flockhart DA (1991) Cerebral abscess associated with dental procedure in hereditary haemorrhagic telangiectasia. Lancet 338:508?509","journal-title":"Lancet"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2796.2000.00725.x","volume":"248","author":"Kjeldsen","year":"2000","unstructured":"Kjeldsen AD, Oxhoj H, Andersen PE, Green A, Vase P (2000) Prevalence of pulmonary arteriovenous malformations (PAVMs) and occurrence of neurological symptoms in patients with hereditary hemorrhagic telangiectasia (HHT). J Intern Med 248:255?262","journal-title":"J Intern Med"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/01.STR.32.4.877","volume":"32","author":"Maher","year":"2001","unstructured":"Maher CO, Piepgras DG, Brown RD, Friedman JA, Pollock BE (2001) Cerebrovascular manifestations in 321 cases of hereditary hemorrhagic telangiectasia. Stroke 32:877?882","journal-title":"Stroke"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1148\/radiology.182.3.1535899","volume":"182","author":"Remy","year":"1992","unstructured":"Remy J, Remy-Jardin M, Wattinne L, Deffontaines C (1992) Pulmonary arteriovenous malformations: evaluation with CT of the chest before and after treatment. Radiology 182:809?816","journal-title":"Radiology"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1378\/chest.118.2.566-a","volume":"118","author":"Faughnan","year":"2000","unstructured":"Faughnan ME, Hyland RH, Nanthakumar K, Redelmeier DA (2000) Screening in hereditary hemorrhagic telangiectasia patients. Chest 118:566?567","journal-title":"Chest"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJM198005223022107","volume":"302","author":"Terry","year":"1980","unstructured":"Terry PB, Barth KH, Kaufman SL, White RI (1980) Balloon embolization for treatmentof pulmonary arteriovenous fistulas. N Engl J Med 302:1189?1190","journal-title":"N Engl J Med"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1001\/archinte.1996.00440210159020","volume":"9","author":"White","year":"1996","unstructured":"White RI (1996) Pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia: embolotherapie using balloons and coils. Arch Intern Med 9:2627?2628","journal-title":"Arch Intern Med"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1148\/radiology.169.3.3186989","volume":"169","author":"White","year":"1988","unstructured":"White RI Jr, Lynch-Nyhan A, Terry P, Buescher PC, Farmlett EJ, Charnas L, et al (1988) Pulmonary arteriovenous malformations: techniques and long-term outcome of embolotherapy. Radiology 169:663?669","journal-title":"Radiology"},{"key":"CR32","doi-asserted-by":"crossref","unstructured":"Cloogman HM, DiCapo RD (1984) Hereditary hemorrhagic telangiectasia: sonographic findings in the liver. Radiology :521?522","DOI":"10.1148\/radiology.150.2.6691112"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1055\/s-2001-15969","volume":"39","author":"Caselitz","year":"2001","unstructured":"Caselitz M, Chavan A, Manns MP, Wagner S (2001) Die Heredit\u00e4re H\u00e4morrhagische Telangiektasie (Morbus Osler-Rendu-Weber) und ihre Manifestation an der Leber. Z Gastroenterol 39:533?542","journal-title":"Z Gastroenterol"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/BF02577971","volume":"10","author":"Derauf","year":"1987","unstructured":"Derauf BJ, Hunter DW, Sirr SA, Cardella JF, Castaneda-Zuniga W, Amplatz K (1987) Peripheral embolization of diffuse hepatic arteriovenous malformations in a patient with hereditary hemorrhagic telangiectasia. Cardiovasc Intervent Radiol 10:80?83","journal-title":"Cardiovasc Intervent Radiol"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S1051-0443(07)61800-4","volume":"11","author":"Whiting","year":"2000","unstructured":"Whiting JH, Korzenic JR, Miller FJ, Pollack JS, White RI (2000) Fatal outcome after embolotherapy for hepatic arteriovenous malformations of the liver in two patients with hereditary hemorrhagic telangectasia. J Vasc Interv Radiol 11:855?858","journal-title":"J Vasc Interv Radiol"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00007890-200107270-00012","volume":"72","author":"Pfitzmann","year":"2001","unstructured":"Pfitzmann R, Heise M, Langrehr JM, Jonas S, Steinmuller T, Podrabsky P, et al (2001) Liver transplantation for treatment of intrahepatic Osler?s disease: first experiences. Transplantation 72:237?241","journal-title":"Transplantation"},{"key":"CR37","first-page":"52","volume":"24","author":"Uhlenbrock","year":"1985","unstructured":"Uhlenbrock D, Antoni D, Kukulies R (1985) Nuclear medicine and X-ray findings in Osler?s disease of the lung. Nuklearmedizin 24:52?54","journal-title":"Nuklearmedizin"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0016-5107(02)70037-0","volume":"56","author":"Lewis","year":"2002","unstructured":"Lewis BS, Swain P (2002) Capsule endoscopy in the evaluation of patients with suspected small intestinal bleeding: results of a pilot study. Gastrointest Endosc 56:349?353","journal-title":"Gastrointest Endosc"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0002-9343(99)80229-0","volume":"99","author":"Haitjema","year":"1995","unstructured":"Haitjema T, Disch F, Overtoom TT, Westermann CJ, Lammers JW (1995) Screening family members of patients with hereditary hemorrhagic telangiectasia. Am J Med 99:519?524","journal-title":"Am J Med"},{"key":"CR40","first-page":"1016","volume":"21","author":"Matsubara","year":"2000","unstructured":"Matsubara S, Manzia JL, Brugge K, Willinsky RA, Montanera W, Faughnan ME (2000) Angiographic and clinical characteristics of patients with cerebral arteriovenous malformations associated with hereditary hemorrhagic telangiectasia. Am J Neuroradiol 21:1016?1020","journal-title":"Am J Neuroradiol"},{"key":"CR41","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1161\/str.32.12.2957","volume":"32","author":"Mandzia","year":"2001","unstructured":"Mandzia J, Henderson K, Faughnan M, White R Jr (2001) Compelling reasons to screen brain in HHT. Stroke 32:2957?2958","journal-title":"Stroke"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/BF00588522","volume":"37","author":"Garcia-Monaco","year":"1995","unstructured":"Garcia-Monaco R, Taylor W, Rodesch G, Alvarez H, Burrows P, Coubes P, Lasjaunias P (1995) Pial arteriovenous fistula in children as presenting manifestation of Rendu-Osler-Weber disease. Neuroradiology 37:60?64","journal-title":"Neuroradiology"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/S0022-5347(05)67159-5","volume":"164","author":"Ziani","year":"2000","unstructured":"Ziani M, Valignat C, Lopez JG, Ruffion A, Plauchu H, Perrin P (2000) Renal arteriovenous malformation requiring surgery in Rendu-Osler-Weber disease (hereditary hemorrhagic telangiectasia). J Urol 164:1292?1293","journal-title":"J Urol"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/000331979804900709","volume":"49","author":"Gurevitch","year":"1998","unstructured":"Gurevitch Y, Hasin Y, Gotsman MS, Rozenman Y (1998) Coronary arteriovenous malformations in a patient with hereditary hemorrhagic telangiectasia?a case report. Angiology 49:577?580","journal-title":"Angiology"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1755-3768.1979.tb00541.x","volume":"57","author":"Vase","year":"1979","unstructured":"Vase I, Vase P (1979) Ocular lesions in hereditary haemorrhagic telangiectasia. Acta Ophthalmol 57:1084?1090","journal-title":"Acta Ophthalmol"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1161\/01.STR.30.4.729","volume":"30","author":"Beech","year":"1999","unstructured":"Beech R, Rudd AG, Tilling K, Wolfe CD (1999) Economic consequences of early inpatient discharge to community-based rehabilitation for stroke in an inner-London teaching hospital. Stroke 30:729?735","journal-title":"Stroke"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-003-0719-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-003-0719-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-003-0719-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T14:00:53Z","timestamp":1559052053000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-003-0719-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,17]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["719"],"URL":"https:\/\/doi.org\/10.1007\/s00405-003-0719-3","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,17]]}}}