{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:11:59Z","timestamp":1767982319786,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T00:00:00Z","timestamp":1119312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1007\/s00405-005-0949-7","type":"journal-article","created":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T19:57:15Z","timestamp":1119297435000},"page":"62-68","source":"Crossref","is-referenced-by-count":19,"title":["Endothelial nitric oxide synthase upregulation in the cochlea of the guinea pig after intratympanic gentamicin injection"],"prefix":"10.1007","volume":"263","author":[{"given":"Ulf-R\u00fcdiger","family":"Heinrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oxana","family":"Selivanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Brieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf J.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,6,21]]},"reference":[{"key":"949_CR1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/path.1250","volume":"199","author":"Albrecht","year":"2002","unstructured":"Albrecht EWJA, Stegeman CA, Heeringa P, Henning RH, van Goor H (2002) Protective role of endothelial nitric oxide synthase. J Pathol 199:8\u201317","journal-title":"J Pathol"},{"key":"949_CR2","unstructured":"Babel J, Bischoff A, Spoendlin H (1970) Ultrastructure of the peripheral nervous system and sense organs. In: Bischoff A (ed) Atlas of normal and pathologic anatomy. Thieme, Stuttgart"},{"key":"949_CR3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1749-6632.1997.tb51884.x","volume":"830","author":"Bagger-Sjoback","year":"1997","unstructured":"Bagger-Sjoback D (1997) Effect of streptomycin and gentamicin on the inner ear. Ann NY Acad Sci 830:120\u2013129","journal-title":"Ann NY Acad Sci"},{"key":"949_CR4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/00016487809124718","volume":"86","author":"Bagger-Sjoback","year":"1978","unstructured":"Bagger-Sjoback D, Wersall J (1978) Gentamicin-induced mitochondrial damage in inner ear sensory cells of the lizard Calotes versicolor. Acta Otolaryngol 86:35\u201351","journal-title":"Acta Otolaryngol"},{"key":"949_CR5","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","volume":"2","author":"Bogdan","year":"2001","unstructured":"Bogdan C (2001) Nitric oxide and the immune response. Nat Immunol 2:907\u2013916","journal-title":"Nat Immunol"},{"key":"949_CR6","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1073\/pnas.95.13.7631","volume":"95","author":"Clementi","year":"1998","unstructured":"Clementi E, Brown GC, Feelisch M, Moncada S (1998) Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci USA 95:7631\u20137636","journal-title":"Proc Natl Acad Sci USA"},{"key":"949_CR7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/(SICI)1096-9861(19990201)404:1<52::AID-CNE4>3.0.CO;2-W","volume":"404","author":"Fessenden","year":"1999","unstructured":"Fessenden JD, Altschuler RA, Seasholtz AF, Schacht J (1999) Nitric oxide\/cyclic guanosine monophosphate pathway in the peripheral and central auditory system of the rat. J Comp Neurology 404:52\u201363","journal-title":"J Comp Neurology"},{"key":"949_CR8","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3109\/00016489609137914","volume":"116","author":"Franz","year":"1996","unstructured":"Franz P, Hauser-Kronberger C, B\u00f6ck P, Quint C, Baumgartner WD (1996) Localization of nitric oxide synthase I and III in the cochlea. Acta Otolaryngol 116:726\u2013731","journal-title":"Acta Otolaryngol"},{"key":"949_CR9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s004050000261","volume":"257","author":"Gosepath","year":"2000","unstructured":"Gosepath K, Heinrich U-R, Ecke U, Maurer J, Amedee R, Mann WJ (2000) Possible role of nitric oxide in the physiology and pathophysiology of the guinea pig cochlea. Eur Arch Otorhinolaryngol 257:418\u2013424","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"949_CR10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0006-8993(97)00977-3","volume":"777","author":"Hashino","year":"1997","unstructured":"Hashino E, Shero M, Salvi RJ (1997) Lysosomal targeting and accumulation of aminoglycoside antibiotics in sensory hair cells. Brain Res 777:75\u201385","journal-title":"Brain Res"},{"key":"949_CR11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s004050050104","volume":"255","author":"Heinrich","year":"1998","unstructured":"Heinrich U-R, Maurer J, Gosepath K, Mann W (1998) Immunoelectron microscopic localization of nitric oxide synthase III in the guinea pig organ of Corti. Eur Arch Otorhinolaryngol 255:483\u2013490","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"949_CR12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00405-003-0648-1","volume":"261","author":"Heinrich","year":"2004","unstructured":"Heinrich U-R, Maurer J, Mann W (2004) Evidence for a possible NOS back-up system in the organ of Corti of the guinea pig. Eur Arch Otorhinolaryngol 261:121\u2013128","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"949_CR13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0006-8993(99)01433-X","volume":"830","author":"Hess","year":"1999","unstructured":"Hess A, Bloch W, Huverstuhl J, Su J, Stennert E, Addicks K, Michel O (1999) Expression of inducible nitric oxide synthase (iNOS\/NOS II) in the cochlea of guinea pigs after intratympanical endotoxin-treatment. Brain Res 830:113\u2013122","journal-title":"Brain Res"},{"key":"949_CR14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3940(99)00195-0","volume":"264","author":"Hess","year":"1999","unstructured":"Hess A, Bloch W, Su J, Stennert E, Addicks K, Michel O (1999) Expression of inducible nitric oxide-synthase in the vestibular system of hydropic guinea pigs. Neurosci Lett 264:145\u2013148","journal-title":"Neurosci Lett"},{"key":"949_CR15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s10162-002-2036-8","volume":"4","author":"Imamura","year":"2003","unstructured":"Imamura S-I, Adams JC (2003) Distribution of Gentamicin in the guinea pig inner ear after local or systemic application. JARO 4:176\u2013195","journal-title":"JARO"},{"key":"949_CR16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejphar.2004.07.030","volume":"500","author":"Kleinert","year":"2004","unstructured":"Kleinert H, Pautz A, Linker K, Schwarz PM (2004) Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol 500:255\u2013266","journal-title":"Eur J Pharmacol"},{"key":"949_CR17","doi-asserted-by":"crossref","unstructured":"Lee JE, Nakagawa T, Kim TS, Iguchi F, Endo T, Kita T, Murai N, Naito Y, Lee SH, Ito J (2004) Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides. Acta Otolaryngol [Suppl] 551:69\u201374","DOI":"10.1080\/03655230310016799"},{"key":"949_CR18","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0006-291X(91)91390-X","volume":"179","author":"Lepoivre","year":"1991","unstructured":"Lepoivre M, Fieschi F, Coves J, Thelander L, Fontecave M (1991) Inactivation of ribonucleotide reductase by nitric oxide. Biochem Biophys Res Commun 179:442\u2013448","journal-title":"Biochem Biophys Res Commun"},{"key":"949_CR19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1089-8603(02)00127-1","volume":"7","author":"Li","year":"2002","unstructured":"Li H, Wallerath T, F\u00f6rstermann U (2002) Physiological mechanisms regulating the expression of endothelial-type NO synthase. Nitric Oxide 7:132\u2013147","journal-title":"Nitric Oxide"},{"key":"949_CR20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1089-8603(02)00111-8","volume":"7","author":"Li","year":"2002","unstructured":"Li H, Wallerath T, M\u00fcnzel T, F\u00f6rstermann U (2002) Regulation of endothelial-type NO synthase expression in pathophysiology and in response to drugs. Nitric Oxide 7:149\u2013164","journal-title":"Nitric Oxide"},{"key":"949_CR21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-5955(00)00018-6","volume":"143","author":"Michel","year":"2000","unstructured":"Michel O, Hess A, Su J, Bloch W, Stennert E, Addicks K (2000) Expression of inducible nitric oxide synthase (iNOS\/NOS II) in the hydropic cochlea of guinea pigs. Hear Res 143:23\u201328","journal-title":"Hear Res"},{"key":"949_CR22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s004050050027","volume":"255","author":"Nakagawa","year":"1998","unstructured":"Nakagawa T, Yamane H, Takayama M, Sunami K (1998) Apoptosis of guinea pig cochlear hair cells following chronic aminoglycoside treatment. Eur Arch Otorhinolaryngol 255:127\u2013131","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"949_CR23","first-page":"3643","volume":"9","author":"Reuss","year":"1998","unstructured":"Reuss S (1998) Nitric oxide synthase in the auditory brain stem. Neuroreport 9:3643\u20133646","journal-title":"Neuroreport"},{"key":"949_CR24","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1749-6632.2002.tb04073.x","volume":"962","author":"Ruan","year":"2002","unstructured":"Ruan R-S (2002) Possible roles of nitric oxide in the physiology and pathophysiology of the mammalian cochlea. Ann NY Acad Sci 962:260\u2013274","journal-title":"Ann NY Acad Sci"},{"key":"949_CR25","doi-asserted-by":"crossref","first-page":"F617","DOI":"10.1152\/ajprenal.00130.2003","volume":"286","author":"Sandoval","year":"2004","unstructured":"Sandoval RM, Molitoris BA (2004) Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum. Am J Physiol Renal Physiol 286:F617\u2013F624","journal-title":"Am J Physiol Renal Physiol"},{"key":"949_CR26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-5955(00)00254-9","volume":"153","author":"Shi","year":"2001","unstructured":"Shi X, Ren T, Nuttall AL (2001) Nitric oxide distribution and production in the guinea pig cochlea. Hear Res 153:23\u201331","journal-title":"Hear Res"},{"key":"949_CR27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000027567","volume":"60","author":"Takumida","year":"1988","unstructured":"Takumida M, Anniko M (1988) Localization of nitric oxide synthase isoforms (NOS I, II and III) in the vestibular end organs of the guinea pig. ORL 60:67\u201372","journal-title":"ORL"},{"key":"949_CR28","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s004050050040","volume":"255","author":"Takumida","year":"1998","unstructured":"Takumida M, Anniko M (1998) Lipopolysaccharide-induced expression of nitric oxide synthase II in the guinea pig vestibular end organs. Eur Arch Otorhinolaryngol 255:184\u2013188","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"949_CR29","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1080\/000164801300366589","volume":"121","author":"Takumida","year":"2001","unstructured":"Takumida M, Anniko M (2001) Detection of nitric oxide in the guinea pig inner ear, using a combination of aldehyde fixative and 4,5-diaminofluorescein diacetate. Acta Otolaryngol 121:460\u2013464","journal-title":"Acta Otolaryngol"},{"key":"949_CR30","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1080\/000164801300366589","volume":"121","author":"Takumida","year":"2001","unstructured":"Takumida M, Anniko M (2001) Nitric oxide in guinea pig vestibular sensory cells following Gentamicin exposure in vitro. Acta Otolaryngol 121:346\u2013350","journal-title":"Acta Otolaryngol"},{"key":"949_CR31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/00016480252775661","volume":"122","author":"Takumida","year":"2002","unstructured":"Takumida M, Anniko M (2002) Brain-derived neuritrophic factor and nitric oxide synthase inhibitor protect the vestibular organ against gentamicin ototoxicity. Acta Otolaryngol 122:10\u201315","journal-title":"Acta Otolaryngol"},{"key":"949_CR32","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000027605","volume":"60","author":"Takumida","year":"1998","unstructured":"Takumida M, Anniko M, Popa R (1998) Possible involvement of free radicals in lipopolysaacharide-induced labyrinthitis in the guinea pig: a morphological and functional investigation. ORL 60:246\u2013253","journal-title":"ORL"},{"key":"949_CR33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000027643","volume":"61","author":"Takumida","year":"1999","unstructured":"Takumida M, Popa R, Anniko M (1999) Free radicals in the guinea pig inner ear following gentamicin exposure. ORL 61:63\u201370","journal-title":"ORL"},{"key":"949_CR34","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1073\/pnas.95.16.9220","volume":"95","author":"V","year":"1998","unstructured":"V\u00e1squez-Vivar J, Kalyanaraman B, Mart\u00e1sek P, Hogg N, Masters BSS, Karoui H, Tordo P, Pritchard KA Jr (1998) Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci 95:9220\u20139225","journal-title":"Proc Natl Acad Sci"},{"key":"949_CR35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0196-0709(98)90083-7","volume":"19","author":"Wanamaker","year":"1998","unstructured":"Wanamaker HH, Gruenwald L, Damm KJ, Ogata Y, Slepecky N (1998) Dose-related vestibular and cochlear effects of transtympanic Gentamicin. Am J Otol 19:170\u2013179","journal-title":"Am J Otol"},{"key":"949_CR36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/10715760000300361","volume":"32","author":"Watanabe","year":"2000","unstructured":"Watanabe K, Hess A, Bloch W, Michel O (2000) Inhibition of inducible nitric oxide synthase lowers the cochlear damage by lipopolysaccharide in guinea pigs. Free Rad Biol Med 32:363\u2013370","journal-title":"Free Rad Biol Med"},{"key":"949_CR37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainres.2004.05.104","volume":"1019","author":"Yamashita","year":"2004","unstructured":"Yamashita D, Jiang H-Y, Schacht J, Miller JM (2004) Delayed production of free radicals following noise exposure. Brain Res 1019:201\u2013209","journal-title":"Brain Res"},{"key":"949_CR38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1161\/01.HYP.32.2.351","volume":"32","author":"Ziegler","year":"1998","unstructured":"Ziegler T, Silacci P, Harrison VJ, Hayoz D (1998) Nitric oxide synthase expression in endothelial cells exposed to mechanical forces. Hypertension 32:351\u2013355","journal-title":"Hypertension"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-005-0949-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-005-0949-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-005-0949-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T18:00:59Z","timestamp":1559066459000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-005-0949-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,21]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["949"],"URL":"https:\/\/doi.org\/10.1007\/s00405-005-0949-7","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,21]]}}}