{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:01:54Z","timestamp":1778184114035,"version":"3.51.4"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T00:00:00Z","timestamp":1142380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1007\/s00405-006-0030-1","type":"journal-article","created":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T17:01:54Z","timestamp":1142355714000},"page":"603-607","source":"Crossref","is-referenced-by-count":31,"title":["Toll-like receptors 2, 3 and 4 (TLR-2, TLR-3 and TLR-4) are expressed in the microenvironment of human acquired cholesteatoma"],"prefix":"10.1007","volume":"263","author":[{"given":"Miros\u0142aw","family":"Szczepa\u0144ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Witold","family":"Szyfter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Jenek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Wr\u00f3bel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona Mozer","family":"Lisewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"\u017beromski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,3,15]]},"reference":[{"key":"30_CR1","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1084\/jem.184.5.2007","volume":"184","author":"D Bruch-Gerharz","year":"1996","unstructured":"Bruch-Gerharz D, Fehsel K, Suschek C, Michel G, Ruzicka T, Kolb-Bachofen V (1996) A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes. J Exp Med 184:2007\u20132012","journal-title":"J Exp Med"},{"key":"30_CR2","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1074\/jbc.M008557200","volume":"276","author":"J Harder","year":"2001","unstructured":"Harder J, Bartels J, Christophers E, Schroder JM (2001) Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 276:5707\u20135713","journal-title":"J Biol Chem"},{"key":"30_CR3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0952-7915(99)80003-X","volume":"11","author":"EB Kopp","year":"1999","unstructured":"Kopp EB, Medzhitov R (1999) The toll-receptor family and control of innate immunity. Curr Opin Immunol 11:13\u201318","journal-title":"Curr Opin Immunol"},{"key":"30_CR4","first-page":"289","volume":"58","author":"J Kuczkowski","year":"2004","unstructured":"Kuczkowski J, Bakowska A, Mikaszewski B (2004) Immunomorphological evaluation of cholesteatoma (in Polish). Otolaryngol Pol 58:289\u2013295","journal-title":"Otolaryngol Pol"},{"key":"30_CR5","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0006-291X(02)00380-7","volume":"293","author":"M Matsumoto","year":"2002","unstructured":"Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T (2002) Establishment of a monoclonal antibody against human toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun 293:1364\u20131369","journal-title":"Biochem Biophys Res Commun"},{"key":"30_CR6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1348-0421.2004.tb03500.x","volume":"48","author":"M Matsumoto","year":"2004","unstructured":"Matsumoto M, Funami K, Oshiumi H, Seya T (2004) Toll-like receptor 3: a link between toll-like receptor, interferon and viruses. Microbiol Immunol 48:147\u2013154","journal-title":"Microbiol Immunol"},{"key":"30_CR7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1677\/joe.0.1790139","volume":"179","author":"PN Moynagh","year":"2003","unstructured":"Moynagh PN (2003) Toll-like receptor signalling pathways as key targets for mediating the anti-inflammatory and immunosuppressive effects of glucocorticoids. J Endocrinol 179:139\u2013144","journal-title":"J Endocrinol"},{"key":"30_CR8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00405-003-0623-x","volume":"261","author":"E Olszewska","year":"2004","unstructured":"Olszewska E, Wagner M, Bernal-Sprekelsen M, Ebmeyer J, Dazert S, Hildmann H, Sudhoff H (2004) Etiopathogenesis of cholesteatoma. Eur Arch Otorhinolaryngol 261:6\u201324","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"30_CR9","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.4049\/jimmunol.172.8.4977","volume":"172","author":"LC Parker","year":"2004","unstructured":"Parker LC, Whyte MK, Vogel SN, Dower SK, Sabroe I (2004) Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells. J Immunol 172:4977\u20134986","journal-title":"J Immunol"},{"key":"30_CR10","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/00129492-200309000-00002","volume":"24","author":"FA Peek","year":"2003","unstructured":"Peek FA, Huisman MA, Berckmans RJ, Sturk A, Van Loon J, Grote JJ (2003) Lipopolysaccharide concentration and bone resorption in cholesteatoma. Otol Neurotol 24:709\u2013713","journal-title":"Otol Neurotol"},{"key":"30_CR11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/intimm\/dxg068","volume":"15","author":"A Pivarcsi","year":"2003","unstructured":"Pivarcsi A, Bodai L, Rethi B, Kenderessy-Szabo A, Koreck A, Szell M, Beer Z, Bata-Csorgoo Z, Magocsi M, Rajnavolgyi E, Dobozy A, Kemeny L (2003) Expression and function of toll-like receptors 2 and 4 in human keratinocytes. Int Immunol 15:721\u2013730","journal-title":"Int Immunol"},{"key":"30_CR12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0165-2478(02)00210-9","volume":"85","author":"KA Remer","year":"2003","unstructured":"Remer KA, Brcic M, Jungi TW (2003) Toll-like receptor-4 is involved in eliciting an LPS-induced oxidative burst in neutrophils. Immunol Lett 85:75\u201380","journal-title":"Immunol Lett"},{"key":"30_CR13","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1046\/j.1398-9995.2003.00225.x","volume":"58","author":"M Seitz","year":"2003","unstructured":"Seitz M (2003) Toll-like receptors: sensors of the innate immune system. Allergy 58:1247\u20131249","journal-title":"Allergy"},{"key":"30_CR14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1046\/j.1523-1747.2002.01847.x","volume":"119","author":"PI Song","year":"2002","unstructured":"Song PI, Park YM, Abraham T, Harten B, Zivony A, Neparidze N, Armstrong CA, Ansel JC (2002) Human keratinocytes express functional CD14 and toll-like receptor 4. J Invest Dermatol 119:424\u2013432","journal-title":"J Invest Dermatol"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-006-0030-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-006-0030-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-006-0030-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T18:00:36Z","timestamp":1559066436000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-006-0030-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,15]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["30"],"URL":"https:\/\/doi.org\/10.1007\/s00405-006-0030-1","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,15]]}}}