{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:09:41Z","timestamp":1790363381023,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,2,21]],"date-time":"2010-02-21T00:00:00Z","timestamp":1266710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s00405-010-1216-0","type":"journal-article","created":{"date-parts":[[2010,2,20]],"date-time":"2010-02-20T09:35:31Z","timestamp":1266658531000},"page":"1207-1212","source":"Crossref","is-referenced-by-count":14,"title":["Does betahistine treatment have additional benefits to vestibular rehabilitation?"],"prefix":"10.1007","volume":"267","author":[{"given":"Hale","family":"Karapolat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nese","family":"Celebisoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Kirazli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Bilgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Eyigor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sercan","family":"Gode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aycan","family":"Akyuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayfun","family":"Kirazli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,21]]},"reference":[{"key":"1216_CR1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1742-1241.2006.01091.x","volume":"62","author":"E Mira","year":"2008","unstructured":"Mira E (2008) Improving the quality of life in patients with vestibular disorders: the role of medical treatments and physical rehabilitation. Int J Clin Pract 62:109\u2013114","journal-title":"Int J Clin Pract"},{"key":"1216_CR2","doi-asserted-by":"crossref","unstructured":"Hillier SL, Hollohan V (2007) Vestibular rehabilitation for unilateral peripheral vestibular dysfunction. Cochrane Database Syst Rev 4:CD005397","DOI":"10.1002\/14651858.CD005397.pub2"},{"key":"1216_CR3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.47102\/annals-acadmedsg.V34N4p289","volume":"34","author":"LH Tee","year":"2005","unstructured":"Tee LH, Chee NW (2005) Vestibular rehabilitation therapy for the dizzy patient. Ann Acad Med Singap 34:289\u2013294","journal-title":"Ann Acad Med Singap"},{"key":"1216_CR4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2005.03.043","volume":"515","author":"M Barresi","year":"2005","unstructured":"Barresi M, Bruschini L, Li Volsi G, Manzoni D (2005) Effects of betahistine on the spatiotemporal response properties of vestibulospinal neurons to labyrinthine volleys. Eur J Pharmacol 515:73\u201382","journal-title":"Eur J Pharmacol"},{"key":"1216_CR5","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejphar.2005.09.017","volume":"523","author":"B Tighilet","year":"2005","unstructured":"Tighilet B, Trottier S, Lacour M (2005) Dose- and duration-dependent effects of betahistine dihydrochloride treatment on histamine turnover in the cat. Eur J Pharmacol 523:54\u201363","journal-title":"Eur J Pharmacol"},{"key":"1216_CR6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/000164800750044461","volume":"544","author":"J Claes","year":"2000","unstructured":"Claes J, Van de Heyning PH (2000) A review of medical treatment for M\u00e9ni\u00e8re\u2019s disease. Acta Otolaryngol Suppl 544:34\u201339","journal-title":"Acta Otolaryngol Suppl"},{"key":"1216_CR7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00405-002-0524-4","volume":"260","author":"E Mira","year":"2003","unstructured":"Mira E, Guidetti G, Ghilardi L, Fattori B, Malannino N, Maiolino L, Mora R, Ottoboni S, Pagnini P, Leprini M, Pallestrini E, Passali D, Nuti D, Russolo M, Tirelli G, Simoncelli C, Brizi S, Vicini C, Frasconi P (2003) Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo. Eur Arch Otorhinolaryngol 260:73\u201377","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1216_CR8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/000164800750044452","volume":"544","author":"V Colletti","year":"2000","unstructured":"Colletti V (2000) Medical treatment in M\u00e9ni\u00e8re\u2019s disease: avoiding vestibular neurectomy and facilitating postoperative compensation. Acta Otolaryngol Suppl 544:27\u201333","journal-title":"Acta Otolaryngol Suppl"},{"key":"1216_CR9","first-page":"65","volume":"24","author":"LB Jongkees","year":"1962","unstructured":"Jongkees LB, Maas JP, Philipszoon AJ (1962) Clinical nystagmography: a detailed study of electro-nystagmography in 341 patients with vertigo. Pract Otorhinolaryngol 24:65\u201393","journal-title":"Pract Otorhinolaryngol"},{"key":"1216_CR10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1001\/archotol.1990.01870040046011","volume":"116","author":"GP Jacobson","year":"1990","unstructured":"Jacobson GP, Newman CW (1990) The development of the Dizziness Handicap Inventory. Arch Otolaryngol Head Neck Surg 116:424\u2013427","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1216_CR11","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/S0003-9993(03)00274-0","volume":"84","author":"DM Wrisley","year":"2003","unstructured":"Wrisley DM, Walker ML, Echternach JL, Strasnick B (2003) Reliability of the Dynamic Gait Index in people with vestibular disorders. Arch Phys Med Rehabil 84:1528\u20131533","journal-title":"Arch Phys Med Rehabil"},{"key":"1216_CR12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3233\/VES-2000-10205","volume":"10","author":"SL Whitney","year":"2000","unstructured":"Whitney SL, Hudak MT, Marchetti GF (2000) The Dynamic Gait Index relates to self-reported fall history in individuals with vestibular dysfunction. J Vestib Res 10:99\u2013105","journal-title":"J Vestib Res"},{"key":"1216_CR13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2466\/pms.1991.73.2.635","volume":"73","author":"R Kohen-Raz","year":"1991","unstructured":"Kohen-Raz R (1991) Application of tetra-ataxiametric posturography in clinical and developmental diagnosis. Percept Mot Skills 73:635\u2013656","journal-title":"Percept Mot Skills"},{"key":"1216_CR14","unstructured":"Turner M (1998) Evaluation of the Tetrax Interactive Balance System and Equitest Using Normal Subjects. Faculty of Engineering and Applied Science Institute of Sound and Vibration Research, University of Southampton, Southhampton"},{"key":"1216_CR15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/00016480310001475","volume":"123","author":"R Albera","year":"2003","unstructured":"Albera R, Ciuffolotti R, Di Cicco M, De Benedittis G, Grazioli I, Melzi G, Mira E, Pallestrini E, Passali D, Serra A, Vicini C (2003) Double-blind, randomized, multicenter study comparing the effect of betahistine and flunarizine on the dizziness handicap in patients with recurrent vestibular vertigo. Acta Otolaryngol 123:588\u2013593","journal-title":"Acta Otolaryngol"},{"key":"1216_CR16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1191\/0269215504cr704oa","volume":"18","author":"O Topuz","year":"2004","unstructured":"Topuz O, Topuz B, Ardi\u00e7 FN, Sarhu\u015f M, Ogmen G, Ardi\u00e7 F (2004) Efficacy of vestibular rehabilitation on chronic unilateral vestibular dysfunction. Clin Rehabil 18:76\u201383","journal-title":"Clin Rehabil"},{"key":"1216_CR17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1067\/mhn.2003.23","volume":"128","author":"HS Cohen","year":"2003","unstructured":"Cohen HS, Kimball KT (2003) Increased independence and decreased vertigo after vestibular rehabilitation. Otolaryngol Head Neck Surg 128:60\u201370","journal-title":"Otolaryngol Head Neck Surg"},{"key":"1216_CR18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/00016480500388885","volume":"126","author":"A Meli","year":"2006","unstructured":"Meli A, Zimatore G, Badaracco C, De Angelis E, Tufarelli D (2006) Vestibular rehabilitation and 6-month follow-up using objective and subjective measures. Acta Otolaryngol 126:259\u2013266","journal-title":"Acta Otolaryngol"},{"key":"1216_CR19","doi-asserted-by":"crossref","first-page":"598","DOI":"10.7326\/0003-4819-141-8-200410190-00007","volume":"141","author":"L Yardley","year":"2004","unstructured":"Yardley L, Donovan-Hall M, Smith HE, Walsh BM, Mullee M, Bronstein AM (2004) Effectiveness of primary care-based vestibular rehabilitation for chronic dizziness. Ann Intern Med 141:598\u2013605","journal-title":"Ann Intern Med"},{"key":"1216_CR20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3233\/VES-2004-14506","volume":"14","author":"SL Whitney","year":"2004","unstructured":"Whitney SL, Marchetti GF, Schade A, Wrisley DM (2004) The sensitivity and specificity of the Timed \u201cUp & Go\u201d and the Dynamic Gait Index for self-reported falls in persons with vestibular disorders. J Vestib Res 14:397\u2013409","journal-title":"J Vestib Res"},{"key":"1216_CR21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1191\/0269215505cr830oa","volume":"19","author":"AS Kammerlind","year":"2005","unstructured":"Kammerlind AS, Ledin TE, Odkvist LM, Skargren EI (2005) Effects of home training and additional physical therapy on recovery after acute unilateral vestibular loss\u2014a randomized study. Clin Rehabil 19:54\u201362","journal-title":"Clin Rehabil"},{"key":"1216_CR22","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.otohns.2003.12.020","volume":"130","author":"HS Cohen","year":"2004","unstructured":"Cohen HS, Kimball KT (2004) Decreased ataxia and improved balance after vestibular rehabilitation. Otolaryngol Head Neck Surg 130:418\u2013425","journal-title":"Otolaryngol Head Neck Surg"},{"key":"1216_CR23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1191\/0269215506cr886oa","volume":"20","author":"AS Kammerlind","year":"2006","unstructured":"Kammerlind AS, Ledin TE, Odkvist LM, Skargren EI (2006) Influence of asymmetry of vestibular caloric response and age on balance and perceived symptoms after acute unilateral vestibular loss. Clin Rehabil 20:142\u2013148","journal-title":"Clin Rehabil"},{"key":"1216_CR24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/019459989210600220","volume":"106","author":"FB Horak","year":"1992","unstructured":"Horak FB, Jones-Rycewicz C, Black FO, Shumway-Cook A (1992) Effects of vestibular rehabilitation on dizziness and imbalance. Otolaryngol Head Neck Surg 106:175\u2013180","journal-title":"Otolaryngol Head Neck Surg"},{"key":"1216_CR25","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1212\/WNL.51.3.838","volume":"51","author":"M Strupp","year":"1998","unstructured":"Strupp M, Arbusow V, Maag KP, Gall C, Brandt T (1998) Vestibular exercises improve central vestibulospinal compensation after vestibular neuritis. Neurology 51:838\u2013844","journal-title":"Neurology"},{"key":"1216_CR26","first-page":"441","volume":"4","author":"M Lacour","year":"2007","unstructured":"Lacour M, van de Heyning PH, Novotny M, Tighilet B (2007) Betahistine in the treatment of M\u00e9ni\u00e8re\u2019s disease. Neuropsychiatr Dis Treat 4:441\u2013453","journal-title":"Neuropsychiatr Dis Treat"},{"key":"1216_CR27","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1080\/00016480701724912","volume":"128","author":"M Strupp","year":"2008","unstructured":"Strupp M, Hupert D, Frenzel C, Wagner J, Hahn A, Jahn K, Zingler VC, Mansmann U, Brandt T (2008) Long-term prophylactic treatment of attacks of vertigo in Meni\u00e8re\u2019s disease\u2014comparison of a high with a low dosage of betahistine in an open trial. Acta Otolaryngol 128:520\u2013524","journal-title":"Acta Otolaryngol"},{"key":"1216_CR28","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/00016488809106433","volume":"106","author":"JH Allum","year":"1988","unstructured":"Allum JH, Keshner EA, Honegger F, Pfaltz CR (1988) Indicators of the influence a peripheral vestibular deficit has on vestibulo-spinal reflex responses controlling postural stability. Acta Otolaryngol 106:252\u2013263","journal-title":"Acta Otolaryngol"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-010-1216-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-010-1216-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-010-1216-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T02:59:13Z","timestamp":1711249153000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-010-1216-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,21]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["1216"],"URL":"https:\/\/doi.org\/10.1007\/s00405-010-1216-0","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,21]]}}}