{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:16:59Z","timestamp":1789193819304,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/s00405-010-1330-z","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T10:04:29Z","timestamp":1279015469000},"page":"247-253","source":"Crossref","is-referenced-by-count":38,"title":["Molecular mechanisms of glucocorticoids action: implications for treatment of rhinosinusitis and nasal polyposis"],"prefix":"10.1007","volume":"268","author":[{"given":"Alicja","family":"Grzanka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Misio\u0142ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Golusi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Jarz\u0105b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,14]]},"reference":[{"key":"1330_CR1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00405-009-1180-8","volume":"267","author":"P Schalek","year":"2010","unstructured":"Schalek P, Otruba L, Hahn A (2010) Quality of life in patients with chronic rhinosinusitis: a validation of the Czech version of SNOT-22 questionnaire. Eur Arch Otorhinolaryngol 267:473\u2013475","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1330_CR2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00405-008-0587-y","volume":"265","author":"Z Dudvarski","year":"2008","unstructured":"Dudvarski Z, Pendjer I, Djukic V, Janosevic L, Mikic A (2008) The analysis of clinical characteristics of the chronic rhinosinusitis: complicated and uncomplicated form. Eur Arch Otorhinolaryngol 265:923\u2013927","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"2","key":"1330_CR3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1365-2222.2007.02889.x","volume":"38","author":"GK Scadding","year":"2008","unstructured":"Scadding GK, Durham SR, Mirakian R et al (2008) BSACI guidelines for the management of rhinosinusitis and nasal polyposis. Clin Exp Allergy 38(2):260\u2013275","journal-title":"Clin Exp Allergy"},{"issue":"2","key":"1330_CR4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3132\/pcrj.2008.00029","volume":"17","author":"M Thomas","year":"2008","unstructured":"Thomas M, Yawn B, Price D et al (2008) EPOS primary care guidelines: European position paper on the primary care diagnosis and management of rhinosinusitis and nasal polyps 2007\u2013\u2013a summary. Prim Care Resp J 17(2):79\u201389","journal-title":"Prim Care Resp J"},{"key":"1330_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaci.2008.06.003","volume":"122","author":"DV Wallace","year":"2008","unstructured":"Wallace DV, Dykewicz MS, Bernstein DI et al (2008) The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 122:1\u201384","journal-title":"J Allergy Clin Immunol"},{"key":"1330_CR6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","volume":"63","author":"J Bousquet","year":"2008","unstructured":"Bousquet J, Khaltaev N, Cruz AA et al (2008) Allergic rhinitis and its impact on asthma (ARIA) 2008 update. Allergy 63:8\u2013160","journal-title":"Allergy"},{"issue":"8","key":"1330_CR7","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1080\/00016480310017063","volume":"124","author":"H Shirasaki","year":"2004","unstructured":"Shirasaki H, Watanabe K, Kanaizumi E, Konno N, Sato J, Narita S, Himi T (2004) Expression and localization of steroid receptors in human nasal mucosa. Acta Otolaryngol 124(8):958\u2013963","journal-title":"Acta Otolaryngol"},{"key":"1330_CR8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1067\/mai.2003.97","volume":"111","author":"DY Leung","year":"2003","unstructured":"Leung DY, Bloom JW (2003) Update on glucocorticoid action and resistance. J Allergy Clin Immunol 111:3\u201322","journal-title":"J Allergy Clin Immunol"},{"key":"1330_CR9","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/j.1398-9995.2004.00635.x","volume":"59","author":"L Pujols","year":"2004","unstructured":"Pujols L, Mullol J, Torrego A, Picado C (2004) Glucocorticoid receptors in human airways. Allergy 59:1042\u20131052","journal-title":"Allergy"},{"key":"1330_CR10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11882-007-0005-3","volume":"7","author":"L Pujols","year":"2007","unstructured":"Pujols L, Mullol J, Picado C (2007) Alpha and beta glucocorticoid receptors: relevance in airway diseases. Curr Allergy Asthma Rep 7:93\u201399","journal-title":"Curr Allergy Asthma Rep"},{"key":"1330_CR11","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/j.1398-9995.2008.01745.x","volume":"63","author":"L Pujols","year":"2008","unstructured":"Pujols L, Alobid I, Benitez P, Martinez-Ant\u00f3n A, Roca-Ferrer J, Fokkens WJ, Mullol J, Picado C (2008) Regulation of glucocorticoid receptor in nasal polyps by systemic and intranasal glucocorticoids. Allergy 63:1377\u20131386","journal-title":"Allergy"},{"issue":"2","key":"1330_CR12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/archotol.132.2.179","volume":"132","author":"P Stj\u00e4rne","year":"2006","unstructured":"Stj\u00e4rne P, M\u00f6sges R, Jorissen M, Pass\u00e0li D, Bellussi L, Staudinger H, Danzig M (2006) A randomized controlled trial of mometasone furoate nasal spray for the treatment of nasal polyposis. Arch Otolaryngol Head Neck Surg 132(2):179\u2013185","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1330_CR13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jsbmb.2006.09.009","volume":"102","author":"D Duma","year":"2006","unstructured":"Duma D, Jewell CM, Cidlowski JA (2006) Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification. J Steroid Biochem Mol Biol 102:11\u201321","journal-title":"J Steroid Biochem Mol Biol"},{"key":"1330_CR14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1096\/fj.03-0328com","volume":"18","author":"B Bartholome","year":"2004","unstructured":"Bartholome B, Spies CM, Gaber T et al (2004) Membrane glucocorticoid receptors (mGCR) are expressed in normal peripheral blood mononuclear cells and upregulated following in vitro stimulation and in patients with rheumatoid arthritis. FASEB J 18:70\u201380","journal-title":"FASEB J"},{"key":"1330_CR15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/sj.bjp.0706736","volume":"148","author":"PJ Barnes","year":"2006","unstructured":"Barnes PJ (2006) How corticosteroids control inflammation: quintiles prize lecture 2005. Br J Pharmacol 148:245\u2013254","journal-title":"Br J Pharmacol"},{"key":"1330_CR16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jaci.2006.01.032","volume":"117","author":"K Ito","year":"2006","unstructured":"Ito K, Chung KF, Adcock IM (2006) Update on glucocorticoid action and resistance. J Allergy Clin Immunol 117:522\u2013543","journal-title":"J Allergy Clin Immunol"},{"key":"1330_CR17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1513\/pats.200402-015MS","volume":"1","author":"C Stellato","year":"2004","unstructured":"Stellato C (2004) Post-transcriptional and nongenomic effects of glucocorticoids. Proc Am Thorac Soc 1:255\u2013263","journal-title":"Proc Am Thorac Soc"},{"key":"1330_CR18","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.jaci.2004.02.028","volume":"113","author":"M Benson","year":"2004","unstructured":"Benson M, Carlsson L, Adner M, Jern\u00e5s M, Rudemo M, Sj\u00f6gren A, Svensson PA, Uddman R, Cardell LO (2004) Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps. J Allergy Clin Immunol 113:1137\u20131143","journal-title":"J Allergy Clin Immunol"},{"key":"1330_CR19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biocel.2008.09.019","volume":"41","author":"AA George","year":"2009","unstructured":"George AA, Schiltz RL, Hager GL (2009) Dynamic access of the glucocorticoid receptor to response elements in chromatin. Int J Biochem Cell Biol 41:214\u2013224","journal-title":"Int J Biochem Cell Biol"},{"key":"1330_CR20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.steroids.2005.09.014","volume":"71","author":"V Urbach","year":"2006","unstructured":"Urbach V, Verriere V, Grumbach Y, Bousquet J, Harvey BJ (2006) Rapid anti-secretory effects of glucocorticoids in human airway epithelium. Steroids 71:323\u2013328","journal-title":"Steroids"},{"key":"1330_CR21","doi-asserted-by":"crossref","first-page":"35807","DOI":"10.1074\/jbc.M506584200","volume":"280","author":"V Verriere","year":"2005","unstructured":"Verriere V, Hynes D, Faherly S, Devaney J, Bousquet J, Harvey BJ, Urbach V (2005) Rapid effects of dexamethasone on intracellular pH and Na+\/H+ exchanger activity in human bronchial epithelial cells. J Biol Chem 280:35807\u201335814","journal-title":"J Biol Chem"},{"issue":"2","key":"1330_CR22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pupt.2006.03.009","volume":"20","author":"G Horvath","year":"2007","unstructured":"Horvath G, Vasas S, Wanner A (2007) Inhaled corticosteroids reduce asthma-associated airway hyperperfusion through genomic and nongenomic mechanisms. Pulm Pharmacol Ther 20(2):157\u2013162","journal-title":"Pulm Pharmacol Ther"},{"key":"1330_CR23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.bjp.0703272","volume":"130","author":"JD Croxtall","year":"2000","unstructured":"Croxtall JD, Choudhury Q, Flower RJ (2000) Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol 130:289\u2013298","journal-title":"Br J Pharmacol"},{"issue":"1","key":"1330_CR24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00011-004-1320-y","volume":"54","author":"L Liu","year":"2005","unstructured":"Liu L, Wang YX, Zhou J, Long F, Sun HW, Liu Y, Chen YZ, Jiang CL (2005) Rapid non-genomic inhibitory effects of glucocorticoids on human neutrophil degranulation. Inflamm Res 54(1):37\u201341","journal-title":"Inflamm Res"},{"key":"1330_CR25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.steroids.2004.10.004","volume":"70","author":"F Long","year":"2005","unstructured":"Long F, Wang YX, Liu L, Zhou J, Cui RY, Jiang CL (2005) Rapid nongenomic inhibitory effects of glucocorticoids on phagocytosis and superoxide anion production by macrophages. Steroids 70:55\u201361","journal-title":"Steroids"},{"key":"1330_CR26","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.steroids.2007.12.002","volume":"73","author":"M L\u00f6wenberg","year":"2008","unstructured":"L\u00f6wenberg M, Stan C, Holmes DW, Buttgereit F (2008) Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands. Steroids 73:1025\u20131029","journal-title":"Steroids"},{"key":"1330_CR27","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1113\/jphysiol.2002.028183","volume":"545","author":"V Urbach","year":"2002","unstructured":"Urbach V, Walsh DE, Mainprice B, Bousquet J, Harvey BJ (2002) Rapid non-genomic inhibition of ATP-induced Cl\u2212 secretion by dexamethasone in human bronchial epithelium. J Physiol 545:869\u2013878","journal-title":"J Physiol"},{"key":"1330_CR28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0091-6749(97)70091-5","volume":"99","author":"JM Bernstein","year":"1997","unstructured":"Bernstein JM, Gorfien J, Noble B, Yankaskas JR (1997) Nasal polyposis: immunohistochemistry and bioelectrical findings (a hypothesis for the development of nasal polyps). J Allergy Clin Immunol 99:165\u2013175","journal-title":"J Allergy Clin Immunol"},{"key":"1330_CR29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2362.2004.01293.x","volume":"34","author":"HC Tillmann","year":"2004","unstructured":"Tillmann HC, Stuck BA, Feuring M, Rossol-Haseroth K, Tran BM, L\u00f6sel R, Schmidt BM, H\u00f6rmann K, Wehling M, Schultz A (2004) Delayed genomic and acute nongenomic action of glucocorticosteroids in seasonal allergic rhinitis. Eur J Clin Invest 34:67\u201373","journal-title":"Eur J Clin Invest"},{"key":"1330_CR30","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/ard.61.8.718","volume":"61","author":"F Buttgereit","year":"2002","unstructured":"Buttgereit F, Silva JA, Boers M, Burmester GR, Cutolo M, Jacobs J, Kirwan J, K\u00f6hler L, Van Riel P, Vischer T, Bijlsma JW (2002) Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology. Ann Rheum Dis 61:718\u2013722","journal-title":"Ann Rheum Dis"},{"key":"1330_CR31","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.yfrne.2007.10.004","volume":"29","author":"J Haller","year":"2008","unstructured":"Haller J, Makara G, Mikics E (2008) The effects of nongenomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings. Front Neuroendocrinol 29:273\u2013291","journal-title":"Front Neuroendocrinol"},{"issue":"3","key":"1330_CR32","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1152\/ajplung.00108.2007","volume":"293","author":"M Salter","year":"2007","unstructured":"Salter M, Biggadike K, Matthews JL et al (2007) Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease. Am J Physiol Lung Cell Mol Physiol 293(3):660\u2013667","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"1330_CR33","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1183\/09031936.06.00060005","volume":"27","author":"M Issar","year":"2006","unstructured":"Issar M, Sahasranaman S, Buchwald P, Hochhaus G (2006) Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids. Eur Respir J 27(3):511\u2013516","journal-title":"Eur Respir J"},{"issue":"2","key":"1330_CR34","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2147\/TCRM.S2379","volume":"4","author":"J Newton","year":"2008","unstructured":"Newton J, Wong Ah-See K (2008) A review of nasal polyposis. Ther Clin Risk Manag 4(2):507\u2013512","journal-title":"Ther Clin Risk Manag"},{"key":"1330_CR35","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1164\/rccm.200905-0740OC","volume":"180","author":"HS Lee","year":"2009","unstructured":"Lee HS, Myers A, Kim J (2009) Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis. Am J Respir Crit Care Med 180:1056\u20131067","journal-title":"Am J Respir Crit Care Med"},{"key":"1330_CR36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jaci.2005.11.005","volume":"117","author":"S Psarras","year":"2006","unstructured":"Psarras S, Volonaki E, Skevaki CL, Xatzipsalti M, Bossios A, Pratsinis H, Tsigkos S, Gourgiotis D, Constantopoulos AG, Papapetropoulos A, Saxoni-Papageorgiou P, Papadopoulos NG (2006) Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinoviruses. J Allergy Clin Immunol 117:291\u2013297","journal-title":"J Allergy Clin Immunol"},{"key":"1330_CR37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/00016488309130931","volume":"95","author":"U Pipkorn","year":"1983","unstructured":"Pipkorn U, Berge T (1983) Long-term treatment with budesonide in vasomotor rhinitis. Acta Otolaryngol 95:167\u2013171","journal-title":"Acta Otolaryngol"},{"issue":"4","key":"1330_CR38","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1081-1206(10)62369-1","volume":"88","author":"DR Webb","year":"2002","unstructured":"Webb DR, Meltzer EO, Finn AF Jr, Rickard KA, Pepsin PJ, Westlund R, Cook CK (2002) Intranasal fluticasone propionate is effective for perennial nonallergic rhinitis with or without eosinophilia. Ann Allergy Asthma Immunol 88(4):385\u2013390","journal-title":"Ann Allergy Asthma Immunol"},{"key":"1330_CR39","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2222.1997.tb00744.x","volume":"27","author":"H Hallen","year":"1997","unstructured":"Hallen H, Enerdal J, Graf P (1997) Fluticasone propionate nasal spray is more effective and has a faster onset of action than placebo in treatment of rhinitis medicamentosa. Clin Exp Allergy 27:552\u2013558","journal-title":"Clin Exp Allergy"},{"key":"1330_CR40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/IJGM.S8184","volume":"3","author":"EO Meltzer","year":"2010","unstructured":"Meltzer EO, Caballero F, Fromer LM, Krouse JH, Scadding G (2010) Treatment of congestion in upper respiratory diseases. Int J Gen Med 3:69\u201391","journal-title":"Int J Gen Med"},{"key":"1330_CR41","first-page":"23","volume":"19","author":"RA Settipane","year":"2007","unstructured":"Settipane RA, Charnock DR (2007) Epidemiology of rhinitis: allergic and nonallergic. Clin Allergy Immunol 19:23\u201334","journal-title":"Clin Allergy Immunol"},{"issue":"6","key":"1330_CR42","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.otohns.2009.08.006","volume":"141","author":"LH Kalish","year":"2009","unstructured":"Kalish LH, Arendts G, Sack R, Craig JC (2009) Topical steroids in chronic rhinosinusitis without polyps: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 141(6):674\u2013683","journal-title":"Otolaryngol Head Neck Surg"},{"key":"1330_CR43","doi-asserted-by":"crossref","unstructured":"Cingi C, Songu M (2009) Nasal steroid perspective: knowledge and attitudes. Eur Arch Otorhinolaryngol. doi: 10.1007\/s00405-009-1159-5","DOI":"10.1007\/s00405-009-1159-5"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s00405-010-1330-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T01:00:07Z","timestamp":1559264407000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-010-1330-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,14]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["1330"],"URL":"https:\/\/doi.org\/10.1007\/s00405-010-1330-z","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,14]]}}}