{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:00:28Z","timestamp":1788926428615,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s00405-016-4060-z","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T17:25:35Z","timestamp":1461864335000},"page":"2591-2597","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy and tolerability of an ectoine mouth and throat spray compared with those of saline lozenges in the treatment of acute pharyngitis and\/or laryngitis: a prospective, controlled, observational clinical trial"],"prefix":"10.1007","volume":"273","author":[{"given":"D\u00f6rte","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Lindemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kija","family":"Shah-Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Scherner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Knop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bilstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"M\u00f6sges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"4060_CR1","first-page":"109","volume-title":"Hals-Nasen-Ohren-Heilkunde","author":"R Probst","year":"2008","unstructured":"Probst R, Grevers G, Iro H (2008) Hals-Nasen-Ohren-Heilkunde, 3rd edn. Georg Thieme Verlag, Stuttgart, pp 109\u2013114","edition":"3"},{"key":"4060_CR2","doi-asserted-by":"publisher","first-page":"CD000023","DOI":"10.1002\/14651858.CD000023.pub4","volume":"11","author":"A Spinks","year":"2013","unstructured":"Spinks A, Glasziou PP, Del Mar CB (2013) Antibiotics for sore throat. Cochrane Database Syst Rev 11:CD000023. doi: 10.1002\/14651858.CD000023.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"4060_CR3","volume-title":"Die EVaS-Studie: eine Erhebung \u00fcber die ambulante medizinische Versorgung in der Bundesrepublik Deutschland","author":"E Schach","year":"1989","unstructured":"Schach E, Schwartz FW, Kerek-Bodden HE (1989) Die EVaS-Studie: eine Erhebung \u00fcber die ambulante medizinische Versorgung in der Bundesrepublik Deutschland. Deutscher \u00c4rzteGmbH, K\u00f6ln"},{"key":"4060_CR4","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1055\/s-2007-968157","volume":"83","author":"W Fink","year":"2007","unstructured":"Fink W, Haidinger G (2007) Die H\u00e4ufigkeit von Gesundheitsst\u00f6rungen in 10 Jahren Allgemeinpraxis [Prevalence of health problems in a family practice observed over 10 years] [article in German]. Z Allg Med 83:102\u2013108. doi: 10.1055\/s-2007-968157","journal-title":"Z Allg Med"},{"key":"4060_CR5","first-page":"366","volume":"47","author":"WJ McIsaac","year":"1998","unstructured":"McIsaac WJ, Levine N, Goel V (1998) Visits by adults to family physicians for the common cold. J Fam Pract 47:366\u2013369","journal-title":"J Fam Pract"},{"key":"4060_CR6","first-page":"453","volume":"28","author":"CE Evans","year":"1982","unstructured":"Evans CE, McFarlane AH, Norman GR, Neale KA, Streiner DL (1982) Sore throats in adults: who sees a doctor? Can Fam Physician 28:453\u2013458","journal-title":"Can Fam Physician"},{"key":"4060_CR7","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1183\/09031936.00132211","volume":"41","author":"U Sydlik","year":"2013","unstructured":"Sydlik U, Peuschel H, Paunel-G\u00f6rg\u00fcl\u00fc A, Keymel S, Kr\u00e4mer U, Wiessenberg A, Kroker M, Seghrouchni S, Heiss C, Windolf J, Bilstein A, Kelm M, Krutmann J, Unfried K (2013) Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation. Eur Respir J 41:433\u2013442. doi: 10.1183\/09031936.00132211","journal-title":"Eur Respir J"},{"key":"4060_CR8","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1021\/acs.jnatprod.5b00115","volume":"78","author":"H Abdel-Aziz","year":"2015","unstructured":"Abdel-Aziz H, Wadie W, Scherner O, Efferth T, Khayyal MT (2015) Bacteria-derived compatible solutes ectoine and 5\u03b1-hydroxyectoine act as intestinal barrier stabilizers to ameliorate experimental inflammatory bowel disease. J Nat Prod 78:1309\u20131315. doi: 10.1021\/acs.jnatprod.5b00115","journal-title":"J Nat Prod"},{"key":"4060_CR9","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1515\/BC.2010.131","volume":"391","author":"H Peuschel","year":"2010","unstructured":"Peuschel H, Sydlik U, Haendeler J, B\u00fcchner N, St\u00f6ckmann D, Kroker M, Wirth R, Brock W, Unfried K (2010) c-Src-mediated activation of Erk1\/2 is a reaction of epithelial cells to carbon nanoparticle treatment and may be a target for a molecular preventive strategy. Biol Chem 391:1327\u20131332. doi: 10.1515\/BC.2010.131","journal-title":"Biol Chem"},{"key":"4060_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000351381","volume":"27","author":"A Marini","year":"2014","unstructured":"Marini A, Reinelt K, Krutmann J, Bilstein A (2014) Ectoine-containing cream in the treatment of mild to moderate atopic dermatitis: a randomised, comparator-controlled, intra-individual double-blind, multi-center trial. Skin Pharmacol Physiol 27:57\u201365. doi: 10.1159\/000351381","journal-title":"Skin Pharmacol Physiol"},{"key":"4060_CR11","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1185\/03007995.2013.800474","volume":"29","author":"A Eichel","year":"2013","unstructured":"Eichel A, Wittig J, Shah-Hosseini K, M\u00f6sges R (2013) A prospective, controlled study of SNS01 (ectoine nasal spray) compared to BNO-101 (phytotherapeutic drag\u00e9es) in patients with acute rhinosinusitis. Curr Med Res Opin 29:739\u2013746. doi: 10.1185\/03007995.2013.800474","journal-title":"Curr Med Res Opin"},{"key":"4060_CR12","doi-asserted-by":"publisher","first-page":"176597","DOI":"10.1155\/2014\/176597","volume":"2014","author":"N Werkh\u00e4user","year":"2014","unstructured":"Werkh\u00e4user N, Bilstein A, Sonnemann U (2014) Treatment of allergic rhinitis with ectoine containing nasal spray and eye drops in comparison with azelastine containing nasal spray and eye drops or with cromoglycic acid containing nasal spray. J Allergy (Cairo) 2014:176597. doi: 10.1155\/2014\/176597","journal-title":"J Allergy (Cairo)"},{"key":"4060_CR13","doi-asserted-by":"publisher","first-page":"273219","DOI":"10.1155\/2014\/273219","volume":"2014","author":"U Sonnemann","year":"2014","unstructured":"Sonnemann U, Scherner O, Werkh\u00e4user N (2014) Treatment of rhinitis sicca anterior with ectoine containing nasal spray. J Allergy (Cairo) 2014:273219. doi: 10.1155\/2014\/273219","journal-title":"J Allergy (Cairo)"},{"key":"4060_CR14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.bpc.2010.02.007","volume":"150","author":"RK Harishchandra","year":"2010","unstructured":"Harishchandra RK, Wulff S, Lentzen G, Neuhaus T, Galla HJ (2010) The effect of compatible solute ectoines on the structural organization of lipid monolayer and bilayer membranes. Biophys Chem 150:37\u201346. doi: 10.1016\/j.bpc.2010.02.007","journal-title":"Biophys Chem"},{"key":"4060_CR15","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1016\/j.bbamem.2014.05.011","volume":"1838","author":"M Dwivedi","year":"2014","unstructured":"Dwivedi M, Backers H, Harishchandra RK, Galla HJ (2014) Biophysical investigations of the structure and function of the tear fluid lipid layer and the effect of ectoine. Part A: natural meibomian lipid films. Biochim Biophys Acta 1838:2708\u20132715. doi: 10.1016\/j.bbamem.2014.05.011","journal-title":"Biochim Biophys Acta"},{"key":"4060_CR16","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1016\/j.bbamem.2014.05.007","volume":"1838","author":"M Dwivedi","year":"2014","unstructured":"Dwivedi M, Brinkk\u00f6tter M, Harishchandra RK, Galla HJ (2014) Biophysical investigations of the structure and function of the tear fluid lipid layers and the effect of ectoine. Part B: artificial lipid films. Biochim Biophys Acta 1838:2716\u20132727. doi: 10.1016\/j.bbamem.2014.05.007","journal-title":"Biochim Biophys Acta"},{"key":"4060_CR17","doi-asserted-by":"publisher","first-page":"e93809","DOI":"10.1371\/journal.pone.0093809","volume":"9","author":"N Widderich","year":"2014","unstructured":"Widderich N, H\u00f6ppner A, Pittelkow M, Heider J, Smits SH, Bremer E (2014) Biochemical properties of ectoine hydroxylases from extremophiles and their wider taxonomic distribution among microorganisms. PLoS ONE 9:e93809. doi: 10.1371\/journal.pone.0093809","journal-title":"PLoS ONE"},{"key":"4060_CR18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-2007-995716","volume":"34","author":"T Dirschka","year":"2008","unstructured":"Dirschka T (2008) Ectoin\u2014Anwendung und Perspektiven f\u00fcr die Dermatologie. Akt Dermatol 34:115\u2013118","journal-title":"Akt Dermatol"},{"key":"4060_CR19","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1055\/s-0029-1202369","volume":"88","author":"R M\u00f6sges","year":"2009","unstructured":"M\u00f6sges R, Pasch N, Sayar A, Schmalz P, Vent J (2009) Erhebung der sensorischen Wahrnehmung und subjektiven Patienteneinsch\u00e4tzung bei der Verabreichung von Nasenspray\u2014Die Nasen-Spray-Sensorik-Skala [Survey of sensory perception and patients\u2019 assessment of the application of nasal sprays\u2014the nasal-spray-sensoric-scale] [article in German]. Laryngorhinootologie 88:587\u2013591. doi: 10.1055\/s-0029-1202369","journal-title":"Laryngorhinootologie"},{"key":"4060_CR20","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1186\/2047-783X-14-9-406","volume":"14","author":"A Schapowal","year":"2009","unstructured":"Schapowal A, Berger D, Klein P, Suter A (2009) Echinacea\/sage or chlorhexidine\/lidocaine for treating acute sore throats: a randomized double-blind trial. Eur J Med Res 14:406\u2013412. doi: 10.1186\/2047-783X-14-9-406","journal-title":"Eur J Med Res"},{"key":"4060_CR21","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.explore.2007.09.004","volume":"3","author":"VG Lizogub","year":"2007","unstructured":"Lizogub VG, Riley DS, Heger M (2007) Efficacy of a pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial. Explore (NY) 3:573\u2013584. doi: 10.1016\/j.explore.2007.09.004","journal-title":"Explore (NY)"},{"key":"4060_CR22","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/S0149-2918(01)80123-5","volume":"23","author":"D Pass\u00e0li","year":"2001","unstructured":"Pass\u00e0li D, Volont\u00e9 M, Pass\u00e0li GC, Damiani V, Bellussi L, MISTRAL Italian Study Group (2001) Efficacy and safety of ketoprofen lysine salt mouthwash versus benzydamine hydrochloride mouthwash in acute pharyngeal inflammation: a randomized, single-blind study. Clin Ther 23:1508\u20131518. doi: 10.1016\/S0149-2918(01)80123-5","journal-title":"Clin Ther"},{"key":"4060_CR23","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.1016\/j.lpm.2014.07.022","volume":"44","author":"C Etienne","year":"2015","unstructured":"Etienne C, Pulcini C (2015) \u00c9valuation prospective des prescriptions antibiotiques d\u2019un \u00e9chantillon de m\u00e9decins g\u00e9n\u00e9ralistes fran\u00e7ais [Prospective cross-sectional study of antibiotic prescriptions in a sample of French general practitioners] [article in French]. Presse Med 44:e59\u201366. doi: 10.1016\/j.lpm.2014.07.022","journal-title":"Presse Med"},{"key":"4060_CR24","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1046\/j.1525-1497.2003.21101.x","volume":"18","author":"JA Linder","year":"2003","unstructured":"Linder JA, Singer DE (2003) Desire for antibiotics and antibiotic prescribing for adults with upper respiratory tract infections. J Gen Intern Med 18:795\u2013801. doi: 10.1046\/j.1525-1497.2003.21101.x","journal-title":"J Gen Intern Med"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-016-4060-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-016-4060-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-016-4060-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T19:16:50Z","timestamp":1553627810000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-016-4060-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["4060"],"URL":"https:\/\/doi.org\/10.1007\/s00405-016-4060-z","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,28]]}}}