{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:57:20Z","timestamp":1785902240290,"version":"3.56.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Shanghai municipal bureau of health youth fund Project","award":["2010Y141"],"award-info":[{"award-number":["2010Y141"]}]},{"name":"Shanghai municipal education commission project for excellent young university teacher","award":["jdy10020"],"award-info":[{"award-number":["jdy10020"]}]},{"name":"National sicence and technology Grant of China","award":["81371086"],"award-info":[{"award-number":["81371086"]}]},{"name":"National sicence and technology Grant of China","award":["81670919"],"award-info":[{"award-number":["81670919"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00405-016-4417-3","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T08:20:33Z","timestamp":1482308433000},"page":"1919-1924","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The therapy with ethosomes containing 5-fluorouracil for laryngotracheal stenosis in rabbit models"],"prefix":"10.1007","volume":"274","author":[{"given":"Xiaohui","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"4417_CR1","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1097\/00005537-199910000-00009","volume":"109","author":"R Eliashar","year":"1999","unstructured":"Eliashar R, Eliachar I, Esclamado R, Gramlich T, Strome M (1999) Can topical mitomycin prevent laryngotracheal stenosis? Laryngoscope 109:1594\u20131600","journal-title":"Laryngoscope"},{"key":"4417_CR2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000279225","volume":"79","author":"AE Melkane","year":"2010","unstructured":"Melkane AE, Matar NE, Haddad AC, Nassar MN (2010) Management of postintubation tracheal stenosis: appropriate indications make outcome differences. Respiration 79:395\u2013401","journal-title":"Respiration"},{"key":"4417_CR3","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1097\/01.mlg.0000228006.21941.12","volume":"116","author":"HC Herrington","year":"2006","unstructured":"Herrington HC, Weber SM, Andersen PE (2006) Modern management of laryngotracheal stenosis. Laryngoscope 116:1553\u20131557","journal-title":"Laryngoscope"},{"key":"4417_CR4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/000348940911800105","volume":"118","author":"DR Johnston","year":"2009","unstructured":"Johnston DR, Curry JM, Rubin R et al (2009) Unusual fibrosclerotic lesion of the laryngotracheal complex presenting as subglottic stenosis. Ann Otol Rhinol Laryngol 118:27\u201329","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"4417_CR5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jtcvs.2002.11.001","volume":"127","author":"SK Ashiku","year":"2004","unstructured":"Ashiku SK, Kuzucu A, Grillo HC et al (2004) Idiopathic laryngotracheal stenosis: effective definitive treatment with laryngotracheal resection. J Thorac Cardiovasc Surg 127:99\u2013107","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4417_CR6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0022-5223(95)70279-2","volume":"109","author":"HC Grillo","year":"1995","unstructured":"Grillo HC, Donahue DM, Mathisen DJ, Wain JC, Wright CD (1995) Postintubation tracheal stenosis: treatment and results. J Thorac Cardiovasc Surg 109:486\u2013493","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4417_CR7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jtcvs.2004.07.005","volume":"128","author":"CD Wright","year":"2004","unstructured":"Wright CD, Grillo HC, Wain JC et al (2004) Anastomotic complications after tracheal resection: prognostic factors and management. J Thorac Cardiovasc Surg 128:731\u2013739","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4417_CR8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.amjoto.2003.07.002","volume":"26","author":"H Cincik","year":"2005","unstructured":"Cincik H, Gungor A, Cakmak A et al (2005) The effects of mitomycin C and 5-fluorouracil\/triamcinolone on fibrosis\/scar tissue formation secondary to subglottic trauma (experimental study). Am J Otolaryngol 26:45\u201350","journal-title":"Am J Otolaryngol"},{"key":"4417_CR9","doi-asserted-by":"publisher","DOI":"10.1039\/C6NR06872C","author":"Z Zhang","year":"2016","unstructured":"Zhang Z, Chen YS, Xu H et al (2016) 5-Aminolevulinic acid loaded ethosomal vesicles with high entrapment efficiency for in vitro topical transdermal delivery and photodynamic therapy of hypertrophic scars. Nanoscale. doi: 10.1039\/C6NR06872C","journal-title":"Nanoscale"},{"key":"4417_CR10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jconrel.2005.04.007","volume":"106","author":"D Paolino","year":"2005","unstructured":"Paolino D, Lucania G, Mardente D et al (2005) Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. J Control Release 106:99\u2013110","journal-title":"J Control Release"},{"key":"4417_CR11","first-page":"127","volume":"49","author":"E Hatamipour","year":"2011","unstructured":"Hatamipour E, Mehrabi S, Hatamipour M, Ghafarian Shirazi HR (2011) Effects of combined intralesional 5-fluorouracil and topical silicone in prevention of keloids: a double blind randomized clinical trial study. Acta Med Iran 49:127\u2013130","journal-title":"Acta Med Iran"},{"key":"4417_CR12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/SAP.0b013e3181afaab0","volume":"64","author":"SM Shridharani","year":"2010","unstructured":"Shridharani SM, Magarakis M, Manson PN, Singh NK, Basdag B, Rosson GD (2010) The emerging role of antineoplastic agents in the treatment of keloids and hypertrophic scars: a review. Ann Plast Surg 64:355\u2013361","journal-title":"Ann Plast Surg"},{"key":"4417_CR13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/PRS.0b013e3181c82dd5","volume":"125","author":"R Ogawa","year":"2010","unstructured":"Ogawa R (2010) The most current algorithms for the treatment and prevention of hypertrophic scars and keloids. Plast Reconstr Surg 125:557\u2013568","journal-title":"Plast Reconstr Surg"},{"key":"4417_CR14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2230.2007.02631.x","volume":"34","author":"A Darougheh","year":"2010","unstructured":"Darougheh A, Asilian A, Shariati F (2010) Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. Clin Exp Dermatol 34:219\u2013223","journal-title":"Clin Exp Dermatol"},{"key":"4417_CR15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1524-4725.1999.08165.x","volume":"25","author":"RE Fitzpatrick","year":"1999","unstructured":"Fitzpatrick RE (1999) Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg 25:224\u2013232","journal-title":"Dermatol Surg"},{"key":"4417_CR16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0168-3659(99)00222-9","volume":"65","author":"E Touitou","year":"2000","unstructured":"Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M (2000) Ethosomes-novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release 65:403\u2013418","journal-title":"J Control Release"},{"key":"4417_CR17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jconrel.2007.08.005","volume":"123","author":"V Dubey","year":"2007","unstructured":"Dubey V, Mishra D, Dutta T, Nahar M, Saraf DK, Jain NK (2007) Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes. J Control Release 123:148\u2013154","journal-title":"J Control Release"},{"key":"4417_CR18","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/01.MLG.0000163105.86513.6D","volume":"115","author":"Y Nakagishi","year":"2005","unstructured":"Nakagishi Y, Morimoto Y, Fujita M, Ozeki Y, Maehara T, Kikuchi M (2005) Rabbit model of airway stenosis induced by scraping of the tracheal mucosa. Laryngoscope 115:1087\u20131092","journal-title":"Laryngoscope"},{"key":"4417_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1288\/00005537-199106000-00021","volume":"101","author":"RT Cotton","year":"1991","unstructured":"Cotton RT (1991) The problem of pediatric laryngotracheal stenosis: a clinical and experimental study on the efficacy of autogenous cartilaginous grafts placed between the vertically divided halves of the posterior lamina of the cricoid cartilage. Laryngoscope 101:1\u201334","journal-title":"Laryngoscope"},{"key":"4417_CR20","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1288\/00005537-199011000-00010","volume":"100","author":"PJ Nicklaus","year":"1990","unstructured":"Nicklaus PJ, Crysdale WS, Conley S et al (1990) Evaluation of neonatal subglottic stenosis: a 3-year prospective study. Laryngoscope 100:1185\u20131190","journal-title":"Laryngoscope"},{"key":"4417_CR21","first-page":"40","volume":"137","author":"I Ratner","year":"1983","unstructured":"Ratner I, Whitfield J (1983) Acquired subglottic stenosis in the verylow-birth-weight infant. Am J Dis Child 137:40\u201343","journal-title":"Am J Dis Child"},{"key":"4417_CR22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0022-3476(86)80395-X","volume":"109","author":"JM Sherman","year":"1986","unstructured":"Sherman JM, Lowitt S, Stephenson C et al (1986) Factors influencing acquired subglottic stenosis in infants. J Pediatr 109:322\u2013327","journal-title":"J Pediatr"},{"key":"4417_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijporl.2003.08.054","volume":"68","author":"D Preciado","year":"2004","unstructured":"Preciado D, Cotton RT, Rutter MJ (2004) Single-stage tracheal resection for severe tracheal stenosis in older children. Int J Pediatr Otorhinolaryngol 68:1\u20136","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"4417_CR24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0022-5223(95)70279-2","volume":"109","author":"HC Grillo","year":"1995","unstructured":"Grillo HC, Donahue DM, Mathisen DJ et al (1995) Postintubation tracheal stenosis: treatment and results. J Thorac Cardiovasc Surg 109:486\u2013492","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4417_CR25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0003-4975(02)03613-5","volume":"74","author":"CD Wright","year":"2002","unstructured":"Wright CD, Graham BB, Grillo HC et al (2002) Pediatric tracheal surgery. Ann Thorac Surg 74:308\u2013313","journal-title":"Ann Thorac Surg"},{"key":"4417_CR26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0022-5223(19)36581-X","volume":"102","author":"TR Weber","year":"1991","unstructured":"Weber TR, Connors RH, Tracy TF Jr (1991) Acquired tracheal stenosis in infants and children. J Thorac Cardiovasc Surg 102:29\u201334","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4417_CR27","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0165-5876(03)00132-0","volume":"67","author":"YS Pata","year":"2003","unstructured":"Pata YS, Akba\u015f Y, \u00dcnal M et al (2003) Prevention of laryngotracheal stenosis with carnitine after tracheotomy: an experimental study on rats. Int J Pediatr Otorhinolaryngol 67:881\u2013888","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"4417_CR28","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1001\/archotol.127.10.1260","volume":"127","author":"CJ Hartnick","year":"2001","unstructured":"Hartnick CJ, Hartley BE, Lacy PD et al (2001) Topical mitomycin application after laryngotracheal reconstruction: a randomized, double-blind, placebo-controlled trial. Arch Otolaryngol Head Neck Surg 127:1260\u20131264","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"4417_CR29","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/00005537-200404000-00028","volume":"114","author":"R Eliashar","year":"2004","unstructured":"Eliashar R, Gross M, Maly B, Sichel JY (2004) Mitomycin does not prevent laryngotracheal repeat stenosis after endoscopic dilation surgery: an animal study. Laryngoscope 114:743\u2013746","journal-title":"Laryngoscope"},{"key":"4417_CR30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.otohns.2004.03.001","volume":"131","author":"I Perepelitsyn","year":"2004","unstructured":"Perepelitsyn I, Shapshay SM (2004) Endoscopic treatment of laryngeal and tracheal stenosis-has mitomycin C improved the outcome? Otolaryngol Head Neck Surg 131:16\u201320","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-016-4417-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-016-4417-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-016-4417-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T10:05:27Z","timestamp":1718964327000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-016-4417-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["4417"],"URL":"https:\/\/doi.org\/10.1007\/s00405-016-4417-3","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}