{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:18:39Z","timestamp":1792783119031,"version":"4.5.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"The study was supported by National Natural Science Foundation of China","award":["81400457"],"award-info":[{"award-number":["81400457"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s00405-016-4422-6","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T01:28:50Z","timestamp":1481938130000},"page":"2071-2078","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma"],"prefix":"10.1007","volume":"274","author":[{"given":"Shumin","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"key":"4422_CR1","first-page":"7","volume":"55","author":"A Maniu","year":"2014","unstructured":"Maniu A, Harabaqiu O, Perde Schrepler M, C\u01cetan\u01ce A, F\u01cenut\u01ce B, Mogoant\u01ce CA (2014) Molecular biology of cholesteatoma. Rom J Morphol Embryol 55:7\u201313","journal-title":"Rom J Morphol Embryol"},{"key":"4422_CR2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1017\/S0022215113000601","volume":"127","author":"L Louw","year":"2013","unstructured":"Louw L (2013) Acquired cholesteatoma: summary of the cascade of molecular events. J Laryngol Otol 127:542\u2013549","journal-title":"J Laryngol Otol"},{"key":"4422_CR3","first-page":"139","volume":"30","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Hong Y, Wang Y, He G, Ye S (2016) The significance of keratinocyte in hyperproliferation of middle ear cholesteatoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 30:139\u2013143","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"4422_CR4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/jamaoto.2013.1750","volume":"139","author":"S Fukudome","year":"2013","unstructured":"Fukudome S, Wang C, Hamajima Y, Ye S, Zheng Y, Narita N, Sunaga H, Fujieda S, Hu X, Feng L, Lin J (2013) Regulation of the angiogenesis of acquired middle ear cholesteatomas by inhibitor of DNA binding transcription factor. JAMA Otolaryngol Head Neck Surg 139:273\u2013278","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"4422_CR5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1001\/archotol.134.3.306","volume":"134","author":"QA Zhang","year":"2008","unstructured":"Zhang QA, Hamajima Y, Zhang Q, Lin J (2008) Identification of Id1 in acquired middle ear cholesteatoma. Arch Otolaryngol Head Neck Surg 134:306\u2013310","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"4422_CR6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2184.2010.00695.x","volume":"43","author":"Y Hamajima","year":"2010","unstructured":"Hamajima Y, Komori M, Preciado DA, Choo DI, Moribe K, Murakami S, Ondrey FG, Lin J (2010) The role of inhibitor DNA-binding (Id1) in hyperproliferation of keratinocytes: the pathological basis for middle ear cholesteatoma from chronic otitis media. Cell Prolif 43:457\u2013463","journal-title":"Cell Prolif"},{"key":"4422_CR7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/00005537-200303000-00009","volume":"113","author":"M Hamzei","year":"2003","unstructured":"Hamzei M, Ventriglia G, Hagnia M, Antonopolous A, Bernal-Sprekelsen M, Dazert S, Hildmann H, Sudhoff H (2003) Osteoclast stimulating and differentiating factors in human cholesteatoma. Laryngoscope 113:436\u2013442","journal-title":"Laryngoscope"},{"key":"4422_CR8","doi-asserted-by":"publisher","first-page":"16683","DOI":"10.1038\/srep16683","volume":"5","author":"Y Si","year":"2015","unstructured":"Si Y, Chen YB, Chen SJ, Zheng YQ, Liu X, Liu Y, Jiang HL, Xu G, Li ZH, Huang QH, Xiong H, Zhang ZG (2015) TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction. Sci Rep 5:16683. doi: 10.1038\/srep16683","journal-title":"Sci Rep"},{"key":"4422_CR9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10162-008-0153-8","volume":"10","author":"R Nason","year":"2009","unstructured":"Nason R, Jung JY, Chole RA (2009) Lipopolysaccharide-induced osteoclastogenesis from mononuclear precursors: a mechanism for osteolysis in chronic otitis. J Assoc Res Otolaryngol 10:151\u2013160","journal-title":"J Assoc Res Otolaryngol"},{"key":"4422_CR10","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/00005537-200306000-00019","volume":"113","author":"H Sudhoff","year":"2003","unstructured":"Sudhoff H, Liebehenz Y, Aschenbrenner J, Jung J, Hildmann H, Dazert S (2003) A murine model of cholesteatoma-induced bone resorption using autologous dermal implantation. Laryngoscope 113:1022\u20131026","journal-title":"Laryngoscope"},{"key":"4422_CR11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12016-015-8523-6","volume":"51","author":"A Sabokbar","year":"2015","unstructured":"Sabokbar A, Mahoney DJ, Hemingway F, Athanasou NA (2015) Non-canonical (RANKL-independent) pathways of osteoclast differentiation and their role in musculoskeletal diseases. Clin Rev Allergy Immunol 51:16\u201326","journal-title":"Clin Rev Allergy Immunol"},{"key":"4422_CR12","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1128\/MCB.01028-15","volume":"36","author":"Y Iwamoto","year":"2016","unstructured":"Iwamoto Y, Nishikawa K, Imai R, Furuya M, Uenaka M, Ohta Y, Morihana T, Itoi-Ochi S, Penninger JM, Katayama I, Inohara H, Ishii M (2016) Intercellular communication between keratinocytes and fibroblasts induces local osteoclast differentiation: a mechanism underlying cholesteatoma-induced bone destruction. Mol Cell Biol 36:1610\u20131620","journal-title":"Mol Cell Biol"},{"key":"4422_CR13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0030-6657(10)70019-6","volume":"64","author":"J Kuczkowski","year":"2010","unstructured":"Kuczkowski J, Kobierska-Gulida G, Izycka-Swieszewska E, Potocka M, Mikaszewski B, Siersze\u0144 W (2010) Molecular control of bone resorption in chronic otitis media with cholesteatoma. Otolaryngol Pol 64:219\u2013224","journal-title":"Otolaryngol Pol"},{"key":"4422_CR14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3109\/00016489.2015.1011789","volume":"135","author":"AP Chen","year":"2015","unstructured":"Chen AP, Wang B, Zhong F, Song GZ, Song HF, Yu K, Wang HB, Jiang ZH (2015) Expression levels of receptor activator of nuclear factor-\u03baB ligand and osteoprotegerin are associated with middle ear cholesteatoma risk. Acta Otolaryngol 135:655\u2013666","journal-title":"Acta Otolaryngol"},{"key":"4422_CR15","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1097\/01.mlg.0000224345.59291.da","volume":"116","author":"JH Jeong","year":"2006","unstructured":"Jeong JH, Park CW, Tae K, Lee SH, Shin DH, Kim KR, Park YW (2006) Expression of RANKL and OPG in middle ear cholesteatoma tissue. Laryngoscope 116:1180\u20131184","journal-title":"Laryngoscope"},{"key":"4422_CR16","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.amjoto.2009.06.004","volume":"31","author":"J Kuczkowski","year":"2010","unstructured":"Kuczkowski J, Sakowicz-Burkiewicz M, I\u017cycka-\u015awieszewska E (2010) Expression of the receptor activator for nuclear factor-kappaB ligand and osteoprotegerin in chronic otitis media. Am J Otolaryngol 31:404\u2013409","journal-title":"Am J Otolaryngol"},{"key":"4422_CR17","first-page":"293","volume":"22","author":"Y Ma","year":"2008","unstructured":"Ma Y, Ye S (2008) The expression of receptor activator nuclear factor-\u03baB ligand and osteoprotegerin in cholesteatoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 22:293\u2013295","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"4422_CR18","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3109\/00016488409132918","volume":"97","author":"M Abramson","year":"1984","unstructured":"Abramson M, Moriyama H, Huang CC (1984) Pathogenic factors in bone resorption in cholesteatoma. Acta Otolaryngol 97:437\u2013442","journal-title":"Acta Otolaryngol"},{"key":"4422_CR19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/00034894840930S421","volume":"112","author":"M Abramson","year":"1984","unstructured":"Abramson M, Moriyama H, Huang CC (1984) Histology, pathogenesis, and treatment of cholesteatoma. Ann Otol Rhinol Laryngol Suppl 112:125\u2013128","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"4422_CR20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/019459988509300102","volume":"93","author":"JR Macri","year":"1985","unstructured":"Macri JR, Chole RA (1985) Bone erosion in experimental cholesteatoma\u2014the effects of implanted barriers. Otolaryngol Head Neck Surg 93:3\u201317","journal-title":"Otolaryngol Head Neck Surg"},{"key":"4422_CR21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/000348948509400214","volume":"94","author":"RA Chole","year":"1985","unstructured":"Chole RA, McGinn MD, Tinling SP (1985) Pressure-induced bone resorption in the middle ear. Ann Otol Rhinol Laryngol 94:165\u2013170","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"4422_CR22","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1001\/archotol.1986.03780100025002","volume":"112","author":"DE Wolfman","year":"1986","unstructured":"Wolfman DE, Chole RA (1986) Osteoclast stimulation by positive middle-ear air pressure. Arch Otolaryngol Head Neck Surg 112:1037\u20131042","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"4422_CR23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1001\/archotol.1987.01860040048015","volume":"113","author":"BS Orisek","year":"1987","unstructured":"Orisek BS, Chole RA (1987) Pressures exerted by experimental cholesteatomas. Arch Otolaryngol Head Neck Surg 113:386\u2013391","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"4422_CR24","first-page":"39","volume":"11","author":"CC Huang","year":"1990","unstructured":"Huang CC, Yi ZX, Yuan QG, Abramson M (1990) A morphometric study of the effects of pressure on bone resorption in the middle ear of rats. Am J Otol 11:39\u201343","journal-title":"Am J Otol"},{"key":"4422_CR25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/08959374990130012201","volume":"13","author":"EH Burger","year":"1999","unstructured":"Burger EH, Klein-Nulen J (1999) Responses of bone cells to biomechanical forces in vitro. Adv Dent Res 13:93\u201398","journal-title":"Adv Dent Res"},{"key":"4422_CR26","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1177\/000348945106000422","volume":"60","author":"TE Walsh","year":"1951","unstructured":"Walsh TE, Covell WP, Ogura JH (1951) The effect of cholesteatosis on bone. Ann Otol Rhinol Laryngol 60:1100\u20131113","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"4422_CR27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/000348948309200122","volume":"92","author":"Y Iino","year":"1983","unstructured":"Iino Y, Hoshino E, Tomioka S, Takasaka T, Kaneko Y, Yuasa R (1983) Organic acid and anaerobic microorganisms in the contents of the cholesteatoma sac. Ann Otol Rhinol Laryngol 92:91\u201396","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"4422_CR28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/lary.23883","volume":"124","author":"KH Nguyen","year":"2014","unstructured":"Nguyen KH, Suzuki H, Ohbuchi T, Wakasugi T, Koizumi H, Hashida K, Baba R, Morimoto H, Doi Y (2014) Possible participation of acidic pH in bone resorption in middle ear cholesteatoma. Laryngoscope 124:245\u2013250","journal-title":"Laryngoscope"},{"key":"4422_CR29","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.archoralbio.2003.12.004","volume":"49","author":"ZF Chen","year":"2004","unstructured":"Chen ZF, Darvell BW, Leung VW (2004) Hydroxyapatite solubility in simple inorganic solutions. Arch Oral Biol 49:359\u2013367","journal-title":"Arch Oral Biol"},{"key":"4422_CR30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4161\/derm.3.2.15140","volume":"3","author":"A Chan","year":"2011","unstructured":"Chan A, Mauro T (2011) Acidification in the epidermis and the role of secretor phospholipases. Dermatoendocrinol 3:84\u201390","journal-title":"Dermatoendocrinol"},{"key":"4422_CR31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/coa.12332","volume":"40","author":"H Koizumi","year":"2015","unstructured":"Koizumi H, Suzuki H, Ohbuchi T, Kitamura T, Hashida K, Nakamura M (2015) Increased permeability of the epithelium of middle ear cholesteatoma. Clin Otolaryngol 40:106\u2013114","journal-title":"Clin Otolaryngol"},{"key":"4422_CR32","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1002\/lary.25834","volume":"126","author":"S Xie","year":"2016","unstructured":"Xie S, Xiang Y, Wang X, Ren H, Yin T, Ren J, Liu W (2016) Acquired cholesteatoma epithelial hyperproliferation: roles of cell proliferation signal pathways. Laryngoscope 126:1923\u20131930","journal-title":"Laryngoscope"},{"key":"4422_CR33","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1210\/en.2015-1345","volume":"156","author":"MV Clarke","year":"2015","unstructured":"Clarke MV, Russell RK, Findlay DM, Sastra S, Anderson PH, Skinner JP, Atkins GJ, Zajac JD, Davey RA (2015) A role for the calcitonin receptor to limit bone loss during lactation in female mice by inhibiting osteocytic osteolysis. Endocrinology 156:3203\u20133214","journal-title":"Endocrinology"},{"key":"4422_CR34","first-page":"241","volume":"18","author":"HB Wang","year":"2004","unstructured":"Wang HB, Xu ZW, Tang AZ, Su JP (2004) Expression of carbonic anhydrase in the cholesteatoma epithelium (in Chinese). J Clin Otorhinolaryngol 18:241\u2013242","journal-title":"J Clin Otorhinolaryngol"},{"key":"4422_CR35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11010-015-2526-8","volume":"409","author":"L Nabai","year":"2015","unstructured":"Nabai L, Kilani RT, Aminuddin F, Li Y, Ghahary A (2015) Methotrexate modulates the expression of MMP-1 and type 1 collagen in dermal fibroblast. Mol Cell Biochem 409:213\u2013224","journal-title":"Mol Cell Biochem"},{"key":"4422_CR36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/7651_2013_44","volume":"1195","author":"T Kobayashi","year":"2014","unstructured":"Kobayashi T (2014) MMP-2, -9 and TIMP-1, -2 assays in keratinocyte cultures. Methods Mol Biol 1195:145\u2013155","journal-title":"Methods Mol Biol"},{"key":"4422_CR37","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1590\/S1808-86942012000300019","volume":"78","author":"CE Rezende","year":"2012","unstructured":"Rezende CE, Souto RP, Rapoport PB, Campos Ld, Generato MB (2012) Cholesteatoma gene expression of matrix metalloproteinases and their inhibitors by RT-PCR. Braz J Otorhinolaryngol 78:116\u2013121","journal-title":"Braz J Otorhinolaryngol"},{"key":"4422_CR38","first-page":"307","volume":"31","author":"E Olszewska","year":"2016","unstructured":"Olszewska E, Matulka M, Mroczko B, Pryczynicz A, Kemona A, Szmitkowski M, Mierzwinski J, Pietrewicz T (2016) Diagnostic value of matrix metalloproteinase 9 and tissue inhibitor of matrix metalloproteinases 1 in cholesteatoma. Histol Histopathol 31:307\u2013315","journal-title":"Histol Histopathol"},{"key":"4422_CR39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/MAO.0b013e31819fe6ed","volume":"30","author":"A Juh\u00e1sz","year":"2009","unstructured":"Juh\u00e1sz A, Sziklai I, R\u00e1kosy Z, Ecsedi S, Ad\u00e1ny R, Bal\u00e1zs M (2009) Elevated level of tenascin and matrix metalloproteinase 9 correlates with the bone destruction capacity of cholesteatoma. Otol Neurotol 30:559\u2013565","journal-title":"Otol Neurotol"},{"key":"4422_CR40","first-page":"628","volume":"37","author":"D Suchozebrska-Jesionek","year":"2008","unstructured":"Suchozebrska-Jesionek D, Szyma\u0144ski M, Kurzepa J, Golabek W, Stryjecka-Zimmer M (2008) Gelatinolytic activity of matrix metalloproteinases 2 and 9 in middle ear cholesteatoma. J Otolaryngol Head Neck Surg 37:628\u2013632","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"4422_CR41","first-page":"30","volume":"37","author":"J Liu","year":"2002","unstructured":"Liu J, Lin G, Huang J, Jiang Z (2002) The expression of matrix metalloproteinase-1 and interleukin-1-alpha messenger ribonucleic acid in human middle ear cholesteatoma. Zhonghua Er Bi Yan Hou Ke Za Zhi 37:30\u201333","journal-title":"Zhonghua Er Bi Yan Hou Ke Za Zhi"},{"key":"4422_CR42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1080\/00016480600781807","volume":"127","author":"D Mehta","year":"2007","unstructured":"Mehta D, Daudia A, Birchall JR, Banerjee AR (2007) The localization of matrix metalloproteinases-8 and -13 in cholesteatoma, deep-meatal and post-auricular skin: a comparative analysis. Acta Otolaryngol 127:138\u2013142","journal-title":"Acta Otolaryngol"},{"key":"4422_CR43","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1365-2230.2012.04381.x","volume":"37","author":"J Meephansan","year":"2012","unstructured":"Meephansan J, Komine M, Tsuda H, Ohtsuki M (2012) Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line. Clin Exp Dermatol 37:889\u2013896","journal-title":"Clin Exp Dermatol"},{"key":"4422_CR44","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1093\/humrep\/det265","volume":"28","author":"SK Halder","year":"2013","unstructured":"Halder SK, Osteen KG, Al-Hendy A (2013) Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells. Hum Reprod 28:2407\u20132416","journal-title":"Hum Reprod"},{"key":"4422_CR45","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1155\/MI.2005.210","volume":"2005","author":"H Kobayashi","year":"2005","unstructured":"Kobayashi H, Asano K, Kanai K, Suzaki H (2005) Suppressive activity of vitamin D3 on matrix metalloproteinase production from cholesteatoma keratinocytes in vitro. Mediators Inflamm 2005:210\u2013215","journal-title":"Mediators Inflamm"},{"key":"4422_CR46","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/000348949910800305","volume":"108","author":"MP Sch\u00f6nermark","year":"1999","unstructured":"Sch\u00f6nermark MP, Issing PR, Erbrich BK, Lenarz T (1999) Expression pattern of the plasminogen activator-plasmin system in human cholesteatoma. Ann Otol Rhinol Laryngol 108:245\u2013252","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"4422_CR47","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12070-010-0011-y","volume":"62","author":"O Celebi","year":"2010","unstructured":"Celebi O, Paksoy M, Aydin S, Sanli A, Tasdemir O, G\u00fcL AE (2010) Myeloperoxydase activity in the pathogenesis of cholesteatoma. Indian J Otolaryngol Head Neck Surg 62:32\u201335","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"4422_CR48","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00129492-200409000-00003","volume":"25","author":"JY Jung","year":"2004","unstructured":"Jung JY, Pashia ME, Nishimoto SY, Faddis BT, Chole RA (2004) A possible role for nitric oxide in osteoclastogenesis associated with cholesteatoma. Otol Neurotol 25:661\u2013668","journal-title":"Otol Neurotol"},{"key":"4422_CR49","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/jcb.10527","volume":"89","author":"JY Jung","year":"2003","unstructured":"Jung JY, Lin AC, Ramos LM, Faddis BT, Chole RA (2003) Nitric oxide synthase I mediates osteoclast activity in vitro and in vivo. J Cell Biochem 89:613\u2013621","journal-title":"J Cell Biochem"},{"key":"4422_CR50","doi-asserted-by":"crossref","first-page":"365","DOI":"10.18388\/abp.2007_3258","volume":"54","author":"E Olszewska","year":"2007","unstructured":"Olszewska E, Olszewski S, Borzym-Kluczyk M, Zwierz K (2007) Role of N-acetyl-\u03b2-d-hexosaminidase in cholesteatoma tissue. Acta Biochim Pol 54:365\u2013370","journal-title":"Acta Biochim Pol"},{"key":"4422_CR51","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/MAO.0b013e31824bae8d","volume":"33","author":"E Olszewska","year":"2012","unstructured":"Olszewska E, Jakimowicz-Rudy J, Knas M, Chilimoniuk M, Pietruski JK, Sieskiewicz A (2012) Cholesteatoma-associated pathogenicity: potential role of lysosomal exolglycosidases. Otol Neurotol 33:596\u2013603","journal-title":"Otol Neurotol"},{"key":"4422_CR52","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00005-015-0373-7","volume":"64","author":"W Likus","year":"2016","unstructured":"Likus W, Siemianowicz K, Markowski J, Wiaderkiewicz J, Kostrz\u0105b-Zdebel A, Jura-Szo\u0142tys E, Dziubdziela W, Wiaderkiewicz R, \u0141os MJ (2016) Bacterial infections and osteoclastogenesis regulators in men and women with cholesteatoma. Arch Immunol Ther Exp (Warsz) 64:241\u2013247","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"4422_CR53","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1808-8694(15)31133-2","volume":"73","author":"RF Vitale","year":"2007","unstructured":"Vitale RF, Ribeiro Fde A (2007) The role of tumor necrosis factor-alpha (TNF-\u03b1) in bone resorption present in middle ear cholesteatoma. Braz J Otorhinolaryngol 73:117\u2013121","journal-title":"Braz J Otorhinolaryngol"},{"key":"4422_CR54","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000323831","volume":"73","author":"J Kuczkowski","year":"2011","unstructured":"Kuczkowski J, Sakowicz-Burkiewicz M, I\u017cycka-\u015awieszewska E, Mikaszewski B, Pawelczyk T (2011) Expression of tumor necrosis factor-\u03b1, interleukin-1\u03b1, interleukin-6 and interleukin-10 in chronic otitis media with bone osteolysis. ORL J Otorhinolaryngol Relat Spec 73:93\u201399","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"4422_CR55","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00011-004-1303-z","volume":"53","author":"DR Haynes","year":"2004","unstructured":"Haynes DR (2004) Bone lysis and inflammation. Inflamm Res 53:596\u2013600","journal-title":"Inflamm Res"},{"key":"4422_CR56","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5301\/ijao.5000445","volume":"38","author":"L Peng","year":"2015","unstructured":"Peng L, Zhang H, Zhou Y, Li W, Jiang P, Zhang Y, Song K (2015) TNF-\u03b1 suppression and osteoprotegerin overexpression inhibits wear debris-induced inflammation and osteoclastogenesis in vitro. Int J Artif Organs 38:565\u2013571","journal-title":"Int J Artif Organs"},{"key":"4422_CR57","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000319897","volume":"72","author":"T Haruyama","year":"2010","unstructured":"Haruyama T, Furukawa M, Kusunoki T, Onoda J, Ikeda K (2010) Expression of IL-17 and its role in bone destruction in human middle ear cholesteatoma. ORL J Otorhinolaryngol Relat Spec 72:325\u2013331","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"4422_CR58","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1128\/IAI.00144-11","volume":"79","author":"M Wu","year":"2011","unstructured":"Wu M, Peng A, Sun M, Deng Q, Hazlett LD, Yuan J, Liu X, Gao Q, Feng L, He J, Zhang P, Huang X (2011) TREM-1 amplifies corneal inflammation after Pseudomonas aeruginosa infection by modulating Toll-like receptor signaling and Th1\/Th2-type immune responses. Infect Immun 79:2709\u20132716","journal-title":"Infect Immun"},{"key":"4422_CR59","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00405-006-0030-1","volume":"263","author":"M Szczepa\u0144ski","year":"2006","unstructured":"Szczepa\u0144ski M, Szyfter W, Jenek R, Wr\u00f3bel M, Lisewska IM, Zeromski J (2006) Toll-like receptors 2, 3 and 4 (TLR-2, TLR-3 and TLR-4) are expressed in the microenvironment of human acquired cholesteatoma. Eur Arch Otorhinolaryngol 263:603\u2013607","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"4422_CR60","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ijporl.2013.01.010","volume":"77","author":"H Hirai","year":"2013","unstructured":"Hirai H, Kariya S, Okano M, Fukushima K, Kataoka Y, Maeda Y, Nishizaki K (2013) Expression of toll-like receptors in chronic otitis media and cholesteatoma. Int J Pediatr Otorhinolaryngol 77:674\u2013676","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"4422_CR61","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11010-014-2275-0","volume":"400","author":"Z Chi","year":"2015","unstructured":"Chi Z, Wang Z, Liang Q, Zhu Y, Du Q (2015) Induction of cytokine production in cholesteatoma keratinocytes by extracellular high-mobility group box chromosomal protein 1 combined with DNA released by apoptotic cholesteatoma keratinocytes. Mol Cell Biochem 400:189\u2013200","journal-title":"Mol Cell Biochem"},{"key":"4422_CR62","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3892\/or.2015.4430","volume":"35","author":"JC Zong","year":"2016","unstructured":"Zong JC, Wang X, Zhou X, Wang C, Chen L, Yin LJ, He BC, Deng ZL (2016) Gut-derived serotonin induced by depression promotes breast cancer bone metastasis through the RUNX2\/PTHrP\/RANKL pathway in mice. Oncol Rep 35:739\u2013748","journal-title":"Oncol Rep"},{"key":"4422_CR63","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1507\/endocrj.46.643","volume":"46","author":"T Horiuchi","year":"1999","unstructured":"Horiuchi T, Yoshida T, Koshihara Y, Sakamoto H, Kanai H, Yamamoto S, Ito H (1999) The increase of parathyroid hormone-related peptide and cytokine levels in synovial fluid of elderly rheumatoid arthritis and osteoarthritis. Endocr J 46:643\u2013649","journal-title":"Endocr J"},{"key":"4422_CR64","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10266-012-0070-5","volume":"100","author":"J Foley","year":"2012","unstructured":"Foley J, Nickerson N, Riese DJ 2nd, Hollenhorst PC, Lorch G, Foley AM (2012) At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone. Odontology 100:109\u2013129","journal-title":"Odontology"},{"key":"4422_CR65","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jbmr.2022","volume":"29","author":"P Cafforio","year":"2014","unstructured":"Cafforio P, Savonarola A, Stucci S, De Matteo M, Tucci M, Brunetti AE, Vecchio VM, Silvestris F (2014) PTHrP produced by myeloma plasma cells regulates their survival and pro-osteoclast activity for bone disease progression. J Bone Miner Res 29:55\u201366","journal-title":"J Bone Miner Res"},{"key":"4422_CR66","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0140-6736(91)91902-7","volume":"338","author":"IM Cheshire","year":"1991","unstructured":"Cheshire IM, Blight A, Ratcliffe WA, Proops DW, Heath DA (1991) Production of parathyroid-hormone-related protein by cholesteatoma cells in culture. Lancet 338:1041\u20131043","journal-title":"Lancet"},{"key":"4422_CR67","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1365-2273.1995.tb00080.x","volume":"20","author":"IM Cheshire","year":"1995","unstructured":"Cheshire IM, Blight A, Ratcliffe WA, Proops DW (1995) In vitro production of parathyroid hormone-related protein by cholesteatoma and normal skin. Clin Otolaryngol Allied Sci 20:448\u2013452","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"4422_CR68","doi-asserted-by":"crossref","first-page":"10909","DOI":"10.1007\/s13277-016-4934-0","volume":"37","author":"Z Liang","year":"2016","unstructured":"Liang Z, Wang Y, Shen Z, Teng X, Li X, Li C, Wu W, Zhou Z, Wang Z (2016) Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP\/TEAD signaling. Tumour Biol 37:10909\u201310915","journal-title":"Tumour Biol"},{"key":"4422_CR69","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3892\/ol.2015.3191","volume":"10","author":"KW Min","year":"2015","unstructured":"Min KW, Chae SW, Kim DH, Do SI, Kim K, Lee HJ, Sohn JH, Pyo JS, Kim DH, Oh S, Choi SH, Park YL, Park CH (2015) Fascin expression predicts an aggressive clinical course in patients with advanced breast cancer. Oncol Lett 10:121\u2013130","journal-title":"Oncol Lett"},{"key":"4422_CR70","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/coa.12373","volume":"40","author":"A Binnetoglu","year":"2015","unstructured":"Binnetoglu A, Sari M, Baglam T, Erbarut Seven I, Yumusakhuylu AC, Topuz MF, Batman C (2015) Fascin expression in cholesteatoma: correlation with destruction of the ossicular chain and extent of disease. Clin Otolaryngol 40:335\u2013340","journal-title":"Clin Otolaryngol"},{"key":"4422_CR71","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.amjoto.2013.06.007","volume":"34","author":"M Oger","year":"2013","unstructured":"Oger M, Alpay HC, Orhan I, Onalan EE, Yanilmaz M, Sapmaz E (2013) The effect of BMP-2, BMP-4 and BMP-6 on bone destruction of cholesteatoma presence. Am J Otolaryngol 34:652\u2013657","journal-title":"Am J Otolaryngol"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-016-4422-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-016-4422-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-016-4422-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T21:08:48Z","timestamp":1601240928000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-016-4422-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,16]]},"references-count":71,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["4422"],"URL":"https:\/\/doi.org\/10.1007\/s00405-016-4422-6","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,16]]}}}