{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:21:48Z","timestamp":1780316508157,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00405-017-4454-6","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T03:22:24Z","timestamp":1485141744000},"page":"1897-1903","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antibiofilm effects of topical corticosteroids and intranasal saline in patients with chronic rhinosinusitis with nasal polyps depend on bacterial species and their biofilm-forming capacity"],"prefix":"10.1007","volume":"274","author":[{"given":"Ivana","family":"Cirkovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Pavlovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana D.","family":"Bozic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Jotic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubica","family":"Bakic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovica","family":"Milovanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"4454_CR1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11882-015-0540-2","volume":"15","author":"K Lam","year":"2015","unstructured":"Lam K, Schleimer R, Kern RC (2015) The etiology and pathogenesis of chronic rhinosinusitis: a review of current hypotheses. Curr Allergy Asthma Rep 15:41","journal-title":"Curr Allergy Asthma Rep"},{"key":"4454_CR2","first-page":"1","volume":"23","author":"WJ Fokkens","year":"2012","unstructured":"Fokkens WJ, Lund VJ, Mullol J et al (2012) European position paper on rhinosinusitis and nasal polyps. Rhinol Suppl 23:1\u2013298","journal-title":"Rhinol Suppl"},{"key":"4454_CR3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/MOO.0b013e3282b97327","volume":"15","author":"JC Post","year":"2007","unstructured":"Post JC, Hiller NL, Nistico L et al (2007) The role of biofilms in otolaryngologic infections: update 2007. Curr Opin Otolaryngol Head Neck Surg 15:347\u2013351","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"4454_CR4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.otc.2010.02.010","volume":"43","author":"JD Suh","year":"2010","unstructured":"Suh JD, Ramakrishnan V, Palmer JN (2010) Biofilms. Otolaryngol Clin North Am 43:521\u2013530","journal-title":"Otolaryngol Clin North Am"},{"key":"4454_CR5","first-page":"93","volume":"72","author":"L Cal\u00f2","year":"2011","unstructured":"Cal\u00f2 L, Pass\u00e0li GC, Galli J et al (2011) Role of biofilms in chronic inflammatory diseases of the upper airways. Adv Otorhinolaryngol 72:93\u201396","journal-title":"Adv Otorhinolaryngol"},{"key":"4454_CR6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","volume":"15","author":"RM Donlan","year":"2002","unstructured":"Donlan RM, Costerton JW (2002) Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 15:167\u2013193","journal-title":"Clin Microbiol Rev"},{"key":"4454_CR7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1078\/1438-4221-00196","volume":"292","author":"PS Stewart","year":"2002","unstructured":"Stewart PS (2002) Mechanisms of antibiotic resistance in bacterial biofilms. Int J Med Microbiol 292:107\u2013113","journal-title":"Int J Med Microbiol"},{"key":"4454_CR8","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/1471-2334-13-210","volume":"13","author":"S Boase","year":"2013","unstructured":"Boase S, Foreman A, Cleland E et al (2013) The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection. BMC Infect Dis 13:210","journal-title":"BMC Infect Dis"},{"key":"4454_CR9","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/35012234","volume":"405","author":"KS McCann","year":"2000","unstructured":"McCann KS (2000) The diversity-stability debate. Nature 405:228\u2013233","journal-title":"Nature"},{"key":"4454_CR10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/1874285801004010008","volume":"4","author":"V Gontcharova","year":"2010","unstructured":"Gontcharova V, Youn E, Sun Y et al (2010) A comparison of bacterial composition in diabetic ulcers and contralateral intact skin. Open Microbiol J 4:8\u201319","journal-title":"Open Microbiol J"},{"key":"4454_CR11","first-page":"1","volume":"6","author":"RB Cain","year":"2013","unstructured":"Cain RB, Lal D (2013) Update on the management of chronic rhinosinusitis. Infect Drug Resist 6:1\u201314.","journal-title":"Infect Drug Resist"},{"key":"4454_CR12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1001\/archoto.2010.62","volume":"136","author":"CJ Hochstim","year":"2010","unstructured":"Hochstim CJ, Choi JY, Lowe D et al (2010) Biofilm detection with hematoxylin-eosin staining. Arch Otolaryngol Head Neck Surg 136:453\u2013456","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"4454_CR13","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1600-0463.2007.apm_630.x","volume":"115","author":"S Stepanovi\u0107","year":"2007","unstructured":"Stepanovi\u0107 S, Vukovi\u0107 D, Hola V et al (2007) Quantification of biofilm in microtiter plates: overview of testing conditions and practical recommendations for assessment of biofilm production by staphylococci. APMIS 115:891\u2013899","journal-title":"APMIS"},{"key":"4454_CR14","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/lary.24322","volume":"124","author":"R Goggin","year":"2014","unstructured":"Goggin R, Jardeleza C, Wormald PJ, Vreugde S (2014) Corticosteroids directly reduce Staphylococcus aureus biofilm growth: an in vitro study. Laryngoscope 124:602\u2013607","journal-title":"Laryngoscope"},{"key":"4454_CR15","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1128\/AAC.45.4.999-1007.2001","volume":"45","author":"K Lewis","year":"2001","unstructured":"Lewis K (2001) Riddle of biofilm resistance. Antimicrob Agents Chemother 45:999\u20131007","journal-title":"Antimicrob Agents Chemother"},{"key":"4454_CR16","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1177\/194589240501900506","volume":"19","author":"BJ Ferguson","year":"2005","unstructured":"Ferguson BJ, Stolz DB (2005) Demonstration of biofilm in human bacterial chronic rhinosinusitis. Am J Rhinol 19:452\u2013457","journal-title":"Am J Rhinol"},{"key":"4454_CR17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/MOO.0b013e3282fdc6d5","volume":"16","author":"DH Hunsaker","year":"2008","unstructured":"Hunsaker DH, Leid JG (2008) The relationship of biofilms to chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 16:237\u2013241","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"4454_CR18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11882-012-0246-7","volume":"12","author":"A Foreman","year":"2012","unstructured":"Foreman A, Boase S, Psaltis A, Wormald PJ (2012) Role of bacterial and fungal biofilms in chronic rhinosinusitis. Curr Allergy Asthma Rep 12:127\u2013135","journal-title":"Curr Allergy Asthma Rep"},{"key":"4454_CR19","first-page":"380","volume":"20","author":"ME Zernotti","year":"2010","unstructured":"Zernotti ME, Angel Villegas N, Roques Revol M et al (2010) Evidence of bacterial biofilms in nasal polyposis. J Investig Allergol Clin Immunol 20:380\u2013385","journal-title":"J Investig Allergol Clin Immunol"},{"key":"4454_CR20","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/alr.21423","volume":"4","author":"A Drilling","year":"2014","unstructured":"Drilling A, Coombs GW, Tan HL, et al. (2014) Cousins, siblings, or copies: the genomics of recurrent Staphylococcus aureus infections in chronic rhinosinusitis. Int Forum Allergy Rhinol 4:953\u2013960.","journal-title":"Int Forum Allergy Rhinol"},{"key":"4454_CR21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/alr.21467","volume":"5","author":"CM Liu","year":"2015","unstructured":"Liu CM, Kohanski MA, Mendiola M et al. (2015) Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota. Int Forum Allergy Rhinol 5:185\u2013190.","journal-title":"Int Forum Allergy Rhinol"},{"key":"4454_CR22","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00405-013-2666-y","volume":"271","author":"P Csomor","year":"2014","unstructured":"Csomor P, Sziklai I, Karosi T (2014) Effects of intranasal steroid treatment on the presence of biofilms in non-allergic patients with chronic rhinosinusitis with nasal polyposis. Eur Arch Otorhinolaryngol 271:1057\u20131065","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"4454_CR23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/alr.21259","volume":"4","author":"R Goggin","year":"2014","unstructured":"Goggin R, Jardeleza C, Wormald PJ, Vreugde S (2014) Colloidal silver: a novel treatment for Staphylococcus aureus biofilms? Int Forum Allergy Rhinol 4:171\u2013175.","journal-title":"Int Forum Allergy Rhinol"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-017-4454-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-017-4454-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-017-4454-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T17:43:42Z","timestamp":1568742222000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-017-4454-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["4454"],"URL":"https:\/\/doi.org\/10.1007\/s00405-017-4454-6","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]}}}