{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:10:53Z","timestamp":1792782653500,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,11,25]],"date-time":"2017-11-25T00:00:00Z","timestamp":1511568000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500768"],"award-info":[{"award-number":["81500768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["2014A030310392"],"award-info":[{"award-number":["2014A030310392"]}]},{"name":"Science and Technology Planning Project of Guangdong Province, China","award":["2016A020215049"],"award-info":[{"award-number":["2016A020215049"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00405-017-4809-z","type":"journal-article","created":{"date-parts":[[2017,11,25]],"date-time":"2017-11-25T01:33:41Z","timestamp":1511573621000},"page":"401-408","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Increased serum amyloid A in nasal polyps is associated with systemic corticosteroid insensitivity in patients with chronic rhinosinusitis with nasal polyps: a pilot study"],"prefix":"10.1007","volume":"275","author":[{"given":"Hangui","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Sheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Mian","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Feng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2382-0429","authenticated-orcid":false,"given":"Yue-Qi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,25]]},"reference":[{"issue":"23","key":"4809_CR1","first-page":"1","volume":"Suppl","author":"WJ Fokkens","year":"2012","unstructured":"Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P et al (2012) European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl(23):1\u2013298 (3 p preceding table of contents)","journal-title":"Rhinol"},{"issue":"5","key":"4809_CR2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/all.12577","volume":"70","author":"JB Shi","year":"2015","unstructured":"Shi JB, Fu QL, Zhang H, Cheng L, Wang YJ, Zhu DD, Lv W, Liu SX, Li PZ, Ou CQ et al (2015) Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities. Allergy 70(5):533\u2013539","journal-title":"Allergy"},{"issue":"5","key":"4809_CR3","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaci.2016.05.041","volume":"138","author":"X Wang","year":"2016","unstructured":"Wang X, Zhang N, Bo M, Holtappels G, Zheng M, Lou H, Wang H, Zhang L, Bachert C (2016) Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: a multicenter study in Europe, Asia, and Oceania. J Allergy Clin Immunol 138(5):1344\u20131353","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"4809_CR4","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1001\/jama.1994.03510290045035","volume":"271","author":"LJ Newman","year":"1994","unstructured":"Newman LJ, Platts-Mills TA, Phillips CD, Hazen KC, Gross CW (1994) Chronic sinusitis: relationship of computed tomographic findings to allergy, asthma, and eosinophilia. JAMA 271(5):363\u2013367","journal-title":"JAMA"},{"issue":"4","key":"4809_CR5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2001.112374","volume":"107","author":"C Bachert","year":"2001","unstructured":"Bachert C, Gevaert P, Holtappels G, Johansson SG, van Cauwenberge P (2001) Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol 107(4):607\u2013614","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"4809_CR6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jaci.2009.05.017","volume":"124","author":"PP Cao","year":"2009","unstructured":"Cao PP, Li HB, Wang BF, Wang SB, You XJ, Cui YH, Wang DY, Desrosiers M, Liu Z (2009) Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. J Allergy Clin Immunol 124(3):478\u2013484 (484 e471\u2013472)","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"4809_CR7","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.jaci.2012.01.079","volume":"129","author":"W Wen","year":"2012","unstructured":"Wen W, Liu W, Zhang L, Bai J, Fan Y, Xia W, Luo Q, Zheng J, Wang H, Li Z et al (2012) Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy. J Allergy Clin Immunol 129(6):1522\u20131528 e1525","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"4809_CR8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1586\/17476348.2016.1133304","volume":"10","author":"NC Thomson","year":"2016","unstructured":"Thomson NC (2016) Addressing corticosteroid insensitivity in adults with asthma. Expert Rev Respir Med 10(2):137\u2013156","journal-title":"Expert Rev Respir Med"},{"issue":"6","key":"4809_CR9","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1189\/jlb.3VMR0315-080R","volume":"98","author":"RD Ye","year":"2015","unstructured":"Ye RD, Sun L (2015) Emerging functions of serum amyloid A in inflammation. J Leukoc Biol 98(6):923\u2013929","journal-title":"J Leukoc Biol"},{"issue":"9","key":"4809_CR10","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1161\/01.CIR.96.9.2914","volume":"96","author":"AI Fyfe","year":"1997","unstructured":"Fyfe AI, Rothenberg LS, DeBeer FC, Cantor RM, Rotter JI, Lusis AJ (1997) Association between serum amyloid A proteins and coronary artery disease: evidence from two distinct arteriosclerotic processes. Circulation 96(9):2914\u20132919","journal-title":"Circulation"},{"issue":"6","key":"4809_CR11","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/ard.42.6.665","volume":"42","author":"RE Chambers","year":"1983","unstructured":"Chambers RE, MacFarlane DG, Whicher JT, Dieppe PA (1983) Serum amyloid-A protein concentration in rheumatoid arthritis and its role in monitoring disease activity. Ann Rheum Dis 42(6):665\u2013667","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"4809_CR12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1620\/tjem.204.209","volume":"204","author":"S Buyukozturk","year":"2004","unstructured":"Buyukozturk S, Gelincik AA, Genc S, Kocak H, Oneriyidogan Y, Erden S, Dal M, Colakoglu B (2004) Acute phase reactants in allergic airway disease. Tohoku J Exp Med 204(3):209\u2013213","journal-title":"Tohoku J Exp Med"},{"issue":"6","key":"4809_CR13","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s00405-012-2295-x","volume":"270","author":"H Wang","year":"2013","unstructured":"Wang H, Bai J, Ding M, Liu W, Xu R, Zhang J, Shi J, Li H (2013) Interleukin-17A contributes to the expression of serum amyloid A in chronic rhinosinusitis with nasal polyps. Eur Arch Otorhinolaryngol 270(6):1867\u20131872","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"3","key":"4809_CR14","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1073\/pnas.1109382109","volume":"109","author":"S Bozinovski","year":"2012","unstructured":"Bozinovski S, Uddin M, Vlahos R, Thompson M, McQualter JL, Merritt AS, Wark PA, Hutchinson A, Irving LB, Levy BD et al (2012) Serum amyloid A opposes lipoxin A(4) to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. Proc Natl Acad Sci USA 109(3):935\u2013940","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"4809_CR15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4049\/jimmunol.1100500","volume":"187","author":"JL Ather","year":"2011","unstructured":"Ather JL, Ckless K, Martin R, Foley KL, Suratt BT, Boyson JE, Fitzgerald KA, Flavell RA, Eisenbarth SC, Poynter ME (2011) Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice. J Immunol 187(1):64\u201373","journal-title":"J Immunol"},{"key":"4809_CR16","doi-asserted-by":"crossref","first-page":"e786","DOI":"10.1038\/cddis.2013.327","volume":"4","author":"JL Ather","year":"2013","unstructured":"Ather JL, Fortner KA, Budd RC, Anathy V, Poynter ME (2013) Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells. Cell Death Dis 4:e786","journal-title":"Cell Death Dis"},{"issue":"2","key":"4809_CR17","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jaci.2014.07.011","volume":"135","author":"J Milara","year":"2015","unstructured":"Milara J, Peiro T, Armengot M, Frias S, Morell A, Serrano A, Cortijo J (2015) Mucin 1 downregulation associates with corticosteroid resistance in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 135(2):470\u2013476","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"4809_CR18","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jaci.2016.06.064","volume":"139","author":"J Milara","year":"2017","unstructured":"Milara J, Morell A, Ballester B, Armengot M, Morcillo E, Cortijo J (2017) MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 139(3):855\u2013862 e813","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"4809_CR19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2500\/ajra.2015.29.4223","volume":"29","author":"DM Poetker","year":"2015","unstructured":"Poetker DM (2015) Oral corticosteroids in the management of chronic rhinosinusitis with and without nasal polyps: Risks and benefits. Am J Rhinol Allergy 29(5):339\u2013342","journal-title":"Am J Rhinol Allergy"},{"issue":"5","key":"4809_CR20","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.jaci.2010.02.020","volume":"125","author":"T Zele Van","year":"2010","unstructured":"Van Zele T, Gevaert P, Holtappels G, Beule A, Wormald PJ, Mayr S, Hens G, Hellings P, Ebbens FA, Fokkens W et al (2010) Oral steroids and doxycycline: two different approaches to treat nasal polyps. J Allergy Clin Immunol 125(5):1069\u20131076 e1064","journal-title":"J Allergy Clin Immunol"},{"issue":"9678","key":"4809_CR21","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/S0140-6736(09)60326-3","volume":"373","author":"PJ Barnes","year":"2009","unstructured":"Barnes PJ, Adcock IM (2009) Glucocorticoid resistance in inflammatory diseases. Lancet 373(9678):1905\u20131917","journal-title":"Lancet"},{"issue":"1","key":"4809_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/all.12040","volume":"68","author":"PW Hellings","year":"2013","unstructured":"Hellings PW, Fokkens WJ, Akdis C, Bachert C, Cingi C, Dietz de Loos D, Gevaert P, Hox V, Kalogjera L, Lund V et al (2013) Uncontrolled allergic rhinitis and chronic rhinosinusitis: where do we stand today? Allergy 68(1):1\u20137","journal-title":"Allergy"},{"issue":"7","key":"4809_CR23","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.rmed.2013.02.018","volume":"107","author":"JF Donohue","year":"2013","unstructured":"Donohue JF, Jain N (2013) Exhaled nitric oxide to predict corticosteroid responsiveness and reduce asthma exacerbation rates. Respir Med 107(7):943\u2013952","journal-title":"Respir Med"},{"issue":"4","key":"4809_CR24","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jaci.2014.10.026","volume":"135","author":"DC Cowan","year":"2015","unstructured":"Cowan DC, Taylor DR, Peterson LE, Cowan JO, Palmay R, Williamson A, Hammel J, Erzurum SC, Hazen SL, Comhair SA (2015) Biomarker-based asthma phenotypes of corticosteroid response. J Allergy Clin Immunol 135(4):877\u2013883 e871","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"4809_CR25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1164\/rccm.201108-1553OC","volume":"186","author":"M Bafadhel","year":"2012","unstructured":"Bafadhel M, McKenna S, Terry S, Mistry V, Pancholi M, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID et al (2012) Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med 186(1):48\u201355","journal-title":"Am J Respir Crit Care Med"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-017-4809-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-017-4809-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-017-4809-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T09:06:25Z","timestamp":1517216785000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-017-4809-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,25]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["4809"],"URL":"https:\/\/doi.org\/10.1007\/s00405-017-4809-z","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,25]]}}}