{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:45:31Z","timestamp":1790772331353,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,1,27]],"date-time":"2018-01-27T00:00:00Z","timestamp":1517011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"The Helsinki University Hospital Research Fund","award":["TYH2015204"],"award-info":[{"award-number":["TYH2015204"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s00405-018-4883-x","type":"journal-article","created":{"date-parts":[[2018,1,27]],"date-time":"2018-01-27T12:46:46Z","timestamp":1517057206000},"page":"959-966","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Olfactory and gustatory functions after free flap reconstruction and radiotherapy for oral and pharyngeal cancer: a prospective follow-up study"],"prefix":"10.1007","volume":"275","author":[{"given":"Markus","family":"Lilja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Markkanen-Lepp\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna","family":"Viitasalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kauko","family":"Saarilahti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lindford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Lassus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-2404","authenticated-orcid":false,"given":"Antti","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,27]]},"reference":[{"issue":"1","key":"4883_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00405-007-0413-y","volume":"265","author":"R Bree de","year":"2008","unstructured":"de Bree R, Rinaldo A, Genden EM, Suarez C, Rodrigo JP, Fagan JJ et al (2008) Modern reconstruction techniques for oral and pharyngeal defects after tumor resection. Eur Arch Otorhinolaryngol 265(1):1\u20139","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"4883_CR2","unstructured":"Markkanen-Leppanen M (2006) Functional outcome after free flap reconstructions in oral and pharyngeal cancer. Thesis. University of Helsinki, Helsinki, Finland. URN:ISBN:952-10-3047-X"},{"issue":"2","key":"4883_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.oraloncology.2009.11.008","volume":"46","author":"JB Epstein","year":"2010","unstructured":"Epstein JB, Barasch A (2010) Taste disorders in cancer patients: pathogenesis, and approach to assessment and management. Oral Oncol 46(2):77\u201381","journal-title":"Oral Oncol"},{"issue":"5","key":"4883_CR4","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1002\/lary.24999","volume":"125","author":"N Bhattacharyya","year":"2015","unstructured":"Bhattacharyya N, Kepnes LJ (2015) Contemporary assessment of the prevalence of smell and taste problems in adults. Laryngoscope 125(5):1102\u20131106","journal-title":"Laryngoscope"},{"issue":"2","key":"4883_CR5","first-page":"58","volume":"7","author":"JH Hong","year":"2009","unstructured":"Hong JH, Omur-Ozbek P, Stanek BT, Dietrich AM, Duncan SE, Lee YW et al (2009) Taste and odor abnormalities in cancer patients. J Support Oncol 7(2):58\u201365","journal-title":"J Support Oncol"},{"issue":"4","key":"4883_CR6","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1007\/s00520-016-3083-8","volume":"24","author":"JB Epstein","year":"2016","unstructured":"Epstein JB, Smutzer G, Doty RL (2016) Understanding the impact of taste changes in oncology care. Support Care Cancer 24(4):1917\u20131931","journal-title":"Support Care Cancer"},{"issue":"2","key":"4883_CR7","first-page":"68","volume":"7","author":"MY Halyard","year":"2009","unstructured":"Halyard MY (2009) Taste and smell alterations in cancer patients\u2014real problems with few solutions. J Support Oncol 7(2):68\u201369","journal-title":"J Support Oncol"},{"issue":"2","key":"4883_CR8","first-page":"70","volume":"7","author":"MN Farmer","year":"2009","unstructured":"Farmer MN, Raddin RS, Roberts JD (2009) The relationship between taste, olfaction, and nutrition in the cancer population. J Support Oncol 7(2):70\u201372","journal-title":"J Support Oncol"},{"issue":"1","key":"4883_CR9","first-page":"49","volume":"21","author":"JE Amoore","year":"1983","unstructured":"Amoore JE, Ollman BG (1983) Practical test kits for quantitatively evaluating the sense of smell. Rhinology 21(1):49\u201354","journal-title":"Rhinology"},{"key":"4883_CR10","first-page":"576","volume":"11","author":"JE Amoore","year":"1986","unstructured":"Amoore JE, O\u2019Neill RS (1986) Clinical olfactometry: improved convenience in squeeze-bottle kits; and a portable olfactometer. Chem Senses 11:576","journal-title":"Chem Senses"},{"issue":"3","key":"4883_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/hed.20329","volume":"28","author":"M Markkanen-Leppanen","year":"2006","unstructured":"Markkanen-Leppanen M, Makitie AA, Haapanen ML, Suominen E, Asko-Seljavaara S (2006) Quality of life after free-flap reconstruction in patients with oral and pharyngeal cancer. Head Neck 28(3):210\u2013216","journal-title":"Head Neck"},{"issue":"6","key":"4883_CR12","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/hed.20347","volume":"28","author":"H Yamashita","year":"2006","unstructured":"Yamashita H, Nakagawa K, Tago M, Nakamura N, Shiraishi K, Eda M et al (2006) Taste dysfunction in patients receiving radiotherapy. Head Neck 28(6):508\u2013516","journal-title":"Head Neck"},{"issue":"1","key":"4883_CR13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/MLG.0b013e318155a276","volume":"118","author":"N Mirza","year":"2008","unstructured":"Mirza N, Machtay M, Devine PA, Troxel A, Abboud SK, Doty RL (2008) Gustatory impairment in patients undergoing head and neck irradiation. Laryngoscope 118(1):24\u201331","journal-title":"Laryngoscope"},{"issue":"7","key":"4883_CR14","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1177\/154405910608500705","volume":"85","author":"PL Sandow","year":"2006","unstructured":"Sandow PL, Hejrat-Yazdi M, Heft MW (2006) Taste loss and recovery following radiation therapy. J Dent Res 85(7):608\u2013611","journal-title":"J Dent Res"},{"issue":"6","key":"4883_CR15","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/0360-3016(82)90166-3","volume":"8","author":"K Mossman","year":"1982","unstructured":"Mossman K, Shatzman A, Chencharick J (1982) Long-term effects of radiotherapy on taste and salivary function in man. Int J Radiat Oncol Biol Phys 8(6):991\u2013997","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"9","key":"4883_CR16","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1001\/jama.1990.03440090067028","volume":"263","author":"RE Frye","year":"1990","unstructured":"Frye RE, Schwartz BS, Doty RL (1990) Dose-related effects of cigarette smoking on olfactory function. JAMA 263(9):1233\u20131236","journal-title":"JAMA"},{"issue":"2","key":"4883_CR17","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/j.1398-9995.1998.tb03869.x","volume":"53","author":"M Simola","year":"1998","unstructured":"Simola M, Malmberg H (1998) Sense of smell in allergic and nonallergic rhinitis. Allergy 53(2):190\u2013194","journal-title":"Allergy"},{"issue":"4","key":"4883_CR18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1053\/ajot.2002.123436","volume":"23","author":"WK Ho","year":"2002","unstructured":"Ho WK, Kwong DL, Wei WI, Sham JS (2002) Change in olfaction after radiotherapy for nasopharyngeal cancer\u2014a prospective study. Am J Otolaryngol 23(4):209\u2013214","journal-title":"Am J Otolaryngol"},{"issue":"2","key":"4883_CR19","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.radonc.2005.09.015","volume":"77","author":"T Holscher","year":"2005","unstructured":"Holscher T, Seibt A, Appold S, Dorr W, Herrmann T, Huttenbrink KB et al (2005) Effects of radiotherapy on olfactory function. Radiother Oncol 77(2):157\u2013163","journal-title":"Radiother Oncol"},{"issue":"4","key":"4883_CR20","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1177\/00220345670460041901","volume":"46","author":"JA Jackson","year":"1967","unstructured":"Jackson JA (1967) Heavy smoking and sodium chloride hypogeusia. J Dent Res 46(4):742\u2013744","journal-title":"J Dent Res"},{"issue":"12","key":"4883_CR21","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1111\/joor.12442","volume":"43","author":"M Uota","year":"2016","unstructured":"Uota M, Ogawa T, Ikebe K, Arai Y, Kamide K, Gondo Y et al (2016) Factors related to taste sensitivity in elderly: cross-sectional findings from SONIC study. J Oral Rehabil 43(12):943\u2013952","journal-title":"J Oral Rehabil"},{"issue":"12","key":"4883_CR22","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1017\/S0022215107000862","volume":"121","author":"EK Ellegard","year":"2007","unstructured":"Ellegard EK, Hay KD, Morton RP (2007) Is electrogustometry useful for screening abnormalities of taste? J Laryngol Otol 121(12):1161\u20131164","journal-title":"J Laryngol Otol"},{"issue":"5","key":"4883_CR23","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1046\/j.1365-2273.2003.00729.x","volume":"28","author":"JA Stillman","year":"2003","unstructured":"Stillman JA, Morton RP, Hay KD, Ahmad Z, Goldsmith D (2003) Electrogustometry: strengths, weaknesses, and clinical evidence of stimulus boundaries. Clin Otolaryngol Allied Sci 28(5):406\u2013410","journal-title":"Clin Otolaryngol Allied Sci"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-018-4883-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-018-4883-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-018-4883-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T19:51:18Z","timestamp":1548532278000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-018-4883-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,27]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["4883"],"URL":"https:\/\/doi.org\/10.1007\/s00405-018-4883-x","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,27]]},"assertion":[{"value":"16 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research ethics committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The Research Ethics Board approved the study design and an institutional study permission was granted.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients filled in an informed consent form.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}