{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:57:01Z","timestamp":1782316621043,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00405-018-5241-8","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T10:59:44Z","timestamp":1545130784000},"page":"575-583","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Organ-preservation (chemo)radiotherapy for T4 laryngeal and hypopharyngeal cancer: is the effort worth?"],"prefix":"10.1007","volume":"276","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0748-6640","authenticated-orcid":false,"given":"Abrahim","family":"Al-Mamgani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Navran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Walraven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willen Hans","family":"Schreuder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot E. T.","family":"Tesselaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem Martin C.","family":"Klop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"5241_CR1","first-page":"1685","volume":"349","author":"The Department of Veterans Affairs Laryngeal Cancer Study Group","year":"1991","unstructured":"The Department of Veterans Affairs Laryngeal Cancer Study Group (1991) Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 349:1685\u20131690","journal-title":"N Engl J Med"},{"key":"5241_CR2","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1093\/jnci\/88.13.890","volume":"88","author":"JL Lefebvre","year":"1996","unstructured":"Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T (1996) Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst 88:890\u2013899","journal-title":"J Natl Cancer Inst"},{"key":"5241_CR3","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1200\/JCO.2012.43.6097","volume":"31","author":"AA Forastiere","year":"2013","unstructured":"Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF et al (2013) Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol 31:845\u2013852","journal-title":"J Clin Oncol"},{"key":"5241_CR4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1200\/JCO.2003.01.008","volume":"21","author":"DJ Adelstein","year":"2003","unstructured":"Adelstein DJ, Li Y, Adams GL, Wagner H Jr, Kish JA et al (2003) An intergroup phase III comparison of standard radi- ation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21:92\u201398","journal-title":"J Clin Oncol"},{"key":"5241_CR5","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1200\/JCO.2000.18.8.1652","volume":"18","author":"EE Vokes","year":"2000","unstructured":"Vokes EE, Kies MS, Haraf DJ, Stenson K, List M, Humerickhouse R et al (2000) Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer. J Clin Oncol 18:1652\u20131661","journal-title":"J Clin Oncol"},{"key":"5241_CR6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/hed.20107","volume":"27","author":"O Altundag","year":"2005","unstructured":"Altundag O, Gullu I, Altundag K, Yalcin S, Ozyar E, Cengiz M et al (2005) Induction chemotherapy with cisplatin and 5-fluorouracil followed by chemoradiotherapy or radiotherapy alone in the treatment of locoregionally advanced resectable cancers of the larynx and hypopharynx: results of single-center study of 45 patients. Head Neck 27:15\u201321","journal-title":"Head Neck"},{"key":"5241_CR7","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/cncr.10661","volume":"95","author":"DM Shin","year":"2002","unstructured":"Shin DM, Glisson BS, Khuri FR, Lippman SM, Ginsberg L, Diaz E Jr et al (2002) Phase II study of induction chemotherapy with paclitaxel, ifosfamide, and carboplatin (TIC) for patients with locally advanced squamous cell carcinoma of the head and neck. Cancer 95:322\u2013330","journal-title":"Cancer"},{"key":"5241_CR8","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.ijrobp.2015.03.004","volume":"92","author":"S Grover","year":"2015","unstructured":"Grover S, Swisher-McClure S, Mitra N, Li J, Cohen RB, Ahn PH et al (2015) Total Laryngectomy versus larynx preservation for T4a larynx cancer: patterns of care and survival outcomes. Int J Radiat Oncol Biol Phys 92:594\u2013601","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5241_CR9","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1200\/JCO.2017.75.7385","volume":"36","author":"AA Forastiere","year":"2018","unstructured":"Forastiere AA, Ismaila N, Lewin JS, Nathan CA, Adelstein DJ, Eisbruch A et al (2018) Use of larynx-preservation strategies in the treatment of laryngeal cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol 36:1143\u20131169","journal-title":"J Clin Oncol"},{"key":"5241_CR10","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1002\/hed.23508","volume":"36","author":"PA Tennant","year":"2014","unstructured":"Tennant PA, Cash E, Bumpous JM, Potts KL (2014) Persistent tracheostomy after primary chemoradiation for advanced laryngeal or hypopharyngeal cancer. Head Neck 36:1628\u20131633","journal-title":"Head Neck"},{"key":"5241_CR11","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/lary.25585","volume":"126","author":"GD Jefferson","year":"2016","unstructured":"Jefferson GD, Wenig BL, Spiotto MT (2016) Predictors and outcomes for chronic tracheostomy after chemoradiation for advanced laryngohypopharyngeal cancer. Laryngoscope 126:385\u2013391","journal-title":"Laryngoscope"},{"key":"5241_CR12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.oraloncology.2018.01.018","volume":"78","author":"SA Byrd","year":"2018","unstructured":"Byrd SA, Xu MJ, cass LM, Wehrmann DJ, Naunheim M, Christopher K et al (2018) Oncologic and functional outcomes of pretreatment tracheotomy in advanced laryngeal squamous cell carcinoma: a multi-institutional analysis. Oral Oncol 78:171\u2013176","journal-title":"Oral Oncol"},{"key":"5241_CR13","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1177\/0194599812459325","volume":"148","author":"OE Tulunay-Ugur","year":"2013","unstructured":"Tulunay-Ugur OE, McClinton C, Young Z, Penagaricano JA, Maddox AM, Vural E (2013) Functional outcomes of chemoradiation in patients with head and neck cancer. Otolaryngol Head Neck Surg 148:64\u201368","journal-title":"Otolaryngol Head Neck Surg"},{"key":"5241_CR14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1067\/mhn.2002.124473","volume":"127","author":"J Staton","year":"2002","unstructured":"Staton J, Robbins KT, Newman L, Samant S, Sebelik M, Vieira F (2002) Factors predictive of poor functional outcome after chemoradiation for advanced laryngeal cancer. Otolaryngol Head Neck Surg 127:43\u201347","journal-title":"Otolaryngol Head Neck Surg"},{"key":"5241_CR15","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0360-3016(98)00226-0","volume":"42","author":"JC Voet van der","year":"1998","unstructured":"van der Voet JC, Keus RB, Hart AA, Hilgers FJ, Bartelink H (1998) The impact of treatment time and smoking on local control and complications in T1 glottic cancer. Int J Radiat Oncol Biol Phys 42:247\u2013255","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5241_CR16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1365-2273.1992.tb01054.x","volume":"17","author":"S Mak-Kregar","year":"1992","unstructured":"Mak-Kregar S, Schouwenburg PF, Baris G, Hilgers FJ, Hart AA (1992) Staging and prognostic factors in carcinoma of the base of the tongue. Clin Otolaryngol Allied Sci 17:107\u2013112","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"5241_CR17","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00405-013-2608-8","volume":"271","author":"A Al-Mamgani","year":"2014","unstructured":"Al-Mamgani A, van Rooij PH, Mehilal R, Verduijn GM, Tans L, Kwa SL (2014) Radiotherapy for T1a glottic cancer: the influence of smoking cessation and fractionation schedule of radiotherapy. Eur Arch Otorhinolaryngol 271:125\u2013132","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"5241_CR18","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1200\/JCO.1997.15.6.2394","volume":"15","author":"WM Mendenhall","year":"1997","unstructured":"Mendenhall WM, Parsons JT, Mancuso AA, Pameijer FJ, Stringer SP, Cassisi NJ (1997) Definitive radiotherapy for T3 squamous cell carcinoma of the glottic larynx. J Clin Oncol 15:2394\u20132402","journal-title":"J Clin Oncol"},{"key":"5241_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0360-3016(98)00030-3","volume":"41","author":"R MacKenzie","year":"1998","unstructured":"MacKenzie R, Franssen E, Balogh J, Birt D, Gilbert R (1998) The prognostic significance of tracheostomy in carcinoma of the larynx treated with radiotherapy and surgery for salvage. Int J Radiat Oncol Biol Phys 41:43\u201351","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5241_CR20","doi-asserted-by":"crossref","first-page":"w14213","DOI":"10.4414\/smw.2015.14213","volume":"145","author":"R Schariatzadeh","year":"2015","unstructured":"Schariatzadeh R, Pezier TF, Studer G, Schmid S, Huber GF (2015) Does airway intervention before primary nonsurgical therapy for T3\/T4 laryngeal squamous cell carcinoma impact on oncological or functional outcomes? Swiss Med Wkly 145:w14213","journal-title":"Swiss Med Wkly"},{"key":"5241_CR21","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1001\/archotol.130.4.401","volume":"4","author":"JE Terrell","year":"2004","unstructured":"Terrell JE, Ronis DL, Fowler KE, Bradford CR, Chepeha DB, Prince ME et al (2004) Clinical predictors of quality of life in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 4:401\u2013418","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"5241_CR22","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1001\/archotol.130.7.875","volume":"130","author":"E Hanna","year":"2004","unstructured":"Hanna E, Sherman A, Cash D, Adams D, Vural E, Fan CY et al (2004) Quality of life for patients following total laryngectomy vs chemoradiation for laryngeal preservation. Arch Otolaryngol Head Neck Surg 130:875\u2013879","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"5241_CR23","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.otohns.2008.06.002","volume":"139","author":"NP Trivedi","year":"2008","unstructured":"Trivedi NP, Swaminathan DK, Thankappan K, Chatni S, Kuriakose MA, Lyer S (2008) Comparison of quality of life in advanced laryngeal cancer patients after concurrent chemoradiation vs total laryngectomy. Otolariyngol Head Neck Surg 139:702\u2013707","journal-title":"Otolariyngol Head Neck Surg"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-018-5241-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-018-5241-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-018-5241-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T16:01:26Z","timestamp":1775318486000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-018-5241-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,18]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["5241"],"URL":"https:\/\/doi.org\/10.1007\/s00405-018-5241-8","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,18]]},"assertion":[{"value":"19 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any experimental study with human participants performed by any of the authors. For this type of work, formal consent is not required due to its retrospective nature.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}