{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:43:15Z","timestamp":1785807795414,"version":"3.56.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81570917"],"award-info":[{"award-number":["No. 81570917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00405-018-5260-5","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:30:42Z","timestamp":1546389042000},"page":"665-672","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Clinical features and management of Meniere\u2019s disease patients with drop attacks"],"prefix":"10.1007","volume":"276","author":[{"given":"Qianru","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6948-7289","authenticated-orcid":false,"given":"Chunfu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"key":"5260_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1136\/bmj.2.3942.175","volume":"2","author":"A Tumarkin","year":"1936","unstructured":"Tumarkin A (1936) The otolithic catastrophe: a new syndrome. Br Med J 2:175\u2013177","journal-title":"Br Med J"},{"key":"5260_CR2","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1177\/019459988209000221","volume":"90","author":"FO Black","year":"1982","unstructured":"Black FO, Effron MZ, Burns DS (1982) Diagnosis and management of drop attacks of vestibular origin: Tumarkin\u2019s otolithic crisis. Otolaryngol Head Neck Surg 90:256\u2013262","journal-title":"Otolaryngol Head Neck Surg"},{"key":"5260_CR3","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1002\/ana.410280314","volume":"28","author":"RW Baloh","year":"1990","unstructured":"Baloh RW, Jacobson K, Winder T (1990) Drop attacks with Meniere\u2019s syndrome. Ann Neurol 28:384\u2013387","journal-title":"Ann Neurol"},{"key":"5260_CR4","first-page":"359","volume":"17","author":"VD Janzen","year":"1988","unstructured":"Janzen VD, Russell RD (1988) Conservative management of Tumarkin\u2019s otolithic crisis. J Otolaryngol 17:359\u2013361","journal-title":"J Otolaryngol"},{"key":"5260_CR5","first-page":"1317","volume":"31","author":"CS Hallpike","year":"1938","unstructured":"Hallpike CS, Cairns H (1938) Observations on the pathology of Meniere\u2019s syndrome: (section of otology). Proc R Soc Med 31:1317\u20131336","journal-title":"Proc R Soc Med"},{"key":"5260_CR6","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/MLG.0b013e31802c300c","volume":"117","author":"T Nakashima","year":"2007","unstructured":"Nakashima T, Naganawa S, Sugiura M et al (2007) Visualization of endolymphatic hydrops in patients with Meniere\u2019s disease. Laryngoscope 117:415\u2013420","journal-title":"Laryngoscope"},{"key":"5260_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/00129492-200501000-00013","volume":"26","author":"SN Merchant","year":"2005","unstructured":"Merchant SN, Adams JC, Nadol JJ (2005) Pathophysiology of Meniere\u2019s syndrome: are symptoms caused by endolymphatic hydrops? Otol Neurotol 26:74\u201381","journal-title":"Otol Neurotol"},{"key":"5260_CR8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1159\/000310899","volume":"15","author":"N Perez-Fernandez","year":"2010","unstructured":"Perez-Fernandez N, Montes-Jovellar L, Cervera-Paz J, Domenech-Vadillo E (2010) Auditory and vestibular assessment of patients with Meniere\u2019s disease who suffer Tumarkin attacks. Audiol Neurootol 15:399\u2013406","journal-title":"Audiol Neurootol"},{"key":"5260_CR9","doi-asserted-by":"publisher","first-page":"e5767","DOI":"10.1097\/MD.0000000000005767","volume":"95","author":"B Liu","year":"2016","unstructured":"Liu B, Leng Y, Zhou R et al (2016) Intratympanic steroids injection is effective for the treatment of drop attacks with Meniere\u2019s disease and delayed endolymphatic hydrops: a retrospective study. Medicine (Baltimore) 95:e5767","journal-title":"Medicine (Baltimore)"},{"key":"5260_CR10","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1002\/lary.24716","volume":"124","author":"LM Viana","year":"2014","unstructured":"Viana LM, Bahmad F, Rauch SD (2014) Intratympanic gentamicin as a treatment for drop attacks in patients with Meniere\u2019s disease. Laryngoscope 124:2151\u20132154","journal-title":"Laryngoscope"},{"key":"5260_CR11","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1002\/lary.25009","volume":"125","author":"YC Rah","year":"2015","unstructured":"Rah YC, Han JJ, Park J, Choi BY, Koo JW (2015) Management of intractable Meniere\u2019s disease after intratympanic injection of gentamicin. Laryngoscope 125:972\u2013978","journal-title":"Laryngoscope"},{"key":"5260_CR12","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1080\/00016480600951475","volume":"127","author":"L Beer De","year":"2007","unstructured":"De Beer L, Stokroos R, Kingma H (2007) Intratympanic gentamicin therapy for intractable Meniere\u2019s disease. Acta Otolaryngol 127:605\u2013612","journal-title":"Acta Otolaryngol"},{"key":"5260_CR13","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1080\/00016489.2016.1224921","volume":"137","author":"H Liu","year":"2017","unstructured":"Liu H, Zhang T, Wu Q, Zhang Y, Dai C (2017) End-point indicators of low-dose intratympanic gentamicin in management of Meniere\u2019s disease. Acta Otolaryngol 137:136\u2013143","journal-title":"Acta Otolaryngol"},{"key":"5260_CR14","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1016\/S0140-6736(16)31461-1","volume":"388","author":"M Patel","year":"2016","unstructured":"Patel M, Agarwal K, Arshad Q et al (2016) Intratympanic methylprednisolone versus gentamicin in patients with unilateral Meniere\u2019s disease: a randomised, double-blind, comparative effectiveness trial. Lancet 388:2753\u20132762","journal-title":"Lancet"},{"key":"5260_CR15","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1288\/00005537-195607000-00005","volume":"66","author":"HF Schuknecht","year":"1956","unstructured":"Schuknecht HF (1956) Ablation therapy for the relief of Meniere\u2019s disease. Laryngoscope 66:859\u2013870","journal-title":"Laryngoscope"},{"key":"5260_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1017\/S0022215110002306","volume":"125","author":"RC Demarco","year":"2011","unstructured":"Demarco RC, Rossato M, de Oliveira JAA, Hyppolito MA (2011) Histological effects of intratympanic gentamicin on the vestibular organ of guinea pigs. J Laryngol Otol 125:357\u2013362","journal-title":"J Laryngol Otol"},{"key":"5260_CR17","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1152\/jn.00160.2004","volume":"93","author":"TP Hirvonen","year":"2005","unstructured":"Hirvonen TP, Minor LB, Hullar TE, Carey JP (2005) Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchilla. J Neurophysiol 93:643\u2013655","journal-title":"J Neurophysiol"},{"key":"5260_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","volume":"25","author":"JA Lopez-Escamez","year":"2015","unstructured":"Lopez-Escamez JA, Carey J, Chung WH et al (2015) Diagnostic criteria for Meniere\u2019s disease. J Vestib Res 25:1\u20137","journal-title":"J Vestib Res"},{"key":"5260_CR19","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.clinph.2017.05.016","volume":"128","author":"YJ Zhou","year":"2017","unstructured":"Zhou YJ, Wu YZ, Cong N et al (2017) Contrasting results of tests of peripheral vestibular function in patients with bilateral large vestibular aqueduct syndrome. Clin Neurophysiol 128:1513\u20131518","journal-title":"Clin Neurophysiol"},{"key":"5260_CR20","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/lary.25576","volume":"126","author":"Q Wu","year":"2016","unstructured":"Wu Q, Dai C, Zhao M, Sha Y (2016) The correlation between symptoms of definite Meniere\u2019s disease and endolymphatic hydrops visualized by magnetic resonance imaging. Laryngoscope 126:974\u2013979","journal-title":"Laryngoscope"},{"key":"5260_CR21","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/00016480902729827","volume":"129","author":"T Nakashima","year":"2009","unstructured":"Nakashima T, Naganawa S, Pyykk\u00f6 I et al (2009) Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Oto-laryngol 129:5\u20138","journal-title":"Acta Oto-laryngol"},{"key":"5260_CR22","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1212\/WNL.57.6.1103","volume":"57","author":"G Ishiyama","year":"2001","unstructured":"Ishiyama G, Ishiyama A, Jacobson K, Baloh RW (2001) Drop attacks in older patients secondary to an otologic cause. Neurology 57:1103\u20131106","journal-title":"Neurology"},{"key":"5260_CR23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/00129492-200201000-00017","volume":"23","author":"M Ballester","year":"2002","unstructured":"Ballester M, Liard P, Vibert D, Hausler R (2002) Meniere\u2019s disease in the elderly. Otol Neurotol 23:73\u201378","journal-title":"Otol Neurotol"},{"key":"5260_CR24","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1212\/WNL.42.8.1635","volume":"42","author":"JG Colebatch","year":"1992","unstructured":"Colebatch JG, Halmagyi GM (1992) Vestibular evoked potentials in human neck muscles before and after unilateral vestibular deafferentation. Neurology 42:1635\u20131636","journal-title":"Neurology"},{"key":"5260_CR25","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1212\/01.wnl.0000259064.80564.21","volume":"68","author":"S Iwasaki","year":"2007","unstructured":"Iwasaki S, McGarvie LA, Halmagyi GM et al (2007) Head taps evoke a crossed vestibulo-ocular reflex. Neurology 68:1227\u20131229","journal-title":"Neurology"},{"key":"5260_CR26","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1097\/MAO.0b013e31826352e8","volume":"33","author":"CH Huang","year":"2012","unstructured":"Huang CH, Young YH (2012) Ocular and cervical vestibular-evoked myogenic potentials in Tumarkin falls. Otol Neurotol 33:1251\u20131256","journal-title":"Otol Neurotol"},{"key":"5260_CR27","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1097\/01.mlg.0000205129.78600.27","volume":"116","author":"FC Timmer","year":"2006","unstructured":"Timmer FC, Zhou G, Guinan JJ, Kujawa SG, Herrmann BS, Rauch SD (2006) Vestibular evoked myogenic potential (VEMP) in patients with Meniere\u2019s disease with drop attacks. Laryngoscope 116:776\u2013779","journal-title":"Laryngoscope"},{"key":"5260_CR28","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.heares.2017.12.010","volume":"362","author":"AN Salt","year":"2018","unstructured":"Salt AN, Hirose K (2018) Communication pathways to and from the inner ear and their contributions to drug delivery. Hear Res 362:25\u201337","journal-title":"Hear Res"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-018-5260-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-018-5260-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-018-5260-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T19:08:23Z","timestamp":1577905703000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-018-5260-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,2]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["5260"],"URL":"https:\/\/doi.org\/10.1007\/s00405-018-5260-5","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,2]]},"assertion":[{"value":"25 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the present study involving human participants were approved by the medical ethics committee of the Eye, Ear, Nose & Throat Hospital and in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients included in the study signed the informed consent. For this type of study formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}