{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T08:25:24Z","timestamp":1748075124550,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s00405-019-05299-7","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T02:49:46Z","timestamp":1548298186000},"page":"977-984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is intensity-modulated radiotherapy superior to conventional techniques to prevent late ear complications of nasopharyngeal cancer?"],"prefix":"10.1007","volume":"276","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-1468","authenticated-orcid":false,"given":"Ayca","family":"Ant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Atabey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferit Ferhat","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzubetul","family":"Duran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samet","family":"Ozlugedik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf Kemal","family":"Kemaloglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"5299_CR1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1177\/014556130608500313","volume":"85","author":"A Jeyakumar","year":"2006","unstructured":"Jeyakumar A, Brickman TM, Jeyakumar A, Doerr T (2006) Review of nasopharyngeal carcinoma. ENT Ear Nose Throat J 85:168\u2013173","journal-title":"ENT Ear Nose Throat J"},{"key":"5299_CR2","first-page":"155","volume-title":"Carcinogenesis, diagnosis, and molecular targeted treatment for nasopharyngeal carcinoma","author":"WKC Low","year":"2012","unstructured":"Low WKC, Rangabashyam M (2012) Ear-related issues in patients with nasopharyngeal carcinoma. In: Carcinogenesis, diagnosis, and molecular targeted treatment for nasopharyngeal carcinoma. InTech, Croatia, pp\u00a0155\u2013178"},{"issue":"5","key":"5299_CR3","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0305-7372(03)00066-5","volume":"29","author":"BA Jereczek-Fossa","year":"2003","unstructured":"Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R (2003) Radiotherapy-induced ear toxicity. Cancer Treat Rev 29(5):417\u2013430","journal-title":"Cancer Treat Rev"},{"issue":"2","key":"5299_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jicru_ndx006","volume":"14","author":"HG Menzel","year":"2014","unstructured":"Menzel HG (2014) International commission on radiation units and measurements. J ICRU 14(2):1\u20132","journal-title":"J ICRU"},{"issue":"2","key":"5299_CR5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.anl.2008.04.006","volume":"36","author":"Y Sumitsawan","year":"2009","unstructured":"Sumitsawan Y, Chaiyasate S, Chitapanarux I, Anansuthiwara M, Roongrotwattanasiri K, Vaseenon V, Tooncam H (2009) Late complications of radiotherapy for nasopharyngeal carcinoma. Auris Nasus Larynx 36(2):205\u2013209","journal-title":"Auris Nasus Larynx"},{"issue":"3","key":"5299_CR6","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ijrobp.2009.04.096","volume":"76","author":"N Bhandare","year":"2010","unstructured":"Bhandare N, Jackson A, Eisbruch A, Pan CC, Flickinger JC, Antonelli P, Mendenhall WM (2010) Radiation therapy and hearing loss. Int J Radiat Oncol Biol Phys 76(3):50\u201357","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4\u20135","key":"5299_CR7","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.canrad.2010.02.011","volume":"14","author":"B Fleury","year":"2010","unstructured":"Fleury B, Lapeyre M (2010) Tolerance of normal tissues to radiation therapy: ear. Cancer Radiother 14(4\u20135):284\u2013289","journal-title":"Cancer Radiother"},{"issue":"11","key":"5299_CR8","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrclinonc.2011.106","volume":"8","author":"X Wang","year":"2011","unstructured":"Wang X, Hu C, Eisbruch A (2011) Organ-sparing radiation therapy for head and neck cancer. Nat Rev Clin Oncol 8(11):639","journal-title":"Nat Rev Clin Oncol"},{"issue":"4","key":"5299_CR9","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.ijrobp.2006.06.013","volume":"66","author":"EH Pow","year":"2006","unstructured":"Pow EH, Kwong DL, McMillan AS, Wong MC, Sham JS, Leung LH, Leung WK (2006) Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys 66(4):981\u2013991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5299_CR10","doi-asserted-by":"publisher","first-page":"769806","DOI":"10.1155\/2015\/769806","volume":"2015","author":"CF Hwang","year":"2015","unstructured":"Hwang CF, Fang FM, Zhuo MY, Yang CH, Yang LN, Hsieh HS (2015) Hearing assessment after treatment of nasopharyngeal carcinoma with CRT and IMRT techniques. BioMed Res Int 2015:769806. https:\/\/doi.org\/10.1155\/2015\/769806","journal-title":"BioMed Res Int"},{"issue":"5","key":"5299_CR11","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/j.ijrobp.2008.07.034","volume":"73","author":"SH Chan","year":"2009","unstructured":"Chan SH, Ng WT, Kam KL, Lee MC, Choi CW, Yau TK et al (2009) Sensorineural hearing loss after treatment of nasopharyngeal carcinoma: a longitudinal analysis. Int J Radiat Oncol Biol Phys 73(5):1335\u20131342","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"5299_CR12","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1017\/S0022215109991435","volume":"124","author":"JJ Li","year":"2010","unstructured":"Li JJ, Guo YK, Tang QL, Li SS, Zhang XL, Wu PA, Yang XM (2010) Prospective study of sensorineural hearing loss following radiotherapy for nasopharyngeal carcinoma. J Laryngol Otol 124(1):32\u201336","journal-title":"J Laryngol Otol"},{"issue":"2","key":"5299_CR13","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1097\/00129492-200403000-00015","volume":"25","author":"LF Wang","year":"2004","unstructured":"Wang LF, Kuo WR, Ho KY, Lee KW, Lin CS (2004) A long-term study on hearing status in patients with nasopharyngeal carcinoma after radiotherapy. Otol Neurotol 25(2):168\u2013173","journal-title":"Otol Neurotol"},{"issue":"1","key":"5299_CR14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.anl.2010.03.012","volume":"38","author":"H Wakisaka","year":"2011","unstructured":"Wakisaka H, Yamada H, Motoyoshi K, Ugumori T, Takahashi H, Hyodo M (2011) Incidence of long-term ipsilateral and contralateral ototoxicity following radiotherapy for nasopharyngeal carcinoma. Auris Nasus Larynx 38(1):95\u2013100","journal-title":"Auris Nasus Larynx"},{"issue":"5","key":"5299_CR15","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.otohns.2010.07.012","volume":"143","author":"CH Hsin","year":"2010","unstructured":"Hsin CH, Chen TH, Young YH, Liu WS (2010) Comparison of otologic complications between intensity-modulated and two-dimensional radiotherapies in nasopharyngeal carcinoma patients. Otolaryngol Head Neck Surg 143(5):662\u2013668","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"5299_CR16","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/bjc.2013.720","volume":"110","author":"L Zeng","year":"2014","unstructured":"Zeng L, Tian YM, Sun XM, Chen CY, Han F, Xiao WW et al (2014) Late toxicities after intensity-modulated radiotherapy for nasopharyngeal carcinoma: patient and treatment-related risk factors. Br J Cancer 110(1):49","journal-title":"Br J Cancer"},{"issue":"2","key":"5299_CR17","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00405-010-1381-1","volume":"268","author":"KL Liang","year":"2011","unstructured":"Liang KL, Su MC, Twu CW, Jiang RS, Lin JC, Shiao JY (2011) Long-term result of management of otitis media with effusion in patients with post-irradiated nasopharyngeal carcinoma. Eur Arch Otorhinolaryngol 268(2):213\u2013217","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"5299_CR18","doi-asserted-by":"publisher","first-page":"13525","DOI":"10.1038\/srep13525","volume":"5","author":"JJ Yao","year":"2015","unstructured":"Yao JJ, Zhou GQ, Lin L, Zhang WJ, Peng YL, Chen L et al (2015) Dose-volume factors associated with ear disorders following intensity modulated radiotherapy in nasopharyngeal carcinoma. Sci Rep 5:13525","journal-title":"Sci Rep"},{"issue":"5","key":"5299_CR19","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1177\/000348949910800510","volume":"108","author":"PJ Lou","year":"1999","unstructured":"Lou PJ, Chen WP, Tai CC (1999) Delayed Irradiation effects on nasal epithelium in patients with nasopharyngeal carcinoma; an ultrastructural study. Ann Otol Rhinol Laryngol 108(5):474\u2013480","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"8","key":"5299_CR20","first-page":"464","volume":"17","author":"Y Zhou","year":"2003","unstructured":"Zhou Y, Tang A, Li J, Chen P, Mao R (2003) The damaged types of eustachian tube function in the patients of nasopharyngeal carcinoma after radiotherapy. Lin Chuang Er Bi Yan Hou Ke Za Zhi 17(8):464\u2013465","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"issue":"6","key":"5299_CR21","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/(SICI)1097-0347(199909)21:6<547::AID-HED8>3.0.CO;2-Y","volume":"21","author":"WK Ho","year":"1999","unstructured":"Ho WK, Wei WI, Kwong DL, Sham JS, Tai PT, Yuen AP, Au DK (1999) Long-term sensorineural hearing deficit following radiotherapy in patients suffering from nasopharyngeal carcinoma: a prospective study. Head Neck J Sci Spec Head Neck 21(6):547\u2013553","journal-title":"Head Neck J Sci Spec Head Neck"},{"issue":"2","key":"5299_CR22","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0360-3016(96)00302-1","volume":"36","author":"DL Kwong","year":"1996","unstructured":"Kwong DL, Wei WI, Sham JS, Ho WK, Yuen PW, Chua DT et al (1996) Sensorineural hearing loss in patients treated for nasopharyngeal carcinoma: a prospective study of the effect of radiation and cisplatin treatment. Int J Rad Oncol Biol Phys 36(2):281\u2013289","journal-title":"Int J Rad Oncol Biol Phys"},{"issue":"1","key":"5299_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0167-8140(02)00211-6","volume":"65","author":"E Raaijmakers","year":"2002","unstructured":"Raaijmakers E, Engelen AM (2002) Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation? A systematic review of the literature. Radiother Oncol 65(1):1\u20137","journal-title":"Radiother Oncol"},{"issue":"7","key":"5299_CR24","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1288\/00005537-198507000-00014","volume":"95","author":"BA Bohne","year":"1985","unstructured":"Bohne BA, Marks JE, Glasgow GP (1985) Delayed effects of ionizing radiation on the ear. Laryngoscope 95(7):818\u2013828","journal-title":"Laryngoscope"},{"issue":"10","key":"5299_CR25","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1097\/01.mlg.0000175061.59315.58","volume":"115","author":"WK Low","year":"2005","unstructured":"Low WK, Burgess R, Fong KW, Wang DY (2005) Effect of radiotherapy on retro-cochlear auditory pathways. Laryngoscope 115(10):1823\u20131826","journal-title":"Laryngoscope"},{"issue":"11","key":"5299_CR26","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1002\/hed.23201","volume":"35","author":"M Mujica\u2013Mota","year":"2013","unstructured":"Mujica\u2013Mota M, Waissbluth S, Daniel SJ (2013) Characteristics of radiation-induced sensorineural hearing loss in head and neck cancer: A systematic review. Head neck 35(11):1662\u20131668","journal-title":"Head neck"},{"issue":"1","key":"5299_CR27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.47102\/annals-acadmedsg.V38N1p91","volume":"38","author":"WK Low","year":"2009","unstructured":"Low WK, Tan MG, Chua AW, Sun L, Wang DY (2009) 12th Yahya cohen memorial lecture\u2014the cellular and molecular basis of radiation-induced sensori-neural hearing loss. Ann Acad Med Singap 38(1):91","journal-title":"Ann Acad Med Singap"},{"issue":"2","key":"5299_CR28","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ijrobp.2006.09.017","volume":"67","author":"N Bhandare","year":"2007","unstructured":"Bhandare N, Antonelli PJ, Morris CG, Malayapa RS, Mendenhall WM (2007) Ototoxicity after radiotherapy for head and neck tumors. Int J Radiat Oncol Biol Phys 67(2):469\u2013479","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"12","key":"5299_CR29","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1200\/JCO.2005.05.0096","volume":"24","author":"WK Low","year":"2006","unstructured":"Low WK, Toh ST, Wee J, Fook-Chong SM, Wang DY (2006) Sensorineural hearing loss after radiotherapy and chemoradiotherapy: a single, blinded, randomized study. J Clin Oncol 24(12):1904\u20131909","journal-title":"J Clin Oncol"},{"issue":"11","key":"5299_CR30","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1001\/archotol.130.11.1265","volume":"130","author":"PHP Liberman","year":"2004","unstructured":"Liberman PHP, Schultz C, Gomez MVSG, Carvalho AL, Pellizzon ACA, Testa JR et al (2004) Auditory effects after organ preservation protocol for laryngeal\/hypopharyngeal carcinomas. Arch Otolaryngol Head Neck Surg 130(11):1265\u20131268","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"5","key":"5299_CR31","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.ijrobp.2007.01.042","volume":"68","author":"CL Zuur","year":"2007","unstructured":"Zuur CL, Simis YJ, Lansdaal PE, Hart AA, Rasch CR, Schornagel JH et al (2007) Risk factors of ototoxicity after cisplatin-based chemo-irradiation in patients with locally advanced head-and-neck cancer: a multivariate analysis. Int J Radiat Oncol Biol Phys 68(5):1320\u20131325","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-019-05299-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-019-05299-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-019-05299-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T03:52:38Z","timestamp":1694577158000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-019-05299-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,22]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["5299"],"URL":"https:\/\/doi.org\/10.1007\/s00405-019-05299-7","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"type":"print","value":"0937-4477"},{"type":"electronic","value":"1434-4726"}],"subject":[],"published":{"date-parts":[[2019,1,22]]},"assertion":[{"value":"23 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}