{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:56:23Z","timestamp":1787316983503,"version":"build-2736575974"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002679","name":"Adnan Menderes \u00dcniversitesi","doi-asserted-by":"publisher","award":["TPF-16015."],"award-info":[{"award-number":["TPF-16015."]}],"id":[{"id":"10.13039\/501100002679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"DOI":"10.1007\/s00405-019-05379-8","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T16:21:12Z","timestamp":1558542072000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased TSLP, IL-33, IL-25, IL-19, IL 21 and amphiregulin (AREG) levels in chronic rhinosinusitis with nasal polyp"],"prefix":"10.1007","author":[{"given":"Murat","family":"Dogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-6389","authenticated-orcid":false,"given":"Mustafa","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cigdem","family":"Yenisey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"issue":"2","key":"5379_CR1","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/cea.12475","volume":"45","author":"L Xiao","year":"2015","unstructured":"Xiao L, Wei Y, Zhang YN, Luo X, Yang BY, Yu SF, Wu XM, Wu CY, Li HB (2015) Increased IL-21 expression in chronic rhinosinusitis with nasal polyps. Clin Exp Allergy 45(2):404\u2013413","journal-title":"Clin Exp Allergy"},{"issue":"12","key":"5379_CR2","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1097\/MLG.0b013e31814539e8","volume":"117","author":"JR Litvack","year":"2007","unstructured":"Litvack JR, Griest S, James KE, Smith TL (2007) Endoscopic and quality-of-life outcomes after revision endoscopic sinus surgery. Laryngoscope 117(12):2233\u20132238","journal-title":"Laryngoscope"},{"issue":"3","key":"5379_CR3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/01.all.0000225154.45027.a4","volume":"6","author":"N Bhattacharyya","year":"2006","unstructured":"Bhattacharyya N (2006) Clinical outcomes after endoscopic sinus surgery. Curr Opin Allergy Clin Immunol 6(3):167\u2013171","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"4","key":"5379_CR4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.amjoto.2018.03.020","volume":"39","author":"G Brescia","year":"2018","unstructured":"Brescia G, Zanotti C, Parrino D, Barion U, Marioni G (2018) Nasal polyposis pathophysiology: endotype and phenotype open issues. Am J Otolaryngol 39(4):441\u2013444","journal-title":"Am J Otolaryngol"},{"issue":"1","key":"5379_CR5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/MOO.0000000000000503","volume":"27","author":"J Yip","year":"2019","unstructured":"Yip J, Monteiro E, Chan Y (2019) Endotypes of chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 27(1):14\u201319","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"5379_CR6","doi-asserted-by":"publisher","first-page":"2643297","DOI":"10.1155\/2016\/2643297","volume":"2016","author":"M Boita","year":"2016","unstructured":"Boita M, Bucca C, Riva G, Heffler E, Rolla G (2016) Release of type 2 cytokines by epithelial cells of nasal polyps. J Immunol Res 2016:2643297","journal-title":"J Immunol Res"},{"issue":"1","key":"5379_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/ACI.0000000000000332","volume":"17","author":"M Lee","year":"2017","unstructured":"Lee M, Kim DW, Shin HW (2017) Targeting IL-25 as a novel therapy in chronic rhinosinusitis with nasal polyps. Curr Opin Allergy Clin Immunol 17(1):17\u201322","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"8","key":"5379_CR8","doi-asserted-by":"publisher","first-page":"898","DOI":"10.3389\/fphys.2017.00898","volume":"19","author":"D Miljkovic","year":"2017","unstructured":"Miljkovic D, Psaltis AJ, Wormald PJ, Vreugde S (2017) Chronic rhinosinusitis with polyps is characterized by increased mucosal and blood Th17 effector cytokine producing cells. Front Physiol 19(8):898","journal-title":"Front Physiol"},{"issue":"2","key":"5379_CR9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","volume":"34","author":"Y Iwakura","year":"2011","unstructured":"Iwakura Y, Ishigame H, Saijo S, Nakae S (2011) Functional specialization of interleukin-17 family members. Immunity 34(2):149\u2013162","journal-title":"Immunity"},{"issue":"6","key":"5379_CR10","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S1074-7613(01)00243-6","volume":"15","author":"MM Fort","year":"2001","unstructured":"Fort MM, Cheung J, Yen D, Li J, Zurawski SM, Lo S, Menon S, Clifford T, Hunte B, Lesley R, Muchamuel T, Hurst SD, Zurawski G, Leach MW, Gorman DM, Rennick DM (2001) IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 15(6):985\u2013995","journal-title":"Immunity"},{"issue":"7","key":"5379_CR11","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1111\/j.1398-9995.2012.02842.x","volume":"67","author":"E Pace","year":"2012","unstructured":"Pace E, Scafidi V, Di Bona D, Siena L, Chiappara G, Ferraro M, La Grutta S, Gallina S, Speciale R, Ballacchino A, Bachert C, Bousquet J, Gjomarkaj M (2012) Increased expression of IL-19 in the epithelium of patients with chronic rhinosinusitis and nasal polyps. Allergy 67(7):878\u2013886","journal-title":"Allergy"},{"issue":"5","key":"5379_CR12","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00281-017-0636-y","volume":"39","author":"XJ Guo","year":"2017","unstructured":"Guo XJ, Thomas PG (2017) New fronts emerge in the influenza cytokine storm. Semin Immunopathol 39(5):541\u2013550","journal-title":"Semin Immunopathol"},{"issue":"2","key":"5379_CR13","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/cea.12612","volume":"46","author":"TH Acciani","year":"2016","unstructured":"Acciani TH, Suzuki T, Trapnell BC, Le Cras TD (2016) Epidermal growth factor receptor signaling regulates granulocyte-macrophage-colony-stimulating factor production by airway epithelial cells and established allergic airway disease. Clin Exp Allergy 46(2):317\u2013328","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"5379_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4193\/Rhino50E2","volume":"50","author":"WJ Fokkens","year":"2012","unstructured":"Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, Georgalas C, Goossens H, Harvey R, Hellings P, Hopkins C, Jones N, Joos G, Kalogjera L, Kern B, Kowalski M, Price D, Riechelmann H, Schlosser R, Senior B, Thomas M, Toskala E, Voegels R, Wang de Y, Wormald PJ (2012) European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 50(1):1\u201312","journal-title":"Rhinology"},{"issue":"12","key":"5379_CR15","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","volume":"24","author":"RP Schleimer","year":"2017","unstructured":"Schleimer RP (2017) Immunopathogenesis of chronic rhinosinusitis and nasal polyposis. Annu Rev Pathol 24(12):331\u2013357","journal-title":"Annu Rev Pathol"},{"issue":"5","key":"5379_CR16","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.jaci.2008.07.008","volume":"122","author":"N Zhang","year":"2008","unstructured":"Zhang N, Van Zele T, Perez-Novo C, Van Bruaene N, Holtappels G, DeRuyck N, Van Cauwenberge P, Bachert C (2008) Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol 122(5):961\u2013968","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"5379_CR17","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4168\/aair.2011.3.3.186","volume":"3","author":"S Kimura","year":"2011","unstructured":"Kimura S, Pawankar R, Mori S, Nonaka M, Masuno S, Yagi T, Okubo K (2011) Increased expression and role of thymic stromal lymphopoietin in nasal polyposis. Allergy Asthma Immunol Res 3(3):186\u2013193","journal-title":"Allergy Asthma Immunol Res"},{"issue":"5","key":"5379_CR18","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.cytogfr.2010.08.005","volume":"21","author":"G Gallagher","year":"2010","unstructured":"Gallagher G (2010) Interleukin-19: multiple roles in immune regulation and disease. Cytokine Growth Factor Rev 21(5):345\u2013352","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2","key":"5379_CR19","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/all.13267","volume":"73","author":"HY Hong","year":"2018","unstructured":"Hong HY, Chen FH, Sun YQ, Hu XT, Wei Y, Fan YP, Zhang J, Wang DH, Xu R, Li HB, Shi JB (2018) Local IL-25 contributes to Th2-biased inflammatory profiles in nasal polyps. Allergy 73(2):459\u2013469","journal-title":"Allergy"},{"issue":"6","key":"5379_CR20","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1016\/j.jaci.2015.01.003","volume":"135","author":"HW Shin","year":"2015","unstructured":"Shin HW, Kim DK, Park MH, Eun KM, Lee M, So D, Kong IG, Mo JH, Yang MS, Jin HR, Park JW, Kim DW (2015) IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis. J Allergy Clin Immunol 135(6):1476\u20131485","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"5379_CR21","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1016\/j.jaci.2015.10.019","volume":"137","author":"EP Lam","year":"2016","unstructured":"Lam EP, Kariyawasam HH, Rana BM, Durham SR, McKenzie AN, Powell N, Orban N, Lennartz-Walker M, Hopkins C, Ying S, Rimmer J, Lund VJ, Cousins DJ, Till SJ (2016) IL-25\/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa. J Allergy Clin Immunol 137(5):1514\u20131524","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"5379_CR22","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00405-016-4260-6","volume":"274","author":"A Ozturan","year":"2017","unstructured":"Ozturan A, Eyigor H, Eyigor M, Osma U, Yilmaz MD, Selcuk OT, Renda L, Gultekin M (2017) The role of IL-25 and IL-33 in chronic rhinosinusitis with or without nasal polyps. Eur Arch Otorhinolaryngol 274(1):283\u2013288","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"5379_CR23","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.jaci.2009.08.044","volume":"124","author":"Y Enomoto","year":"2009","unstructured":"Enomoto Y, Orihara K, Takamasu T, Matsuda A, Gon Y, Saito H, Ra C, Okayama Y (2009) Tissue remodeling induced by hyper-secreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack. J Allergy Clin Immunol 124:913\u2013920","journal-title":"J Allergy Clin Immunol"},{"key":"5379_CR24","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jaci.2004.10.004","volume":"115","author":"S Okumura","year":"2005","unstructured":"Okumura S, Sagara H, Fukuda T, Saito H, Okayama Y (2005) Fc-epsilon-RI-mediated amphiregulin production by human mast cells increases mucin gene expression in epithelial cells. J Allergy Clin Immunol 115:272\u2013279","journal-title":"J Allergy Clin Immunol"},{"key":"5379_CR25","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1007\/s00204-012-0903-6","volume":"86","author":"S Val","year":"2012","unstructured":"Val S, Belade E, George I, Boczkowski J, Baeza-Squiban A (2012) Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin. Arch Toxicol 86:1851\u20131859","journal-title":"Arch Toxicol"},{"issue":"7","key":"5379_CR26","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1111\/all.13411","volume":"73","author":"B Liao","year":"2018","unstructured":"Liao B, Liu JX, Li ZY, Zhen Z, Cao PP, Yao Y, Long XB, Wang H, Wang Y, Schleimer R, Liu Z (2018) Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes. Allergy 73(7):1459\u20131469","journal-title":"Allergy"},{"issue":"5","key":"5379_CR27","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/j.jaci.2017.10.050","volume":"141","author":"H Hong","year":"2018","unstructured":"Hong H, Chen F, Sun Y, Yang Q, Gao W, Cao Y, Fan Y, Shi J, Li H (2018) Nasal IL-25 predicts the response to oral corticosteroids in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 141(5):1890\u20131892","journal-title":"J Allergy Clin Immunol"},{"key":"5379_CR28","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1056\/NEJMoa1403290","volume":"371","author":"HG Ortega","year":"2014","unstructured":"Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, Humbert M, Katz LE, Keene ON, Yancey SW, Chanez P, MENSA Investigators (2014) Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 371:1198\u20131207","journal-title":"N Engl J Med"},{"key":"5379_CR29","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S2213-2600(15)00042-9","volume":"3","author":"M Castro","year":"2015","unstructured":"Castro M, Zangrilli J, Wechsler ME, Bateman ED, Brusselle GG, Bardin P, Murphy K, Maspero JF, O\u2019Brien C, Korn S (2015) Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Respir Med 3:355\u2013366","journal-title":"Lancet Respir Med"},{"key":"5379_CR30","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.jaci.2017.05.044","volume":"140","author":"C Bachert","year":"2017","unstructured":"Bachert C, Sousa AR, Lund VJ, Scadding GK, Gevaert P, Nasser S, Durham SR, Cornet ME, Kariyawasam HH, Gilbert J, Austin D, Maxwell AC, Marshall RP, Fokkens WJ (2017) Reduced need for surgery in severe nasal polyposis with mepolizumab: randomized trial. J Allergy Clin Immunol 140:1024\u20131031","journal-title":"J Allergy Clin Immunol"},{"key":"5379_CR31","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1001\/jama.2015.19330","volume":"315","author":"C Bachert","year":"2016","unstructured":"Bachert C, Mannent L, Naclerio RM, Mullol J, Ferguson BJ, Gevaert P, Hellings P, Jiao L, Wang L, Evans RR, Pirozzi G, Graham NM, Swanson B, Hamilton JD, Radin A, Gandhi NA, Stahl N, Yancopoulos GD, Sutherland ER (2016) Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial. JAMA 315:469\u2013479","journal-title":"JAMA"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-019-05379-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-019-05379-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-019-05379-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T05:46:36Z","timestamp":1585892796000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-019-05379-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":31,"alternative-id":["5379"],"URL":"https:\/\/doi.org\/10.1007\/s00405-019-05379-8","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"9 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declared that there was no conflict of interest between the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the university\u2019s Ethical Review Board (2017\/1084).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}