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We aim to evaluate its value in salivary gland cancer (SGC).<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Records of SGC patients from Surveillance, Epidemiology, and End Results database (SEER, training set, <jats:italic>N<\/jats:italic>\u2009=\u20094262) and Fudan University Shanghai Cancer Center (FUSCC, validating set, <jats:italic>N<\/jats:italic>\u2009=\u2009154) were analyzed for the prognostic value of LNR. Kaplan\u2013Meier survival estimates, the Log-rank <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test and Cox proportional hazards model were used for univariate and multivariate analysis. Optimal LNR cutoff points were identified by X-tile.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Optimal LNR cutoff points classified patients into four risk groups, R0, R1 (\u2264\u20090.17), R2 (0.17\u20130.56) and R3 (&gt;\u20090.56), corresponding to 5-year cause-specific survival in SEER patients of 88.6%, 57.2%, 53.1% and 39.7%, disease-free survival in FUSCC patients of 69.2%, 63.3%, 34.6% and 0%, and disease-specific survival in FUSCC patients of 92.3%, 90.0%, 71.4% and 0%, respectively. Compared with TNM staging, TNM\u2009+\u2009R staging showed smaller AIC values and higher <jats:italic>C<\/jats:italic>-index values in the Cox regression model in both patient sets.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>LNR classification should be considered as a complementary system to TNM staging and LNR classification based clinical trials deserve further research.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-019-05597-0","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T13:03:59Z","timestamp":1568207039000},"page":"3425-3434","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lymph node ratio (LNR) as a complementary staging system to TNM staging in salivary gland cancer"],"prefix":"10.1007","volume":"276","author":[{"given":"Bo-Wen","family":"Lei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Qian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-Cheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Jun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Wu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1006-8503","authenticated-orcid":false,"given":"Qing-Hai","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"issue":"6","key":"5597_CR1","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/S1368-8375(01)00109-9","volume":"38","author":"MT Canto","year":"2002","unstructured":"Canto MT, Devesa SS (2002) Oral cavity and pharynx cancer incidence rates in the United States, 1975\u20131998. 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