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Genetic susceptibility is a major contributing factor in determining the individual risk of NPC in these areas. To test the association between NPC and variants in <jats:italic>regenerating gene 1A (REG1A)<\/jats:italic>, we conducted a hospital-based case\u2013control study in a Cantonese-speaking population from Guangdong province.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We endeavored to determine whether genetic variants of the <jats:italic>REG1A<\/jats:italic> gene were associated with the risk of NPC amidst the Cantonese population in a hospital-based case\u2013control study using polymerase chain reaction-restriction and direct sequencing analysis in 211 NPC patients and 150 healthy controls. The association between NPC risk and the 14C\/T, 20C\/T, 369G\/T, 1201A\/G, and 2922C\/T polymorphisms was examined after adjustment for age and sex.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>We found an increased risk of developing NPC in individuals with <jats:italic>REG1A<\/jats:italic> 2922C\/T variant genotype (<jats:italic>p<\/jats:italic>\u2009=\u20090.003, OR 0.419, 95% CI 0.235\u20130.746), and after adjustment for sex and age (<jats:italic>p<\/jats:italic>\u2009=\u20090.003, OR 0.406, 95% CI 0.226\u20130.732). No association between other polymorphisms (14C\/T, 20C\/T, 369G\/T, and 1201A\/G) and the risk of NPC was observed, before or after adjustment for age and sex.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our findings suggest that the <jats:italic>REG1A<\/jats:italic> 2922C\/T polymorphism is associated with an increased risk of developing NPC in a Cantonese population from Guangdong province. Larger studies are required to confirm our findings and unravel the underlying mechanisms.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00405-019-05645-9","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T06:34:02Z","timestamp":1568961242000},"page":"221-226","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of regenerating gene 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma susceptibility in southern Chinese population"],"prefix":"10.1007","volume":"277","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6429-0519","authenticated-orcid":false,"given":"Haijie","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaofeng","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanshu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"issue":"1","key":"5645_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21332","volume":"66","author":"RL Siegel","year":"2016","unstructured":"Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. 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