{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:20:53Z","timestamp":1773116453458,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00405-019-05656-6","type":"journal-article","created":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T12:02:28Z","timestamp":1569067348000},"page":"135-140","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative analysis of sublingual immunotherapy medicines for adherence and clinical outcomes"],"prefix":"10.1007","volume":"277","author":[{"given":"Ji-A","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Mi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keun-Ik","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Dong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue-Jean","family":"Mun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-6996","authenticated-orcid":false,"given":"Kyu-Sup","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,21]]},"reference":[{"key":"5656_CR1","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1016\/j.jaci.2009.05.013","volume":"124","author":"EO Meltzer","year":"2009","unstructured":"Meltzer EO, Blaiss MS, Derebery MJ, Mahr TA, Gordon BR, Sheth KK et al (2009) Burden of allergic rhinitis: results from the pediatric allergies in American survey. J Allergy Clin Immunol 124:S43\u2013S70","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR2","doi-asserted-by":"publisher","first-page":"S147","DOI":"10.1067\/mai.2001.118891","volume":"108","author":"J Bousquet","year":"2001","unstructured":"Bousquet J, Van Cauwenberge P, Khaltaev N (2001) Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 108:S147\u2013S334","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","volume":"63","author":"J Bousquet","year":"2008","unstructured":"Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al (2008) Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 63:8\u2013160","journal-title":"Allergy"},{"key":"5656_CR4","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1056\/NEJMcp1412282","volume":"372","author":"LM Wheatley","year":"2015","unstructured":"Wheatley LM, Togias A (2015) Clinical practice: allergic rhinitis. N Engl J Med 372:456\u2013463","journal-title":"N Engl J Med"},{"key":"5656_CR5","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1016\/S0140-6736(11)60130-X","volume":"378","author":"AN Greiner","year":"2011","unstructured":"Greiner AN, Hellings PW, Rotiroti G, Scadding GK (2011) Allergic rhinitis. Lancet 378:2112\u20132122","journal-title":"Lancet"},{"key":"5656_CR6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.drudis.2015.07.010","volume":"21","author":"JN Larsen","year":"2016","unstructured":"Larsen JN, Broge L, Jacobi H (2016) Allergy immunotherapy: the future of allergy treatment. Drug Discov Today 21:26\u201337","journal-title":"Drug Discov Today"},{"key":"5656_CR7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1398-9995.2006.01159.x","volume":"61","author":"CA Akdis","year":"2006","unstructured":"Akdis CA, Barlan IB, Bahceciler N, Akdis M (2006) Immunological mechanisms of sublingual immunotherapy. Allergy 61:11\u201314","journal-title":"Allergy"},{"key":"5656_CR8","first-page":"CD001936","volume":"1","author":"MA Calderon","year":"2007","unstructured":"Calderon MA, Alves B, Jacobson M, Hurwitz B, Sheikh A, Durham S (2007) Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst Rev 1:CD001936","journal-title":"Cochrane Database Syst Rev"},{"key":"5656_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13601-017-0180-9","volume":"7","author":"A Bozek","year":"2017","unstructured":"Bozek A, Kolodziejczyk K, Kozlowska R, Canonica GW (2017) Evidence of the efficacy and safety of house dust mite subcutaneous immunotherapy in elderly allergic rhinitis patients: a randomized, double-blind placebo-controlled trial. Clin Transl Allergy 7:43","journal-title":"Clin Transl Allergy"},{"key":"5656_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.anl.2015.08.015","volume":"43","author":"K Masuyama","year":"2016","unstructured":"Masuyama K, Goto M, Takeno S, Ohta N, Okano M, Kamijo A et al (2016) Guiding principles of sublingual immunotherapy for allergic rhinitis in Japanese patients. Auris Nasus Larynx 43:1\u20139","journal-title":"Auris Nasus Larynx"},{"key":"5656_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S1081-1206(10)61440-8","volume":"93","author":"G Passalacqua","year":"2004","unstructured":"Passalacqua G, Guerra L, Pasquali M, Lombardi C, Canonica GW (2004) Efficacy and safety of sublingual immunotherapy. Ann Allergy Asthma Immunol 93:3\u201312","journal-title":"Ann Allergy Asthma Immunol"},{"key":"5656_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.2147\/JAA.S107830","volume":"9","author":"A Moral","year":"2016","unstructured":"Moral A, Moreno V, Giron F, El-Qutob D, Moure JD, Alcantara M et al (2016) Adverse reactions and tolerability of high-dose sublingual allergen immunotherapy. J Asthma Allergy 9:129\u2013133","journal-title":"J Asthma Allergy"},{"key":"5656_CR13","first-page":"3","volume":"19","author":"R Mosges","year":"2010","unstructured":"Mosges R, Ritter B, Kayoko G, Allekotte S (2010) Carbamylated monomeric allergoids as a therapeutic option for sublingual immunotherapy of dust mite- and grass pollen-induced allergic rhinoconjunctivitis: a systematic review of published trials with a meta-analysis of treatment using Lais\u00ae tablets. Acta Dermatovenerol Alp Pannonica Adriat 19:3\u201310","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"5656_CR14","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1517\/14712590903146869","volume":"9","author":"F Frati","year":"2009","unstructured":"Frati F, Scurati S, Puccinelli P, Justicia JL, Adamec T, Sieber HJ et al (2009) Development of an allergen extract for sublingual immunotherapy-evolution of Staloral. Expert Opin Biol Ther 9:1207\u20131215","journal-title":"Expert Opin Biol Ther"},{"key":"5656_CR15","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/s11882-013-0412-6","volume":"14","author":"JB Morjaria","year":"2014","unstructured":"Morjaria JB, Caruso M, Rosalia E, Russo C, Polosa R (2014) Preventing progression of allergic rhinitis to asthma. Curr Allergy Asthma Rep 14:412","journal-title":"Curr Allergy Asthma Rep"},{"key":"5656_CR16","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jaci.2011.12.973","volume":"129","author":"SR Durham","year":"2012","unstructured":"Durham SR, Emminger W, Kapp A, de Monchy JG, Rak S, Scadding GK et al (2012) SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2\u00a0years after 3\u00a0years of treatment in a randomized trial. J Allergy Clin Immunol 129:717\u2013725","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR17","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.jaci.2015.12.1298","volume":"137","author":"SR Durham","year":"2016","unstructured":"Durham SR, Penagos M (2016) Sublingual or subcutaneous immunotherapy for allergic rhinitis? J Allergy Clin Immunol 137:339\u2013349","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR18","doi-asserted-by":"publisher","first-page":"100","DOI":"10.2500\/aap.2015.36.3830","volume":"36","author":"F Tabatabaian","year":"2015","unstructured":"Tabatabaian F, Casale TB (2015) Selection of patients for sublingual immunotherapy (SLIT) versus subcutaneous immunotherapy (SCIT). Allergy Asthma Proc 36:100\u2013104","journal-title":"Allergy Asthma Proc"},{"key":"5656_CR19","doi-asserted-by":"publisher","first-page":"106","DOI":"10.2500\/ajra.2015.29.4148","volume":"29","author":"S Lee","year":"2015","unstructured":"Lee S, Nolte H, Benninger MS (2015) Clinical considerations in the use of sublingual immunotherapy for allergic rhinitis. Am J Rhinol Allergy 29:106\u2013114","journal-title":"Am J Rhinol Allergy"},{"key":"5656_CR20","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.jaci.2013.02.013","volume":"131","author":"J Dretzke","year":"2013","unstructured":"Dretzke J, Meadows A, Novielli N, Huissoon A, Fry-Smith A, Meads C (2013) Subcutaneous and sublingual immunotherapy for seasonal allergic rhinitis: a systematic review and indirect comparison. J Allergy Clin Immunol 131:1361\u20131366","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR21","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.jaci.2012.08.012","volume":"130","author":"D Di Bona","year":"2012","unstructured":"Di Bona D, Plaia A, Leto-Barone MS, La Piana S, Di Lorenzo G (2012) Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: a meta-analysis-based comparison. J Allergy Clin Immunol 130:1097\u20131107","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR22","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1016\/j.jaci.2013.11.012","volume":"133","author":"KC Bergmann","year":"2014","unstructured":"Bergmann KC, Demoly P, Worm M, Fokkens WJ, Carrillo T, Tabar AI et al (2014) Efficacy and safety of sublingual tablets of house dust mite allergen extracts in adults with allergic rhinitis. J Allergy Clin Immunol 133:1608\u20131614","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR23","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1159\/000381059","volume":"166","author":"Y Okamoto","year":"2015","unstructured":"Okamoto Y, Okubo K, Yonekura S, Hashiguchi K, Goto M, Otsuka T et al (2015) Efficacy and safety of sublingual immunotherapy for two seasons in patients with Japanese cedar pollinosis. Int Arch Allergy Immunol 166:177\u2013188","journal-title":"Int Arch Allergy Immunol"},{"key":"5656_CR24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.anai.2013.11.018","volume":"112","author":"J Maloney","year":"2014","unstructured":"Maloney J, Bernstein DI, Nelson H, Creticos P, Hebert J, Noonan M et al (2014) Efficacy and safety of grass sublingual immunology tablet, MK-7243: a large randomized controlled trial. Ann Allergy Asthma Immunol 112:146\u2013153","journal-title":"Ann Allergy Asthma Immunol"},{"key":"5656_CR25","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1097\/ACI.0000000000000118","volume":"14","author":"JP Allam","year":"2014","unstructured":"Allam JP, Novak N (2014) Immunological mechanisms of sublingual immunotherapy. Curr Opin Allergy Clin Immunol 14:564\u2013569","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"5656_CR26","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.jaci.2008.06.034","volume":"122","author":"L Mascarell","year":"2008","unstructured":"Mascarell L, Lombardi V, Louise A, Saint-Lu N, Chabre H, Moussu H et al (2008) Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4\u2009+\u2009T cells. J Allergy Clin Immunol 122:603\u2013609","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR27","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1067\/mai.2003.1607","volume":"112","author":"JP Allam","year":"2003","unstructured":"Allam JP, Novak N, Fuchs C, Asen S, Berge S, Appel T et al (2003) Characterization of dendritic cells from human oral mucosa: a new Langerhans\u2019 cell type with high constitutive FcepsilonRI expression. J Allergy Clin Immunol 112:141\u2013148","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR28","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.jaci.2013.12.1088","volume":"133","author":"M Akdis","year":"2014","unstructured":"Akdis M, Akdis CA (2014) Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens. J Allergy Clin Immunol 133:621\u2013631","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR29","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/all.12385","volume":"69","author":"M Makatsori","year":"2014","unstructured":"Makatsori M, Scadding GW, Lombardo C, Bisoffi G, Ridolo E, Durham SR et al (2014) Dropouts in sublingual allergen immunotherapy trials-a systematic review. Allergy 69:571\u2013580","journal-title":"Allergy"},{"key":"5656_CR30","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1097\/ACI.0b013e328332b8df","volume":"9","author":"G Senna","year":"2009","unstructured":"Senna G, Ridolo E, Calderon M, Lombardi C, Canonica GW, Passalacqua G (2009) Evidence of adherence to allergen-specific immunotherapy. Curr Opin Allergy Clin Immunol 9:544\u2013548","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"5656_CR31","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.jaci.2010.06.045","volume":"126","author":"G Senna","year":"2010","unstructured":"Senna G, Lombardi C, Canonica GW, Passalacqua G (2010) How adherent to sublingual immunotherapy prescriptions are patients? The manufacturers\u2019 viewpoint. J Allergy Clin Immunol 126:668\u2013669","journal-title":"J Allergy Clin Immunol"},{"key":"5656_CR32","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/alr.21707","volume":"6","author":"JG Chester","year":"2016","unstructured":"Chester JG, Bremberg MG, Reisacher WR (2016) Patient preferences for route of allergy immunotherapy: a comparison of four delivery methods. Int Forum Allergy Rhinol 6:454\u2013459","journal-title":"Int Forum Allergy Rhinol"},{"key":"5656_CR33","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/alr.21037","volume":"2","author":"NM Hsu","year":"2012","unstructured":"Hsu NM, Reisacher WR (2012) A comparison of attrition rates in patients undergoing sublingual immunotherapy vs subcutaneous immunotherapy. Int Forum Allergy Rhinol 2:280\u2013284","journal-title":"Int Forum Allergy Rhinol"},{"key":"5656_CR34","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2147\/PPA.S3806","volume":"2","author":"C Incorvaia","year":"2008","unstructured":"Incorvaia C, Mauro M, Ridolo E, Puccinelli P, Liuzzo M, Scurati S et al (2008) Patient\u2019s compliance with allergen immunotherapy. Patient Prefer Adheren 2:247\u2013251","journal-title":"Patient Prefer Adheren"},{"key":"5656_CR35","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1097\/MOO.0b013e32835f8048","volume":"21","author":"WR Reisacher","year":"2013","unstructured":"Reisacher WR, Visaya JM (2013) Patient adherence to allergy immunotherapy. Curr Opin Otolaryngol Head Neck Surg 21:256\u2013262","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"5656_CR36","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/alr.21920","volume":"7","author":"MS Kumar","year":"2017","unstructured":"Kumar MS, Oh MS, Leader B, Rotella M, Stillman L, DelGaudio JM et al (2017) Perceived compliance and barriers to care in sublingual immunotherapy. Int Forum Allergy Rhinol 7:525\u2013529","journal-title":"Int Forum Allergy Rhinol"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-019-05656-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-019-05656-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-019-05656-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T23:31:34Z","timestamp":1600558294000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-019-05656-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,21]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["5656"],"URL":"https:\/\/doi.org\/10.1007\/s00405-019-05656-6","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,21]]},"assertion":[{"value":"24 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no funding, financial relationships, or conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study protocol was approved by the Institutional Review Board of Pusan National University Hospital (PNUHIRB 1804-013-066).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was not obtained from each parent prior to the patient\u2019s participation in the study because of retrospective chart reviews.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}