{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:07:21Z","timestamp":1792886841969,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Persistent unilateral vocal fold paralysis (UFVP) with glottal insufficiency often requires type I medialization thyroplasty (MT). Previous implants cannot be adjusted postoperatively if necessary. The newly developed APrevent<jats:sup>\u00ae<\/jats:sup>VOIS implant (VOIS) can provide postoperative re-adjustment to avoid revision MT. The objective of this pilot study is to evaluate the VOIS intraoperatively concerning voice improvement, surgical feasibility and device handling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During routine MT, VOIS was applied short time in eight patients before the regular implantation of the Titanium Vocal Fold Medialization Implant (TVFMI\u2122). In all patients, perceptual voice sound analysis using R(oughness)\u2013B(reathiness)\u2013H(oarseness)-scale, measurement of M(aximum)\u2013P(honation)\u2013T(ime) and glottal closure in videolaryngoscopy were performed before and after implanting VOIS\/TVFMI\u2122. Acoustic analyses of voice recordings were performed using freeware praat. Surgical feasibility, operative handling and device fitting of VOIS and TVFMI\u2122 were assessed by the surgeon using V(isual)-A(nalog)-S(cale). Data were statistically analyzed with paired<jats:italic>t<\/jats:italic>test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>All patients showed significant improvement of voice sound parameters after VOIS\/TVFMI\u2122 implantation. The mean RBH-scale improved from preoperative<jats:italic>R<\/jats:italic>\u2009=\u20092.1,<jats:italic>B<\/jats:italic>\u2009=\u20092.3,<jats:italic>H<\/jats:italic>\u2009=\u20092.5 to<jats:italic>R<\/jats:italic>\u2009=\u20090.6,<jats:italic>B<\/jats:italic>\u2009=\u20090.3,<jats:italic>H<\/jats:italic>\u2009=\u20090.8 after VOIS and<jats:italic>R<\/jats:italic>\u2009=\u20090.5,<jats:italic>B<\/jats:italic>\u2009=\u20090.3,<jats:italic>H<\/jats:italic>\u2009=\u20090.8 after TVFMI\u2122 implantation. The mean MPT increased from preoperative 7.9 to 14.6\u00a0s after VOIS and 13.8\u00a0s after TVFMI\u2122 implantation. VOIS\/TVFMI\u2122 achieved complete glottal closure in 7\/8 patients. The satisfaction with intraoperative device fitting and device handling of VOIS was as good as that of TVFMI\u2122.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel APrevent<jats:sup>\u00ae<\/jats:sup>VOIS implant showed similar intraoperative voice improvement compared to routinely used TVFMI\u2122 without adverse device events and with safe device fitting.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00405-019-05756-3","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T12:02:49Z","timestamp":1576497769000},"page":"809-817","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pre- and intraoperative acoustic and functional assessment of the novel APrevent\u00ae VOIS implant during routine medialization thyroplasty"],"prefix":"10.1007","volume":"277","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-6057","authenticated-orcid":false,"given":"Guan-Yuh","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Leonhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris-Maria","family":"Denk-Linnert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Schneider-Stickler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"5756_CR1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1067\/S0892-1997(03)00080-8","volume":"17","author":"TD Anderson","year":"2003","unstructured":"Anderson TD, Spiegel JR, Sataloff RT (2003) Thyroplasty revisions: frequency and predictive factors. J Voice 17:442\u2013448","journal-title":"J Voice"},{"key":"5756_CR2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1097-0347(199903)21:2<139::AID-HED7>3.0.CO;2-P","volume":"21","author":"RL Carrau","year":"1999","unstructured":"Carrau RL, Pou A, Eibling DE et al (1999) Laryngeal framework surgery for the management of aspiration. Head Neck 21:139\u2013145","journal-title":"Head Neck"},{"key":"5756_CR3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0194-5998(03)01390-1","volume":"129","author":"MW Chester","year":"2003","unstructured":"Chester MW, Stewart MG (2003) Arytenoid adduction combined with medialization thyroplasty: an evidence-based review. Otolaryngol Head Neck Surg 129:305\u2013310","journal-title":"Otolaryngol Head Neck Surg"},{"key":"5756_CR4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0892-1997(05)80323-6","volume":"8","author":"RL Crumley","year":"1994","unstructured":"Crumley RL (1994) Unilateral recurrent laryngeal nerve paralysis. J Voice 8:79\u201383","journal-title":"J Voice"},{"key":"5756_CR5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s40136-014-0044-y","volume":"2","author":"JJ Daniero","year":"2014","unstructured":"Daniero JJ, Garrett CG, Francis DO (2014) Framework surgery for treatment of unilateral vocal fold paralysis. Curr Otorhinolaryngol Rep 2:119\u2013130","journal-title":"Curr Otorhinolaryngol Rep"},{"key":"5756_CR6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00405-014-3292-z","volume":"272","author":"G Desuter","year":"2015","unstructured":"Desuter G, Henrard S, Boucquey D et al (2015) Learning curve of medialization thyroplasty using a Montgomery implant. Eur Arch Otorhinolaryngol 272:385\u2013390","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"5756_CR7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.anorl.2010.08.001","volume":"127","author":"M Devos","year":"2010","unstructured":"Devos M, Schultz P, Guillere F et al (2010) Thyroplasty for unilateral vocal fold paralysis using an adjustable implant in porous titanium. Eur Ann Otorhinolaryngol Head Neck Dis 127:204\u2013212","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"5756_CR8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0194-5998(97)70272-9","volume":"116","author":"PW Flint","year":"1997","unstructured":"Flint PW, Purcell LL, Cummings CW (1997) Pathophysiology and indications for medialization thyroplasty in patients with dysphagia and aspiration. Otolaryngol Head Neck Surg 116:349\u2013354","journal-title":"Otolaryngol Head Neck Surg"},{"key":"5756_CR9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/000348949910800112","volume":"108","author":"G Friedrich","year":"1999","unstructured":"Friedrich G (1999) Titanium vocal fold medializing implant: introducing a novel implant system for external vocal fold medialization. Ann Otol Rhinol Laryngol 108:79\u201386","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"5756_CR10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/00005537-199902000-00020","volume":"109","author":"A Giovanni","year":"1999","unstructured":"Giovanni A, Vallicioni JM, Gras R et al (1999) Clinical experience with Gore-Tex for vocal fold medialization. Laryngoscope 109:284\u2013288","journal-title":"Laryngoscope"},{"key":"5756_CR11","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00405-010-1429-2","volume":"268","author":"M Hess","year":"2011","unstructured":"Hess M, Schroeder D, Puschel K (2011) Sling arytenoid adduction. Eur Arch Otorhinolaryngol 268:1023\u20131028","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"5756_CR12","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/lary.24409","volume":"124","author":"MR Hoffman","year":"2014","unstructured":"Hoffman MR, Devine EE, Mcculloch TM et al (2014) Excised larynx evaluation of wedge-shaped adjustable balloon implant for minimally invasive type I thyroplasty. Laryngoscope 124:942\u2013949","journal-title":"Laryngoscope"},{"key":"5756_CR13","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/lary.21431","volume":"121","author":"MR Hoffman","year":"2011","unstructured":"Hoffman MR, Witt RE, Mcculloch TM et al (2011) Preliminary investigation of adjustable balloon implant for type I thyroplasty. Laryngoscope 121:793\u2013800","journal-title":"Laryngoscope"},{"key":"5756_CR14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3109\/00016487409126379","volume":"78","author":"N Isshiki","year":"1974","unstructured":"Isshiki N, Morita H, Okamura H et al (1974) Thyroplasty as a new phonosurgical technique. Acta Otolaryngol 78:451\u2013457","journal-title":"Acta Otolaryngol"},{"key":"5756_CR15","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/archotol.1978.00790100009002","volume":"104","author":"N Isshiki","year":"1978","unstructured":"Isshiki N, Tanabe M, Sawada M (1978) Arytenoid adduction for unilateral vocal cord paralysis. Arch Otolaryngol 104:555\u2013558","journal-title":"Arch Otolaryngol"},{"key":"5756_CR16","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1097\/01.mlg.0000168059.12949.a6","volume":"115","author":"O Laccourreye","year":"2005","unstructured":"Laccourreye O, El Sharkawy L, Holsinger FC et al (2005) Thyroplasty type I with Montgomery implant among native French language speakers with unilateral laryngeal nerve paralysis. Laryngoscope 115:1411\u20131417","journal-title":"Laryngoscope"},{"key":"5756_CR17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jvoice.2009.11.001","volume":"25","author":"AJ Li","year":"2011","unstructured":"Li AJ, Johns MM, Jackson-Menaldi C et al (2011) Glottic closure patterns: type I thyroplasty versus type I thyroplasty with arytenoid adduction. J Voice 25:259\u2013264","journal-title":"J Voice"},{"key":"5756_CR18","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/lary.21455","volume":"121","author":"MR Lundeberg","year":"2011","unstructured":"Lundeberg MR, Flint PW, Purcell LL et al (2011) Revision medialization thyroplasty with hydroxylapatite implants. Laryngoscope 121:999\u20131002","journal-title":"Laryngoscope"},{"key":"5756_CR19","first-page":"533","volume":"122","author":"DS Lundy","year":"2000","unstructured":"Lundy DS, Casiano RR, Xue JW et al (2000) Thyroplasty type I: short- versus long-term results. Otolaryngol Head Neck Surg 122:533\u2013536","journal-title":"Otolaryngol Head Neck Surg"},{"key":"5756_CR20","first-page":"224","volume":"3","author":"KH Ma","year":"1997","unstructured":"Ma KH, Wan YM, Cho LS et al (1997) Silastic medialization for unilateral vocal fold palsy. Hong Kong Med J 3:224\u2013230","journal-title":"Hong Kong Med J"},{"key":"5756_CR21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1177\/000348949810700512","volume":"107","author":"TM Mcculloch","year":"1998","unstructured":"Mcculloch TM, Hoffman HT (1998) Medialization laryngoplasty with expanded polytetrafluoroethylene. Surgical technique and preliminary results. Ann Otol Rhinol Laryngol 107:427\u2013432","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"5756_CR22","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1097\/00005537-200008000-00015","volume":"110","author":"TM Mcculloch","year":"2000","unstructured":"Mcculloch TM, Hoffman HT, Andrews BT et al (2000) Arytenoid adduction combined with Gore-Tex medialization thyroplasty. Laryngoscope 110:1306\u20131311","journal-title":"Laryngoscope"},{"key":"5756_CR23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/000348940010900410","volume":"109","author":"A Mclean-Muse","year":"2000","unstructured":"Mclean-Muse A, Montgomery WW, Hillman RE et al (2000) Montgomery thyroplasty implant for vocal fold immobility: phonatory outcomes. Ann Otol Rhinol Laryngol 109:393\u2013400","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"5756_CR24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5005\/jp-journals-10023-1003","volume":"1","author":"S Mohanty","year":"2011","unstructured":"Mohanty S, Gopinath M, Subramanian M (2011) Gore-Tex medialization thyroplasty in patients with unilateral vocal cord paralysis: an audit of 47 cases. Int J Phonosurg Laryngol 1:11\u201313","journal-title":"Int J Phonosurg Laryngol"},{"key":"5756_CR25","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1067\/mtc.2001.112533","volume":"121","author":"T Mom","year":"2001","unstructured":"Mom T, Filaire M, Advenier D et al (2001) Concomitant type I thyroplasty and thoracic operations for lung cancer: preventing respiratory complications associated with vagus or recurrent laryngeal nerve injury. J Thorac Cardiovasc Surg 121:642\u2013648","journal-title":"J Thorac Cardiovasc Surg"},{"key":"5756_CR26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1177\/000348949310200801","volume":"102","author":"WW Montgomery","year":"1993","unstructured":"Montgomery WW, Blaugrund SM, Varvares MA (1993) Thyroplasty: a new approach. Ann Otol Rhinol Laryngol 102:571\u2013579","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"5756_CR27","first-page":"1","volume":"170","author":"WW Montgomery","year":"1997","unstructured":"Montgomery WW, Montgomery SK (1997) Montgomery thyroplasty implant system. Ann Otol Rhinol Laryngol Suppl 170:1\u201316","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"5756_CR28","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/lary.21762","volume":"121","author":"T Murata","year":"2011","unstructured":"Murata T, Yasuoka Y, Shimada T et al (2011) A new and less invasive procedure for arytenoid adduction surgery: endoscopic-assisted arytenoid adduction surgery. Laryngoscope 121:1274\u20131280","journal-title":"Laryngoscope"},{"key":"5756_CR29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/000348949310200602","volume":"102","author":"JL Netterville","year":"1993","unstructured":"Netterville JL, Stone RE, Luken ES et al (1993) Silastic medialization and arytenoid adduction: the Vanderbilt experience. A review of 116 phonosurgical procedures. Ann Otol Rhinol Laryngol 102:413\u2013424","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"5756_CR30","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1080\/00016480310016875","volume":"124","author":"J Nouwen","year":"2004","unstructured":"Nouwen J, Hans S, De Mones E et al (2004) Thyroplasty type I without arytenoid adduction in patients with unilateral laryngeal nerve paralysis: the montgomery implant versus the Gore-Tex implant. Acta Otolaryngol 124:732\u2013738","journal-title":"Acta Otolaryngol"},{"key":"5756_CR31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0196-0709(98)90060-6","volume":"19","author":"S Perie","year":"1998","unstructured":"Perie S, Laccourreye O, Bou-Malhab F et al (1998) Aspiration in unilateral recurrent laryngeal nerve paralysis after surgery. Am J Otolaryngol 19:18\u201323","journal-title":"Am J Otolaryngol"},{"key":"5756_CR32","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1097\/00005537-199811000-00020","volume":"108","author":"CA Rosen","year":"1998","unstructured":"Rosen CA (1998) Complications of phonosurgery: results of a national survey. Laryngoscope 108:1697\u20131703","journal-title":"Laryngoscope"},{"key":"5756_CR33","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1288\/00005537-199008000-00010","volume":"100","author":"CT Sasaki","year":"1990","unstructured":"Sasaki CT, Leder SB, Petcu L et al (1990) Longitudinal voice quality changes following Isshiki thyroplasty type I: the Yale experience. Laryngoscope 100:849\u2013852","journal-title":"Laryngoscope"},{"key":"5756_CR34","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s00405-013-2416-1","volume":"270","author":"B Schneider-Stickler","year":"2013","unstructured":"Schneider-Stickler B, Gaechter J, Bigenzahn W (2013) Long-term results after external vocal fold medialization thyroplasty with titanium vocal fold medialization implant (TVFMI). Eur Arch Otorhinolaryngol 270:1689\u20131694","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"5756_CR35","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0194-5998(03)00359-0","volume":"128","author":"B Schneider","year":"2003","unstructured":"Schneider B, Denk DM, Bigenzahn W (2003) Acoustic assessment of the voice quality before and after medialization thyroplasty using the titanium vocal fold medialization implant (TVFMI). Otolaryngol Head Neck Surg 128:815\u2013822","journal-title":"Otolaryngol Head Neck Surg"},{"key":"5756_CR36","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/00005537-200304000-00008","volume":"113","author":"B Schneider","year":"2003","unstructured":"Schneider B, Denk DM, Bigenzahn W (2003) Functional results after external vocal fold medialization thyroplasty with the titanium vocal fold medialization implant. Laryngoscope 113:628\u2013634","journal-title":"Laryngoscope"},{"key":"5756_CR37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0892-1997(03)00025-0","volume":"17","author":"J Selber","year":"2003","unstructured":"Selber J, Sataloff R, Spiegel J et al (2003) Gore-Tex medialization thyroplasty: objective and subjective evaluation. J Voice 17:88\u201395","journal-title":"J Voice"},{"key":"5756_CR38","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1044\/jshr.3303.601","volume":"33","author":"M S\u00f6dersten","year":"1990","unstructured":"S\u00f6dersten M, Lindestad PA (1990) Glottal closure and perceived breathiness during phonation in normally speaking subjects. J Speech Hear Res 33:601\u2013611","journal-title":"J Speech Hear Res"},{"key":"5756_CR39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0892-1997(01)00015-7","volume":"15","author":"CR Stasney","year":"2001","unstructured":"Stasney CR, Beaver ME, Rodriguez M (2001) Minifenestration type I thyroplasty using an expanded polytetrafluoroethylene implant. J Voice 15:151\u2013157","journal-title":"J Voice"},{"key":"5756_CR40","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1097\/MLG.0b013e318041f6ed","volume":"117","author":"C Storck","year":"2007","unstructured":"Storck C, Brockmann M, Schnellmann E et al (2007) Functional outcome of vocal fold medialization thyroplasty with a hydroxyapatite implant. Laryngoscope 117:1118\u20131122","journal-title":"Laryngoscope"},{"key":"5756_CR41","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/hed.21370","volume":"32","author":"C Storck","year":"2010","unstructured":"Storck C, Fischer C, Cecon M et al (2010) Hydroxyapatite versus titanium implant: comparison of the functional outcome after vocal fold medialization in unilateral recurrent nerve paralysis. Head Neck 32:1605\u20131612","journal-title":"Head Neck"},{"key":"5756_CR42","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1097\/MLG.0b013e3180d09ef9","volume":"117","author":"R Tokashiki","year":"2007","unstructured":"Tokashiki R, Hiramatsu H, Tsukahara K et al (2007) A \"fenestration approach\" for arytenoid adduction through the thyroid ala combined with type I thyroplasty. Laryngoscope 117:1882\u20131887","journal-title":"Laryngoscope"},{"key":"5756_CR43","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/00016480510028555","volume":"125","author":"R Tokashiki","year":"2005","unstructured":"Tokashiki R, Hiramatsu H, Tsukahara K et al (2005) Direct pull of lateral cricoarytenoid muscle for unilateral vocal cord paralysis. Acta Otolaryngol 125:753\u2013758","journal-title":"Acta Otolaryngol"},{"key":"5756_CR44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00405-010-1327-7","volume":"268","author":"N Van Ardenne","year":"2011","unstructured":"Van Ardenne N, Vanderwegen J, Van Nuffelen G et al (2011) Medialization thyroplasty: vocal outcome of silicone and titanium implant. Eur Arch Otorhinolaryngol 268:101\u2013107","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"5756_CR45","first-page":"2","volume":"173","author":"SM Zeitels","year":"1998","unstructured":"Zeitels SM, Hochman I, Hillman RE (1998) Adduction arytenopexy: a new procedure for paralytic dysphonia with implications for implant medialization. Ann Otol Rhinol Laryngol Suppl 173:2\u201324","journal-title":"Ann Otol Rhinol Laryngol Suppl"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-019-05756-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00405-019-05756-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-019-05756-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T18:02:59Z","timestamp":1722189779000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00405-019-05756-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,16]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["5756"],"URL":"https:\/\/doi.org\/10.1007\/s00405-019-05756-3","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,16]]},"assertion":[{"value":"1 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the Medical University of Vienna, EK number 1049\/2018 and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}