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HRQOL was measured using the EORTC QLQ-C30. Questionnaire and covariate data were available from 2171 participants diagnosed as follows: oral cavity (655), oropharynx HPV+\u2009(723) and HPV\u2212 (277), and larynx (516). On average, participants were followed up 3.2\u00a0years (SD 1.2) after diagnosis. Data were adjusted for age, gender, co-morbidity, intended treatment, education level, income from benefits, smoking status and alcohol consumption.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>There was a clinically meaningful difference between Global HRQOL scores at diagnosis and survival in an unadjusted and adjusted model: [HR\u2009=\u20090.86, CI 0.82\u20130.89, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 (unadjusted) and HR\u2009=\u20090.90, CI 0.86\u20130.94, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 (adjusted)]. In analyses stratified by tumour site and HPV status, this association was similarly noted before adjustment and persisted after. There were some tumour sub-site variations: improved survival for people with laryngeal cancer reporting higher levels of physical role or social functioning and people with oral cancer reporting higher levels of role or social functioning.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>As survival is the main priority for most people diagnosed with cancer, pre-treatment HRQOL is an additional factor to be included in risk stratification and case-mix adjustments. There is merit in incorporating HRQOL into routine clinical care as this is a useful facet in patient-clinician decision making, prognostication and recovery.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00405-020-05850-x","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T10:02:28Z","timestamp":1581760948000},"page":"1515-1523","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: analysis of cases from the Head and Neck 5000 study"],"prefix":"10.1007","volume":"277","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5989-6142","authenticated-orcid":false,"given":"S. N.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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