{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:00:31Z","timestamp":1760014831685,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00405-020-06127-z","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T18:04:11Z","timestamp":1592417051000},"page":"2767-2773","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Device-related epistaxis risk: continuous-flow left ventricular assist device-supported patients"],"prefix":"10.1007","volume":"277","author":[{"given":"Alper","family":"Koycu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-0850","authenticated-orcid":false,"given":"Omer","family":"Vural","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melike","family":"Bahcecitapar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabuhi","family":"Jafarov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulfem","family":"Beyazpinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz Sarp","family":"Beyazpinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"6127_CR1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s12070-018-1284-9","volume":"71","author":"A Raj","year":"2019","unstructured":"Raj A, Wadhwa V, Jain A (2019) Epidemiological profile of ent emergencies: our experience. Indian J Otolaryngol Head Neck Surg 71:301\u2013304","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"issue":"1\u201302","key":"6127_CR2","first-page":"12","volume":"115","author":"R Beck","year":"2018","unstructured":"Beck R, Sorge M, Schneider A, Dietz A (2018) Current approaches to epistaxis treatment in primary and secondary care. Dtsch Arztebl Int 115(1\u201302):12\u201322","journal-title":"Dtsch Arztebl Int"},{"key":"6127_CR3","doi-asserted-by":"publisher","first-page":"263987","DOI":"10.1155\/2015\/263987","volume":"2015","author":"H Traboulsi","year":"2015","unstructured":"Traboulsi H, Alam E, Hadi U (2015) Changing trends in the management of epistaxis. Int J Otolaryngol 2015:263987","journal-title":"Int J Otolaryngol"},{"key":"6127_CR4","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1007\/s00405-019-05392-x","volume":"276","author":"E Marin","year":"2019","unstructured":"Marin E, Watelet J, Gevaert P et al (2019) Severe spontaneous epistaxis: retrospective study in a tertiary ENT centre. Eur Arch Otorhinolaryngol 276:1693\u20131699","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"6127_CR5","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1007\/s00405-018-5043-z","volume":"275","author":"AMS Buchberger","year":"2018","unstructured":"Buchberger AMS, Baumann A, Johnson F et al (2018) The role of oral anticoagulants in epistaxis. Eur Arch Otorhinolaryngol 275:2035\u20132043","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"489","key":"6127_CR6","first-page":"312","volume":"53","author":"J Hollowell","year":"2003","unstructured":"Hollowell J, Ruig\u00f3mez A, Johansson S, Wallander MA, Garc\u00eda- Rodr\u00edguez LA (2003) The incidence of bleeding complications associated with warfarin treatment in general practice in the United Kingdom. Brit J Gen Pract 53(489):312\u2013314","journal-title":"Brit J Gen Pract"},{"issue":"1","key":"6127_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.healun.2013.12.001","volume":"33","author":"SS Najjar","year":"2014","unstructured":"Najjar SS, Slaughter MS, Pagani FD et al (2014) An analysis of pump thrombus events in patients in the HeartWare advance bridge to transplant and continued access protocol trial. J Heart Lung Transplant 33(1):23\u201334","journal-title":"J Heart Lung Transplant"},{"issue":"3","key":"6127_CR8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1097\/00000658-199509000-00010","volume":"222","author":"OH Frazier","year":"1995","unstructured":"Frazier OH, Rose EA, McCarthy P et al (1995) Improved mortality and rehabilitation of transplant candidates treated with a long-term implantable left ventricular assist system. Ann Surg 222(3):327\u2013338","journal-title":"Ann Surg"},{"issue":"20","key":"6127_CR9","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1056\/NEJMoa012175","volume":"345","author":"EA Rose","year":"2001","unstructured":"Rose EA, Gelijns AC, Moskowitz AJ et al (2001) Randomized evaluation of mechanical assistance for the treatment of congestive heart failure (REMATCH) study group. Long- term use of a left ventricular assist device for end-stage heart failure. N Engl J Med 345(20):1435\u20131443","journal-title":"N Engl J Med"},{"issue":"1","key":"6127_CR10","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jtcvs.2008.07.032","volume":"137","author":"S Crow","year":"2009","unstructured":"Crow S, John R, Boyle A et al (2009) Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices. J Thorac Cardiovasc Surg 137(1):208\u2013215","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"6127_CR11","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/j.athoracsur.2009.06.028","volume":"88","author":"EA Genovese","year":"2009","unstructured":"Genovese EA, Dew MA, Teuteberg JJ et al (2009) Incidence and patterns of adverse event onset during the first 60 days after ventricular assist device implantation. Ann Thorac Surg 88(4):1162\u20131170","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"6127_CR12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jacc.2009.03.055","volume":"54","author":"FD Pagani","year":"2009","unstructured":"Pagani FD, Miller LW, Russell SD et al (2009) HeartMate II investigators extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. J Am Coll Cardiol. 54(4):312\u2013321","journal-title":"J Am Coll Cardiol."},{"issue":"2","key":"6127_CR13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.healun.2010.12.001","volume":"30","author":"JK Kirklin","year":"2011","unstructured":"Kirklin JK, Naftel DC, Kormos RL et al (2011) Third INTERMACS Annual Report: the evolution of destination therapy in the United States. J Heart Lung Transplant 30(2):115\u2013123","journal-title":"J Heart Lung Transplant"},{"issue":"10","key":"6127_CR14","doi-asserted-by":"publisher","first-page":"E1321","DOI":"10.21037\/jtd.2016.10.81","volume":"8","author":"SR Patel","year":"2016","unstructured":"Patel SR, Vukelic S, Jorde UP (2016) Bleeding in continuous flow left ventricular assist device recipients: an acquired vasculopathy? J Thorac Dis 8(10):E1321\u2013E1327","journal-title":"J Thorac Dis"},{"issue":"10","key":"6127_CR15","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1111\/jth.13120","volume":"13","author":"S Susen","year":"2015","unstructured":"Susen S, Rauch A, Van Belle E, Vincentelli A, Lenting PJ (2015) Circulatory support devices: fundamental aspects and clinical management of bleeding and thrombosis. J Thromb Haemost 13(10):1757\u20131767","journal-title":"J Thromb Haemost"},{"key":"6127_CR16","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1016\/j.jtcvs.2014.07.091","volume":"148","author":"M Fiore","year":"2014","unstructured":"Fiore M, James C, Mouton C, Calderon J, Barandon L, Ouattara A, Picard F (2014) Assessment of platelet function with light transmission aggregometry in 24 patients supported with a continuous- flow left ventricular assist device: a single-center experience. J Thorac Cardiovasc Surg 148:3119\u20133125","journal-title":"J Thorac Cardiovasc Surg"},{"key":"6127_CR17","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1055\/s-0038-1649623","volume":"70","author":"E Fressinaud","year":"1993","unstructured":"Fressinaud E, Meyer D (1993) International survey of patients with von Willebrand disease and angiodysplasia. Thromb Haemost 70:546","journal-title":"Thromb Haemost"},{"issue":"2","key":"6127_CR18","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jchf.2013.10.008","volume":"2","author":"AL Meyer","year":"2014","unstructured":"Meyer AL, Malehsa D, Budde U, Bara C, Haverich A, Strueber M (2014) Acquired von Willebrand syndrome in patients with a centrifugal or axial continuous flow left ventricular assist device. JACC Heart Fail 2(2):141\u2013145","journal-title":"JACC Heart Fail"},{"issue":"4","key":"6127_CR19","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.athoracsur.2010.04.099","volume":"90","author":"S Crow","year":"2010","unstructured":"Crow S, Chen D, Milano C et al (2010) Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients. Ann Thorac Surg 90(4):1263\u20131269","journal-title":"Ann Thorac Surg"},{"issue":"15","key":"6127_CR20","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/j.jacc.2010.05.016","volume":"56","author":"N Uriel","year":"2010","unstructured":"Uriel N, Pak SW, Jorde UP et al (2010) Acquired von Willebrand syndrome after continuous-flow mechanical device support contributes to a high prevalence of bleeding during long-term support and at the time of transplantation. J Am Coll Cardiol 56(15):1207\u20131213","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"6127_CR21","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40463-018-0295-6","volume":"47","author":"CS Brown","year":"2018","unstructured":"Brown CS, Hachem R, Jang DW (2018) Management of epistaxis in patients with ventricular assist device: a retrospective review. J Otolaryngol Head Neck Surg 47(1):48","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"6127_CR22","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1017\/S0022215113000492","volume":"127","author":"TC Biggs","year":"2013","unstructured":"Biggs TC, Baruah P, Mainwaring J, Harries PG, Salib RJ (2013) Treatment algorithm for oral anticoagulant and antiplatelet therapy in epistaxis patients. J Laryngol Otol 127:483\u2013488","journal-title":"J Laryngol Otol"},{"key":"6127_CR23","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1017\/S0022215115003424","volume":"130","author":"S Bola","year":"2016","unstructured":"Bola S, Marsh R, Braggins S, Potter C, Hickey S (2016) Does the continuation of warfarin change management outcomes in epistaxis patients? J Laryngol Otol 130:256\u2013260","journal-title":"J Laryngol Otol"},{"key":"6127_CR24","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1007\/s00405-016-3913-9","volume":"273","author":"RR Stadler","year":"2016","unstructured":"Stadler RR, Kindler R, Holzmann D et al (2016) The long-term fate of epistaxis patients with exposure to antithrombotic medication. Eur Arch Otorhinolaryngol 273:2561\u20132567","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"6127_CR25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jacc.2009.03.044","volume":"54","author":"DR Holmes Jr","year":"2009","unstructured":"Holmes DR Jr, Kereiakes DJ, Kleiman NS, Moliterno DJ, Patti G, Grines CL (2009) Combining antiplatelet and anticoagulant therapies. J Am Coll Cardiol 54:95\u2013109","journal-title":"J Am Coll Cardiol"},{"key":"6127_CR26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.blre.2011.01.007","volume":"25","author":"JS Paikin","year":"2011","unstructured":"Paikin JS, Wright DS, Eikelboom JW (2011) Effectiveness and safety of combined antiplatelet and anticoagulant therapy: a critical review of the evidence from randomized controlled trials. Blood Rev 25:123\u2013129","journal-title":"Blood Rev"},{"key":"6127_CR27","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.athoracsur.2010.11.007","volume":"91","author":"JM Schaffer","year":"2011","unstructured":"Schaffer JM, Arnaoutakis GJ, Allen JG et al (2011) Bleeding complications and blood product utilization with left ventricular assist device implantation. Ann Thorac Surg 91:740\u2013747","journal-title":"Ann Thorac Surg"},{"key":"6127_CR28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/MAT.0b013e318283815c","volume":"59","author":"S Dassanayaka","year":"2013","unstructured":"Dassanayaka S, Slaughter MS, Bartoli CR (2013) Mechanistic pathway (s) of acquired von Willebrand syndrome with a continuous-flow ventricular assist device: in vitro findings. ASAIO J 59:123\u2013129","journal-title":"ASAIO J"},{"key":"6127_CR29","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1161\/CIRCHEARTFAILURE.109.877597","volume":"3","author":"AL Meyer","year":"2010","unstructured":"Meyer AL, Malehsa D, Bara C et al (2010) Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device. Circ Heart Fail 3:675\u2013681","journal-title":"Circ Heart Fail"},{"key":"6127_CR30","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1182\/blood-2010-01-264507","volume":"117","author":"RD Starke","year":"2011","unstructured":"Starke RD, Ferraro F, Paschalaki KE et al (2011) Endothelial von Willebrand factor regulates angiogenesis. Blood 117:1071\u20131080","journal-title":"Blood"},{"key":"6127_CR31","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1093\/ejcts\/ezu510","volume":"48","author":"M Baghai","year":"2015","unstructured":"Baghai M, Heilmann C, Beyersdorf F et al (2015) Platelet dysfunction and acquired von Willebrand syndrome in patients with left ventricular assist devices. Eur J Cardiothorac Surg 48:421\u2013427","journal-title":"Eur J Cardiothorac Surg"},{"key":"6127_CR32","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1161\/CIRCHEARTFAILURE.112.000206","volume":"6","author":"O Wever-Pinzon","year":"2013","unstructured":"Wever-Pinzon O, Selzman CH, Drakos SG et al (2013) Pulsatility and the risk of nonsurgical bleeding in patients supported with the continuous-flow left ventricular assist device HeartMate II. Circ Heart Fail 6:517\u2013526","journal-title":"Circ Heart Fail"},{"key":"6127_CR33","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.healun.2014.01.642","volume":"33","author":"P Bhat","year":"2014","unstructured":"Bhat P, Nassif ME, Vader JM et al (2014) Epistaxis in patients with left ventricular assist devices - incidence, risk factors, and implications. J Heart Lung Transplant 33:256","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"6127_CR34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2500\/ajra.2012.26.3696","volume":"26","author":"L Rudmik","year":"2012","unstructured":"Rudmik L, Smith TL (2012) Management of intractable spontaneous epistaxis. Am J Rhinol Allergy 26(1):55\u201360","journal-title":"Am J Rhinol Allergy"},{"key":"6127_CR35","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1056\/NEJMoa067758","volume":"357","author":"LW Miller","year":"2007","unstructured":"Miller LW, Pagani FD, Russell SD et al (2007) Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med 357:885\u2013896","journal-title":"N Engl J Med"},{"key":"6127_CR36","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.healun.2014.04.010","volume":"33","author":"JK Kirklin","year":"2014","unstructured":"Kirklin JK, Naftel DC, Pagani FD et al (2014) Sixth INTERMACS annual report: a 10.000-patient database. J Heart Lung Transplant 33:555\u2013564","journal-title":"J Heart Lung Transplant"},{"key":"6127_CR37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.healun.2013.07.020","volume":"33","author":"JM Stulak","year":"2014","unstructured":"Stulak JM, Lee D, Haft JW et al (2014) Gastrointestinal bleeding and subsequent risk of thromboembolic events during support with a left ventricular assist device. J Heart Lung Transplant 33:60\u201364","journal-title":"J Heart Lung Transplant"},{"key":"6127_CR38","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1111\/j.1538-7836.2007.02562.x","volume":"5","author":"A Borel-Derlon","year":"2007","unstructured":"Borel-Derlon A, Federici AB, Roussel-Robert V et al (2007) Treatment of severe von Willebrand disease with a high-purity von Willebrand factor concentrate (Wilfactin): a prospective study of 50 patients. J Thromb Haemost 5:1115\u20131124","journal-title":"J Thromb Haemost"},{"key":"6127_CR39","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/trf.12788","volume":"55","author":"Q Fischer","year":"2015","unstructured":"Fischer Q, Huisse MG, Voiriot G et al (2015) Von Willebrand factor, a versatile player in gastrointestinal bleeding in left ventricular assist device recipients? Transfusion 55:51\u201354","journal-title":"Transfusion"},{"key":"6127_CR40","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1111\/j.1537-2995.2011.03500.x","volume":"52","author":"M Cushing","year":"2012","unstructured":"Cushing M, Kawaguchi K, Friedman KD, Mark T (2012) Factor VIII\/ von Willebrand factor concentrate therapy for ventricular assist device-associated acquired von Willebrand disease. Transfusion 52:1535\u20131541","journal-title":"Transfusion"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-020-06127-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-020-06127-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-020-06127-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T23:31:06Z","timestamp":1623713466000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-020-06127-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["6127"],"URL":"https:\/\/doi.org\/10.1007\/s00405-020-06127-z","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"type":"print","value":"0937-4477"},{"type":"electronic","value":"1434-4726"}],"subject":[],"published":{"date-parts":[[2020,6,15]]},"assertion":[{"value":"6 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This retrospective study was performed after approval of the Ethical Committee of the University Hospital (Baskent University Medical and Health Sciences Research Council and Ethics Committee, KA 19\/90) and has been performed according to the ethical standards of the Helsinki Declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval:"}},{"value":"This was a retrospective data analysis study and it did not need informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}