{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:08:12Z","timestamp":1788588492761,"version":"build-2803163510"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s00405-020-06224-z","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T13:02:42Z","timestamp":1595336562000},"page":"1321-1335","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Transoral robotic surgery and intensity-modulated radiotherapy in the treatment of the oropharyngeal carcinoma: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"278","author":[{"given":"Armando","family":"De Virgilio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-7785","authenticated-orcid":false,"given":"Andrea","family":"Costantino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mercante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Pellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Ferreli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Malvezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cugini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Petruzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Spriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"issue":"5","key":"6224_CR1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/hed.22015","volume":"35","author":"H Mehanna","year":"2013","unstructured":"Mehanna H, Beech T, Nicholson T et al (2013) Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer\u2014systematic review and meta-analysis of trends by time and region. Head Neck 35(5):747\u2013755","journal-title":"Head Neck"},{"issue":"8","key":"6224_CR2","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","volume":"11","author":"S Marur","year":"2010","unstructured":"Marur S, D\u2019Souza G, Westra WH, Forastiere AA (2010) HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol 11(8):781\u2013789","journal-title":"Lancet Oncol"},{"issue":"6","key":"6224_CR3","doi-asserted-by":"crossref","first-page":"djv403","DOI":"10.1093\/jnci\/djv403","volume":"108","author":"X Castellsagu\u00e9","year":"2016","unstructured":"Castellsagu\u00e9 X, Alemany L, Quer M et al (2016) HPV involvement in head and neck cancers: comprehensive assessment of biomarkers in 3680 patients. J Natl Cancer Inst 108(6):djv403","journal-title":"J Natl Cancer Inst"},{"key":"6224_CR4","unstructured":"National Comprehensive Cancer Network (2019) Head and neck cancers (version 3.2019). https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf. Accessed 29 Jan 2020"},{"issue":"1","key":"6224_CR5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","volume":"363","author":"KK Ang","year":"2010","unstructured":"Ang KK, Harris J, Wheeler R et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363(1):24\u201335","journal-title":"N Engl J Med"},{"issue":"36","key":"6224_CR6","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1200\/JCO.2005.04.6136","volume":"24","author":"L Licitra","year":"2006","unstructured":"Licitra L, Perrone F, Bossi P et al (2006) High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma. J Clin Oncol 24(36):5630\u20135636","journal-title":"J Clin Oncol"},{"issue":"4","key":"6224_CR7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djn011","volume":"100","author":"C Fakhry","year":"2008","unstructured":"Fakhry C, Westra WH, Li S et al (2008) Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 100(4):261\u2013269","journal-title":"J Natl Cancer Inst"},{"issue":"21","key":"6224_CR8","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1200\/JCO.2007.14.8841","volume":"26","author":"M Machtay","year":"2008","unstructured":"Machtay M, Moughan J, Trotti A et al (2008) Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 26(21):3582\u20133589","journal-title":"J Clin Oncol"},{"issue":"4","key":"6224_CR9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1177\/0194599814542939","volume":"151","author":"SE Ford","year":"2014","unstructured":"Ford SE, Brandwein-Gensler M, Carroll WR, Rosenthal EL, Magnuson JS (2014) Transoral robotic versus open surgical approaches to oropharyngeal squamous cell carcinoma by human papillomavirus status. Otolaryngol Head Neck Surg 151(4):606\u2013611","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"8","key":"6224_CR10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/jamaoto.2013.3866","volume":"139","author":"H White","year":"2013","unstructured":"White H, Ford S, Bush B et al (2013) Salvage surgery for recurrent cancers of the oropharynx: comparing TORS with standard open surgical approaches. JAMA Otolaryngol Head Neck Surg 139(8):773\u2013778","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"8","key":"6224_CR11","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.jcms.2015.06.024","volume":"43","author":"G Mercante","year":"2015","unstructured":"Mercante G, Masiello A, Sperduti I et al (2015) Quality of life and functional evaluation in patients with tongue base tumors treated exclusively with transoral robotic surgery: a 1-year follow-up study. J Craniomaxillofac Surg 43(8):1561\u20131566","journal-title":"J Craniomaxillofac Surg"},{"issue":"15","key":"6224_CR12","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/j.ejca.2014.07.001","volume":"50","author":"L Masterson","year":"2014","unstructured":"Masterson L, Moualed D, Liu ZW et al (2014) De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis of current clinical trials. Eur J Cancer 50(15):2636\u20132648","journal-title":"Eur J Cancer"},{"key":"6224_CR13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ctro.2017.10.005","volume":"8","author":"H Mirghani","year":"2018","unstructured":"Mirghani H, Blanchard P (2018) Treatment de-escalation for HPV-driven oropharyngeal cancer: Where do we stand? Clin Transl Radiat Oncol 8:4\u201311","journal-title":"Clin Transl Radiat Oncol"},{"key":"6224_CR14","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1186\/s12885-015-1598-x","volume":"15","author":"W Owadally","year":"2015","unstructured":"Owadally W, Hurt C, Timmins H et al (2015) PATHOS: a phase II\/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV) positive oropharyngeal cancer. BMC Cancer 15:602","journal-title":"BMC Cancer"},{"issue":"15_suppl","key":"6224_CR15","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.1200\/JCO.2018.36.15_suppl.6004","volume":"36","author":"RS Siegel","year":"2018","unstructured":"Siegel RS, Rafei H, Joshi A et al (2018) Phase II study: Induction chemotherapy and transoral surgery as definitive treatment (Tx) for locally advanced oropharyngeal squamous cell carcinoma (OPSCC): a novel approach. J Clin Oncol 36(15_suppl):6004\u20136004","journal-title":"J Clin Oncol"},{"issue":"2","key":"6224_CR16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/(SICI)1097-0215(20000420)90:2<92::AID-IJC5>3.0.CO;2-9","volume":"90","author":"KS Chao","year":"2000","unstructured":"Chao KS, Low DA, Perez CA, Purdy JA (2000) Intensity-modulated radiation therapy in head and neck cancers: the Mallinckrodt experience. Int J Cancer 90(2):92\u2013103","journal-title":"Int J Cancer"},{"issue":"5","key":"6224_CR17","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1200\/JCO.2016.68.3300","volume":"35","author":"S Marur","year":"2017","unstructured":"Marur S, Li S, Cmelak AJ et al (2017) E1308: phase II trial of induction chemotherapy followed by reduced-dose radiation and weekly cetuximab in patients with HPV-associated resectable squamous cell carcinoma of the oropharynx\u2014ECOG-ACRIN Cancer Research Group. J Clin Oncol 35(5):490\u2013497","journal-title":"J Clin Oncol"},{"key":"6224_CR18","first-page":"170","volume":"95","author":"K Misiukiewicz","year":"2019","unstructured":"Misiukiewicz K, Gupta V, Miles BA et al (2019) Standard of care vs reduced-dose chemoradiation after induction chemotherapy in HPV+ oropharyngeal carcinoma patients: the Quarterback trial. OralOncol 95:170\u2013177","journal-title":"OralOncol"},{"issue":"5","key":"6224_CR19","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/ijc.24842","volume":"126","author":"CA Fischer","year":"2010","unstructured":"Fischer CA, Zlobec I, Green E et al (2010) Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality? Int J Cancer 126(5):1256\u20131262","journal-title":"Int J Cancer"},{"issue":"10","key":"6224_CR20","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S1470-2045(19)30410-3","volume":"20","author":"AC Nichols","year":"2019","unstructured":"Nichols AC, Theurer J, Prisman E et al (2019) Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial. Lancet Oncol 20(10):1349\u20131359","journal-title":"Lancet Oncol"},{"issue":"7","key":"6224_CR21","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","volume":"6","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 6(7):e1000100","journal-title":"PLoS Med"},{"issue":"9","key":"6224_CR22","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","volume":"73","author":"K Slim","year":"2003","unstructured":"Slim K, Nini E, Forestier D et al (2003) Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg 73(9):712\u2013716","journal-title":"ANZ J Surg"},{"key":"6224_CR23","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JPT Higgins","year":"2011","unstructured":"Higgins JPT, Altman DG, G\u00f8tzsche PC et al (2011) The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ 343:d5928","journal-title":"BMJ"},{"issue":"1","key":"6224_CR24","doi-asserted-by":"crossref","first-page":"1334318","DOI":"10.1080\/2331205X.2017.1334318","volume":"4","author":"MJ Rousseau","year":"2017","unstructured":"Rousseau MJ, Evans JC (2017) Key statistical assumptions and methods in one-arm meta-analyses with binary endpoints and low event rates, including a real-life example in the area of endoscopic colonic stenting. Cogent Med 4(1):1334318","journal-title":"Cogent Med"},{"issue":"4","key":"6224_CR25","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/hed.25522","volume":"41","author":"P Di Maio","year":"2019","unstructured":"Di Maio P, Iocca O, De Virgilio A et al (2019) Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: a systematic review and meta-analysis. Head Neck 41(4):1112\u20131121","journal-title":"Head Neck"},{"issue":"1","key":"6224_CR26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jrsm.1164","volume":"7","author":"AA Veroniki","year":"2016","unstructured":"Veroniki AA, Jackson D, Viechtbauer W et al (2016) Methods to estimate the between-study variance and its uncertainty in meta-analysis. Res Synth Methods 7(1):55\u201379","journal-title":"Res Synth Methods"},{"issue":"6","key":"6224_CR27","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1001\/jama.295.6.676","volume":"295","author":"JL Peters","year":"2006","unstructured":"Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2006) Comparison of two methods to detect publication bias in meta-analysis. JAMA 295(6):676\u2013680","journal-title":"JAMA"},{"issue":"1","key":"6224_CR28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/coa.12674","volume":"42","author":"T Bird","year":"2017","unstructured":"Bird T, De Felice F, Michaelidou A et al (2017) Outcomes of intensity-modulated radiotherapy as primary treatment for oropharyngeal squamous cell carcinoma\u2014 a European single institution analysis. Clin Otolaryngol 42(1):115\u2013122","journal-title":"Clin Otolaryngol"},{"issue":"1","key":"6224_CR29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.radonc.2016.05.022","volume":"120","author":"P Blanchard","year":"2016","unstructured":"Blanchard P, Garden AS, Gunn GB et al (2016) Intensity-modulated proton beam therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for patients with oropharynx cancer\u2014a case matched analysis. Radiother Oncol 120(1):48\u201355","journal-title":"Radiother Oncol"},{"issue":"12","key":"6224_CR30","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1002\/hed.23231","volume":"35","author":"MA Broglie","year":"2013","unstructured":"Broglie MA, Soltermann A, Rohrbach D et al (2013) Impact of p16, p53, smoking, and alcohol on survival in patients with oropharyngeal squamous cell carcinoma treated with primary intensity-modulated chemoradiation. Head Neck 35(12):1698\u20131706","journal-title":"Head Neck"},{"key":"6224_CR31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.oraloncology.2019.03.013","volume":"92","author":"AR Burr","year":"2019","unstructured":"Burr AR, Harari PM, Ko HC et al (2019) Reducing radiotherapy target volume expansion for patients with HPV-associated oropharyngeal cancer. Oral Oncol 92:52\u201356","journal-title":"Oral Oncol"},{"issue":"3","key":"6224_CR32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0167-8140(01)00449-2","volume":"61","author":"KS Chao","year":"2001","unstructured":"Chao KS, Majhail N, Huang CJ et al (2001) Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. Radiother Oncol 61(3):275\u2013280","journal-title":"Radiother Oncol"},{"issue":"5","key":"6224_CR33","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.ijrobp.2015.08.033","volume":"93","author":"BS Chera","year":"2015","unstructured":"Chera BS, Amdur RJ, Tepper J et al (2015) Phase 2 trial of de-intensified chemoradiation therapy for favorable-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma. Int J Radiat Oncol Biol Phys 93(5):976\u2013985","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"6224_CR34","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.ijrobp.2009.04.006","volume":"76","author":"ME Daly","year":"2010","unstructured":"Daly ME, Le Q-T, Maxim PG et al (2010) Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure. Int J Radiat Oncol Biol Phys 76(5):1339\u20131346","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"6224_CR35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.21873\/invivo.11083","volume":"31","author":"F De Felice","year":"2017","unstructured":"De Felice F, Galdieri A, Abate G et al (2017) Definitive intensity-modulated radiation therapy in elderly patients with locally advanced oropharyngeal cancer. Vivo 31(3):455\u2013459","journal-title":"Vivo"},{"issue":"5","key":"6224_CR36","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.ijrobp.2009.04.011","volume":"76","author":"A Eisbruch","year":"2010","unstructured":"Eisbruch A, Harris J, Garden AS et al (2010) Multi-institutional trial of accelerated hypofractionated intensity-modulated radiation therapy for early-stage oropharyngeal cancer (RTOG 00-22). Int J Radiat Oncol Biol Phys 76(5):1333\u20131338","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"16","key":"6224_CR37","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1200\/JCO.2009.24.6199","volume":"28","author":"FY Feng","year":"2010","unstructured":"Feng FY, Kim HM, Lyden TH et al (2010) Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results. J Clin Oncol 28(16):2732\u20132738","journal-title":"J Clin Oncol"},{"issue":"2","key":"6224_CR38","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ijrobp.2006.08.078","volume":"67","author":"AS Garden","year":"2007","unstructured":"Garden AS, Morrison WH, Wong P-F et al (2007) Disease-control rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 67(2):438\u2013444","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"6224_CR39","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.ijrobp.2012.08.004","volume":"85","author":"AS Garden","year":"2013","unstructured":"Garden AS, Dong L, Morrison WH et al (2013) Patterns of disease recurrence following treatment of oropharyngeal cancer with intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys 85(4):941\u2013947","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10166","key":"6224_CR40","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(18)32779-X","volume":"393","author":"ML Gillison","year":"2019","unstructured":"Gillison ML, Trotti AM, Harris J et al (2019) Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial. Lancet 393(10166):40\u201350","journal-title":"Lancet"},{"issue":"3","key":"6224_CR41","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/cncr.23578","volume":"113","author":"K Huang","year":"2008","unstructured":"Huang K, Xia P, Chuang C et al (2008) Intensity-modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma: the University of California-San Francisco experience. Cancer 113(3):497\u2013507","journal-title":"Cancer"},{"issue":"4","key":"6224_CR42","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ijrobp.2012.08.030","volume":"85","author":"KU Hunter","year":"2013","unstructured":"Hunter KU, Schipper M, Feng FY et al (2013) Toxicities affecting quality of life after chemo-IMRT of oropharyngeal cancer: prospective study of patient-reported, observer-rated, and objective outcomes. Int J Radiat Oncol Biol Phys 85(4):935\u2013940","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"6224_CR43","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1758-3284-2-28","volume":"2","author":"CJ Ingle","year":"2010","unstructured":"Ingle CJ, Yip K, Caskie V et al (2010) Intensity modulated radiotherapy (IMRT) in the management of locally advanced oropharyngeal squamous cell carcinomata (SCC): disease control and functional outcome using the therapy outcome measure (TOM) score\u2014report from a single UK institution. Head Neck Oncol 2:28","journal-title":"Head Neck Oncol"},{"issue":"5","key":"6224_CR44","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/hed.25077","volume":"40","author":"MR Kanakamedala","year":"2018","unstructured":"Kanakamedala MR, Giri SPG, Hamilton RD, Bhanat E, Vijayakumar S (2018) Outcomes utilizing intensity-modulated radiotherapy in oropharyngeal cancers: tonsils versus base of tongue. Head Neck 40(5):1034\u20131039","journal-title":"Head Neck"},{"issue":"4","key":"6224_CR45","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1001\/jamaoto.2013.6777","volume":"140","author":"S Lohia","year":"2014","unstructured":"Lohia S, Rajapurkar M, Nguyen SA et al (2014) A comparison of outcomes using intensity-modulated radiation therapy and 3-dimensional conformal radiation therapy in treatment of oropharyngeal cancer. JAMA Otolaryngol Head Neck Surg 140(4):331\u2013337","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"1","key":"6224_CR46","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s10147-016-1034-5","volume":"22","author":"T Matsuura","year":"2017","unstructured":"Matsuura T, Nishimura Y, Nakamatsu K et al (2017) Clinical outcomes of IMRT planned with or without PET\/CT simulation for patients with pharyngeal cancers. Int J Clin Oncol 22(1):52\u201358","journal-title":"Int J Clin Oncol"},{"issue":"12","key":"6224_CR47","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/hed.23245","volume":"35","author":"JT May","year":"2013","unstructured":"May JT, Rao N, Sabater RD et al (2013) Intensity-modulated radiation therapy as primary treatment for oropharyngeal squamous cell carcinoma. Head Neck 35(12):1796\u20131800","journal-title":"Head Neck"},{"issue":"10166","key":"6224_CR48","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(18)32752-1","volume":"393","author":"H Mehanna","year":"2019","unstructured":"Mehanna H, Robinson M, Hartley A et al (2019) Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Lancet 393(10166):51\u201360","journal-title":"Lancet"},{"issue":"11","key":"6224_CR49","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/lary.21144","volume":"120","author":"WM Mendenhall","year":"2010","unstructured":"Mendenhall WM, Amdur RJ, Morris CG, Kirwan JM, Li JG (2010) Intensity-modulated radiotherapy for oropharyngeal squamous cell carcinoma. Laryngoscope 120(11):2218\u20132222","journal-title":"Laryngoscope"},{"issue":"2","key":"6224_CR50","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.otohns.2008.11.025","volume":"140","author":"AC Nichols","year":"2009","unstructured":"Nichols AC, Faquin WC, Westra WH et al (2009) HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg 140(2):228\u2013234","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"11","key":"6224_CR51","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/hed.21120","volume":"31","author":"NF Saba","year":"2009","unstructured":"Saba NF, Edelman S, Tighiouart M et al (2009) Concurrent chemotherapy with intensity-modulated radiation therapy for locally advanced squamous cell carcinoma of the larynx and oropharynx: a retrospective single-institution analysis. Head Neck 31(11):1447\u20131455","journal-title":"Head Neck"},{"issue":"1","key":"6224_CR52","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ijrobp.2010.10.041","volume":"82","author":"J Setton","year":"2012","unstructured":"Setton J, Caria N, Romanyshyn J et al (2012) Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: an update of the Memorial Sloan-Kettering Cancer Center experience. Int J Radiat Oncol Biol Phys 82(1):291\u2013298","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"6224_CR53","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/cncr.25040","volume":"116","author":"A Shoushtari","year":"2010","unstructured":"Shoushtari A, Meeneghan M, Sheng K et al (2010) Intensity-modulated radiotherapy outcomes for oropharyngeal squamous cell carcinoma patients stratified by p16 status. Cancer 116(11):2645\u20132654","journal-title":"Cancer"},{"issue":"6","key":"6224_CR54","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/01.coc.0000242294.89536.d6","volume":"29","author":"M Yao","year":"2006","unstructured":"Yao M, Nguyen T, Buatti JM et al (2006) Changing failure patterns in oropharyngeal squamous cell carcinoma treated with intensity modulated radiotherapy and implications for future research. Am J Clin Oncol 29(6):606\u2013612","journal-title":"Am J Clin Oncol"},{"issue":"1","key":"6224_CR55","first-page":"18","volume":"144","author":"V Achim","year":"2018","unstructured":"Achim V, Bolognone RK, Palmer AD et al (2018) Long-term functional and quality-of-life outcomes after transoral robotic surgery in patients with oropharyngeal cancer. JAMA Otolaryngol Head Neck Surg 144(1):18\u201327","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"6224_CR56","doi-asserted-by":"crossref","first-page":"190364","DOI":"10.1155\/2013\/190364","volume":"2013","author":"S Al-Khudari","year":"2013","unstructured":"Al-Khudari S, Bendix S, Lindholm J et al (2013) Gastrostomy tube use after transoral robotic surgery for oropharyngeal cancer. ISRN Otolaryngol 2013:190364","journal-title":"ISRN Otolaryngol"},{"issue":"11","key":"6224_CR57","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1089\/lap.2013.0261","volume":"23","author":"RGF Blanco","year":"2013","unstructured":"Blanco RGF, Fakhry C, Ha PK et al (2013) Transoral robotic surgery experience in 44 cases. J Laparoendosc Adv Surg Tech A 23(11):900\u2013907","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"6224_CR58","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.oraloncology.2018.10.001","volume":"86","author":"RB Cannon","year":"2018","unstructured":"Cannon RB, Houlton JJ, Patel S et al (2018) Patterns of cervical node positivity, regional failure rates, and fistula rates for HPV+ oropharyngeal squamous cell carcinoma treated with transoral robotic surgery (TORS). Oral Oncol 86:296\u2013300","journal-title":"Oral Oncol"},{"issue":"4","key":"6224_CR59","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/hed.21500","volume":"33","author":"MA Cohen","year":"2011","unstructured":"Cohen MA, Weinstein GS, O\u2019Malley BW, Feldman M, Quon H (2011) Transoral robotic surgery and human papillomavirus status: oncologic results. Head Neck 33(4):573\u2013580","journal-title":"Head Neck"},{"key":"6224_CR60","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.oraloncology.2017.04.010","volume":"69","author":"S Dabas","year":"2017","unstructured":"Dabas S, Gupta K, Ranjan R et al (2017) Oncological outcome following de-intensification of treatment for stage I and II HPV negative oropharyngeal cancers with transoral robotic surgery (TORS): a prospective trial. Oral Oncol 69:80\u201383","journal-title":"Oral Oncol"},{"issue":"11","key":"6224_CR61","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.ejso.2019.06.027","volume":"45","author":"S Dabas","year":"2019","unstructured":"Dabas S, Gupta K, Sharma AK et al (2019) Oncological outcome following initiation of treatment for stage III and IV HPV negative oropharyngeal cancers with transoral robotic surgery (TORS). Eur J Surg Oncol 45(11):2137\u20132142","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"6224_CR62","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1001\/archoto.2010.40","volume":"136","author":"NR Dean","year":"2010","unstructured":"Dean NR, Rosenthal EL, Carroll WR et al (2010) Robotic-assisted surgery for primary or recurrent oropharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 136(4):380\u2013384","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"5","key":"6224_CR63","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.amjoto.2019.06.001","volume":"40","author":"B Dhanireddy","year":"2019","unstructured":"Dhanireddy B, Burnett NP, Sanampudi S et al (2019) Outcomes in surgically resectable oropharynx cancer treated with transoral robotic surgery versus definitive chemoradiation. Am J Otolaryngol 40(5):673\u2013677","journal-title":"Am J Otolaryngol"},{"issue":"11","key":"6224_CR64","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1001\/jamaoto.2013.2747","volume":"139","author":"PT Dziegielewski","year":"2013","unstructured":"Dziegielewski PT, Teknos TN, Durmus K et al (2013) Transoral robotic surgery for oropharyngeal cancer: long-term quality of life and functional outcomes. JAMA Otolaryngol Head Neck Surg 139(11):1099\u20131108","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"8","key":"6224_CR65","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/hed.23424","volume":"36","author":"SY Lee","year":"2014","unstructured":"Lee SY, Park YM, Byeon HK, Choi EC, Kim S-H (2014) Comparison of oncologic and functional outcomes after transoral robotic lateral oropharyngectomy versus conventional surgery for T1 to T3 tonsillar cancer. Head Neck 36(8):1138\u20131145","journal-title":"Head Neck"},{"issue":"11","key":"6224_CR66","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/hed.23809","volume":"37","author":"BB L\u00f6rincz","year":"2015","unstructured":"L\u00f6rincz BB, M\u00f6ckelmann N, Busch C-J, Knecht R (2015) Functional outcomes, feasibility, and safety of resection of transoral robotic surgery: single-institution series of 35 consecutive cases of transoral robotic surgery for oropharyngeal squamous cell carcinoma. Head Neck 37(11):1618\u20131624","journal-title":"Head Neck"},{"issue":"2","key":"6224_CR67","doi-asserted-by":"crossref","first-page":"75","DOI":"10.14639\/0392-100X-2199","volume":"39","author":"G Meccariello","year":"2019","unstructured":"Meccariello G, Montevecchi F, D\u2019Agostino G et al (2019) Trans-oral robotic surgery for the management of oropharyngeal carcinomas: a 9-year institutional experience. Acta Otorhinolaryngol Ital 39(2):75\u201383","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"4","key":"6224_CR68","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/hed.25055","volume":"40","author":"EJ Moore","year":"2018","unstructured":"Moore EJ, Van Abel KM, Price DL et al (2018) Transoral robotic surgery for oropharyngeal carcinoma: surgical margins and oncologic outcomes. Head Neck 40(4):747\u2013755","journal-title":"Head Neck"},{"issue":"2","key":"6224_CR69","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1177\/014556131309200211","volume":"92","author":"SM Olsen","year":"2013","unstructured":"Olsen SM, Moore EJ, Laborde RR et al (2013) Transoral surgery alone for human-papillomavirus-associated oropharyngeal squamous cell carcinoma. Ear Nose Throat J 92(2):76\u201383","journal-title":"Ear Nose Throat J"},{"issue":"5","key":"6224_CR70","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s00405-016-4433-3","volume":"274","author":"N Rubek","year":"2017","unstructured":"Rubek N, Channir HI, Charabi BW et al (2017) Primary transoral robotic surgery with concurrent neck dissection for early stage oropharyngeal squamous cell carcinoma implemented at a Danish head and neck cancer center: a phase II trial on feasibility and tumour margin status. Eur Arch Otorhinolaryngol 274(5):2229\u20132237","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"7","key":"6224_CR71","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1001\/archoto.2012.1166","volume":"138","author":"GS Weinstein","year":"2012","unstructured":"Weinstein GS, Quon H, Newman HJ et al (2012) Transoral robotic surgery alone for oropharyngeal cancer: an analysis of local control. Arch Otolaryngol Head Neck Surg 138(7):628\u2013634","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"Suppl 10","key":"6224_CR72","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/lary.25534","volume":"125","author":"RV Smith","year":"2015","unstructured":"Smith RV, Schiff BA, Garg M, Haigentz M (2015) The impact of transoral robotic surgery on the overall treatment of oropharyngeal cancer patients. Laryngoscope 125(Suppl 10):S1\u201315","journal-title":"Laryngoscope"},{"key":"6224_CR73","first-page":"104450","volume":"99","author":"A De Virgilio","year":"2019","unstructured":"De Virgilio A, Kim S-H, Magnuson JS et al (2019) Anatomical-based classification for transoral lateral oropharyngectomy. OralOncol 99:104450","journal-title":"OralOncol"},{"key":"6224_CR74","doi-asserted-by":"crossref","first-page":"104581","DOI":"10.1016\/j.oraloncology.2020.104581","volume":"103","author":"A De Virgilio","year":"2020","unstructured":"De Virgilio A, Costantino A, Mercante G et al (2020) Trans-oral robotic surgery in the management of parapharyngeal space tumors: a systematic review. Oral Oncol 103:104581","journal-title":"Oral Oncol"},{"issue":"3","key":"6224_CR75","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.anl.2012.07.017","volume":"40","author":"A De Virgilio","year":"2013","unstructured":"De Virgilio A, Park YM, Kim WS, Baek SJ, Kim S-H (2013) How to optimize laryngeal and hypopharyngeal exposure in transoral robotic surgery. Auris Nasus Larynx 40(3):312\u2013319","journal-title":"Auris Nasus Larynx"},{"issue":"9","key":"6224_CR76","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1002\/lary.24712","volume":"124","author":"JR de Almeida","year":"2014","unstructured":"de Almeida JR, Byrd JK, Wu R et al (2014) A systematic review of transoral robotic surgery and radiotherapy for early oropharynx cancer: a systematic review. Laryngoscope 124(9):2096\u20132102","journal-title":"Laryngoscope"},{"issue":"12","key":"6224_CR77","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.ejso.2015.09.007","volume":"41","author":"DH Yeh","year":"2015","unstructured":"Yeh DH, Tam S, Fung K et al (2015) Transoral robotic surgery vs radiotherapy for management of oropharyngeal squamous cell carcinoma\u2014a systematic review of the literature. Eur J Surg Oncol 41(12):1603\u20131614","journal-title":"Eur J Surg Oncol"},{"key":"6224_CR78","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3389\/fonc.2019.00999","volume":"9","author":"J-J Stelmes","year":"2019","unstructured":"Stelmes J-J, Gregoire V, Poorten VV et al (2019) Organ preservation and late functional outcome in oropharyngeal carcinoma: rationale of EORTC 1420, the \u201cbest of\u201d trial. Front Oncol 9:999","journal-title":"Front Oncol"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-020-06224-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-020-06224-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-020-06224-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T09:40:27Z","timestamp":1723282827000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-020-06224-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,21]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["6224"],"URL":"https:\/\/doi.org\/10.1007\/s00405-020-06224-z","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,21]]},"assertion":[{"value":"19 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Because of the nature of this project, no institutional review board approval was necessary.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}