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Local\/locoregional control (LRC), progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan\u2013Meier method, and the influence of clinical parameters on patient outcomes was assessed. A matched-pair analysis was performed after matching with patients\u2009&lt;\u200965\u00a0years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Nine patients (31.0%) received definitive (chemo)radiotherapy, and 20 patients (69.0%) were treated in the adjuvant setting. 2-year LRC, PFS and OS ranged at 82.4%, 53.7% and 71.8%, respectively. Smoking (HR 3.980, <jats:italic>p<\/jats:italic>\u2009=\u20090.020), reduced performance status (HR 3.735, <jats:italic>p<\/jats:italic>\u2009=\u20090.016) and higher comorbidity burden (HR 4.601, <jats:italic>p<\/jats:italic>\u2009=\u20090.005) correlated with inferior OS. Using a matched-pair analysis with younger patients, elderly patients exhibited a trend towards reduced OS (HR 3.015, <jats:italic>p<\/jats:italic>\u2009=\u20090.065), but not PFS (HR 1.474, <jats:italic>p<\/jats:italic>\u2009=\u20090.371) or LRC (HR 1.324, <jats:italic>p<\/jats:italic>\u2009=\u20090.633). Acute and chronic grade 3 toxicities occurred in 31.0% and 12.5% of elderly patients, respectively, and the matched-pair analysis revealed no significant differences between age groups regarding treatment-related toxicities.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Treatment-related toxicities as well as LRC and PFS were comparable for salivary gland cancer patients undergoing radiotherapy. Therefore, concerns for more pronounced toxicities or reduced local\/locoregional response rates should not guide treatment decisions in affected elderly patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-020-06393-x","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T21:03:01Z","timestamp":1601499781000},"page":"2537-2548","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Radiation-induced toxicities and outcomes after radiotherapy are independent of patient age in elderly salivary gland cancer patients: results from a matched-pair analysis of a rare disease"],"prefix":"10.1007","volume":"278","author":[{"given":"Alexander","family":"R\u00fchle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie","family":"Rothhaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Haehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Kalckreuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Sprave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca","family":"Stoian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantinos","family":"Zamboglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Gkika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Knopf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca-Ligia","family":"Grosu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-1410","authenticated-orcid":false,"given":"Nils H.","family":"Nicolay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"issue":"7","key":"6393_CR1","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.oraloncology.2011.04.020","volume":"47","author":"K Bj\u00f8rndal","year":"2011","unstructured":"Bj\u00f8rndal K, Krogdahl A, Therkildsen MH, Overgaard J, Johansen J, Kristensen CA, Hom\u00f8e P, S\u00f8rensen CH, Andersen E, Bundgaard T, Primdahl H, Lambertsen K, Andersen LJ, Godballe C (2011) Salivary gland carcinoma in Denmark 1990\u20132005: a national study of incidence, site and histology. 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