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ABR were used to estimate hearing thresholds and the effect of early intervention strategies using hearing aids (HA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Click-evoked ABRs were measured in 102 infants aged from 0 to 12\u00a0months to determine their individual auditory threshold. Early therapy intervention was recommended before 12\u00a0months of age and analyzed. To evaluate the effect of hearing amplification on auditory maturation, different subgroups of infants with moderate hearing loss were analyzed and the auditory pathway maturation was determined based on IPL I\u2013V shortening.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Overall, 110 ears (54.0% of 204 ears) with mild to profound HL showed threshold changes of 10\u00a0dB up to 60\u00a0dB in the follow-up ABR testing. HA were prescribed at the age of 3.8\u2009\u00b1\u20093.9\u00a0months. Cochlear implantation (CI) was performed in cases of repeated profound HL at the age of 9.9\u00a0months\u2009\u00b1\u20094.5\u00a0months. A significant shortening of IPL I\u2013V in all subgroups of infants (with and without risk factors) who received HA was shown and assumed auditory pathway maturation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>An early intervention using optimally fitted HA influenced auditory pathway maturation and may lead to improvements of hearing thresholds during the first year of life in infants. This study underscores the importance of not only providing HAs to infants, but also controlling for hearing threshold changes ensuring that HAs provide the optimal level of intervention or CI is indicated.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-020-06498-3","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T03:03:01Z","timestamp":1608260581000},"page":"4187-4197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Monitoring of the auditory pathway maturation after early intervention during the first year of life in infants with sensorineural hearing loss"],"prefix":"10.1007","volume":"278","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-112X","authenticated-orcid":false,"given":"F.","family":"Matin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9138-0277","authenticated-orcid":false,"given":"S.","family":"Haumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-8661","authenticated-orcid":false,"given":"W.","family":"Ro\u00dfberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mitovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-5989","authenticated-orcid":false,"given":"T.","family":"Lenarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1057-0245","authenticated-orcid":false,"given":"A.","family":"Lesinski-Schiedat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"issue":"6","key":"6498_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1055\/s-2004-835872","volume":"208","author":"M Gross","year":"2004","unstructured":"Gross M et al (2004) Universal hearing screening for babies\u2013recommendations for the organization and performance of the universal screening of babies for hereditary hearing disorders in Germany. 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