{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:20:21Z","timestamp":1791534021910,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Johann Wolfgang Goethe-Universit\u00e4t, Frankfurt am Main"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Salivary gland carcinomas (SGC) cover a heterogeneous group of malignancies with a lack of data of high-level evidence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Clinical data of 127 patients treated for SGC at a university cancer center between 2002 and 2017 were analyzed retrospectively. The association of clinicopathological characteristics, treatment modalities, adverse events, and outcome was assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients received surgery (<jats:italic>n<\/jats:italic>\u2009=\u200965), surgery followed by (chemo-)radiotherapy (<jats:italic>n<\/jats:italic>\u2009=\u200956), or primary (chemo-)radiotherapy (<jats:italic>n<\/jats:italic>\u2009=\u20096). Injury to the cranial nerves or their branches was the most frequent surgical complication affecting 40 patients (33.1%). Ten year overall and progression-free survival\u00a0rates were 73.2% and 65.4%, respectively. Parotid tumor site, advanced tumor, and positive nodal stage remained independent negative prognostic factors for overall survival, loco-regional and distant tumor control in multivariate analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Optimizing treatment strategies for SGC, depending on distinct clinicopathological factors, remains challenging due to the low incidence rates of the disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00405-021-06652-5","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T05:02:49Z","timestamp":1616562169000},"page":"4411-4421","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Patterns of care, toxicity and outcome in the treatment of salivary gland carcinomas: long-term experience from a tertiary cancer center"],"prefix":"10.1007","volume":"278","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-7814","authenticated-orcid":false,"given":"Jens","family":"von der Gr\u00fcn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ria","family":"Winkelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"R\u00f6del","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Balster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Neumayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Ghanaati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Brandts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Burck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"R\u00f6del","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolina","family":"Kesar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Balermpas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"6652_CR1","unstructured":"El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (eds) (2017) WHO classification of head and neck tumours, 4th ed. World Health Organization Classification of Tumours, Ninth International Agency for Research on Cancer (IARC), Lyon, France, pp 159\u2013183"},{"issue":"17","key":"6652_CR2","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1200\/JCO.2005.05.3025","volume":"24","author":"SA Laurie","year":"2006","unstructured":"Laurie SA, Licitra L (2006) Systemic therapy in the palliative management of advanced salivary gland cancers. J Clin Oncol 24(17):2673\u20132678. https:\/\/doi.org\/10.1200\/JCO.2005.05.3025","journal-title":"J Clin Oncol"},{"issue":"2","key":"6652_CR3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s40136-014-0040-2","volume":"2","author":"V Vander Poorten","year":"2014","unstructured":"Vander Poorten V, Meulemans J, Delaere P, Nuyts S, Clement P (2014) Molecular markers and chemotherapy for advanced salivary cancer. CurrOtorhinolaryngol Rep 2(2):85\u201396. https:\/\/doi.org\/10.1007\/s40136-014-0040-2","journal-title":"CurrOtorhinolaryngol Rep"},{"key":"6652_CR4","unstructured":"National Comprehensive Cancer Network Head and Neck Cancers (Version 2, 2020, June 9, 2020). https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf. Accessed 20 October 2020"},{"issue":"7","key":"6652_CR5","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1002\/lary.20501","volume":"119","author":"M Cianchetti","year":"2009","unstructured":"Cianchetti M, Sandow PS, Scarborough LD, Morris CG, Kirwan J, Werning JW, Mendenhall WM (2009) Radiation therapy for minor salivary gland carcinoma. Laryngoscope 119(7):1334\u20131338. https:\/\/doi.org\/10.1002\/lary.20501","journal-title":"Laryngoscope"},{"issue":"12","key":"6652_CR6","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1002\/cncr.21083","volume":"103","author":"WM Mendenhall","year":"2005","unstructured":"Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Villaret DB (2005) Radiotherapy alone or combined with surgery for salivary gland carcinoma. Cancer 103(12):2544\u20132550. https:\/\/doi.org\/10.1002\/cncr.21083","journal-title":"Cancer"},{"key":"6652_CR7","doi-asserted-by":"publisher","unstructured":"Terhaard CH, Lubsen H, Van der Tweel I, Hilgers FJ, Eijkenboom WM, Marres HA, Tjho-Heslinga RE, de Jong JM, Roodenburg JL, Dutch H, Neck Oncology Cooperative G (2004) Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head Neck 26(8):681\u2013692; discussion 692\u2013683. https:\/\/doi.org\/10.1002\/hed.10400","DOI":"10.1002\/hed.10400"},{"issue":"3","key":"6652_CR8","doi-asserted-by":"publisher","first-page":"3946","DOI":"10.18632\/oncotarget.13952","volume":"8","author":"X Wang","year":"2017","unstructured":"Wang X, Luo Y, Li M, Yan H, Sun M, Fan T (2017) Management of salivary gland carcinomas\u2014a review. Oncotarget 8(3):3946\u20133956","journal-title":"Oncotarget"},{"key":"6652_CR9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.oraloncology.2018.11.006","volume":"88","author":"MA Timoshchuk","year":"2019","unstructured":"Timoshchuk MA, Dekker P, Hippe DS, Parvathaneni U, Liao JJ, Laramore GE, Dillon JK (2019) The efficacy of neutron radiation therapy in treating salivary gland malignancies. Oral Oncol 88:51\u201357. https:\/\/doi.org\/10.1016\/j.oraloncology.2018.11.006","journal-title":"Oral Oncol"},{"issue":"2","key":"6652_CR10","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.radonc.2015.05.010","volume":"118","author":"AD Jensen","year":"2016","unstructured":"Jensen AD, Poulakis M, Nikoghosyan AV, Welzel T, Uhl M, Federspil PA, Freier K, Krauss J, Hoss A, Haberer T, Jakel O, Munter MW, Schulz-Ertner D, Huber PE, Debus J (2016) High-LET radiotherapy for adenoid cystic carcinoma of the head and neck: 15 years\u2019 experience with raster-scanned carbon ion therapy. Radiother Oncol 118(2):272\u2013280. https:\/\/doi.org\/10.1016\/j.radonc.2015.05.010","journal-title":"Radiother Oncol"},{"key":"6652_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1758-3284-4-19","volume":"4","author":"A Lagha","year":"2012","unstructured":"Lagha A, Chraiet N, Ayadi M, Krimi S, Allani B, Rifi H, Raies H, Mezlini A (2012) Systemic therapy in the management of metastatic or advanced salivary gland cancers. Head Neck Oncol 4:19. https:\/\/doi.org\/10.1186\/1758-3284-4-19","journal-title":"Head Neck Oncol"},{"key":"6652_CR12","doi-asserted-by":"crossref","unstructured":"Fayette J, Even C, Digue L, Geoffrois L, Rolland F (2019) NISCAHN: a phase II, multicenter nonrandomized trial aiming at evaluating nivolumab (N) in two cohorts of patients (pts) with recurrent\/metastatic (R\/M) salivary gland carcinoma of the head and neck (SGCHN), on behalf of the Unicancer Head & Neck Group. J Clin Oncol 37(suppl; abstr 6083)","DOI":"10.1200\/JCO.2019.37.15_suppl.6083"},{"key":"6652_CR13","doi-asserted-by":"crossref","unstructured":"Tchekmedyian V, Sherman EJ, Dunn L, Fetten JV, Michel LS, Kriplani A (2019) A phase II trial cohort of nivolumab plus ipilimumab in patients (Pts) with recurrent\/metastatic adenoid cystic carcinoma (R\/M ACC). J Clin Oncol 37(suppl; abstr 6084)","DOI":"10.1200\/JCO.2019.37.15_suppl.6084"},{"issue":"1","key":"6652_CR14","doi-asserted-by":"publisher","first-page":"12724","DOI":"10.1038\/s41598-019-49215-9","volume":"9","author":"D Vital","year":"2019","unstructured":"Vital D, Ikenberg K, Moch H, Rossle M, Huber GF (2019) The expression of PD-L1 in salivary gland carcinomas. Sci Rep 9(1):12724. https:\/\/doi.org\/10.1038\/s41598-019-49215-9","journal-title":"Sci Rep"},{"issue":"1","key":"6652_CR15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s12105-009-0102-9","volume":"3","author":"RR Seethala","year":"2009","unstructured":"Seethala RR (2009) An update on grading of salivary gland carcinomas. Head Neck Pathol 3(1):69\u201377. https:\/\/doi.org\/10.1007\/s12105-009-0102-9","journal-title":"Head Neck Pathol"},{"issue":"10","key":"6652_CR16","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1007\/s00405-016-3916-6","volume":"273","author":"M Quer","year":"2016","unstructured":"Quer M, Guntinas-Lichius O, Marchal F, Vander Poorten V, Chevalier D, Leon X, Eisele D, Dulguerov P (2016) Classification of parotidectomies: a proposal of the European Salivary Gland Society. Eur Arch Otorhinolaryngol 273(10):3307\u20133312. https:\/\/doi.org\/10.1007\/s00405-016-3916-6","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"3","key":"6652_CR17","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/s00405-016-4407-5","volume":"274","author":"D Stodulski","year":"2017","unstructured":"Stodulski D, Mikaszewski B, Majewska H, Wisniewski P, Stankiewicz C (2017) Probability and pattern of occult cervical lymph node metastases in primary parotid carcinoma. Eur Arch Otorhinolaryngol 274(3):1659\u20131664. https:\/\/doi.org\/10.1007\/s00405-016-4407-5","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"12","key":"6652_CR18","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/0895-4356(95)00048-8","volume":"48","author":"P Peduzzi","year":"1995","unstructured":"Peduzzi P, Concato J, Feinstein AR, Holford TR (1995) Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J ClinEpidemiol 48(12):1503\u20131510. https:\/\/doi.org\/10.1016\/0895-4356(95)00048-8","journal-title":"J ClinEpidemiol"},{"issue":"4","key":"6652_CR19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/brain\/66.4.237","volume":"66","author":"HJ Seddon","year":"1943","unstructured":"Seddon HJ (1943) Three types of nerve injury. Brain 66(4):237\u2013288. https:\/\/doi.org\/10.1093\/brain\/66.4.237","journal-title":"Brain"},{"issue":"4","key":"6652_CR20","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/brain\/74.4.491","volume":"74","author":"S Sunderland","year":"1951","unstructured":"Sunderland S (1951) A classification of peripheral nerve injuries producing loss of function. Brain 74(4):491\u2013516. https:\/\/doi.org\/10.1093\/brain\/74.4.491","journal-title":"Brain"},{"issue":"2","key":"6652_CR21","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1177\/019459988509300202","volume":"93","author":"JW House","year":"1985","unstructured":"House JW, Brackmann DE (1985) Facial nerve grading system. Otolaryngol Head Neck Surg 93(2):146\u2013147. https:\/\/doi.org\/10.1177\/019459988509300202","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"6652_CR22","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/s0360-3016(01)01724-2","volume":"51","author":"MR Storey","year":"2001","unstructured":"Storey MR, Garden AS, Morrison WH, Eicher SA, Schechter NR, Ang KK (2001) Postoperative radiotherapy for malignant tumors of the submandibular gland. Int J Radiat Oncol Biol Phys 51(4):952\u2013958. https:\/\/doi.org\/10.1016\/s0360-3016(01)01724-2","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"6652_CR23","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/0360-3016(90)90304-3","volume":"18","author":"CA North","year":"1990","unstructured":"North CA, Lee DJ, Piantadosi S, Zahurak M, Johns ME (1990) Carcinoma of the major salivary glands treated by surgery or surgery plus postoperative radiotherapy. Int J Radiat Oncol Biol Phys 18(6):1319\u20131326. https:\/\/doi.org\/10.1016\/0360-3016(90)90304-3","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"6652_CR24","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/hed.10380","volume":"26","author":"WM Mendenhall","year":"2004","unstructured":"Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Hinerman RW, Villaret DB (2004) Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck. Head Neck 26(2):154\u2013162. https:\/\/doi.org\/10.1002\/hed.10380","journal-title":"Head Neck"},{"issue":"10","key":"6652_CR25","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1017\/S0022215109990338","volume":"123","author":"TA Iseli","year":"2009","unstructured":"Iseli TA, Karnell LH, Graham SM, Funk GF, Buatti JM, Gupta AK, Robinson RA, Hoffman HT (2009) Role of radiotherapy in adenoid cystic carcinoma of the head and neck. J LaryngolOtol 123(10):1137\u20131144. https:\/\/doi.org\/10.1017\/S0022215109990338","journal-title":"J LaryngolOtol"},{"key":"6652_CR26","first-page":"27","volume":"23","author":"AS Jones","year":"1998","unstructured":"Jones AS, Beasley NJP, Houghton DJ (1998) Tumours of the minor salivary glands. ClinOtolaryngol 23:27\u201333","journal-title":"ClinOtolaryngol"},{"key":"6652_CR27","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06205-2","author":"M Westergaard-Nielsen","year":"2020","unstructured":"Westergaard-Nielsen M, Godballe C, Eriksen JG, Larsen SR, Kiss K, Agander T, Ulhoi BP, Charabi B, Klug TE, Jacobsen H, Johansen J, Kristensen CA, Andersen E, Andersen M, Andreasen S, Bjorndal K (2020) Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome. Eur Arch Otorhinolaryngol. https:\/\/doi.org\/10.1007\/s00405-020-06205-2","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"1","key":"6652_CR28","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1758-3284-3-40","volume":"3","author":"K Ho","year":"2011","unstructured":"Ho K, Lin H, Ann DK, Chu PG, Yen Y (2011) An overview of the rare parotid gland cancer. Head Neck Oncol 3(1):40. https:\/\/doi.org\/10.1186\/1758-3284-3-40","journal-title":"Head Neck Oncol"},{"issue":"12","key":"6652_CR29","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1002\/bjs.1800831228","volume":"83","author":"A Renehan","year":"1996","unstructured":"Renehan A, Gleave EN, Hancock BD, Smith P, McGurk M (1996) Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. Br J Surg 83(12):1750\u20131754. https:\/\/doi.org\/10.1002\/bjs.1800831228","journal-title":"Br J Surg"},{"issue":"2","key":"6652_CR30","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.oraloncology.2011.09.005","volume":"48","author":"K Bjorndal","year":"2012","unstructured":"Bjorndal K, Krogdahl A, Therkildsen MH, Overgaard J, Johansen J, Kristensen CA, Homoe P, Sorensen CH, Andersen E, Bundgaard T, Primdahl H, Lambertsen K, Andersen LJ, Godballe C (2012) Salivary gland carcinoma in Denmark 1990\u20132005: outcome and prognostic factors. Results of the Danish Head and Neck Cancer Group (DAHANCA). Oral Oncol 48(2):179\u2013185. https:\/\/doi.org\/10.1016\/j.oraloncology.2011.09.005","journal-title":"Oral Oncol"},{"issue":"7\u20138","key":"6652_CR31","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1080\/028418698430089","volume":"37","author":"MH Therkildsen","year":"1998","unstructured":"Therkildsen MH, Christensen M, Andersen LJ, Schiodt T, Hansen HS (1998) Salivary gland carcinomas\u2014prognostic factors. Acta Oncol 37(7\u20138):701\u2013713. https:\/\/doi.org\/10.1080\/028418698430089","journal-title":"Acta Oncol"},{"key":"6652_CR32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1758-3284-3-31","volume":"3","author":"AW Pederson","year":"2011","unstructured":"Pederson AW, Salama JK, Haraf DJ, Witt ME, Stenson KM, Portugal L, Seiwert T, Villaflor VM, Cohen EE, Vokes EE, Blair EA (2011) Adjuvant chemoradiotherapy for locoregionally advanced and high-risk salivary gland malignancies. Head Neck Oncol 3:31. https:\/\/doi.org\/10.1186\/1758-3284-3-31","journal-title":"Head Neck Oncol"},{"issue":"1","key":"6652_CR33","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.ijrobp.2010.09.042","volume":"82","author":"JD Schoenfeld","year":"2012","unstructured":"Schoenfeld JD, Sher DJ, Norris CM Jr, Haddad RI, Posner MR, Balboni TA, Tishler RB (2012) Salivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or without concurrent chemotherapy. Int J Radiat Oncol Biol Phys 82(1):308\u2013314. https:\/\/doi.org\/10.1016\/j.ijrobp.2010.09.042","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"6652_CR34","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13014-016-0617-7","volume":"11","author":"CE Hsieh","year":"2016","unstructured":"Hsieh CE, Lin CY, Lee LY, Yang LY, Wang CC, Wang HM, Chang JT, Fan KH, Liao CT, Yen TC, Fang KH, Tsang YM (2016) Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but not overall survival in patients with salivary gland adenoid cystic carcinoma-a propensity score matched study. Radiat Oncol 11:47. https:\/\/doi.org\/10.1186\/s13014-016-0617-7","journal-title":"Radiat Oncol"},{"issue":"6","key":"6652_CR35","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/hed.24172","volume":"38","author":"T Tanvetyanon","year":"2016","unstructured":"Tanvetyanon T, Fisher K, Caudell J, Otto K, Padhya T, Trotti A (2016) Adjuvant chemoradiotherapy versus with radiotherapy alone for locally advanced salivary gland carcinoma among older patients. Head Neck 38(6):863\u2013870. https:\/\/doi.org\/10.1002\/hed.24172","journal-title":"Head Neck"},{"issue":"3","key":"6652_CR36","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/hed.2890080309","volume":"8","author":"RH Spiro","year":"1986","unstructured":"Spiro RH (1986) Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 8(3):177\u2013184. https:\/\/doi.org\/10.1002\/hed.2890080309","journal-title":"Head Neck Surg"},{"issue":"3","key":"6652_CR37","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1001\/archotol.1989.01860270058015","volume":"115","author":"RH Spiro","year":"1989","unstructured":"Spiro RH, Armstrong J, Harrison L, Geller NL, Lin SY, Strong EW (1989) Carcinoma of major salivary glands. Recent trends. Arch Otolaryngol Head Neck Surg 115(3):316\u2013321. https:\/\/doi.org\/10.1001\/archotol.1989.01860270058015","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"3","key":"6652_CR38","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1001\/archotol.1990.01870030054008","volume":"116","author":"JG Armstrong","year":"1990","unstructured":"Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY (1990) Malignant tumors of major salivary gland origin. A matched-pair analysis of the role of combined surgery and postoperative radiotherapy. Arch Otolaryngol Head Neck Surg 116(3):290\u2013293. https:\/\/doi.org\/10.1001\/archotol.1990.01870030054008","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"6","key":"6652_CR39","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1002\/1097-0142(197712)40:6<2882::AID-CNCR2820400618>3.0.CO;2-I","volume":"40","author":"KK Fu","year":"1977","unstructured":"Fu KK, Leibel SA, Levine ML, Friedlander LM, Boles R, Phillips TL (1977) Carcinoma of the major and minor salivary glands: analysis of treatment results and sites and causes of failures. Cancer 40(6):2882\u20132890. https:\/\/doi.org\/10.1002\/1097-0142(197712)40:6%3c2882::AID-CNCR2820400618%3e3.0.CO;2-I","journal-title":"Cancer"},{"issue":"10","key":"6652_CR40","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1016\/0360-3016(86)90314-7","volume":"12","author":"PJ Fitzpatrick","year":"1986","unstructured":"Fitzpatrick PJ, Theriault C (1986) Malignant salivary gland tumors. Int J Radiat Oncol Biol Phys 12(10):1743\u20131747. https:\/\/doi.org\/10.1016\/0360-3016(86)90314-7","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"6652_CR41","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/0360-3016(86)90032-5","volume":"12","author":"A Borthne","year":"1986","unstructured":"Borthne A, Kjellevold K, Kaalhus O, Vermund H (1986) Salivary gland malignant neoplasms: treatment and prognosis. Int J Radiat Oncol Biol Phys 12(5):747\u2013754. https:\/\/doi.org\/10.1016\/0360-3016(86)90032-5","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"6652_CR42","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1002\/(sici)1097-0142(19990515)85:10<2255::aid-cncr22>3.3.co;2-4","volume":"85","author":"VL Vander Poorten","year":"1999","unstructured":"Vander Poorten VL, Balm AJ, Hilgers FJ, Tan IB, Loftus-Coll BM, Keus RB, Hart AA (1999) Prognostic factors for long term results of the treatment of patients with malignant submandibular gland tumors. Cancer 85(10):2255\u20132264. https:\/\/doi.org\/10.1002\/(sici)1097-0142(19990515)85:10%3c2255::aid-cncr22%3e3.3.co;2-4","journal-title":"Cancer"},{"issue":"2","key":"6652_CR43","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.ijom.2019.03.963","volume":"49","author":"TM Croonenborghs","year":"2020","unstructured":"Croonenborghs TM, Van Hevele J, Scheerlinck J, Nout E, Schoenaers J, Politis C (2020) A multicentre retrospective clinico-histopathological review of 250 patients after parotidectomy. Int J Oral MaxillofacSurg 49(2):149\u2013156. https:\/\/doi.org\/10.1016\/j.ijom.2019.03.963","journal-title":"Int J Oral MaxillofacSurg"},{"issue":"3","key":"6652_CR44","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jcms.2007.02.003","volume":"35","author":"O Zernial","year":"2007","unstructured":"Zernial O, Springer IN, Warnke P, Harle F, Risick C, Wiltfang J (2007) Long-term recurrence rate of pleomorphic adenoma and postoperative facial nerve paresis (in parotid surgery). J CraniomaxillofacSurg 35(3):189\u2013192. https:\/\/doi.org\/10.1016\/j.jcms.2007.02.003","journal-title":"J CraniomaxillofacSurg"},{"issue":"7","key":"6652_CR45","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.joms.2005.03.006","volume":"63","author":"RB Bell","year":"2005","unstructured":"Bell RB, Dierks EJ, Homer L, Potter BE (2005) Management and outcome of patients with malignant salivary gland tumors. J Oral MaxillofacSurg 63(7):917\u2013928. https:\/\/doi.org\/10.1016\/j.joms.2005.03.006","journal-title":"J Oral MaxillofacSurg"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-021-06652-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-021-06652-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-021-06652-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T05:29:58Z","timestamp":1633066198000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-021-06652-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["6652"],"URL":"https:\/\/doi.org\/10.1007\/s00405-021-06652-5","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,24]]},"assertion":[{"value":"7 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This retrospective analysis was approved by the institutional ethics board of the University Hospital Frankfurt, Germany (No. 30\/17).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}