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Univariate and multivariate statistical analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ISSNHL was diagnosed in 490 patients (85%), NISSNHL in 84 patients (15%). 49% of these cases had hearing loss due to acute otitis media, 37% through varicella-zoster infection or Lyme disease, 10% through Meni\u00e8re disease and 7% due to other reasons. Patients with ISSNHL and NISSNHL showed no difference between age, gender, side of hearing loss, presence of tinnitus or vertigo and their comorbidities. 45% of patients with ISSNHL and 62% with NISSNHL had an outpatient treatment prior to inpatient treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The mean interval between onset of hearing loss to inpatient treatment was shorter in ISSNHL (7.7\u00a0days) than in NISSNHL (8.9\u00a0days;<jats:italic>p<\/jats:italic>\u2009=\u20090.02). The initial hearing loss of the three most affected frequencies in pure-tone average (3PTAmax) scaled 72.9 dBHL\u2009\u00b1\u200931.3 dBHL in ISSNHL and 67.4 dBHL\u2009\u00b1\u200930.5 dBHL in NISSNHL. In the case of acute otitis media, 3PTAmax (59.7 dBHL\u2009\u00b1\u200924.6 dBHL) was lower than in the case of varicella-zoster infection or Lyme disease (80.11 dBHL\u2009\u00b1\u200934.19 dBHL;<jats:italic>p<\/jats:italic>\u2009=\u20090.015). Mean absolute hearing gain (\u03943PTAmax<jats:sub>abs<\/jats:sub>) was 8.1\u00a0dB\u2009\u00b1\u200918.8\u00a0dB in patients with ISSNHL, and not different in NISSNHL patients with 10.2\u00a0dB\u2009\u00b1\u200917.6\u00a0dB. A \u03943PTAmax<jats:sub>abs<\/jats:sub>\u2009\u2265\u200910\u00a0dB was reached\u00a0in 34.3% of the patients with ISSNHL and to a significantly higher rate of 48.8% in NISSNHL patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ISSNHL and NISSNHL show no relevant baseline differences. ISSNHL tends to have a higher initial hearing loss. NISSHNL shows a better outcome than ISSNHL.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00405-021-06691-y","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T10:03:56Z","timestamp":1615197836000},"page":"663-675","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Patients with non-idiopathic sudden sensorineural hearing loss show hearing improvement more often than patients with idiopathic sudden sensorineural hearing loss"],"prefix":"10.1007","volume":"279","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-0111","authenticated-orcid":false,"given":"Jovanna","family":"Thielker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Heuschkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Boeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Buentzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Esser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Radtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Guntinas-Lichius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"issue":"8","key":"6691_CR1","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1097\/MAO.0b013e3182a1e925","volume":"34","author":"CS Wu","year":"2013","unstructured":"Wu CS et al (2013) Sudden sensorineural hearing loss associated with chronic periodontitis: a population-based study. 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