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Thirty patients planned for TL were randomized in two groups. For the ND part, forty-two operative sides were likewise randomized. In both parts, Thunderbeat was used in addition to the standard instrumentation in the intervention groups, while only standard instrumentation was used in the control groups. Primary outcome values were blood loss, operative time and complication rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the TL part there was no difference in mean blood loss (<jats:italic>p<\/jats:italic>\u2009=\u20090.062), operative time (<jats:italic>p<\/jats:italic>\u2009=\u20090.512) and complications (<jats:italic>p<\/jats:italic>\u2009=\u20090.662) between both hemostatic techniques. For the neck dissection part, there was a reduction in blood loss (mean 210\u00a0mL versus 431\u00a0mL,<jats:italic>p<\/jats:italic>\u2009=\u20090.046) and in operative time (median 101 (IQR 85\u2013130) minutes versus 150 (IQR 130\u2013199) minutes,<jats:italic>p<\/jats:italic>\u2009=\u20090.014) when Thunderbeat was used. There was no difference in complication rate between both hemostatic systems (<jats:italic>p<\/jats:italic>\u2009=\u20090.261).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Thunderbeat hemostatic device significantly reduces operative blood loss and operative time for neck dissections, without increase in complications. In TL, blood loss using Thunderbeat was comparable with the standard technique, but the operative time tended to be shorter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>UMCG Research Register, Reg. no. 201700041, date of registration: 18\/1\/2017<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00405-021-06739-z","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T10:58:40Z","timestamp":1616151520000},"page":"4987-4996","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A comparison of the Thunderbeat and standard electrocautery devices in head and neck surgery: a prospective randomized controlled trial"],"prefix":"10.1007","volume":"278","author":[{"given":"N. C.","family":"Kuipers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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E. C. Plaat has a consultancy role for and has received research funding by Olympus Europa SE and CO. KG for a different research project. Other authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was checked by the Institutional Review Board of the University Medical Center Groningen (UMCG) and a waiver was released. The study was performed in accordance with Good Clinical Practice principles and the Consolidated Standards of Reporting Trials (CONSORT) statement.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors are aware of the content of the manuscript and agree publishing it.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}